JP5763758B2 - Ｋｖ７カリウムチャネル開口薬としてのピペリジニルピリミジンアミド - Google Patents
Ｋｖ７カリウムチャネル開口薬としてのピペリジニルピリミジンアミド Download PDFInfo
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- JP5763758B2 JP5763758B2 JP2013517611A JP2013517611A JP5763758B2 JP 5763758 B2 JP5763758 B2 JP 5763758B2 JP 2013517611 A JP2013517611 A JP 2013517611A JP 2013517611 A JP2013517611 A JP 2013517611A JP 5763758 B2 JP5763758 B2 JP 5763758B2
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36250510P | 2010-07-08 | 2010-07-08 | |
| US61/362,505 | 2010-07-08 | ||
| PCT/IB2011/052686 WO2012004698A1 (en) | 2010-07-08 | 2011-06-20 | Piperidinyl pyrimidine amides as kv7 potassium channel openers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531006A JP2013531006A (ja) | 2013-08-01 |
| JP2013531006A5 JP2013531006A5 (https=) | 2014-06-05 |
| JP5763758B2 true JP5763758B2 (ja) | 2015-08-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2013517611A Expired - Fee Related JP5763758B2 (ja) | 2010-07-08 | 2011-06-20 | Ｋｖ７カリウムチャネル開口薬としてのピペリジニルピリミジンアミド |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8883812B2 (https=) |
| EP (1) | EP2590961A1 (https=) |
| JP (1) | JP5763758B2 (https=) |
| KR (1) | KR101449348B1 (https=) |
| CN (1) | CN102971307A (https=) |
| AU (1) | AU2011275393B2 (https=) |
| CA (1) | CA2804165C (https=) |
| MX (1) | MX2013000138A (https=) |
| SG (1) | SG186409A1 (https=) |
| WO (1) | WO2012004698A1 (https=) |
| ZA (1) | ZA201300499B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013067591A1 (en) * | 2011-11-10 | 2013-05-16 | Relevare Australia Pty Ltd | Topical formulations for pain management |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| WO2014145852A2 (en) | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
| SMT202300362T1 (it) * | 2014-09-12 | 2023-11-13 | Biohaven Therapeutics Ltd | Benzoimidazol-1,2-il-ammidi come attivatori di canale kv7 |
| EP4241843B1 (en) * | 2018-02-20 | 2025-05-21 | H. Lundbeck A/S | Alcohol derivatives as kv7 potassium channel openers |
| SG11202008030WA (en) | 2018-03-19 | 2020-10-29 | Knopp Biosciences Llc | Kv7 channel activators compositions and methods of use |
| AR119521A1 (es) * | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| BR112022004847A2 (pt) * | 2019-09-17 | 2022-06-07 | Knopp Biosciences Llc | Método para tratar uma doença ou distúrbio de neurodesenvolvimento |
| WO2021119018A1 (en) * | 2019-12-09 | 2021-06-17 | The Board Of Trustees Of The Leland Stanford Junior University | A method to improve sleep quality in the elderly by controlling excitability of hypocretin neurons |
| WO2021211867A1 (en) * | 2020-04-16 | 2021-10-21 | Attune Neurosciences, Inc. | Kv7 modulators for treating sleep or anxiety disorders |
| BR112023003624A2 (pt) * | 2020-08-28 | 2023-03-28 | Pfizer | Ferramenta de suporte à decisão computadorizada e dispositivo médico para monitoramento e cuidado de condição respiratória |
| GB202306914D0 (en) * | 2023-05-10 | 2023-06-21 | Sania Rx Ltd | Method |
| CN119661413B (zh) * | 2024-12-28 | 2025-06-24 | 齐鲁医药学院 | Kv7钾离子通道开放剂及其制备方法和应用 |
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| CZ20032233A3 (cs) * | 2001-02-20 | 2004-12-15 | Bristol-Myers Squibb Company | Derivát 2,4-disubstituovaného pyrimidin-5-karboxamidu jako modulátor draslíkového kanálku KCNQ |
| TWI349666B (en) | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
| US7091202B2 (en) * | 2004-09-15 | 2006-08-15 | Bristol-Myers Squibb Company | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators |
| US20080261918A1 (en) | 2004-12-17 | 2008-10-23 | Graham Andrew Showell | Silicon Compounds and Their Use |
| US7322249B2 (en) | 2005-07-07 | 2008-01-29 | Delphi Technologies, Inc. | Mounting for a probe sensor |
| US7683058B2 (en) * | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
| KR20080043314A (ko) * | 2005-09-09 | 2008-05-16 | 하. 룬트벡 아크티에 셀스카브 | 피리미딘 유도체 및 ｋｃｎｑ 포타슘 채널 개방제로서의그의 용도 |
| TWI453013B (zh) | 2006-02-07 | 2014-09-21 | Lundbeck & Co As H | N-(2,4-二甲基-6-嗎啉-4-基-吡啶-3-基〉3,3-二甲基-丁醯胺之用途以及包含該化合物之醫藥品 |
| SG174095A1 (en) * | 2006-08-23 | 2011-09-29 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| AR070513A1 (es) | 2007-08-01 | 2010-04-14 | Lundbeck & Co As H | Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sis-tema dopaminergico como por ejemplo esquizofrenia y trastorno depresivo mayor |
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- 2011-06-20 WO PCT/IB2011/052686 patent/WO2012004698A1/en not_active Ceased
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| ZA201300499B (en) | 2013-09-25 |
| KR101449348B1 (ko) | 2014-10-08 |
| CA2804165C (en) | 2015-02-24 |
| AU2011275393B2 (en) | 2014-04-10 |
| US8883812B2 (en) | 2014-11-11 |
| SG186409A1 (en) | 2013-02-28 |
| US20130150391A1 (en) | 2013-06-13 |
| KR20130031323A (ko) | 2013-03-28 |
| WO2012004698A1 (en) | 2012-01-12 |
| EP2590961A1 (en) | 2013-05-15 |
| MX2013000138A (es) | 2013-03-05 |
| AU2011275393A1 (en) | 2013-01-10 |
| JP2013531006A (ja) | 2013-08-01 |
| CA2804165A1 (en) | 2012-01-12 |
| CN102971307A (zh) | 2013-03-13 |
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