JP5756751B2 - 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 - Google Patents

非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 Download PDF

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JP5756751B2
JP5756751B2 JP2011516724A JP2011516724A JP5756751B2 JP 5756751 B2 JP5756751 B2 JP 5756751B2 JP 2011516724 A JP2011516724 A JP 2011516724A JP 2011516724 A JP2011516724 A JP 2011516724A JP 5756751 B2 JP5756751 B2 JP 5756751B2
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polypeptide
composition
glyrs
cell
seq
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JP2011526153A5 (enExample
JP2011526153A (ja
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レスリー アン グリーン，
レスリー アン グリーン，
ライアン アンドリュー アダムス，
ライアン アンドリュー アダムス，
フェイ ホン，
フェイ ホン，
チャオ，　チー
チー チャオ，
エバ レベッカ ステファニー アームアー，
エバ レベッカ ステファニー アームアー，
クリスティ ヘレン ピエール，
クリスティ ヘレン ピエール，
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エータイアー ファーマ， インコーポレイテッド
エータイアー ファーマ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/53—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
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    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01014—Glycine-tRNA ligase (6.1.1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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JP2011516724A 2008-06-26 2009-06-26 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 Active JP5756751B2 (ja)

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US7609808P 2008-06-26 2008-06-26
US61/076,098 2008-06-26
US9554808P 2008-09-09 2008-09-09
US61/095,548 2008-09-09
PCT/US2009/048915 WO2009158649A1 (en) 2008-06-26 2009-06-26 Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities

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JP2015042000A Division JP6025889B2 (ja) 2008-06-26 2015-03-04 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法

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JP2011526153A JP2011526153A (ja) 2011-10-06
JP2011526153A5 JP2011526153A5 (enExample) 2012-08-02
JP5756751B2 true JP5756751B2 (ja) 2015-07-29

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JP2015042000A Active JP6025889B2 (ja) 2008-06-26 2015-03-04 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法
JP2016104002A Withdrawn JP2016154561A (ja) 2008-06-26 2016-05-25 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法

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JP2016104002A Withdrawn JP2016154561A (ja) 2008-06-26 2016-05-25 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法

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US (5) US8404471B2 (enExample)
EP (2) EP3176261A1 (enExample)
JP (3) JP5756751B2 (enExample)
CN (2) CN102159708B (enExample)
WO (1) WO2009158649A1 (enExample)

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CN106434576A (zh) 2017-02-22
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US20130236455A1 (en) 2013-09-12
US20170296635A1 (en) 2017-10-19
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US20160114016A1 (en) 2016-04-28
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