JP2011526153A5 - - Google Patents
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- Publication number
- JP2011526153A5 JP2011526153A5 JP2011516724A JP2011516724A JP2011526153A5 JP 2011526153 A5 JP2011526153 A5 JP 2011526153A5 JP 2011516724 A JP2011516724 A JP 2011516724A JP 2011516724 A JP2011516724 A JP 2011516724A JP 2011526153 A5 JP2011526153 A5 JP 2011526153A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- regulation
- glycyl
- trna synthetase
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 48
- 229920001184 polypeptide Polymers 0.000 claims description 47
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 47
- 239000000203 mixture Substances 0.000 claims description 23
- 108010051724 Glycine-tRNA Ligase Proteins 0.000 claims description 22
- 102000019220 Glycyl-tRNA synthetases Human genes 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 16
- 230000000694 effects Effects 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 14
- 230000033228 biological regulation Effects 0.000 claims description 12
- 230000005754 cellular signaling Effects 0.000 claims description 12
- 230000001404 mediated effect Effects 0.000 claims description 12
- 108091033319 polynucleotide Proteins 0.000 claims description 11
- 102000040430 polynucleotide Human genes 0.000 claims description 11
- 239000002157 polynucleotide Substances 0.000 claims description 11
- 230000004071 biological effect Effects 0.000 claims description 8
- 230000009134 cell regulation Effects 0.000 claims description 8
- 230000001413 cellular effect Effects 0.000 claims description 7
- 238000012216 screening Methods 0.000 claims description 7
- 101001072736 Homo sapiens Glycine-tRNA ligase Proteins 0.000 claims description 6
- -1 IL1-β Proteins 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 239000013604 expression vector Substances 0.000 claims description 6
- 108020001507 fusion proteins Proteins 0.000 claims description 6
- 102000037865 fusion proteins Human genes 0.000 claims description 6
- 239000011541 reaction mixture Substances 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 239000012636 effector Substances 0.000 claims description 5
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical group OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 4
- 101001027327 Bos taurus Growth-regulated protein homolog alpha Proteins 0.000 claims description 4
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims description 4
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims description 4
- 102000001326 Chemokine CCL4 Human genes 0.000 claims description 4
- 108010055165 Chemokine CCL4 Proteins 0.000 claims description 4
- 102000016950 Chemokine CXCL1 Human genes 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 4
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 4
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 4
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims description 4
- 108090000174 Interleukin-10 Proteins 0.000 claims description 4
- 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 claims description 4
- 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 claims description 4
- 108090001005 Interleukin-6 Proteins 0.000 claims description 4
- 108090001007 Interleukin-8 Proteins 0.000 claims description 4
- 101150018665 MAPK3 gene Proteins 0.000 claims description 4
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 4
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 230000016396 cytokine production Effects 0.000 claims description 4
- 102000009634 interleukin-1 receptor antagonist activity proteins Human genes 0.000 claims description 4
- 108040001669 interleukin-1 receptor antagonist activity proteins Proteins 0.000 claims description 4
- 230000025915 regulation of apoptotic process Effects 0.000 claims description 4
- 230000007980 regulation of cell activation Effects 0.000 claims description 4
- 230000012760 regulation of cell migration Effects 0.000 claims description 4
- 230000024833 regulation of cytokine production Effects 0.000 claims description 4
- 230000011664 signaling Effects 0.000 claims description 4
- 102100036589 Glycine-tRNA ligase Human genes 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 3
- 230000025053 regulation of cell proliferation Effects 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 208000012902 Nervous system disease Diseases 0.000 claims description 2
- 208000025966 Neurological disease Diseases 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 230000033115 angiogenesis Effects 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims description 2
- 230000004927 fusion Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 230000002452 interceptive effect Effects 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 230000001613 neoplastic effect Effects 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 description 3
- 239000000556 agonist Substances 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229940126062 Compound A Drugs 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7609808P | 2008-06-26 | 2008-06-26 | |
| US61/076,098 | 2008-06-26 | ||
| US9554808P | 2008-09-09 | 2008-09-09 | |
| US61/095,548 | 2008-09-09 | ||
| PCT/US2009/048915 WO2009158649A1 (en) | 2008-06-26 | 2009-06-26 | Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015042000A Division JP6025889B2 (ja) | 2008-06-26 | 2015-03-04 | 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011526153A JP2011526153A (ja) | 2011-10-06 |
| JP2011526153A5 true JP2011526153A5 (enExample) | 2012-08-02 |
| JP5756751B2 JP5756751B2 (ja) | 2015-07-29 |
Family
ID=41136705
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516724A Active JP5756751B2 (ja) | 2008-06-26 | 2009-06-26 | 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 |
| JP2015042000A Active JP6025889B2 (ja) | 2008-06-26 | 2015-03-04 | 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 |
| JP2016104002A Withdrawn JP2016154561A (ja) | 2008-06-26 | 2016-05-25 | 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015042000A Active JP6025889B2 (ja) | 2008-06-26 | 2015-03-04 | 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 |
| JP2016104002A Withdrawn JP2016154561A (ja) | 2008-06-26 | 2016-05-25 | 非正準的な生物学的活性を有するグリシル−ｔＲＮＡ合成酵素を含む組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US8404471B2 (enExample) |
| EP (2) | EP2310498A1 (enExample) |
| JP (3) | JP5756751B2 (enExample) |
| CN (2) | CN106434576A (enExample) |
| WO (1) | WO2009158649A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105164A (zh) | 2008-06-11 | 2011-06-22 | Atyr医药公司 | 酪氨酰-trna合成酶多肽的血小板生成活性 |
| EP2310498A1 (en) | 2008-06-26 | 2011-04-20 | Atyr Pharma, Inc. | Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities |
| KR101102485B1 (ko) * | 2008-10-10 | 2012-01-05 | 서울대학교산학협력단 | Ｇｒｓ단백질 또는 이의 단편의 신규한 용도 |
| ES2552773T3 (es) | 2009-02-27 | 2015-12-02 | Atyr Pharma, Inc. | Motivos estructurales de polipéptidos asociados con la actividad de señalización celular |
| JP5730280B2 (ja) | 2009-03-16 | 2015-06-03 | パング バイオファーマ リミテッド | 非カノニカル生物学的活性を有するヒスチジル−ｔＲＮＡシンテターゼスプライスバリアントを含む組成物および方法 |
| WO2010120509A2 (en) * | 2009-03-31 | 2010-10-21 | Atyr Pharma, Inc. | Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities |
| US20110150885A1 (en) * | 2009-12-11 | 2011-06-23 | Atyr Pharma, Inc. | Aminoacyl trna synthetases for modulating hematopoiesis |
| ES2535951T3 (es) | 2009-12-11 | 2015-05-19 | Atyr Pharma, Inc. | Histidil ARNt sintetasas para reducir la inflamación |
| US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
| CA2797093C (en) | 2010-04-26 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| CA2797362C (en) | 2010-04-27 | 2020-12-08 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
| CA2797259C (en) * | 2010-04-27 | 2020-09-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases |
| WO2011139853A2 (en) | 2010-04-28 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
| EP2563383B1 (en) | 2010-04-29 | 2017-03-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
| US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
| WO2011139986A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
| CA2797977C (en) | 2010-05-03 | 2019-08-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
| CN103140233B (zh) | 2010-05-03 | 2017-04-05 | Atyr 医药公司 | 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| AU2011248357B2 (en) | 2010-05-03 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases |
| EP2566499B1 (en) | 2010-05-04 | 2017-01-25 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
| US9062301B2 (en) | 2010-05-04 | 2015-06-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
| CA2799197C (en) | 2010-05-14 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
| US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
| EP2571513B1 (en) * | 2010-05-17 | 2016-09-07 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
| AU2011258106B2 (en) | 2010-05-27 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
| CN103118694B (zh) | 2010-06-01 | 2016-08-03 | Atyr医药公司 | 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| CA2804278C (en) * | 2010-07-12 | 2021-07-13 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| EP2593126B1 (en) * | 2010-07-12 | 2017-09-20 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| JP6116479B2 (ja) | 2010-07-12 | 2017-04-19 | エータイアー ファーマ， インコーポレイテッド | グリシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP5964304B2 (ja) | 2010-08-25 | 2016-08-03 | エータイアー ファーマ， インコーポレイテッド | チロシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CA2812795C (en) | 2010-10-06 | 2021-08-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| US20160144003A1 (en) * | 2011-05-19 | 2016-05-26 | The Scripps Research Institute | Compositions and methods for treating charcot-marie-tooth diseases and related neuronal diseases |
| WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
| KR101398079B1 (ko) * | 2011-10-10 | 2014-05-27 | 재단법인 의약바이오컨버젼스연구단 | 글리실-티알엔에이 합성효소 및 캐드헤린을 이용한 암 예방 또는 치료제의 스크리닝 방법 |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| CN104220461A (zh) | 2011-12-29 | 2014-12-17 | Atyr医药公司 | 天冬氨酰-tRNA合成酶-FC缀合物 |
| EP2814514B1 (en) | 2012-02-16 | 2017-09-13 | Atyr Pharma, Inc. | Histidyl-trna synthetases for treating autoimmune and inflammatory diseases |
| CN114717206A (zh) | 2013-03-15 | 2022-07-08 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
| WO2015038853A1 (en) * | 2013-09-12 | 2015-03-19 | Lanzatech New Zealand Limited | Recombinant microorganisms and methods of use thereof |
| KR101771068B1 (ko) * | 2015-07-14 | 2017-08-24 | 재단법인 의약바이오컨버젼스연구단 | 케모카인 활성을 가지는 신규한 폴리펩타이드 |
| EP3362086A1 (en) * | 2015-10-14 | 2018-08-22 | The Scripps Research Institute | INHIBITION OF NEDDYLATION USING GLYCYL-tRNA SYNTHETASE INHIBITORS |
| ES2994451T3 (en) | 2017-04-20 | 2025-01-24 | Atyr Pharma Inc | Compositions for treating lung inflammation |
| KR102167755B1 (ko) * | 2018-05-23 | 2020-10-19 | 주식회사 큐어바이오 | 단편화된 grs 폴리펩타이드, 이의 변이체 및 이들의 용도 |
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-
2009
- 2009-06-26 EP EP09771180A patent/EP2310498A1/en not_active Withdrawn
- 2009-06-26 US US12/492,925 patent/US8404471B2/en active Active
- 2009-06-26 JP JP2011516724A patent/JP5756751B2/ja active Active
- 2009-06-26 WO PCT/US2009/048915 patent/WO2009158649A1/en not_active Ceased
- 2009-06-26 EP EP16183399.1A patent/EP3176261A1/en not_active Withdrawn
- 2009-06-26 CN CN201610829018.1A patent/CN106434576A/zh active Pending
- 2009-06-26 CN CN200980132761.XA patent/CN102159708B/zh active Active
-
2013
- 2013-01-29 US US13/753,272 patent/US8747840B2/en active Active
-
2014
- 2014-04-25 US US14/262,247 patent/US9157076B2/en active Active
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2015
- 2015-03-04 JP JP2015042000A patent/JP6025889B2/ja active Active
- 2015-09-03 US US14/844,666 patent/US9585946B2/en active Active
-
2016
- 2016-05-25 JP JP2016104002A patent/JP2016154561A/ja not_active Withdrawn
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2017
- 2017-01-25 US US15/415,328 patent/US20170296635A1/en not_active Abandoned
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