JP5749651B2 - 多形核細胞の動員および/または遊走を減少させる化合物および方法 - Google Patents

多形核細胞の動員および/または遊走を減少させる化合物および方法 Download PDF

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JP5749651B2
JP5749651B2 JP2011535537A JP2011535537A JP5749651B2 JP 5749651 B2 JP5749651 B2 JP 5749651B2 JP 2011535537 A JP2011535537 A JP 2011535537A JP 2011535537 A JP2011535537 A JP 2011535537A JP 5749651 B2 JP5749651 B2 JP 5749651B2
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oligonucleotide
seq
cells
pmn
idx9059
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JP2012507307A5 (cg-RX-API-DMAC7.html
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アドミレ,シャーロット
アクセルッソン,ラース−ゴエラン
ヴォン,ステイン・オリバー
ザルガリ,アレゾウ
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インデックス・ファーマシューティカルズ・アクチエボラーグ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/17Immunomodulatory nucleic acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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JP2011535537A 2008-11-04 2009-10-28 多形核細胞の動員および/または遊走を減少させる化合物および方法 Expired - Fee Related JP5749651B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11128408P 2008-11-04 2008-11-04
SE0802338 2008-11-04
SE0802338-4 2008-11-04
US61/111,284 2008-11-04
PCT/SE2009/051227 WO2010053430A1 (en) 2008-11-04 2009-10-28 Compounds and methods for reducing the recruitment and/or migration of polymorphonuclear cells

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JP2012507307A JP2012507307A (ja) 2012-03-29
JP2012507307A5 JP2012507307A5 (cg-RX-API-DMAC7.html) 2012-11-29
JP5749651B2 true JP5749651B2 (ja) 2015-07-15

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US (2) US8877724B2 (cg-RX-API-DMAC7.html)
EP (2) EP2806028B1 (cg-RX-API-DMAC7.html)
JP (1) JP5749651B2 (cg-RX-API-DMAC7.html)
AU (1) AU2009311748B2 (cg-RX-API-DMAC7.html)
CA (1) CA2778938C (cg-RX-API-DMAC7.html)
DK (2) DK2806028T3 (cg-RX-API-DMAC7.html)
ES (2) ES2464731T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20171360T1 (cg-RX-API-DMAC7.html)
LT (1) LT2806028T (cg-RX-API-DMAC7.html)
PL (1) PL2806028T3 (cg-RX-API-DMAC7.html)
WO (1) WO2010053430A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2350283T3 (en) * 2008-11-04 2016-02-01 Index Pharmaceuticals Ab RELATIONS AND PROCEDURES FOR THE TREATMENT OF INFLAMMATORY DISEASES IN THE CENTRAL NERVOUS SYSTEM
WO2012084996A2 (en) 2010-12-21 2012-06-28 Index Pharmaceuticals Ab Methods for identifying biologically active oligonucleotides capable of modulating the immune system
EP2468867A1 (en) 2010-12-21 2012-06-27 Index Pharmaceuticals AB Methods for identifying biologically active oligonucleotides capable of modulating the immune system
EP2468866A1 (en) 2010-12-21 2012-06-27 Index Pharmaceuticals AB Biologically active oligonucleotides capable of modulating the immune system
WO2012084991A1 (en) 2010-12-21 2012-06-28 Index Pharmaceuticals Ab Biologically active oligonucleotides capable of modulating the immune system ii
US9873878B2 (en) * 2015-03-30 2018-01-23 University Of Louisville Research Foundation, Inc. Compositions and methods for use in treating silicosis and lung cancer
EP3548005A4 (en) 2016-11-29 2020-06-17 Puretech Health LLC Exosomes for delivery of therapeutic agents
JP2021131228A (ja) * 2018-04-27 2021-09-09 国立大学法人 東京大学 難治性喘息の予防又は治療剤をスクリーニングする方法、及び難治性喘息の予防又は治療剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6172208B1 (en) * 1992-07-06 2001-01-09 Genzyme Corporation Oligonucleotides modified with conjugate groups
SE9602300D0 (sv) * 1996-06-11 1996-06-11 Karolinska Innovations Ab New composition and methods
PT1163204E (pt) 1999-03-18 2005-11-30 Brigham & Womens Hospital Compostos a base de lipoxina e sua utilizacao
US6489311B1 (en) * 2000-05-02 2002-12-03 Charlotte-Mecklenburg Hospital Authoirty Method for the prevention of apoptosis
JP2006527741A (ja) * 2003-06-19 2006-12-07 シーティーティー キャンサー ターゲッティング テクノロジーズ オイ 細胞遊走の阻害剤
SE0400399D0 (sv) * 2004-02-20 2004-02-20 Index Pharmaceuticals Ab Methods and compositions for the treatment or prevention of secondary ischemic injury
EP1940419A2 (en) 2005-09-09 2008-07-09 Oregon Health and Science University Neuroprotectants
WO2007030580A2 (en) 2005-09-09 2007-03-15 Oregon Health & Science University Neuroprotectants
DK2573176T3 (en) 2007-05-04 2016-08-01 Index Pharmaceuticals Ab Tumor growth retardant compounds and methods of use thereof
DK2350283T3 (en) 2008-11-04 2016-02-01 Index Pharmaceuticals Ab RELATIONS AND PROCEDURES FOR THE TREATMENT OF INFLAMMATORY DISEASES IN THE CENTRAL NERVOUS SYSTEM
US20110280934A1 (en) 2008-11-04 2011-11-17 Asa Karlsson Increased Expression of Specific Antigens

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Publication number Publication date
US20150099799A1 (en) 2015-04-09
WO2010053430A1 (en) 2010-05-14
JP2012507307A (ja) 2012-03-29
US10046006B2 (en) 2018-08-14
EP2342341B1 (en) 2014-03-05
DK2342341T3 (da) 2014-05-12
US8877724B2 (en) 2014-11-04
HRP20171360T1 (hr) 2017-11-03
ES2464731T3 (es) 2014-06-03
AU2009311748A1 (en) 2010-05-14
LT2806028T (lt) 2017-12-11
CA2778938C (en) 2019-07-02
US20110301225A1 (en) 2011-12-08
CA2778938A1 (en) 2010-05-14
AU2009311748B2 (en) 2014-08-21
PL2806028T3 (pl) 2017-11-30
EP2342341A1 (en) 2011-07-13
EP2806028A3 (en) 2015-03-11
DK2806028T3 (en) 2017-10-09
ES2641751T3 (es) 2017-11-13
EP2342341A4 (en) 2013-01-09
EP2806028B1 (en) 2017-07-12
EP2806028A2 (en) 2014-11-26

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