JP5732603B2 - 骨標的アルカリホスファターゼ、キット及びその使用方法 - Google Patents

骨標的アルカリホスファターゼ、キット及びその使用方法 Download PDF

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JP5732603B2
JP5732603B2 JP2010507770A JP2010507770A JP5732603B2 JP 5732603 B2 JP5732603 B2 JP 5732603B2 JP 2010507770 A JP2010507770 A JP 2010507770A JP 2010507770 A JP2010507770 A JP 2010507770A JP 5732603 B2 JP5732603 B2 JP 5732603B2
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alkaline phosphatase
amino acid
sequence
seq
residue
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JP2010526543A (ja
JP2010526543A5 (show.php
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クライン、フィリップ
ボアロー、ガイ
ロワゼル、トーマス、ピー．
レミール、イザベル
レオナルド、ピエール
ヘフト、ロバート
ランディー、ハル
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アレクション ファーマ ホールディング
アレクション ファーマ ホールディング
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cereal-Derived Products (AREA)
  • Adornments (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2010507770A 2007-05-11 2008-05-12 骨標的アルカリホスファターゼ、キット及びその使用方法 Active JP5732603B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91758907P 2007-05-11 2007-05-11
US60/917,589 2007-05-11
PCT/CA2008/000923 WO2008138131A1 (en) 2007-05-11 2008-05-12 Bone targeted alkaline phosphatase, kits and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2010526543A JP2010526543A (ja) 2010-08-05
JP2010526543A5 JP2010526543A5 (show.php) 2011-06-30
JP5732603B2 true JP5732603B2 (ja) 2015-06-10

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US (1) US20100297119A1 (show.php)
EP (3) EP2662448B1 (show.php)
JP (1) JP5732603B2 (show.php)
AT (1) ATE536413T1 (show.php)
AU (1) AU2008250945B2 (show.php)
BR (2) BR122019000505B1 (show.php)
CA (1) CA2687001C (show.php)
CY (1) CY2016005I1 (show.php)
DE (1) DE202008018131U1 (show.php)
DK (3) DK2662448T3 (show.php)
ES (3) ES2471915T3 (show.php)
FR (1) FR16C0007I2 (show.php)
HR (1) HRP20140416T1 (show.php)
HU (2) HUE031655T2 (show.php)
IL (1) IL202057A0 (show.php)
LT (1) LTC2368999I2 (show.php)
LU (1) LU92976I2 (show.php)
ME (1) ME01828B (show.php)
NL (1) NL300798I1 (show.php)
NO (1) NO2016002I1 (show.php)
PL (3) PL2368999T3 (show.php)
PT (3) PT2662448T (show.php)
RS (1) RS53302B (show.php)
SI (2) SI2662448T1 (show.php)
WO (1) WO2008138131A1 (show.php)

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US20130156765A1 (en) 2010-07-28 2013-06-20 David S. Block FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN Fc COMPOSITIONS
CA2823066A1 (en) 2010-12-27 2012-07-05 Alexion Pharma International Sarl Compositions comprising natriuretic peptides and methods of use thereof
CA2852874A1 (en) 2011-10-19 2013-04-25 Alexion Pharma Holding Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
HK1210792A1 (en) 2012-08-20 2016-05-06 Gliknik Inc. Molecules with antigen binding and polyvalent fc gamma receptor binding activity
CN111778228A (zh) 2014-01-24 2020-10-16 安-法玛公司 嵌合型碱性磷酸酶样蛋白
WO2016007873A1 (en) * 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
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JP6868561B2 (ja) 2015-01-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼ欠損を有する被験者を治療する方法
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WO2017171871A1 (en) * 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
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CN110114065A (zh) * 2016-11-30 2019-08-09 珀杜研究基金会 通过甲状旁腺激素受体刺激进行的骨折靶向性骨再生
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BRPI0811198B1 (pt) 2021-03-09
RS53302B (sr) 2014-08-29
HRP20140416T1 (hr) 2014-06-20
PL2368999T3 (pl) 2014-08-29
SI2368999T1 (sl) 2014-07-31
WO2008138131A4 (en) 2008-12-31
PL2158319T3 (pl) 2012-05-31
HK1191372A1 (en) 2014-07-25
HK1141047A1 (en) 2010-10-29
FR16C0007I1 (show.php) 2016-04-15
FR16C0007I2 (fr) 2017-01-27
BR122019000505B1 (pt) 2022-01-18
EP2662448B1 (en) 2016-12-21
CA2687001C (en) 2019-02-12
LTC2368999I2 (lt) 2017-09-25
PT2368999E (pt) 2014-05-26
AU2008250945A1 (en) 2008-11-20
WO2008138131A1 (en) 2008-11-20
PL2662448T3 (pl) 2017-07-31
NL300798I2 (show.php) 2016-03-16
EP2158319A4 (en) 2010-07-21
EP2158319B1 (en) 2011-12-07
EP2662448A1 (en) 2013-11-13
HUE031655T2 (hu) 2017-07-28
NO2016002I2 (no) 2016-02-02
AU2008250945A2 (en) 2009-12-24
ATE536413T1 (de) 2011-12-15
CY2016005I2 (el) 2016-08-31
CY2016005I1 (el) 2016-08-31
DE202008018131U1 (de) 2011-12-30
LTPA2016004I1 (lt) 2016-02-25
HUS1600005I1 (hu) 2016-02-29
CA2687001A1 (en) 2008-11-20
EP2158319A1 (en) 2010-03-03
PT2662448T (pt) 2017-03-29
SI2662448T1 (sl) 2017-05-31
EP2368999A1 (en) 2011-09-28
LU92976I2 (en) 2016-04-11
ES2619332T3 (es) 2017-06-26
BRPI0811198A8 (pt) 2018-08-14
EP2368999B1 (en) 2014-03-12
NO2016002I1 (no) 2016-02-02
NL300798I1 (show.php) 2016-03-16
HK1162589A1 (en) 2012-08-31
ES2380546T3 (es) 2012-05-16
PL2158319T4 (pl) 2016-04-29
ME01828B (me) 2014-12-20
US20100297119A1 (en) 2010-11-25
BR122019000505A2 (pt) 2021-12-14
BRPI0811198A2 (pt) 2014-10-21
DK2662448T3 (en) 2017-03-20
DK2158319T3 (da) 2012-03-19
JP2010526543A (ja) 2010-08-05
ES2471915T3 (es) 2014-06-27
PT2158319E (pt) 2012-03-06
DK2368999T3 (da) 2014-05-26
WO2008138131A9 (en) 2009-08-06
AU2008250945B2 (en) 2013-12-12
IL202057A0 (en) 2011-08-01
BRPI0811198B8 (pt) 2021-05-25

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