CA2687001C - Bone targeted alkaline phosphatase, kits and methods of use thereof - Google Patents
Bone targeted alkaline phosphatase, kits and methods of use thereof Download PDFInfo
- Publication number
- CA2687001C CA2687001C CA2687001A CA2687001A CA2687001C CA 2687001 C CA2687001 C CA 2687001C CA 2687001 A CA2687001 A CA 2687001A CA 2687001 A CA2687001 A CA 2687001A CA 2687001 C CA2687001 C CA 2687001C
- Authority
- CA
- Canada
- Prior art keywords
- alkaline phosphatase
- administration
- composition
- amino acid
- hpp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cereal-Derived Products (AREA)
- Adornments (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91758907P | 2007-05-11 | 2007-05-11 | |
| US60/917,589 | 2007-05-11 | ||
| PCT/CA2008/000923 WO2008138131A1 (en) | 2007-05-11 | 2008-05-12 | Bone targeted alkaline phosphatase, kits and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2687001A1 CA2687001A1 (en) | 2008-11-20 |
| CA2687001C true CA2687001C (en) | 2019-02-12 |
Family
ID=40001639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2687001A Active CA2687001C (en) | 2007-05-11 | 2008-05-12 | Bone targeted alkaline phosphatase, kits and methods of use thereof |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20100297119A1 (show.php) |
| EP (3) | EP2662448B1 (show.php) |
| JP (1) | JP5732603B2 (show.php) |
| AT (1) | ATE536413T1 (show.php) |
| AU (1) | AU2008250945B2 (show.php) |
| BR (2) | BR122019000505B1 (show.php) |
| CA (1) | CA2687001C (show.php) |
| CY (1) | CY2016005I1 (show.php) |
| DE (1) | DE202008018131U1 (show.php) |
| DK (3) | DK2662448T3 (show.php) |
| ES (3) | ES2471915T3 (show.php) |
| FR (1) | FR16C0007I2 (show.php) |
| HR (1) | HRP20140416T1 (show.php) |
| HU (2) | HUE031655T2 (show.php) |
| IL (1) | IL202057A0 (show.php) |
| LT (1) | LTC2368999I2 (show.php) |
| LU (1) | LU92976I2 (show.php) |
| ME (1) | ME01828B (show.php) |
| NL (1) | NL300798I1 (show.php) |
| NO (1) | NO2016002I1 (show.php) |
| PL (3) | PL2368999T3 (show.php) |
| PT (3) | PT2662448T (show.php) |
| RS (1) | RS53302B (show.php) |
| SI (2) | SI2662448T1 (show.php) |
| WO (1) | WO2008138131A1 (show.php) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE505551T1 (de) | 2004-04-21 | 2011-04-15 | Enobia Pharma Inc | Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| US8784833B2 (en) * | 2006-06-27 | 2014-07-22 | Saint Louis University | Prenatal enzyme replacement therapy for hypophosphatasia |
| MX2009013004A (es) | 2007-06-01 | 2010-01-20 | Univ Maryland | Agentes de union al receptor de la region constante fc de inmunoglobulina. |
| ES2628841T3 (es) | 2010-03-12 | 2017-08-04 | Alexion Pharmaceuticals, Inc. | Proteínas de fusión npp1 |
| JP5986986B2 (ja) * | 2010-04-30 | 2016-09-06 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 基質石灰化障害を治療する方法、組成物、およびキット |
| US20130156765A1 (en) | 2010-07-28 | 2013-06-20 | David S. Block | FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN Fc COMPOSITIONS |
| CA2823066A1 (en) | 2010-12-27 | 2012-07-05 | Alexion Pharma International Sarl | Compositions comprising natriuretic peptides and methods of use thereof |
| CA2852874A1 (en) | 2011-10-19 | 2013-04-25 | Alexion Pharma Holding | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| HK1210792A1 (en) | 2012-08-20 | 2016-05-06 | Gliknik Inc. | Molecules with antigen binding and polyvalent fc gamma receptor binding activity |
| CN111778228A (zh) | 2014-01-24 | 2020-10-16 | 安-法玛公司 | 嵌合型碱性磷酸酶样蛋白 |
| WO2016007873A1 (en) * | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| WO2016090251A1 (en) * | 2014-12-05 | 2016-06-09 | Alexion Pharmaceuticals, Inc. | Treating seizure with recombinant alkaline phosphatase |
| JP6868561B2 (ja) | 2015-01-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼ欠損を有する被験者を治療する方法 |
| KR20250053203A (ko) | 2015-07-24 | 2025-04-21 | 글리크닉 인코포레이티드 | 향상된 상보체 결합을 갖는 규칙적으로 다형체화된 면역글로불린 fc 조성물을 생성하기 위한 인간 단백질 단편의 융합 단백질 |
| JP6993961B2 (ja) * | 2015-08-17 | 2022-01-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼの製造 |
| EP3355904A4 (en) * | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA |
| WO2017074466A1 (en) | 2015-10-30 | 2017-05-04 | Alexion Pharmaceuticals, Inc. | Methods for treating craniosynostosis in a patient |
| WO2017155569A1 (en) * | 2016-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| US11186832B2 (en) * | 2016-04-01 | 2021-11-30 | Alexion Pharmaceuticals, Inc. | Treating muscle weakness with alkaline phosphatases |
| WO2017171871A1 (en) * | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| WO2017173395A1 (en) * | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| US11034775B2 (en) | 2016-06-07 | 2021-06-15 | Gliknik Inc. | Cysteine-optimized stradomers |
| US20200306350A1 (en) | 2016-06-27 | 2020-10-01 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children and adolescents |
| US11116821B2 (en) | 2016-08-18 | 2021-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating tracheobronchomalacia |
| CN110114065A (zh) * | 2016-11-30 | 2019-08-09 | 珀杜研究基金会 | 通过甲状旁腺激素受体刺激进行的骨折靶向性骨再生 |
| MX2019006573A (es) | 2016-12-09 | 2019-11-18 | Gliknik Inc | Optimizacion de fabricacion de gl-2045 un stradomer multimerizante. |
| US11331372B2 (en) | 2016-12-09 | 2022-05-17 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent Fc compounds |
| US20220348977A1 (en) * | 2017-03-09 | 2022-11-03 | Alexion Pharmaceuticals, Inc. | Glycoprotein manufacturing process |
| JP2020512363A (ja) * | 2017-03-31 | 2020-04-23 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法 |
| CA3096821A1 (en) | 2017-09-27 | 2019-04-04 | Inozyme Pharma, Inc. | Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (npp1) |
| EP3737750B1 (en) | 2018-01-09 | 2024-06-05 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| JP7214962B2 (ja) * | 2018-01-17 | 2023-01-31 | 東ソー株式会社 | アルカリホスファターゼ高発現動物細胞 |
| WO2019183208A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| EP3773686B1 (en) | 2018-03-20 | 2023-06-07 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| US11913039B2 (en) | 2018-03-30 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Method for producing recombinant alkaline phosphatase |
| CN110499283A (zh) * | 2018-05-17 | 2019-11-26 | 西安组织工程与再生医学研究所 | Wnt信号通路激活剂在制备改善低碱性磷酸酯酶症干细胞成骨分化能力异常产品中的应用 |
| WO2019232285A1 (en) | 2018-05-30 | 2019-12-05 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| EP3833377B1 (en) | 2018-08-10 | 2023-11-22 | Alexion Pharmaceuticals, Inc. | Bone healing at implants using alkaline phosphatase |
| EP3965805A4 (en) | 2019-05-06 | 2023-01-25 | Synthetic Biologics, Inc. | ALKALINE PHOSPHATE BASED ONCOLOGICAL TREATMENTS |
| CA3161266A1 (en) | 2019-12-09 | 2021-06-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| US12478662B2 (en) | 2020-01-03 | 2025-11-25 | The United States of America as represented by the Secretary Department of Heath and Human Services | TNAP locally administered for promoting periodontal health |
| CN116848146A (zh) * | 2020-09-03 | 2023-10-03 | I·S·Y·陈 | 可溶性碱性磷酸酶构建体和包含编码可溶性碱性磷酸酶构建体的多核苷酸的表达载体 |
| KR102571967B1 (ko) * | 2021-01-21 | 2023-08-30 | 주식회사 마라나노텍코리아 | Alp 측정용 바이오 센서 |
| EP4291224A4 (en) * | 2021-02-12 | 2025-01-01 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| WO2024050464A2 (en) * | 2022-08-31 | 2024-03-07 | University Of Utah Research Foundation | Gja1-20k compositions and methods for mitigating ischemia-reperfusion injury |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7008A (en) * | 1850-01-08 | Improvement in alloys for points of lightning-rods | ||
| WO1995000655A1 (en) | 1993-06-24 | 1995-01-05 | Mc Master University | Adenovirus vectors for gene therapy |
| DK0797676T3 (da) | 1993-10-25 | 2006-04-18 | Canji Inc | Rekombinant adenoviral vektor og fremgangsmåder til anvendelse deraf |
| US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
| AU1920201A (en) | 1999-11-16 | 2001-05-30 | Genzyme Corporation | Improved regulatory elements for delivery to the liver |
| US6808905B2 (en) | 2001-05-14 | 2004-10-26 | Cell Genesys, Inc. | Lentiviral vectors encoding clotting factors for gene therapy |
| CA2433479A1 (en) | 2002-07-22 | 2004-01-22 | F. Hoffmann-La Roche Ag | Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof |
| ATE505551T1 (de) * | 2004-04-21 | 2011-04-15 | Enobia Pharma Inc | Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| BRPI0512496A (pt) | 2004-06-23 | 2008-03-04 | Genzyme Corp | processos e composições para o tratamento de doenças policìsticas |
| WO2006039480A2 (en) * | 2004-09-29 | 2006-04-13 | The Burnham Institute For Medical Research | Tissue non-specific alkaline phosphate (tnap): a therapeutic target for arterial calcification |
| CN101068575A (zh) | 2004-12-01 | 2007-11-07 | 建新公司 | 向肝脏定向递送遗传物质的方法 |
-
2008
- 2008-05-12 HU HUE13002327A patent/HUE031655T2/hu unknown
- 2008-05-12 JP JP2010507770A patent/JP5732603B2/ja active Active
- 2008-05-12 ES ES11004496.3T patent/ES2471915T3/es active Active
- 2008-05-12 SI SI200831780A patent/SI2662448T1/sl unknown
- 2008-05-12 ME MEP-2014-48A patent/ME01828B/me unknown
- 2008-05-12 BR BR122019000505-2A patent/BR122019000505B1/pt active Search and Examination
- 2008-05-12 CA CA2687001A patent/CA2687001C/en active Active
- 2008-05-12 EP EP13002327.8A patent/EP2662448B1/en active Active
- 2008-05-12 DK DK13002327.8T patent/DK2662448T3/en active
- 2008-05-12 ES ES13002327T patent/ES2619332T3/es active Active
- 2008-05-12 PL PL11004496T patent/PL2368999T3/pl unknown
- 2008-05-12 ES ES08757088T patent/ES2380546T3/es active Active
- 2008-05-12 DK DK08757088.3T patent/DK2158319T3/da active
- 2008-05-12 PT PT130023278T patent/PT2662448T/pt unknown
- 2008-05-12 EP EP08757088A patent/EP2158319B1/en active Active
- 2008-05-12 AT AT08757088T patent/ATE536413T1/de active
- 2008-05-12 DK DK11004496.3T patent/DK2368999T3/da active
- 2008-05-12 PT PT110044963T patent/PT2368999E/pt unknown
- 2008-05-12 SI SI200831200T patent/SI2368999T1/sl unknown
- 2008-05-12 AU AU2008250945A patent/AU2008250945B2/en active Active
- 2008-05-12 PL PL13002327T patent/PL2662448T3/pl unknown
- 2008-05-12 BR BRPI0811198A patent/BRPI0811198B8/pt active IP Right Grant
- 2008-05-12 PT PT08757088T patent/PT2158319E/pt unknown
- 2008-05-12 WO PCT/CA2008/000923 patent/WO2008138131A1/en not_active Ceased
- 2008-05-12 US US12/599,679 patent/US20100297119A1/en not_active Abandoned
- 2008-05-12 DE DE202008018131U patent/DE202008018131U1/de not_active Expired - Lifetime
- 2008-05-12 EP EP11004496.3A patent/EP2368999B1/en active Active
- 2008-05-12 PL PL08757088T patent/PL2158319T4/pl unknown
- 2008-05-12 RS RS20140237A patent/RS53302B/sr unknown
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2009
- 2009-11-11 IL IL202057A patent/IL202057A0/en unknown
-
2014
- 2014-05-08 HR HRP20140416AT patent/HRP20140416T1/hr unknown
-
2016
- 2016-01-15 HU HUS1600005C patent/HUS1600005I1/hu unknown
- 2016-01-28 LT LTPA2016004C patent/LTC2368999I2/lt unknown
- 2016-02-02 NO NO2016002C patent/NO2016002I1/no not_active IP Right Cessation
- 2016-02-10 LU LU92976C patent/LU92976I2/xx unknown
- 2016-02-19 FR FR16C0007C patent/FR16C0007I2/fr active Active
- 2016-02-23 CY CY2016005C patent/CY2016005I1/el unknown
- 2016-02-26 NL NL300798C patent/NL300798I1/nl unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130424 |