JP5727374B2 - 大型置換基を有する非フェノール性アミンオピオイド - Google Patents
大型置換基を有する非フェノール性アミンオピオイド Download PDFInfo
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- JP5727374B2 JP5727374B2 JP2011520127A JP2011520127A JP5727374B2 JP 5727374 B2 JP5727374 B2 JP 5727374B2 JP 2011520127 A JP2011520127 A JP 2011520127A JP 2011520127 A JP2011520127 A JP 2011520127A JP 5727374 B2 JP5727374 B2 JP 5727374B2
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- 125000001424 substituent group Chemical group 0.000 title description 10
- 229940005483 opioid analgesics Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 67
- 150000001875 compounds Chemical class 0.000 claims description 58
- 125000000217 alkyl group Chemical group 0.000 claims description 46
- 125000003118 aryl group Chemical group 0.000 claims description 31
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 31
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 9
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000000304 alkynyl group Chemical group 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
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- 125000004433 nitrogen atom Chemical group N* 0.000 description 14
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- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 5
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- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 4
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- PUJDIJCNWFYVJX-UHFFFAOYSA-N benzyl carbamate Chemical group NC(=O)OCC1=CC=CC=C1 PUJDIJCNWFYVJX-UHFFFAOYSA-N 0.000 description 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 4
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- 125000005842 heteroatom Chemical group 0.000 description 4
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- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 4
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- 125000006239 protecting group Chemical group 0.000 description 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 4
- 125000005017 substituted alkenyl group Chemical group 0.000 description 4
- 125000004426 substituted alkynyl group Chemical group 0.000 description 4
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Chemical group OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 4
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- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
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- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
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- Obesity (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8225508P | 2008-07-21 | 2008-07-21 | |
| US61/082,255 | 2008-07-21 | ||
| PCT/US2009/051200 WO2010011619A1 (en) | 2008-07-21 | 2009-07-21 | Large substituent, non-phenolic amine opioids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014204620A Division JP2015044819A (ja) | 2008-07-21 | 2014-10-03 | 大型置換基を有する非フェノール性アミンオピオイド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528718A JP2011528718A (ja) | 2011-11-24 |
| JP2011528718A5 JP2011528718A5 (enExample) | 2012-01-12 |
| JP5727374B2 true JP5727374B2 (ja) | 2015-06-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520127A Active JP5727374B2 (ja) | 2008-07-21 | 2009-07-21 | 大型置換基を有する非フェノール性アミンオピオイド |
| JP2014204620A Pending JP2015044819A (ja) | 2008-07-21 | 2014-10-03 | 大型置換基を有する非フェノール性アミンオピオイド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014204620A Pending JP2015044819A (ja) | 2008-07-21 | 2014-10-03 | 大型置換基を有する非フェノール性アミンオピオイド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100190817A1 (enExample) |
| EP (1) | EP2318372B9 (enExample) |
| JP (2) | JP5727374B2 (enExample) |
| AU (1) | AU2009274147B2 (enExample) |
| CA (1) | CA2731429C (enExample) |
| ES (1) | ES2534055T3 (enExample) |
| WO (1) | WO2010011619A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015044819A (ja) * | 2008-07-21 | 2015-03-12 | レンセラール ポリテクニック インスティチュート | 大型置換基を有する非フェノール性アミンオピオイド |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2782529C (en) | 2009-12-04 | 2015-05-26 | Alkermes, Inc. | Morphinan derivatives for the treatment of drug overdose |
| ES2582306T3 (es) | 2010-03-22 | 2016-09-12 | Rensselaer Polytechnic Institute | Derivados de morfinano que contienen un grupo carboxamida como ligandos de receptores opioides |
| HUE041981T2 (hu) | 2010-08-23 | 2019-06-28 | Alkermes Pharma Ireland Ltd | Eljárások antipszichotikum által kiváltott súlygyarapodás kezelésére |
| PL2725908T3 (pl) | 2011-06-29 | 2017-10-31 | Alkermes Inc | Działające obwodowo związki opioidowe |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| JP2016519161A (ja) | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002036573A2 (en) * | 2000-10-31 | 2002-05-10 | Rensselaer Polytechnic Institute | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| WO2004007449A1 (en) * | 2002-07-16 | 2004-01-22 | Rensselaer Polytechnic Institute | Process for conversion of phenols to carboxamides via the succinimide esters |
| EP1924559B1 (en) * | 2005-07-21 | 2014-04-16 | Rensselaer Polytechnic Institute | 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents |
| CA2731429C (en) * | 2008-07-21 | 2016-12-13 | Mark P. Wentland | Large substituent, non-phenolic amine opioids |
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2009
- 2009-07-21 CA CA2731429A patent/CA2731429C/en active Active
- 2009-07-21 US US12/506,354 patent/US20100190817A1/en not_active Abandoned
- 2009-07-21 JP JP2011520127A patent/JP5727374B2/ja active Active
- 2009-07-21 WO PCT/US2009/051200 patent/WO2010011619A1/en not_active Ceased
- 2009-07-21 ES ES09790652.3T patent/ES2534055T3/es active Active
- 2009-07-21 AU AU2009274147A patent/AU2009274147B2/en active Active
- 2009-07-21 EP EP20090790652 patent/EP2318372B9/en active Active
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2014
- 2014-10-03 JP JP2014204620A patent/JP2015044819A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015044819A (ja) * | 2008-07-21 | 2015-03-12 | レンセラール ポリテクニック インスティチュート | 大型置換基を有する非フェノール性アミンオピオイド |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2534055T3 (es) | 2015-04-16 |
| JP2011528718A (ja) | 2011-11-24 |
| US20100190817A1 (en) | 2010-07-29 |
| EP2318372B9 (en) | 2015-05-06 |
| WO2010011619A1 (en) | 2010-01-28 |
| JP2015044819A (ja) | 2015-03-12 |
| EP2318372B1 (en) | 2015-01-14 |
| CA2731429C (en) | 2016-12-13 |
| AU2009274147A1 (en) | 2010-01-28 |
| ES2534055T9 (es) | 2016-05-31 |
| EP2318372A1 (en) | 2011-05-11 |
| AU2009274147B2 (en) | 2014-09-04 |
| CA2731429A1 (en) | 2010-01-28 |
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