JP5702434B2 - 経皮薬物送達システムにおいて有用な非反応型接着剤 - Google Patents
経皮薬物送達システムにおいて有用な非反応型接着剤 Download PDFInfo
- Publication number
- JP5702434B2 JP5702434B2 JP2013101967A JP2013101967A JP5702434B2 JP 5702434 B2 JP5702434 B2 JP 5702434B2 JP 2013101967 A JP2013101967 A JP 2013101967A JP 2013101967 A JP2013101967 A JP 2013101967A JP 5702434 B2 JP5702434 B2 JP 5702434B2
- Authority
- JP
- Japan
- Prior art keywords
- adhesive
- drug
- drug delivery
- transdermal
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/04—Homopolymers or copolymers of esters
- C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09J133/08—Homopolymers or copolymers of acrylic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/04—Homopolymers or copolymers of esters
- C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09J133/062—Copolymers with monomers not covered by C09J133/06
Description
本発明の別な面は、非反応型粘着剤および治療薬剤を含む経皮薬物送達システムを目指す。一つの態様において、接着剤は生理的に活性な薬剤に対する担体として役立つ。
特記のない限り、質量%は乾燥質量%を意味する。
本発明は、反応性水素部分を含有する官能基を含まず、重合後の化学架橋を含有しない接着剤組成物を提供する。接着剤は、約50〜約98質量%のアクリル酸アルキルおよび/またはメタクリル酸アルキル・モノマーおよび約2〜約50質量%の重合性非環式窒素含有モノマーを含む。
重合後の化学架橋がないとは、多重合部位を有するモノマーを本発明の接着剤を調製するために用いることができるが、重合後は反応部位がポリマー中に存在しないことを意味する。
重合性窒素含有モノマーには、ビニルアセトアミド、N−置換アクリルアミドおよびN−置換メタクリルアミドおよびメタクリロニトリルまたはアクリル酸2−シアノエチルなどのニトリル並びにそれらの混合物が挙げられる。
N−置換アクリルアミドまたはメタクリルアミドには、以下の式を有する化合物が挙げられる:
R1はHまたはCH3であり、
R2はH、直鎖アルキル、分岐鎖アルキルまたは芳香族であり、
R3は直鎖アルキル、分岐鎖アルキル、芳香族、または以下の式の置換基である:
直鎖および分岐鎖アルキル基は約17個以下の炭素原子数を有するものであり、例えば、メチル、エチル、プロピルおよびイソプロピル基などが挙げられる。芳香族置換基には、例えば、ベンジル、フェニルおよびトルイル基が挙げられる。
本発明の接着剤組成物には、場合により、酢酸ビニルおよびスチレンなどのビニルモノマー、メタクリル酸メチルなどのメタクリル酸アルキルおよびジメタクリル酸アルキルに限定されないがそれらを含む他のモノマーを挙げることができる。
本発明の接着剤は、意外なことに、重合後架橋の必要なしでその接着剤特性を維持する。優れた接着剤性能および優れた非反応性性能を与える好ましい態様は、45質量%のアクリル酸2−エチルヘキシル、35質量%のアクリル酸メチルおよび20質量%のN−置換アクリルアミドを含む接着剤コポリマー組成物である。好ましいN−置換アクリルアミドはt−オクチルアクリルアミドである。
局所的に塗布された薬物は皮膚中におよび/または皮膚を通して通過することが可能である。用語皮膚、真皮および表皮は、特記のない限り、交換可能に用いられる。従って、「経皮」は、局部的に、すなわち、例えばニキビを治療するために用いられるブレミッシュ・パッチなどの皮膚の表面でまたは皮膚内で作用する薬物の局所的投与および皮膚を通して拡散し血流に入ることにより全身的に作用する薬物の局所的投与を指すために広く用いられる。
農業および園芸用薬剤には、例えば、ラン成長ホルモンが挙げられる。
動物用および園芸用用途における経皮薬物送達は、食品/灌漑用水中での投与よりも一層正確な投与量および一層少ない浪費量を可能とすることが理解される。
剥離
感圧接着テープ委員会(Pressure Sensitive Tape Council)によりPSTC No.1において記載される方法を用いて、180°剥離を試験した。試験には、比較的軽い圧力下での塗布後、180°角度でテープを基板から剥離することが含まれる。接着剤と試験パネルとの20分(初期剥離)、24時間および1週間の接触を与えることにより試験を行った。結果をインチ幅当りオンスで測定したテープを除去するために必要とされる力として報告する。
室温で1,000グラム(g)質量を用いPSTC No.7に従って剪断接着性を測定した。接着面積は2.54 cm×1.27 cm(1インチ×0.5インチ)であった。結果を接着部が壊れるまでに要した時間として報告する。
アクリル酸2−エチルヘキシル44.7g、アクリル酸メチル25.8g、t−オクチルアクリルアミド5g、酢酸エチル(溶媒)69.4g、アセトン(溶媒)9.8g、および2,2'-アゾビスイソブチロニトリル(AIBN)(重合開始剤)0.035gを含有する初期充填物を調製し、ステンレス鋼攪拌器、温度計、凝縮器、水槽および緩慢添加漏斗を備えた1-L4ツ口丸底フラスコに充填した。
上述の一般的な手順を用いて、追加の7接着剤をモノマーの量および/または組成を変動させることにより調製した。
本発明の多くの修正および変化は、当業者に明白であるように、その精神および範囲から逸脱することなく行うことができる。本明細書において記載される特定の態様は例示としてのみ提供され、本発明は、添付のクレーム、およびこうしたクレームにより権利を与えられる同等物の十分な範囲の条件によってのみ限定することができる。
Claims (2)
- 非反応型感圧接着剤および治療薬剤を含む経皮薬物送達システムであって、当該接着剤がアクリルポリマーを含み、当該アクリルポリマーが、45%のアクリル酸2−エチルへキシル、35%のアクリル酸メチル、および20%のt−オクチルアクリルアミドから製造され、ここで%は合計モノマー重量の乾燥重量ベースに基づく重量%であり、そして重合後の化学架橋を含まない、ことを特徴とする経皮薬物送達システム。
- 前記治療薬剤がフェンタニルである、請求項1に記載の経皮薬物送達システム。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23424800P | 2000-09-19 | 2000-09-19 | |
US60/234,248 | 2000-09-19 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2002528194A Division JP2004509222A (ja) | 2000-09-19 | 2001-09-18 | 経皮薬物送達システムにおいて有用な非反応型接着剤 |
Publications (2)
Publication Number | Publication Date |
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JP2013163820A JP2013163820A (ja) | 2013-08-22 |
JP5702434B2 true JP5702434B2 (ja) | 2015-04-15 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP2002528194A Pending JP2004509222A (ja) | 2000-09-19 | 2001-09-18 | 経皮薬物送達システムにおいて有用な非反応型接着剤 |
JP2013101967A Expired - Fee Related JP5702434B2 (ja) | 2000-09-19 | 2013-05-14 | 経皮薬物送達システムにおいて有用な非反応型接着剤 |
Family Applications Before (1)
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JP2002528194A Pending JP2004509222A (ja) | 2000-09-19 | 2001-09-18 | 経皮薬物送達システムにおいて有用な非反応型接着剤 |
Country Status (7)
Country | Link |
---|---|
US (1) | US9056060B2 (ja) |
EP (1) | EP1318843B1 (ja) |
JP (2) | JP2004509222A (ja) |
KR (1) | KR100940245B1 (ja) |
AU (1) | AU2001292781A1 (ja) |
ES (1) | ES2410532T3 (ja) |
WO (1) | WO2002024157A2 (ja) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001292781A1 (en) * | 2000-09-19 | 2002-04-02 | National Starch And Chemical Investment Holding Corporation | Acryl adhesive useful in transdermal drug delivery systems |
DE10141652B4 (de) * | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung |
DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
US8252319B2 (en) | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
SI1814531T1 (sl) | 2004-10-21 | 2010-10-29 | Durect Corp | Transdermalni dostavni sistem |
WO2007035940A2 (en) | 2005-09-23 | 2007-03-29 | Alza Corporation | Transdermal norelgestromin delivery system |
EP2308480B1 (en) | 2005-09-23 | 2014-08-13 | ALZA Corporation | High Enhancer-Loading Polyacrylate Formulation for Transdermal Applications |
US20090130188A9 (en) * | 2005-09-29 | 2009-05-21 | National Starch And Chemical Investment Holding Company | Acrylic pressure sensitive adhesives |
DE102005050654A1 (de) * | 2005-10-20 | 2007-04-26 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Lippenpflaster |
CN101431988A (zh) * | 2006-02-27 | 2009-05-13 | 诺芬药品公司 | 包含东莨菪碱的透皮治疗系统 |
US20100087768A1 (en) * | 2008-10-02 | 2010-04-08 | Forlano Paula | Transdermal drug delivery system for liquid active ingredient |
US9717697B2 (en) | 2012-10-15 | 2017-08-01 | Noven Pharmaceuticals, Inc. | Compositions and methods for the transdermal delivery of methylphenidate |
US10493024B2 (en) | 2015-10-12 | 2019-12-03 | Hk Tumescent Pharma Corporation | Tumescent infiltration drug delivery of high subcutaneous drug concentrations with prolonged local and systemic effects and minimal local or systemic toxicity |
US11241412B2 (en) | 2015-10-12 | 2022-02-08 | Hk Pharma | Tumescent infiltration drug delivery of cannabinoids |
US20200131409A1 (en) * | 2017-04-17 | 2020-04-30 | 3M Innovative Properties Company | Blended block copolymer/silicone pressure sensitive adhesives |
MX2020011269A (es) * | 2018-04-25 | 2020-12-11 | Shinkei Therapeutics Llc | Dispositivo de administración transdérmica de tetrabenazina. |
KR102207590B1 (ko) * | 2018-08-06 | 2021-01-26 | 고세윤 | 생체의료용 고분자를 포함하는 피부 무자극 점착제 조성물 및 이를 이용한 점착시트 |
MX2022000274A (es) * | 2019-07-11 | 2022-02-03 | Henkel Ag & Co Kgaa | Polimero acrilico y composiciones adhesivas. |
DK3854388T3 (da) | 2020-01-24 | 2023-11-27 | Luye Pharma Switzerland Ag | Transdermalt terapeutisk system omfattende rotigotin og mindst et ikke-aminresistent silikoneklæbestof |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3008850A (en) | 1959-04-27 | 1961-11-14 | Minnesota Mining & Mfg | Pressure-sensitive adhesive sheet material |
US3189581A (en) | 1961-06-05 | 1965-06-15 | Pittsburgh Plate Glass Co | Pressure sensitive adhesives comprising interpolymers of alkylacrylates, vinyl esters and n-alkoxyalkyl acrylamides |
US3325459A (en) | 1963-08-01 | 1967-06-13 | Johnson & Johnson | Sheet materials |
US3307544A (en) | 1963-09-10 | 1967-03-07 | Johnson & Johnson | Surgical pressure-sensitive adhesive sheet with n-tert-butylacrylamide copolymer adhesive |
GB1166682A (en) * | 1965-12-23 | 1969-10-08 | Johnson & Johnson | Pressure-Sensitive Acrylate Adhesives |
GB1168333A (en) | 1966-03-29 | 1969-10-22 | Johnson & Johnson | Acrylate Adhesive containing Trifunctional Acrylamide |
US3491070A (en) * | 1966-11-25 | 1970-01-20 | Goodrich Co B F | 2 - ethylhexyl acrylate - n - octyl acrylamide - methacrylamide / acrylamide terpolymer |
US3922464A (en) * | 1972-05-26 | 1975-11-25 | Minnesota Mining & Mfg | Removable pressure-sensitive adhesive sheet material |
DE2244543B2 (de) | 1972-09-11 | 1974-08-01 | Interorgana Chemiehandel Gmbh, 5000 Koeln | Tri-(2,3-dibrompropyl)-isocy anurat, Verfahren zu dessen Herstellung sowie dessen Verwendung als flammhemmender Zusatz für Polymere |
JPS58138462A (ja) | 1982-02-12 | 1983-08-17 | 積水化学工業株式会社 | 治療用接着テ−プもしくはシ−ト |
US4458036A (en) * | 1983-02-28 | 1984-07-03 | Stauffer Chemical Company | Flexible polyurethane foams containing glycoluril reaction products for a flame and ember drip retardance |
JPS59181214A (ja) | 1983-03-29 | 1984-10-15 | Sekisui Chem Co Ltd | 治療用接着テ−プもしくはシ−ト |
US4514524A (en) * | 1984-07-13 | 1985-04-30 | Stauffer Chemical Company | Intumescent flexible polyurethane foam |
US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
AU576889B2 (en) * | 1984-07-24 | 1988-09-08 | Key Pharmaceuticals, Inc. | Adhesive transdermal dosage layer |
US4655767A (en) * | 1984-10-29 | 1987-04-07 | Dow Corning Corporation | Transdermal drug delivery devices with amine-resistant silicone adhesives |
JPS61126020A (ja) * | 1984-11-26 | 1986-06-13 | Sekisui Chem Co Ltd | 外用貼付剤 |
US4616044A (en) * | 1985-01-25 | 1986-10-07 | Stauffer Chemical Company | Heat laminatable polyether urethane foam |
US4584349A (en) | 1985-01-28 | 1986-04-22 | The B. F. Goodrich Company | Method and composition for improved melt processability of chlorinated polyvinyl chloride |
JPH0635538B2 (ja) * | 1985-04-04 | 1994-05-11 | 住友化学工業株式会社 | ポリウレタン組成物 |
US4732808A (en) * | 1985-11-14 | 1988-03-22 | Minnesota Mining And Manufacturing Company | Macromer reinforced pressure sensitive skin adhesive sheet material |
DE3643987A1 (de) * | 1986-12-22 | 1988-06-23 | Lohmann Therapie Syst Lts | Basische, wirkstoffdurchlaessige haftklebende polymermasse, insbesondere zum einsatz mit basischen wirkstoffen, verfahren zu ihrer herstellung und ihre verwendung |
IE65163B1 (en) * | 1987-06-29 | 1995-10-04 | Squibb & Sons Inc | Process for preparing a wound dressing comprising a hydrophilic acrylic adhesive layer |
ATE115157T1 (de) | 1987-08-17 | 1994-12-15 | Bostik Inc | Flammwidrige prägefolie. |
US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5234957A (en) * | 1991-02-27 | 1993-08-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
DE3924393A1 (de) | 1989-07-24 | 1991-01-31 | Roehm Gmbh | Wasserloeslicher druckempfindlicher hauthaftkleber, dessen verwendung und damit ausgeruestete mittel |
US4988567A (en) * | 1990-02-27 | 1991-01-29 | Minnesota Mining And Manufacturing Company | Hollow acid-free acrylate polymeric microspheres having multiple small voids |
US4968562A (en) | 1990-02-27 | 1990-11-06 | Minnesota Mining And Manufacturing Company | Hollow acid-free acrylate polymeric microspheres having multiple small voids |
AU642055B2 (en) | 1990-11-28 | 1993-10-07 | Scholl Plc | An emulsion polymerised polymer |
CA2077369A1 (en) | 1991-09-09 | 1993-03-10 | Hitoshi Akemi | Acrylic gel material and gel-based medical preparation for percutaneous absorption employing the same |
AU665567B2 (en) * | 1991-09-23 | 1996-01-11 | Minnesota Mining And Manufacturing Company | Pressure sensitive adhesive composition which is repulpable under acidic pH conditions |
CA2092764C (en) * | 1993-03-26 | 1998-07-28 | Peter Romaniuk | Rescue alert kit |
DE4310012A1 (de) * | 1993-03-27 | 1994-09-29 | Roehm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung |
US5391406A (en) * | 1994-03-25 | 1995-02-21 | National Starch And Chemical Investment Holding Corporation | Process of preparing hot melt pressure sensitive adhesives on a substrate |
EP0781122B1 (en) * | 1994-09-14 | 2000-07-05 | Minnesota Mining And Manufacturing Company | Matrix for transdermal drug delivery |
US5827505A (en) * | 1994-12-22 | 1998-10-27 | The Procter & Gamble Company | Oral compositions |
TW411277B (en) | 1996-05-13 | 2000-11-11 | Hisamitsu Pharmaceutical Co | Percutaneous tape preparation containing fentanyl |
JP3836566B2 (ja) * | 1996-05-13 | 2006-10-25 | 久光製薬株式会社 | フェンタニル含有経皮投与テープ製剤 |
US5723534A (en) * | 1996-10-11 | 1998-03-03 | Polyfoam Products, Inc. | Two part polyurethane-based adhesive system |
US6239228B1 (en) * | 1997-02-21 | 2001-05-29 | Adhesives Research, Inc. | Pressure sensitive adhesive containing macromer having repeat hydrophilic moieties |
EP0979072B1 (en) * | 1997-02-28 | 2005-04-27 | Minnesota Mining And Manufacturing Company | Transdermal device for the delivery of testosterone |
US7150881B2 (en) * | 1997-06-26 | 2006-12-19 | Mylan Technologies, Inc. | Adhesive mixture for transdermal delivery of highly plasticizing drugs |
US6077527A (en) | 1997-10-28 | 2000-06-20 | National Starch And Chemical Investment Holding Corporation | Enhancer tolerant pressure sensitive adhesives for transdermal drug delivery |
DE69932397T2 (de) | 1998-04-30 | 2007-07-19 | Shiseido Co. Ltd. | Zusammensetzung zur äusserlichen anwendung |
US6312715B1 (en) * | 1998-05-01 | 2001-11-06 | 3M Innovative Properties Company | Adhesive microsphere drug delivery composition |
US6541566B1 (en) * | 1998-10-05 | 2003-04-01 | National Starch And Chemical Investment Holding Corporation | Pressure sensitive adhesive compositions prepared with a sterically hindered alkoxylated silane |
US6472545B2 (en) | 2000-08-29 | 2002-10-29 | Abbott Laboratories | Protein tyrosine phosphatase inhibitors |
AU2001292781A1 (en) * | 2000-09-19 | 2002-04-02 | National Starch And Chemical Investment Holding Corporation | Acryl adhesive useful in transdermal drug delivery systems |
US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
DE20113761U1 (de) | 2001-08-20 | 2001-12-20 | Lohmann & Rauscher Gmbh & Co | Wundversorgungsprodukt |
DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
DE10141652B4 (de) | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung |
EP1894563B2 (de) | 2002-05-28 | 2022-04-27 | ratiopharm GmbH | Pflaster, enthaltend Fentanylum |
-
2001
- 2001-09-18 AU AU2001292781A patent/AU2001292781A1/en not_active Abandoned
- 2001-09-18 KR KR1020037003644A patent/KR100940245B1/ko active IP Right Grant
- 2001-09-18 JP JP2002528194A patent/JP2004509222A/ja active Pending
- 2001-09-18 EP EP01973175.1A patent/EP1318843B1/en not_active Expired - Lifetime
- 2001-09-18 US US09/955,644 patent/US9056060B2/en not_active Expired - Fee Related
- 2001-09-18 WO PCT/US2001/029241 patent/WO2002024157A2/en active Application Filing
- 2001-09-18 ES ES01973175T patent/ES2410532T3/es not_active Expired - Lifetime
-
2013
- 2013-05-14 JP JP2013101967A patent/JP5702434B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR100940245B1 (ko) | 2010-02-04 |
EP1318843A2 (en) | 2003-06-18 |
WO2002024157A2 (en) | 2002-03-28 |
EP1318843B1 (en) | 2013-04-17 |
AU2001292781A1 (en) | 2002-04-02 |
WO2002024157A3 (en) | 2003-01-23 |
US20020077437A1 (en) | 2002-06-20 |
KR20040030408A (ko) | 2004-04-09 |
JP2004509222A (ja) | 2004-03-25 |
US9056060B2 (en) | 2015-06-16 |
JP2013163820A (ja) | 2013-08-22 |
ES2410532T3 (es) | 2013-07-02 |
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