JP5702371B2 - Muc1のアンタゴニストを使用した、炎症の阻害 - Google Patents

Muc1のアンタゴニストを使用した、炎症の阻害 Download PDF

Info

Publication number
JP5702371B2
JP5702371B2 JP2012513262A JP2012513262A JP5702371B2 JP 5702371 B2 JP5702371 B2 JP 5702371B2 JP 2012513262 A JP2012513262 A JP 2012513262A JP 2012513262 A JP2012513262 A JP 2012513262A JP 5702371 B2 JP5702371 B2 JP 5702371B2
Authority
JP
Japan
Prior art keywords
muc1
peptide
cells
pharmaceutical composition
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2012513262A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012528191A (ja
JP2012528191A5 (enExample
Inventor
ドナルド ダブリュー. クーフェ
ドナルド ダブリュー. クーフェ
スレンデル カルバンダ
スレンデル カルバンダ
Original Assignee
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド
ジーナス オンコロジー リミテッド ライアビリティ カンパニー
ジーナス オンコロジー リミテッド ライアビリティ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド, デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド, ジーナス オンコロジー リミテッド ライアビリティ カンパニー, ジーナス オンコロジー リミテッド ライアビリティ カンパニー filed Critical デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド
Publication of JP2012528191A publication Critical patent/JP2012528191A/ja
Publication of JP2012528191A5 publication Critical patent/JP2012528191A5/ja
Application granted granted Critical
Publication of JP5702371B2 publication Critical patent/JP5702371B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1735—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012513262A 2009-05-27 2010-05-27 Muc1のアンタゴニストを使用した、炎症の阻害 Expired - Fee Related JP5702371B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18153009P 2009-05-27 2009-05-27
US61/181,530 2009-05-27
US25373009P 2009-10-21 2009-10-21
US61/253,730 2009-10-21
US30399710P 2010-02-12 2010-02-12
US61/303,997 2010-02-12
PCT/US2010/036436 WO2010138740A1 (en) 2009-05-27 2010-05-27 Inhibition 0f inflammation using antagonists of muc1

Publications (3)

Publication Number Publication Date
JP2012528191A JP2012528191A (ja) 2012-11-12
JP2012528191A5 JP2012528191A5 (enExample) 2013-01-10
JP5702371B2 true JP5702371B2 (ja) 2015-04-15

Family

ID=43223089

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012513262A Expired - Fee Related JP5702371B2 (ja) 2009-05-27 2010-05-27 Muc1のアンタゴニストを使用した、炎症の阻害

Country Status (9)

Country Link
US (2) US8614186B2 (enExample)
EP (1) EP2435062A4 (enExample)
JP (1) JP5702371B2 (enExample)
CN (1) CN102665748A (enExample)
AU (1) AU2010253834B2 (enExample)
CA (1) CA2763327C (enExample)
IL (1) IL216612A0 (enExample)
MX (1) MX2011012625A (enExample)
WO (1) WO2010138740A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011004082A (es) 2008-10-17 2011-10-14 Dana Farber Cancer Inst Inc Peptidos de dominio citoplasmico muc-1 como inhibidores del cancer.
WO2011100688A1 (en) * 2010-02-12 2011-08-18 Dana-Farber Cancer Institute, Inc. Improved antagonists of muc1
US20130101664A1 (en) 2011-08-18 2013-04-25 Donald W. Kufe Muc1 ligand traps for use in treating cancers
US9044421B2 (en) 2012-03-28 2015-06-02 Genus Oncology, Llc Treating MUC1-expressing cancers with combination therapies
US20150087598A1 (en) * 2012-05-11 2015-03-26 Dana-Farber Cancer Institute, Inc. Treating muc1-expressing cancers with helicase inhibitors
CN103848890B (zh) * 2012-11-30 2015-09-09 北京市结核病胸部肿瘤研究所 Muc1自身抗体识别的抗原多肽
US9572855B2 (en) 2013-03-11 2017-02-21 Dana-Farber Cancer Institute, Inc. Combination anti-estrogen receptor cancer therapy using MUC1 peptides and chemotherapeutics
US10507227B2 (en) 2014-04-15 2019-12-17 The Hospital For Sick Children Cationic antimicrobial peptides
JP6994939B2 (ja) * 2014-07-02 2022-02-04 インフレクティス・バイオサイエンス プロテオパチーの処置のためのベンジリデングアニジン誘導体の新規な治療的使用
EP3197474B1 (en) 2014-09-26 2023-06-07 Rajendra Sahai Bhatnagar Inhibitors of nf kappa-b activity for treatment of diseases and disorders
JP7366007B2 (ja) * 2017-09-13 2023-10-20 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング プロアドレノメジュリンに基づく輸液療法のガイダンスのための方法
CN107952069A (zh) * 2017-11-24 2018-04-24 长春百克生物科技股份公司 重组疫苗及其应用
CN114555624A (zh) * 2019-06-06 2022-05-27 悉尼大学 抗炎剂
CN117929754B (zh) * 2024-01-25 2025-02-11 广州医科大学附属第一医院(广州呼吸中心) Muc1-c段在肺动脉高压预防或治疗药物制备中的应用
WO2025217515A2 (en) * 2024-04-12 2025-10-16 Dana-Farber Cancer Institute, Inc. Identification of muc1-c as a target for the treatment of squamous cell carcinomas
WO2025231266A1 (en) * 2024-05-01 2025-11-06 Emory University Use of muc1 mimetic peptide inhibitors for inhibition of mucus secretion
CN119236051B (zh) * 2024-09-29 2025-12-19 北京大学 Muc1抑制剂在制备预防、治疗细菌感染药物中的应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5912232A (en) * 1994-09-23 1999-06-15 Board Of Regents Of The University Of Nebraska Anti-inflammatory polypeptide antagonists of human I1-8
US6548643B1 (en) * 1994-11-16 2003-04-15 Austin Research Institute Antigen carbohydrate compounds and their use in immunotherapy
NO961031D0 (no) 1996-03-13 1996-03-13 Det Norske Radiumshospital Tum Fremgangsmåte til å drepe uönskede målceller
US20020044943A1 (en) * 1997-09-10 2002-04-18 Longenecker B. Michael MUC-1 as an immunosuppressive therapeutic agent for the treatment of inflammatory and autoimmune conditions
CA2354644A1 (en) * 1998-12-11 2000-06-15 Biomira, Inc. Muc-1 antagonists and methods of treating immune disorders
WO2001018035A2 (en) * 1999-09-08 2001-03-15 Transgene S.A. Muc-1 derived peptides
WO2001057068A1 (en) 2000-02-01 2001-08-09 The Austin Research Institute Mucin-1 derived antigens and their use in immunotherapy
WO2002022685A2 (en) 2000-09-11 2002-03-21 Kufe Donald W Muc1 extracellular domain and cancer treatment compositions and methods derived therefrom
ATE552859T1 (de) * 2000-09-13 2012-04-15 Praecis Pharm Inc Pharmazeutische formulierungen zur kontinuierlichen abgabe von peptiden
WO2002058450A2 (en) 2000-12-22 2002-08-01 Dana-Faber Cancer Institute, Inc. Regulation of cell growth by muc1
AU2002303390A1 (en) 2001-04-18 2002-11-05 Dana-Farber Cancer Institute, Inc. Induction of apoptosis by cellular stress
US7247297B2 (en) 2001-09-14 2007-07-24 The University Of Chicago Use of DF3/MUC1 regulated expression in gene therapy
CA2842429A1 (en) * 2001-10-19 2003-05-01 Genentech, Inc. Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders
US7696306B2 (en) 2003-07-11 2010-04-13 Board of Agents of the University of Nebraska Compositions and methods for preventing or treating cancer
WO2005042573A1 (en) 2003-10-24 2005-05-12 Dana-Farber Cancer Institute, Inc. Modulation of the interaction of muc1 with muc1 ligands
EP1538164A1 (en) * 2003-12-04 2005-06-08 Vectron Therapeutics AG RGD targeting moiety its production and use
JP2007523092A (ja) 2004-02-17 2007-08-16 キャンサーバックス コーポレイション 新脈管形成阻害のための方法および組成物
EP1718367A1 (en) 2004-02-23 2006-11-08 Genzyme Corporation Muc1 antagonist enhancement of death receptor ligand-induced apoptosis
WO2005101021A1 (en) 2004-04-13 2005-10-27 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled adrenergic alpha-1d-receptor (adra1d)
US20070207209A1 (en) 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
JP2008537095A (ja) * 2005-02-15 2008-09-11 ダナ−ファーバー キャンサー インスティテュート インク. Muc1活性の調節
JP5116663B2 (ja) * 2005-04-15 2013-01-09 アリゾナ バイオメディカル リサーチ コミッション 転移癌の処置のための治療用ペプチド
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP1946113A4 (en) 2005-08-22 2010-03-10 Dana Farber Cancer Inst Inc MITOCHONDRIAL LOCALIZATION OF MUC1
GB0519303D0 (en) 2005-09-21 2005-11-02 Oxford Biomedica Ltd Chemo-immunotherapy method
WO2008097844A2 (en) 2007-02-02 2008-08-14 Dana -Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins
WO2008097840A2 (en) 2007-02-02 2008-08-14 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of muc1 by hsf1 and stat3
WO2008101121A2 (en) 2007-02-14 2008-08-21 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to promoter regulation by muc1 and klf proteins
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
MX2011004082A (es) * 2008-10-17 2011-10-14 Dana Farber Cancer Inst Inc Peptidos de dominio citoplasmico muc-1 como inhibidores del cancer.
WO2011100688A1 (en) * 2010-02-12 2011-08-18 Dana-Farber Cancer Institute, Inc. Improved antagonists of muc1
WO2011115819A2 (en) * 2010-03-15 2011-09-22 Genus Oncology, Llc Small molecule inhibitors of muc1 and methods of identifying the same

Also Published As

Publication number Publication date
IL216612A0 (en) 2012-02-29
CA2763327A1 (en) 2010-12-02
CN102665748A (zh) 2012-09-12
US9096687B2 (en) 2015-08-04
MX2011012625A (es) 2012-04-20
AU2010253834B2 (en) 2013-12-19
EP2435062A4 (en) 2013-01-02
US20110015138A1 (en) 2011-01-20
CA2763327C (en) 2019-04-02
JP2012528191A (ja) 2012-11-12
AU2010253834A1 (en) 2011-12-08
WO2010138740A1 (en) 2010-12-02
US8614186B2 (en) 2013-12-24
US20140187494A1 (en) 2014-07-03
EP2435062A1 (en) 2012-04-04

Similar Documents

Publication Publication Date Title
US9096687B2 (en) Inhibition of inflammation using antagonists of MUC1
CN108367048B (zh) 用于组织修复的双特异性治疗性蛋白质
RU2539832C2 (ru) Пептиды цитоплазматического домена белка muc-1 в качестве ингибиторов раковых заболеваний
US20140322332A1 (en) Antagonists of muc1
CN105378084A (zh) 用于治疗癌症的方法和组合物
CN110724203A (zh) 一种促进tfeb核转位的短肽及基于其的线性短肽和其减轻脑缺血损伤的应用
KR20250023442A (ko) 세포 투과성 펩타이드 변이체
SG11202112252UA (en) Bnip3 peptides for treatment of reperfusion injury
US20130101664A1 (en) Muc1 ligand traps for use in treating cancers
US20250270268A1 (en) Amelioration and treatment of infarction damage
TW201200151A (en) Methods and compositions related to reduced MET phosphorylation by leukocyte cell-derived chemotaxin 2 in tumor cells
WO2024188347A1 (zh) 抑制过激炎性反应的蛋白及其应用
WO2017144016A1 (zh) 多肽、其衍生物及其在制备抗肺纤维化的药物中的应用
US20210052701A1 (en) Methods of Treating Vascular Leakage Using CXCL12 Peptides
CN120818506A (zh) Baf170突变体及其制药用途
HK40058660B (en) Bi-specific therapeutic proteins for tissue repair
CN120796234A (zh) Wwp2泛素化的baf170蛋白及其制药用途
HK1255701A1 (zh) 使用BCL-9的安定的α螺旋将癌症中失调WNT信号传递订为目标
HK1258376B (en) Bi-specific therapeutic proteins for tissue repair

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121113

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20121113

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140120

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140415

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140422

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140514

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20141210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141211

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150122

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150219

R150 Certificate of patent or registration of utility model

Ref document number: 5702371

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

LAPS Cancellation because of no payment of annual fees