JP5697455B2 - グリア成長因子2の所望の血漿レベルを達成するための方法 - Google Patents

グリア成長因子2の所望の血漿レベルを達成するための方法 Download PDF

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JP5697455B2
JP5697455B2 JP2010548749A JP2010548749A JP5697455B2 JP 5697455 B2 JP5697455 B2 JP 5697455B2 JP 2010548749 A JP2010548749 A JP 2010548749A JP 2010548749 A JP2010548749 A JP 2010548749A JP 5697455 B2 JP5697455 B2 JP 5697455B2
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ggf2
myelination
composition
disease
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JP2011513310A (ja
JP2011513310A5 (enExample
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ヘソン キム
へソン キム
アンソニー オー. カッジャーノ
アンソニー オー. カッジャーノ
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アコーダ セラピューティクス インコーポレイテッド
アコーダ セラピューティクス インコーポレイテッド
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis

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  • Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2010548749A 2008-02-29 2009-03-02 グリア成長因子2の所望の血漿レベルを達成するための方法 Expired - Fee Related JP5697455B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6758908P 2008-02-29 2008-02-29
US61/067,589 2008-02-29
PCT/US2009/001356 WO2009108390A2 (en) 2008-02-29 2009-03-02 Method for achieving desired glial growth factor 2 plasma levels

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JP2014212193A Division JP5964920B2 (ja) 2008-02-29 2014-10-17 グリア成長因子2の所望の血漿レベルを達成するための方法

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JP2011513310A JP2011513310A (ja) 2011-04-28
JP2011513310A5 JP2011513310A5 (enExample) 2012-04-19
JP5697455B2 true JP5697455B2 (ja) 2015-04-08

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JP2014212193A Expired - Fee Related JP5964920B2 (ja) 2008-02-29 2014-10-17 グリア成長因子2の所望の血漿レベルを達成するための方法

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US (5) US8410050B2 (enExample)
EP (3) EP3120863B1 (enExample)
JP (2) JP5697455B2 (enExample)
CN (2) CN102026651B (enExample)
AU (1) AU2009217606B2 (enExample)
BR (1) BRPI0908271A2 (enExample)
CA (1) CA2717193C (enExample)
ES (2) ES2811127T3 (enExample)
PL (2) PL3120863T3 (enExample)
RU (3) RU2530650C2 (enExample)
WO (1) WO2009108390A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015042656A (ja) * 2008-02-29 2015-03-05 アコーダ セラピューティクス インコーポレイテッド グリア成長因子2の所望の血漿レベルを達成するための方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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EP3338791B1 (en) 2008-07-17 2019-09-18 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin in the treatment or prophylaxis of heart failure
CN104707130A (zh) 2008-08-15 2015-06-17 阿索尔达治疗公司 在cns神经性损伤后非-急性期间处理的组合物及方法
AU2010306777C1 (en) 2009-10-14 2016-03-17 Acorda Therapeutics, Inc. Use of a neuregulin to treat peripheral nerve injury
WO2011147981A2 (en) * 2010-05-28 2011-12-01 Mind-Nrg Sa Neuregulin isoforms, neuregulin polypeptides and uses thereof
WO2012021818A2 (en) * 2010-08-13 2012-02-16 Georgetown University Ggf2 and methods of use
WO2013149163A1 (en) * 2012-03-30 2013-10-03 Acorda Therapeutics, Inc. Use of neuregulin to treat peripheral nerve injury
WO2018056412A1 (ja) * 2016-09-23 2018-03-29 国立大学法人大阪大学 シュワン細胞分化促進剤及び末梢神経再生促進剤
CN108653274B (zh) * 2017-04-01 2022-09-16 鲁南制药集团股份有限公司 牛蒡子苷元在制备治疗骨髓损伤药物中的用途

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US5530109A (en) * 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US5716930A (en) 1991-04-10 1998-02-10 Ludwig Institute For Cancer Research Glial growth factors
US7319019B1 (en) 1991-04-10 2008-01-15 Acorda Therapeutics, Inc. Glial mitogenic factors lacking an N-terminal signal sequence
US7135456B1 (en) 1991-04-10 2006-11-14 Acorda Therapeutics, Inc. Glial mitogenic factors, their preparation and use
US7037888B1 (en) * 1992-04-03 2006-05-02 Acorda Therapeutics, Inc. Methods for treating muscle diseases and disorders
GB9217316D0 (en) 1992-08-14 1992-09-30 Ludwig Inst Cancer Res Schwann cell mitogenic factor,its preparation and use
US5912326A (en) 1995-09-08 1999-06-15 President And Fellows Of Harvard College Cerebellum-derived growth factors
AU3003701A (en) * 1999-11-19 2001-05-30 Axxima Pharmaceuticals Ag Inhibitors of helicobacter pylori induced gastrointestinal diseases
US20030232761A1 (en) 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
MX351062B (es) * 2003-05-16 2017-09-29 Acorda Therapeutics Inc Proteinas de fusion para el tratamiento del snc.
WO2005079458A2 (en) * 2004-02-19 2005-09-01 The Regents Of The University Of California ENHANCEMENT OF Th2-DEPENDENT AND INFLAMMATORY RESPONSE
AU2006210537A1 (en) 2005-02-02 2006-08-10 Fox Chase Cencer Center Amine derivative containing compositions and methods for the treatment of viral infections related to the etiology of cancer
CA2658326C (en) 2005-09-02 2013-04-23 Morehouse School Of Medicine Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue
US20080003013A1 (en) * 2006-06-30 2008-01-03 Static Control Components, Inc. Cartridge split rail clip
CN102026651B (zh) * 2008-02-29 2015-06-03 阿索尔达治疗公司 达到所需胶质生长因子2血浆水平的方法
WO2011123606A1 (en) 2010-04-01 2011-10-06 The Procter & Gamble Company Fabric softener
WO2012021818A2 (en) 2010-08-13 2012-02-16 Georgetown University Ggf2 and methods of use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015042656A (ja) * 2008-02-29 2015-03-05 アコーダ セラピューティクス インコーポレイテッド グリア成長因子2の所望の血漿レベルを達成するための方法
US9744215B2 (en) 2008-02-29 2017-08-29 Acorda Therapeutics, Inc. Method for achieving desired glial growth factor 2 plasma levels
US10675331B2 (en) 2008-02-29 2020-06-09 Acorda Therapeutics, Inc. Method for achieving desired glial growth factor 2 plasma levels

Also Published As

Publication number Publication date
JP2011513310A (ja) 2011-04-28
US20180055909A1 (en) 2018-03-01
US20130345131A1 (en) 2013-12-26
US8410050B2 (en) 2013-04-02
US9272015B2 (en) 2016-03-01
EP3750551A1 (en) 2020-12-16
EP3120863A1 (en) 2017-01-25
PL2262527T3 (pl) 2017-07-31
EP2262527B1 (en) 2016-08-03
ES2613177T3 (es) 2017-05-23
JP5964920B2 (ja) 2016-08-03
EP3120863B1 (en) 2020-05-06
AU2009217606B2 (en) 2015-03-05
WO2009108390A3 (en) 2010-11-18
US20160367634A1 (en) 2016-12-22
AU2009217606A1 (en) 2009-09-03
CA2717193A1 (en) 2009-09-03
US20210060128A1 (en) 2021-03-04
US10675331B2 (en) 2020-06-09
RU2010139906A (ru) 2012-04-10
RU2687097C2 (ru) 2019-05-07
RU2014131265A (ru) 2016-02-20
ES2811127T3 (es) 2021-03-10
RU2019110452A (ru) 2020-10-09
CN102026651A (zh) 2011-04-20
EP2262527A2 (en) 2010-12-22
RU2530650C2 (ru) 2014-10-10
WO2009108390A2 (en) 2009-09-03
US9744215B2 (en) 2017-08-29
US20100029559A1 (en) 2010-02-04
CN104645315A (zh) 2015-05-27
CN102026651B (zh) 2015-06-03
BRPI0908271A2 (pt) 2017-06-13
CA2717193C (en) 2022-08-16
PL3120863T3 (pl) 2021-02-22
PL2262527T4 (pl) 2017-07-31
JP2015042656A (ja) 2015-03-05

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