JP5686602B2 - 滴定装置及び方法 - Google Patents
滴定装置及び方法 Download PDFInfo
- Publication number
- JP5686602B2 JP5686602B2 JP2010537040A JP2010537040A JP5686602B2 JP 5686602 B2 JP5686602 B2 JP 5686602B2 JP 2010537040 A JP2010537040 A JP 2010537040A JP 2010537040 A JP2010537040 A JP 2010537040A JP 5686602 B2 JP5686602 B2 JP 5686602B2
- Authority
- JP
- Japan
- Prior art keywords
- titration
- titrant
- electrode
- vessel
- ion source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004448 titration Methods 0.000 title claims description 95
- 238000000034 method Methods 0.000 title description 19
- 150000002500 ions Chemical class 0.000 claims description 61
- 239000000523 sample Substances 0.000 claims description 47
- 239000002253 acid Substances 0.000 claims description 35
- 230000008384 membrane barrier Effects 0.000 claims description 26
- 239000012488 sample solution Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 15
- 229910052709 silver Inorganic materials 0.000 claims description 15
- 239000004332 silver Substances 0.000 claims description 15
- 239000003014 ion exchange membrane Substances 0.000 claims description 12
- 238000001514 detection method Methods 0.000 claims description 7
- 238000005868 electrolysis reaction Methods 0.000 claims description 7
- 230000004888 barrier function Effects 0.000 claims description 6
- 230000000903 blocking effect Effects 0.000 claims description 5
- 150000007513 acids Chemical class 0.000 claims description 4
- 230000009969 flowable effect Effects 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 2
- 230000007613 environmental effect Effects 0.000 claims 1
- 238000005342 ion exchange Methods 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- 239000000243 solution Substances 0.000 description 21
- 239000012528 membrane Substances 0.000 description 15
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 15
- -1 silver-silver halide Chemical class 0.000 description 12
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000005443 coulometric titration Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 5
- 238000005341 cation exchange Methods 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- 229910052697 platinum Inorganic materials 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000004809 Teflon Substances 0.000 description 4
- 229920006362 Teflon® Polymers 0.000 description 4
- 150000001450 anions Chemical class 0.000 description 4
- 150000001768 cations Chemical class 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000007792 addition Methods 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000003011 anion exchange membrane Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 229910021607 Silver chloride Inorganic materials 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910052946 acanthite Inorganic materials 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000003869 coulometry Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 229940098779 methanesulfonic acid Drugs 0.000 description 2
- 229910000510 noble metal Inorganic materials 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 239000012898 sample dilution Substances 0.000 description 2
- XUARKZBEFFVFRG-UHFFFAOYSA-N silver sulfide Chemical compound [S-2].[Ag+].[Ag+] XUARKZBEFFVFRG-UHFFFAOYSA-N 0.000 description 2
- 229940056910 silver sulfide Drugs 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 241000270728 Alligator Species 0.000 description 1
- 229910000497 Amalgam Inorganic materials 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000004696 Poly ether ether ketone Substances 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000004082 amperometric method Methods 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000008713 feedback mechanism Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004442 gravimetric analysis Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002530 polyetherether ketone Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000003115 supporting electrolyte Substances 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000003221 volumetric titration Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/16—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using titration
- G01N31/162—Determining the equivalent point by means of a discontinuity
- G01N31/164—Determining the equivalent point by means of a discontinuity by electrical or electrochemical means
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/952,013 US8475639B2 (en) | 2007-12-06 | 2007-12-06 | Titration device and method |
| US11/952,013 | 2007-12-06 | ||
| PCT/US2008/085466 WO2009076144A1 (en) | 2007-12-06 | 2008-12-04 | Titration device and method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506930A JP2011506930A (ja) | 2011-03-03 |
| JP2011506930A5 JP2011506930A5 (cg-RX-API-DMAC7.html) | 2012-01-19 |
| JP5686602B2 true JP5686602B2 (ja) | 2015-03-18 |
Family
ID=40404148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010537040A Expired - Fee Related JP5686602B2 (ja) | 2007-12-06 | 2008-12-04 | 滴定装置及び方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8475639B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2217915B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5686602B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009076144A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130203171A1 (en) * | 2010-10-14 | 2013-08-08 | Sportsman Consulting Llc | Analytical method and titration device |
| JP5643605B2 (ja) * | 2010-10-27 | 2014-12-17 | サントリーホールディングス株式会社 | 測定装置および測定方法 |
| CN104023551A (zh) | 2011-11-04 | 2014-09-03 | 生物辐射实验室股份有限公司 | 细胞组分的同时纯化 |
| US9766207B2 (en) | 2011-11-04 | 2017-09-19 | Bio-Rad Laboratories, Inc. | Affinity methods and compositions employing electronic control of pH |
| EP2814597A4 (en) | 2012-02-15 | 2015-10-28 | Bio Rad Laboratories | ELECTRONIC CONTROL OF PH-VALUE AND ION STRENGTH |
| US9321012B2 (en) | 2012-04-04 | 2016-04-26 | Bio-Rad Laboratories, Inc. | Electronic protein fractionation |
| EP2840390A1 (de) * | 2013-08-19 | 2015-02-25 | Mettler-Toledo AG | Coulometrische Titrationszelle |
| EP3475689B1 (en) * | 2016-06-23 | 2021-01-27 | Hach Company | Alkalinity sensor |
| US11714059B2 (en) * | 2020-12-23 | 2023-08-01 | Hach Company | Isolating interferences in alkalinity measurement |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2744061A (en) | 1951-04-16 | 1956-05-01 | Research Corp | Coulometric titration |
| US2954336A (en) | 1957-07-30 | 1960-09-27 | Standard Oil Co | Universal titrating agent generator |
| NL259614A (cg-RX-API-DMAC7.html) | 1959-12-31 | |||
| US3308041A (en) | 1961-12-05 | 1967-03-07 | Beckman Instruments Inc | Method and apparatus for titration |
| US3374161A (en) * | 1964-10-28 | 1968-03-19 | Beckman Instruments Inc | External coulometric generator |
| US3856633A (en) | 1971-01-07 | 1974-12-24 | Foxboro Co | Concentration measurements utilizing coulometric generation of reagents |
| US4007105A (en) | 1975-07-11 | 1977-02-08 | Beckman Instruments, Inc. | Electrode module for titration apparatus |
| JPS5362637A (en) | 1976-11-12 | 1978-06-05 | Matsushita Electric Industrial Co Ltd | Automatic controlling method and device for ph of culture solution |
| JPS61241663A (ja) * | 1985-04-19 | 1986-10-27 | Mitsui Petrochem Ind Ltd | ヒドロペルオキシドの連続定量法 |
| JPH03216543A (ja) * | 1990-01-23 | 1991-09-24 | Nippon Hyomen Kagaku Kk | 過酸化水素濃度測定装置 |
| US5045204A (en) | 1990-02-13 | 1991-09-03 | Dionex Corporation | Method and apparatus for generating a high purity chromatography eluent |
| JPH0635950U (ja) * | 1992-10-13 | 1994-05-13 | 住友金属工業株式会社 | 鋼材の硫化水素試験装置 |
| JP2000501173A (ja) * | 1995-11-14 | 2000-02-02 | フーア、ギュンター | イオン濃度を調整するための装置および方法 |
| US6225129B1 (en) * | 1998-02-02 | 2001-05-01 | Dionex Corporation | Large capacity acid or base generation apparatus and method of use |
| US7402283B2 (en) | 2002-09-11 | 2008-07-22 | Dionex Corporation | Electrolytic eluent generator and method of use |
| RU2229325C1 (ru) | 2003-11-12 | 2004-05-27 | ЗАО "Научно-Производственная Коммерческая Фирма Аквилон" | Электродиализный генератор элюента для ионной хроматографии |
-
2007
- 2007-12-06 US US11/952,013 patent/US8475639B2/en active Active
-
2008
- 2008-12-04 WO PCT/US2008/085466 patent/WO2009076144A1/en not_active Ceased
- 2008-12-04 JP JP2010537040A patent/JP5686602B2/ja not_active Expired - Fee Related
- 2008-12-04 EP EP08858643.3A patent/EP2217915B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011506930A (ja) | 2011-03-03 |
| EP2217915B1 (en) | 2015-10-14 |
| US20090145777A1 (en) | 2009-06-11 |
| WO2009076144A1 (en) | 2009-06-18 |
| EP2217915A1 (en) | 2010-08-18 |
| US8475639B2 (en) | 2013-07-02 |
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