JP5683471B2 - 蛍光色素を含む歯科用組成物 - Google Patents
蛍光色素を含む歯科用組成物 Download PDFInfo
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- JP5683471B2 JP5683471B2 JP2011532154A JP2011532154A JP5683471B2 JP 5683471 B2 JP5683471 B2 JP 5683471B2 JP 2011532154 A JP2011532154 A JP 2011532154A JP 2011532154 A JP2011532154 A JP 2011532154A JP 5683471 B2 JP5683471 B2 JP 5683471B2
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 125000005641 methacryl group Chemical group 0.000 description 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 229940029985 mineral supplement Drugs 0.000 description 1
- 235000020786 mineral supplement Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000012766 organic filler Substances 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 150000004968 peroxymonosulfuric acids Chemical class 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000005365 phosphate glass Substances 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000068 pit and fissure sealant Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001444 polymaleic acid Polymers 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000011164 primary particle Substances 0.000 description 1
- QTECDUFMBMSHKR-UHFFFAOYSA-N prop-2-enyl prop-2-enoate Chemical compound C=CCOC(=O)C=C QTECDUFMBMSHKR-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- BOQSSGDQNWEFSX-UHFFFAOYSA-N propan-2-yl 2-methylprop-2-enoate Chemical compound CC(C)OC(=O)C(C)=C BOQSSGDQNWEFSX-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- DNXIASIHZYFFRO-UHFFFAOYSA-N pyrazoline Chemical compound C1CN=NC1 DNXIASIHZYFFRO-UHFFFAOYSA-N 0.000 description 1
- 239000001044 red dye Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010557 suspension polymerization reaction Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 150000003585 thioureas Chemical class 0.000 description 1
- 239000013008 thixotropic agent Substances 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003623 transition metal compounds Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000012463 white pigment Substances 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000001043 yellow dye Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/78—Pigments
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Dental Preparations (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
Description
本明細書で使用するとき、語句「天然歯の蛍光」とは、365nmの紫外線下で見たとき、組成物が天然歯に類似の蛍光強度及び色を呈することを意味する。天然歯の蛍光は、被験体によって異なるが、組成物の蛍光と天然歯の蛍光との所望の整合の近似性は、正確な位置及び/又は患者の審美的要求に依存する(例えば、臼歯及び容易には見えない他の歯は、前歯ほど天然歯の蛍光と一致する必要がない可能性がある)。典型的には、本発明の組成物は、約20カウント/秒〜約100カウント/秒、より典型的には約30カウント/秒〜約90カウント/秒、最も典型的には約35カウント/秒〜約85カウント/秒の範囲の蛍光強度を呈する。
本発明の歯科用組成物は、典型的には重合性成分が存在するため、硬化性である。幾つかの実施形態では、組成物は、口腔表面に塗布する前に硬化させ得る(例えば、従来の光重合及び/又は化学重合技術によって重合し得る)。他の実施形態では、組成物は、口腔表面に塗布された後に硬化させ得る(例えば、従来の光重合及び/又は化学重合技術によって重合し得る)。
特定の実施形態では、本発明の組成物は光重合性である、即ち、この組成物は、化学線の照射時に、組成物の重合(又は硬化)を開始する光重合性成分及び光反応開始剤系を含有する。このような光重合性組成物は、フリーラジカル重合性又はカチオン重合性であってもよい。
特定の実施形態では、本発明の組成物は、化学的に硬化可能である、即ち、組成物は、化学硬化性成分と、化学線の照射に依存することなく重合、硬化、又は別の方法で組成物を硬化できる化学反応開始剤(即ち、反応開始剤系)とを含有する。このような化学的硬化性組成物は、時に、「自己硬化」組成物と呼ばれる。
本発明の組成物は、少なくとも1種の蛍光有機色素成分を含み、これは、天然歯の蛍光を発する組成物、及び/又はその組成物から作製される硬化製品若しくは材料(例えば、歯科修復材)を提供するための蛍光剤として機能する。
本発明の組成物は、所望により、1種以上の充填剤を含有することができる。充填剤は、例えば歯科修復剤組成物に現在使用されている充填剤等、歯科用途に使用されている組成物内への組み込みに適した多種多様な物質の1種以上から選択されてよい。
所望により、本発明の組成物は、溶媒(例えば、アルコール(例えば、プロパノール、エタノール)、ケトン(例えば、アセトン、メチルエチルケトン)、エステル(例えば、酢酸エチル)、他の非水性溶媒(例えば、ジメチルホルムアミド、ジメチルアセトアミド、ジメチルスルホキシド、1−メチル−2−ピロロリジノン))、又はこれらの混合物を含有してもよい。
本発明の歯科用組成物は、従来の混合技術を使用して様々な成分を全て組み合わせて調製できる。得られる組成物は、所望により、充填剤、溶媒、水及び本発明で記載したような他の添加剤を含有してよい。典型的には、本発明の光重合性組成物は、「安全光(safe light)」の下で本発明の組成物の成分を単純に混合させて調製される。この混合物を処置する場合、必要に応じて、好適な不活性溶媒を取り入れてもよい。本発明の組成物の成分とはそれほど反応しない、いずれの溶媒を使用してよい。好適な溶媒の例には、アセトン、ジクロロメタン、アセトニトリル、及びラクトンが挙げられる。重合される液体材料を、重合される別の液体又は固体の材料に対する溶媒として使用できる。無溶媒の組成物は、ヨードニウム錯塩、増感剤、及び電子供与体を重合性樹脂の中に、溶解を容易にするために温和な加熱を使用して又は使用しないで、単純に溶解することにより調製できる。
「CAMP」は、国際公開/US2006/122081号の実施例1に記載のように調製された1−(2−メタクリロイルオキシエチル)−2−(7−メチレン−1,5,ジチアオクタン−3−イル)フタレートを指し、
「TrisMAP」は、本質的に2007年11月2日出願の米国仮出願第60/984,785号(Kalgutkarら)に記載のように調製された、2−[4−(2−ヒドロキシ−3−メタクリロイルオキシプロポキシ)フェニル−2−[4−(2−[2−メタクリルオキシエトキシ]フタリルオキシ−3−メタクリルオキシプロポキシ)フェニル]−プロパンを指し、
「UDMA」は、Rohm America LLC,Piscataway,NJから商品名「ROHAMERE 6661−0」として入手した、ジウレタンジメタクリレートを指し、
「ビスEMA6」は、Sartomer Co.,Inc.,Exton,PAから入手した、エトキシ化ビスフェノールAジメタクリレートを指し、
「TEGDMA」は、Sartomer Co.,Inc.,Exton,PAから入手した、トリエチレングリコールジメタクリレートを指し、
「ビスGMA」は、2,2−ビス[4−(2−ヒドロキシ−3−メタクリロイルオキシプロポキシ)フェニル]プロパンを指し、
「BHT」は、ブチル化ヒドロキシトルエンを指し、
「SiO2/ZrO2充填剤1」は、本質的に米国特許第6,730,156号に記載のように調製され、下記のように表面処理された、シラン処理ジルコニア−シリカナノクラスタ充填剤を指し、
「SiO2/ZrO2充填剤2」は、本質的に米国特許第6,730,156号に記載のように調製され、下記のように表面処理された、シラン処理ジルコニア−シリカナノクラスタ充填剤を指し、
「SiO2/ZrO2充填剤3」は、本質的に米国特許第6,730,156号に記載のように調製された、シラン処理ジルコニア−シリカナノクラスタ充填剤を指し、
「ZrO2充填剤」は、A−174及びA−1230のブレンドの代わりにGF31を用いたことを除いて、本質的に米国特許公開第2005/0252413号の予備実施例1Aに記載のように調製されたシラン処理ナノサイズジルコニアを指し、
「SiO2充填剤」は、本質的に米国特許公開第2005/0252413号に充填剤Fに記載のように調製された、およそ20ナノメートルの公称粒径を有するシラン処理ナノサイズシリカを指し、
「ENMAP」は、N−メチルアニリンのエチルアクリレートへのマイケル付加により調製されたエチル−(N−メチル−N−フェニル)アミノプロピオネートを指し(J.Chem.Soc.,Supplement,p.144〜152(1949))、63524US002、
「EDMAB」は、エチル4−ジメチルアミノベンゾエートを指し、
「EDMOA」は、2−エチル−9,10−ジメトキシアントラセンを指し、
「DPIPF6」は、Alfa Aesar,Ward Hill,MAから入手した、ジフェニルヨードニウムヘキサフルオロホスフェートを指し、
「CPQ」は、カンファーキノンを指し、
「Irgacure 819」は、Ciba,Inc.,Tarrytown,NYから入手したビス(2,4,6−トリメチルベンゾイル)フェニルホスフィンオキシドを指し、
「TINUVIN」は、Ciba Specialty Chemicals,Tarrytown,NYから商品名TINUVIN R 796として入手した重合性紫外線安定剤を指し、
「L−88」は、Beaver Luminescers(Newton,MA)から入手した有機蛍光色素を指し、
「QBK58/UF−A2」は、Phosphor Technology(Stevenage,Hertfordshire,England)から入手したY2Si05:Ceを指し、
「A−594−5」又は「A−594」は、DayGlo Corp,Cleveland,OHから入手した蛍光色素を指し、
「Lumilux White」は、Honeywell Inc.,Morristown,NJから入手したLumilux Natural White Zを指し、
「Uvitex OB」は、Ciba Specialty Chemicals(Tarrytown,NY)から入手した、2,5−ビス(5−tert−ブチル−2−ベンゾキサゾリル)チオフェン(BBOT)を指し、
「GENIOSIL GF−31」又は「GF−31」は、Wacker Chemie AG,Munich,Germanyから得られる3−メタクリルオキシプロピルトリメトキシシラン組成物を指し、
「赤色色素分散物」は、2007年11月2日出願の米国仮出願第60/984,785号(Kalgutkarら)に記載のような、赤色酸化鉄(III)色素を含有する分散物を指し、
「黄色色素分散物」は、2007年11月2日出願の米国仮出願第60/984,785号(Kalgutkarら)に記載のような、黄色酸化鉄(III)色素を含有する分散物を指し、
「白色色素分散物」は、2007年11月2日出願の米国仮出願第60/984,785号(Kalgutkarら)に記載のような、ルチル形二酸化チタン色素を含有する分散物を指す。
特に明記しない限り、試薬及び溶媒は、Sigma−Aldrich Corp.,St.Louis,MOから入手した。コンポジットの混合は全て、DAC−150FZ高速ミキサ(Flacktec Corp.,Landrum SC)内で成分を混合することにより行われた。混合は、コンポジットに更なる変化が見られなくなるまで、混合サイクル間に冷却のための20秒間の間隔をおいて、2000rpmから2400rpmまで徐々に速くなる速度で実施された。カンファーキノン、EDMAB、及びロドニウムヘキサフルオロホスフェートを、固体が見えなくなるまで、ガラス瓶内にてローラ上で製剤を回転させることにより、それぞれの樹脂に溶解させた。全てのコンポジットをシリンジに充填し、45℃で16時間プランジャに負荷を適用することにより脱気した。コンポジットを、黄色光下で保存し、取り扱った。
蛍光安定性は、ISO 4049:2000に記載されている色の安定性についての設備及び測定技術を用いて、4時間にわたって試験された。Hanau sun試験装置を、中程度の強度のXeアークランプと共に用いた。蛍光安定性試験に供されたディスクを、循環浴を用いて37℃に維持された水中に浸漬した。ディスクを装置から取り出し、Tecan Infinite 200蛍光分光計(Durham,NC)を用いて蛍光強度を測定した。全てのサンプルに365nmで照射し、1nm間隔で390〜730nmにて放射データを回収した。ゲインを用手的に70に固定し、20マイクロ秒間各データ点を積分し、10回を平均した。必ずXeアークランプに曝露したディスク側面と同じ面を蛍光測定に用いるよう注意した。次いで、Gunter Wyszecki及びW.S.Stiles、「Color Science.Concepts and Methods.Quantitative Data and Formulae.」、2nd edition,John Wiley(1982)の第3.3.8章に記載のようにデータを解析した。1931 CIE 2°標準観測者等色関数のデータは、CIE publication CIE 15:2004(ISBN 3901906339)から入手した。分析の結果をCIE 2°色度座標の観点で報告し、それは知覚された蛍光の色に一致する。CIELABパラメータ及びコントラスト比のデータは、Hunterlab UltraScan VIS分光光度計(Reston,VA)を用いて、同じディスクについて入手した。
Y2SiO5:Ceは、以下のように11.6重量%の(3−メタクリルオキシ)プロピルトリメトキシシラン(Genosil GF31)を用いてシラン処理された、Phosphor Technology(Stevenage,Hertfordshire,England)から得られる無機発光色素である。0.8010グラムのY2SiO5:Ceのスラリーを、撹拌しながら、1:1の脱イオン水:1−メトキシ−2−プロパノール溶媒10.0242グラム中で調製した。10重量%のトリフルオロ酢酸数滴を用いて、pHを2.65に調整した。GF−31(0.0932グラム)を1度に全て添加し、70℃で5.25時間、溶媒の損失を防ぐために、凝縮器を備える丸底反応槽を磁気的に撹拌することにより反応を実行させた。次いで、52分間にわたってrotvap(80℃、真空)を用いて溶媒を除去し、オフホワイトの粉末としてS/T Y2SiO5:Ceを得た。乳鉢と乳棒を用いて粉末を砕き、更に加工を行うことなく使用した。
シリカ−ジルコニアナノクラスタのスラリー(米国特許第6,572,693号に記載のような)を、磁気混合により、脱イオン水と1−メトキシ−2−プロパノールの1:1混合物中で調製した。10重量%のトリフルオロ酢酸数滴を用いて、pHを3.00に調整した。このスラリーを、1度に全て添加した、17.98グラムの(3−メタクリルオキシ)プロピルトリメトキシシラン(Genosil GF31)でシラン処理した。室温で、封止されたバイアル瓶を回転させることにより、一晩反応を実行させた。次の日の朝、スラリーをギャップ乾燥させた。ギャップ乾燥機のホットプレート設定点は290°F(143℃)であり、実際の入口は263°F(128℃)であり、出口は255°F(124℃)であり、ホットプレートとコールドプレートとのギャップは約2インチ(5.08cm)であり、コーティングは0.015インチ(0.038cm)であり、ライン速度は約3フィート/分(91.4cm/分)であった。粉末は、75mの篩を通過した。更なる加工を行うことなく使用した。
5.47gのA部(下記)と7.93gのB部(下記)との混合物を調製することにより、充填剤を作製した。
A部は、以下のように調製した。31.3590グラムの(3−メタクリルオキシ)プロピルトリメトキシシラン(Genosil GF31、11−0021−2849−1)を丸底フラスコに添加し、次に330.3グラムの酢酸エチル及び299.6グラムのシリカ−ジルコニア(米国特許第6,572,693号)を磁気的に混合しているフラスコに添加した。次に、7.21グラムの水酸化アンモニウム(28/30%)を添加した。室温で、封止されたバイアル瓶を磁気的に撹拌することにより、一晩反応を実行させた。次の日、溶媒の大部分が除去されるまで、rotovap(35℃/真空)内で溶媒を除去し、次いで目視検査により粉末が乾燥するまで、浴を90℃にした。このプロセスには35分かかった。次に、粉末を85℃のオーブンに2時間入れた。粉末は、75mの篩を通過した。更なる加工を行うことなく使用した。
有機蛍光色素L−88を含有する組成物(実施例E−1及びE−2)のCIELABパラメータ及びコントラスト比(不透明度の測定)を、無機発光色素QBK58/UF−A2を含有する組成物(比較例CE−1、CE−2、及びCE−3)、又は蛍光色素を含有しない組成物(比較例CE−4及びCE−5)のCIELABパラメータ及びコントラスト比と比較するために、上記一般的な技術により、表1に記載のコンポジットを調製した(列挙された成分は全て重量%による)。L−88は、ヒドロキシル置換アリールグアナミンである有機蛍光色素である。QBK58/UF−A2は、セリウムドーピングを用いて、Y2SiO5から調製された無機発光色素材料である。
有機染料及び色素を含有する歯科用コンポジットについて、時限曝露試験を行った。表4に記載の配合を有するペーストを、上記一般的な技術により調製した。これら配合は、Beaver Luminescers(Newton,MA)から入手したL−88を、別の蛍光色素である、DayGlo Corporation(Cleveland,OH)から入手したA−594−5、又は有機蛍光染料である、Ciba Specialty Chemicals(Tarrytown,NY)から商品名Uvitex OBとして入手した2,5−ビス(5−tert−ブチル−2−ベンゾキサゾリル)チオフェン(BBOT)と組み合わせる。各製剤のサンプルを紫外線に曝露し、蛍光の変化を経時的に測定した。次いで、得られた蛍光減衰データを表5に示す。
表6に記載の配合を有するペーストを、上記一般的な技術により調製した。これらペーストは、知覚される蛍光の色を調節するために、様々な比で有機蛍光色素L−88及びA−594−5の組み合わせを含有していた。
に組み込まれたかのように、その全体が参考として組み込まれる。なお、本願発明は以下のものを含む。
1. 蛍光有機色素を含む硬化性歯科用組成物。
2. 硬化した際に、天然歯の蛍光を有する、第1項に記載の組成物。
3. 前記蛍光有機色素が、ポリマー内に封入された又はポリマーに結合した蛍光化合物を含む、前記第1項に記載の組成物。
4. 前記蛍光有機色素が、本質的に蛍光有機化合物を含む、前記第3項に記載の組成物。
5. 前記蛍光有機色素成分が、前記組成物の1重量%未満の量で存在する、前記第1〜4項のいずれか一項に記載の組成物。
6. 重合性成分を更に含む、前記第1〜5項のいずれか一項に記載の組成物。
7. 前記重合性成分が、エチレン性不飽和化合物を含む、前記第6項に記載の組成物。
8. 前記エチレン性不飽和化合物が、(メタ)アクリレートである、前記第7項に記載の組成物。
9. 反応開始剤系を更に含む、前記第1〜8項のいずれか一項に記載の組成物。
10. 前記組成物が、光硬化性であり、前記反応開始剤系が、光反応開始剤を含む、前記第9項に記載の組成物。
11. 充填剤系を更に含む、前記第1〜10項のいずれか一項に記載の組成物。
12. 前記充填剤系が、シリカナノ粒子、ジルコニアナノ粒子、シリカ及びジルコニアナノ粒子のナノクラスタ、又はこれらの組み合わせを含む、前記第11項に記載の組成物。
13. 前記ナノ粒子又はナノクラスタが、シラン処理されている、前記第12項に記載の組成物。
14. 天然歯の蛍光を有する歯科用組成物を作製する方法であって、
(a)硬化時に、天然歯とは異なる蛍光を有する材料を提供する歯科用樹脂系を提供する工程と、
(b)前記樹脂系に十分な量の有機蛍光成分を添加して、硬化時に、天然歯の蛍光を有する組成物を提供する工程と、を含む、方法。
15. (c)前記組成物の蛍光と、前記天然歯の蛍光とを比較する工程を更に含む、前記第14項に記載の方法。
16. 前記樹脂系が、エチレン性不飽和成分を含む、前記第14項又は第15項に記載の方法。
17. 前記エチレン性不飽和成分が、(メタ)アクリレートである、前記第16項に記載の方法。
18. 前記組成物が、反応開始剤系を更に含む、前記第14項〜第17項のいずれか一項に記載の方法。
19. 前記組成物が、光硬化性であり、前記反応開始剤系が、光反応開始剤を含む、前記第18項に記載の方法。
20. 前記組成物が、充填剤系を更に含む、前記第14項〜18項のいずれか一項に記載の方法。
21. 前記充填剤系が、シリカナノ粒子、ジルコニアナノ粒子、シリカ及びジルコニアナノ粒子を含むナノクラスタ、又はこれらの組み合わせを含む、前記第20項に記載の方法。
22. 前記ナノ粒子が、シラン処理されている、前記第21項に記載の方法。
23. 前記第1項〜第13項のいずれか一項に記載の組成物を硬化させることにより作製される歯科用製品。
Claims (1)
- 蛍光ベンゾキサゾール有機色素および蛍光ヒドロキシル置換アリールグアナミン有機色素を含む硬化性歯科用組成物。
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PCT/US2009/060082 WO2010045096A2 (en) | 2008-10-15 | 2009-10-09 | Dental compositions with fluorescent pigment |
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Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2214622B1 (en) * | 2007-11-01 | 2014-12-03 | 3M Innovative Properties Company | Dental compositions and initiator systems with color-stable amine electron donors |
JP5435892B2 (ja) * | 2008-05-21 | 2014-03-05 | 株式会社トクヤマデンタル | 光重合性組成物 |
JP6385828B2 (ja) * | 2012-02-27 | 2018-09-05 | ベイ マテリアルズ, リミテッド ライアビリティー カンパニーBay Materials, LLC | 歯牙に適合する高分子シェルを作製する方法 |
JP5894861B2 (ja) * | 2012-05-25 | 2016-03-30 | 株式会社ジーシー | 識別情報記録部の識別情報を蛍光により確認できる義歯を製造する方法及び義歯に蛍光により確認できる識別情報を付与する組成物キット |
CA2875502C (en) | 2012-06-04 | 2018-01-02 | Dentsply International Inc. | Dental restorative composite with luminescent crystals |
JP6204785B2 (ja) | 2012-10-24 | 2017-09-27 | 株式会社松風 | 可視光線硬化型の歯科用硬化性組成物及びその存在識別方法 |
CN102973416B (zh) * | 2012-12-07 | 2014-07-23 | 东华大学 | 以二氧化硅及其团簇为填料的齿科修复树脂的制备方法 |
US20160324730A1 (en) * | 2012-12-18 | 2016-11-10 | Dentca, Inc. | Photo-curable resin compositions and method of using the same in three-dimensional printing for manufacturing artificial teeth and denture base |
CN105452349B (zh) * | 2013-08-13 | 2022-09-27 | 3M创新有限公司 | 包含二氧化硅纳米粒子和分散剂的纳米复合材料、复合材料、制品及其制备方法 |
WO2015064090A1 (ja) * | 2013-10-31 | 2015-05-07 | クラレノリタケデンタル株式会社 | 歯科用色調調整材キット |
JP6255498B2 (ja) | 2013-12-31 | 2017-12-27 | デンツプライ インターナショナル インコーポレーテッド | アップコンバージョン蛍光体を含有する歯科用組成物及び使用方法 |
BR112018016029B1 (pt) | 2016-02-05 | 2021-11-16 | 3M Innovative Properties Company | Composiqoes dentais compreendendo nanoparticulas que fornecem um diferencial de indice de refraqao entre resina polimerizavel e carga |
AU2017230543B2 (en) * | 2016-03-09 | 2022-02-17 | Tokuyama Dental Corporation | Photopolymerization initiator and photocurable composition |
WO2018031821A1 (en) * | 2016-08-10 | 2018-02-15 | President And Fellows Of Harvard College | Composite resins with superior optical, mechanical, and therapeutic properties by incorporation of structured microparticles |
EP3547988A1 (en) * | 2016-12-01 | 2019-10-09 | 3M Innovative Properties Company | Basic core material encapsulated in an inorganic shell suitable for use in biological carrier materials |
WO2018194609A1 (en) * | 2017-04-20 | 2018-10-25 | Hewlett-Packard Development Company, L.P. | Build compositions |
US11553996B2 (en) * | 2017-09-11 | 2023-01-17 | 3M Innovative Properties Company | Radiation curable compositions and composite articles made using an additive manufacturing process |
CN107737379B (zh) * | 2017-11-30 | 2020-11-13 | 中国人民武装警察部队总医院 | 一种荧光胶体组合物及近红外荧光钛夹 |
JP2021517979A (ja) * | 2018-01-15 | 2021-07-29 | プリズミアン ソチエタ ペル アツィオーニ | 光ファイバリボン、光ファイバリボンの製造方法、光ファイバリボンの製造システムおよび光ファイバリボンの試験方法 |
DE102018127854A1 (de) | 2018-11-08 | 2020-05-14 | Delo Industrie Klebstoffe Gmbh & Co. Kgaa | Feuchtigkeitshärtbare Einkomponentenmasse und Verfahren zum Fügen, Vergießen und Beschichten unter Verwendung der Masse |
JPWO2021125246A1 (ja) * | 2019-12-17 | 2021-06-24 | ||
CN112426367A (zh) * | 2020-12-11 | 2021-03-02 | 西安邮电大学 | 用于齿科的可标记发光修复材料及制备方法、粘结剂及制备方法和修复结构 |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2938873A (en) | 1958-06-11 | 1960-05-31 | Switzer Brothers Inc | Pigment materials |
US3412036A (en) | 1962-05-21 | 1968-11-19 | Switzer Brothers Inc | Synthetic resin and pigment production |
US3412035A (en) | 1963-04-22 | 1968-11-19 | Switzer Brothers Inc | Method for producing fine pigment particles in a liquid vehicle |
NL6810272A (ja) * | 1964-05-13 | 1969-01-30 | ||
DE1544923A1 (de) * | 1965-10-22 | 1969-10-09 | Bayer Ag | Verfahren zur Herstellung von kuenstlichen Zaehnen nach dem Pulver-Fluessigkeits-Verfahren |
DE2063948C3 (de) | 1970-03-20 | 1975-01-02 | G. Siegle & Co Gmbh, 7000 Stuttgart | Verwendung von Harzen oder Harzgemischen zur Herstellung fluoreszierender Pigmente |
GB1428672A (en) * | 1972-04-25 | 1976-03-17 | Amalgamated Dental Co Ltd | Polymerizable compositions suitable for dental use |
US3915884A (en) | 1972-05-17 | 1975-10-28 | Day Glo Color Corp | Modified amides for pigments and method for producing the same |
US3922232A (en) * | 1973-11-23 | 1975-11-25 | Hercules Inc | Fluorescent colorants |
GB1569021A (en) | 1976-03-17 | 1980-06-11 | Kuraray Co | Adhesive cementing agents containing partial phosphonic orphosphonic acid esters |
DE2909994A1 (de) | 1979-03-14 | 1980-10-02 | Basf Ag | Acylphosphinoxidverbindungen, ihre herstellung und verwendung |
DE2909992A1 (de) | 1979-03-14 | 1980-10-02 | Basf Ag | Photopolymerisierbare aufzeichnungsmassen, insbesondere zur herstellung von druckplatten und reliefformen |
DE2830927A1 (de) | 1978-07-14 | 1980-01-31 | Basf Ag | Acylphosphinoxidverbindungen und ihre verwendung |
US4695251A (en) | 1980-04-07 | 1987-09-22 | Minnesota Mining And Manufacturing Company | Orthodontic bracket adhesive and abrasive for removal thereof |
US4324774A (en) * | 1980-07-17 | 1982-04-13 | Fertilizer Development S.A. | Method for the manufacture of defluorinated phosphatic products |
US4356296A (en) | 1981-02-25 | 1982-10-26 | The United States Of America As Represented By The Secretary Of The Navy | Fluorinated diacrylic esters and polymers therefrom |
EP0079940B1 (en) * | 1981-06-01 | 1988-08-24 | Kerr Manufacturing Company (a Delaware corporation) | Fluorine containing dental materials |
US4539382A (en) | 1981-07-29 | 1985-09-03 | Kuraray Co., Ltd. | Adhesive composition |
JPS59135272A (ja) | 1983-01-21 | 1984-08-03 | Kuraray Co Ltd | 接着剤 |
US4503169A (en) | 1984-04-19 | 1985-03-05 | Minnesota Mining And Manufacturing Company | Radiopaque, low visual opacity dental composites containing non-vitreous microparticles |
GR852068B (ja) | 1984-08-30 | 1985-12-24 | Johnson & Johnson Dental Prod | |
DE3443221A1 (de) | 1984-11-27 | 1986-06-05 | ESPE Fabrik pharmazeutischer Präparate GmbH, 8031 Seefeld | Bisacylphosphinoxide, ihre herstellung und verwendung |
DE3502594A1 (de) | 1985-01-26 | 1986-07-31 | Etablissement Dentaire Ivoclar, Schaan | Roentgenopaker dentalwerkstoff |
US4642126A (en) | 1985-02-11 | 1987-02-10 | Norton Company | Coated abrasives with rapidly curable adhesives and controllable curvature |
DE3516257A1 (de) | 1985-05-07 | 1986-11-13 | Bayer Ag, 5090 Leverkusen | (meth)-acrylsaeureester und ihre verwendung |
DE3516256A1 (de) | 1985-05-07 | 1986-11-13 | Bayer Ag, 5090 Leverkusen | (meth)-acrylsaeureester und ihre verwendung |
US4648843A (en) | 1985-07-19 | 1987-03-10 | Minnesota Mining And Manufacturing Company | Method of dental treatment using poly(ethylenically unsaturated) carbamoyl isocyanurates and dental materials made therewith |
US4652274A (en) | 1985-08-07 | 1987-03-24 | Minnesota Mining And Manufacturing Company | Coated abrasive product having radiation curable binder |
DE3536076A1 (de) | 1985-10-09 | 1987-04-09 | Muehlbauer Ernst Kg | Polymerisierbare zementmischungen |
DE3609038A1 (de) | 1986-03-18 | 1987-09-24 | Espe Stiftung | Roentgenopake polymerisierbare dentalmassen |
CA1323949C (en) | 1987-04-02 | 1993-11-02 | Michael C. Palazzotto | Ternary photoinitiator system for addition polymerization |
AU618772B2 (en) | 1987-12-30 | 1992-01-09 | Minnesota Mining And Manufacturing Company | Photocurable ionomer cement systems |
US5076844A (en) | 1988-12-10 | 1991-12-31 | Goldschmidt AG & GDF Gesellschaft fur Dentale Forschung u. Innovationen GmbH | Perfluoroalkyl group-containing (meth-)acrylate esters, their synthesis and use in dental technology |
DE3841617C1 (ja) | 1988-12-10 | 1990-05-10 | Th. Goldschmidt Ag, 4300 Essen, De | |
DE3939998A1 (de) * | 1989-12-02 | 1991-06-06 | Ivoclar Ag | Verfahren zur optischen unterscheidung eines dentalwerkstoffes sowie dentalwerkstoff dafuer |
US5154762A (en) | 1991-05-31 | 1992-10-13 | Minnesota Mining And Manufacturing Company | Universal water-based medical and dental cement |
US5530038A (en) | 1993-08-02 | 1996-06-25 | Sun Medical Co., Ltd. | Primer composition and curable composition |
US5501727A (en) | 1994-02-28 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Color stability of dental compositions containing metal complexed ascorbic acid |
EP0712622B1 (en) | 1994-11-21 | 1999-09-01 | Tokuyama Corporation | Dental composition and kit |
JPH11237852A (ja) | 1998-02-20 | 1999-08-31 | Rohm Co Ltd | ドットマトリクス表示装置 |
US6030606A (en) | 1998-06-22 | 2000-02-29 | 3M Innovative Properties Company | Dental restoratives comprising Bis-EMA6 |
US6306926B1 (en) | 1998-10-07 | 2001-10-23 | 3M Innovative Properties Company | Radiopaque cationically polymerizable compositions comprising a radiopacifying filler, and method for polymerizing same |
SE9904080D0 (sv) | 1998-12-03 | 1999-11-11 | Ciba Sc Holding Ag | Fotoinitiatorberedning |
DE19860361A1 (de) | 1998-12-24 | 2000-06-29 | Espe Dental Ag | Vernetzbare Monomere auf Cyclosiloxanbasis, deren Herstellung und deren Verwendung in polymerisierbaren Massen |
DE19860364C2 (de) | 1998-12-24 | 2001-12-13 | 3M Espe Ag | Polymerisierbare Dentalmassen auf der Basis von zur Aushärtung befähigten Siloxanverbindungen, deren Verwendung und Herstellung |
WO2000058316A1 (en) | 1999-03-31 | 2000-10-05 | Kuraray Co., Ltd. | Organophosphorus compounds for dental polymerizable compositions |
TWI284540B (en) | 1999-05-13 | 2007-08-01 | Kuraray Co | Bonding composition suitable to tooth tissue |
DE19934407A1 (de) | 1999-07-22 | 2001-01-25 | Espe Dental Ag | Hydrolysierbare und polymerisierbare Silane mit geringer Viskosität und deren Verwendung |
US6387981B1 (en) | 1999-10-28 | 2002-05-14 | 3M Innovative Properties Company | Radiopaque dental materials with nano-sized particles |
US6730156B1 (en) | 1999-10-28 | 2004-05-04 | 3M Innovative Properties Company | Clustered particle dental fillers |
US6572693B1 (en) | 1999-10-28 | 2003-06-03 | 3M Innovative Properties Company | Aesthetic dental materials |
JP4800535B2 (ja) | 1999-10-28 | 2011-10-26 | スリーエム イノベイティブ プロパティズ カンパニー | ナノサイズシリカ粒子を含有する歯科材料 |
US7114951B2 (en) | 1999-11-10 | 2006-10-03 | Dentsply International Inc. | Method and shaped product-formed from low tack and fluorescing polymerizable dental material |
DE10026432A1 (de) | 2000-05-29 | 2002-02-14 | 3M Espe Ag | Präpolymere (Meth)acrylate mit polycyclischen oder aromatischen Segmenten |
JP4993053B2 (ja) * | 2001-02-27 | 2012-08-08 | 株式会社トクヤマ | 歯科用硬化性組成物 |
DE60135302D1 (de) * | 2000-08-22 | 2008-09-25 | Tokuyama Corp | Aushärtbare dentalzusammensetzung |
DE10146883B4 (de) | 2001-09-24 | 2006-05-24 | Dentona Ag | Mineralischer Rohstoff zur Herstellung dentaler Gipsmodelle mit fluoreszierender Oberfläche |
US7173074B2 (en) | 2001-12-29 | 2007-02-06 | 3M Innovative Properties Company | Composition containing a polymerizable reducing agent, kit, and method |
US6765036B2 (en) | 2002-01-15 | 2004-07-20 | 3M Innovative Properties Company | Ternary photoinitiator system for cationically polymerizable resins |
EP1471875A1 (en) | 2002-01-31 | 2004-11-03 | 3M Innovative Properties Company | DENTAL PASTES, DENTAL ARTICLES, AND METHODS |
US6982288B2 (en) | 2002-04-12 | 2006-01-03 | 3M Innovative Properties Company | Medical compositions containing an ionic salt, kits, and methods |
DE10249518B3 (de) * | 2002-10-23 | 2004-02-19 | Heraeus Kulzer Gmbh & Co. Kg | Dentales Formteil, insbesondere künstlicher Zahn |
US7407899B2 (en) * | 2003-01-10 | 2008-08-05 | Milliken & Company | Textile substrates having layered finish structure for improving liquid repellency and stain release |
GB0319165D0 (en) | 2003-06-04 | 2003-09-17 | Unilever Plc | Improved cleaning composition |
US7090721B2 (en) | 2004-05-17 | 2006-08-15 | 3M Innovative Properties Company | Use of nanoparticles to adjust refractive index of dental compositions |
US7649029B2 (en) | 2004-05-17 | 2010-01-19 | 3M Innovative Properties Company | Dental compositions containing nanozirconia fillers |
US7156911B2 (en) | 2004-05-17 | 2007-01-02 | 3M Innovative Properties Company | Dental compositions containing nanofillers and related methods |
US20060194895A1 (en) * | 2005-02-25 | 2006-08-31 | Dan Loveridge | Dental compositions having dual dental diagnostic capabilities and methods of use |
US20060241205A1 (en) * | 2005-04-20 | 2006-10-26 | Weitao Jia | Filler materials for dental composites |
CN102512329A (zh) | 2005-05-09 | 2012-06-27 | 3M创新有限公司 | 含有杂化单体的牙科组合物 |
EP1940343B1 (en) * | 2005-09-29 | 2010-11-10 | DENTSPLY International Inc. | Methods for using dental compositions containing fluorescent agents |
US20070232718A1 (en) * | 2006-03-28 | 2007-10-04 | Weitao Jia | Radiopaque dental materials |
MX2009006011A (es) * | 2006-12-07 | 2009-06-17 | Oreal | Composicion de maquillaje para la piel. |
WO2008083067A2 (en) * | 2006-12-28 | 2008-07-10 | 3M Innovative Properties Company | Dental compositions with natural tooth fluorescence |
EP2149360A4 (en) | 2007-05-31 | 2014-01-22 | Tokuyama Dental Corp | ADHESIVE FOR DENTAL ELEMENTS |
JP5435892B2 (ja) | 2008-05-21 | 2014-03-05 | 株式会社トクヤマデンタル | 光重合性組成物 |
JP2010037254A (ja) * | 2008-08-04 | 2010-02-18 | Gc Corp | 光重合型歯科用表面被覆材 |
JP2010064989A (ja) | 2008-09-11 | 2010-03-25 | Gc Corp | ペースト系歯科用セメント |
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- 2009-10-09 US US13/123,868 patent/US9205029B2/en active Active
- 2009-10-09 EP EP09744256.0A patent/EP2344107B1/en not_active Not-in-force
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EP3243499B1 (en) | 2020-01-08 |
EP2344107B1 (en) | 2017-02-08 |
WO2010045096A2 (en) | 2010-04-22 |
BRPI0914427B8 (pt) | 2018-06-05 |
CN102245154B (zh) | 2014-09-03 |
BRPI0914427A2 (pt) | 2015-10-20 |
RU2011114369A (ru) | 2012-10-20 |
CN102245154A (zh) | 2011-11-16 |
BRPI0914427B1 (pt) | 2017-03-21 |
BRPI0914427C8 (pt) | 2018-07-24 |
EP2344107A2 (en) | 2011-07-20 |
RU2488377C2 (ru) | 2013-07-27 |
US9205029B2 (en) | 2015-12-08 |
JP2012505889A (ja) | 2012-03-08 |
US20110200971A1 (en) | 2011-08-18 |
WO2010045096A3 (en) | 2010-07-15 |
EP3243499A1 (en) | 2017-11-15 |
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