JP5675344B2 - グルタミニルシクラーゼ阻害剤としてのニトロビニルジアミン誘導体 - Google Patents
グルタミニルシクラーゼ阻害剤としてのニトロビニルジアミン誘導体 Download PDFInfo
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- JP5675344B2 JP5675344B2 JP2010503516A JP2010503516A JP5675344B2 JP 5675344 B2 JP5675344 B2 JP 5675344B2 JP 2010503516 A JP2010503516 A JP 2010503516A JP 2010503516 A JP2010503516 A JP 2010503516A JP 5675344 B2 JP5675344 B2 JP 5675344B2
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- Prior art keywords
- alkyl
- inhibitor
- compound
- phenyl
- imidazol
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Animal Behavior & Ethology (AREA)
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- Diabetes (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91253507P | 2007-04-18 | 2007-04-18 | |
| US60/912,535 | 2007-04-18 | ||
| PCT/EP2008/054717 WO2008128987A1 (en) | 2007-04-18 | 2008-04-18 | Novel inhibitors |
Publications (3)
| Publication Number | Publication Date |
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| JP2010524899A JP2010524899A (ja) | 2010-07-22 |
| JP2010524899A5 JP2010524899A5 (cg-RX-API-DMAC7.html) | 2011-06-02 |
| JP5675344B2 true JP5675344B2 (ja) | 2015-02-25 |
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| JP2010503516A Expired - Fee Related JP5675344B2 (ja) | 2007-04-18 | 2008-04-18 | グルタミニルシクラーゼ阻害剤としてのニトロビニルジアミン誘導体 |
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| Country | Link |
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| US (1) | US8202897B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2142515B1 (cg-RX-API-DMAC7.html) |
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| ES (1) | ES2473621T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008128987A1 (cg-RX-API-DMAC7.html) |
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| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| JP5676249B2 (ja) * | 2007-04-20 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体 |
| NZ583799A (en) * | 2007-09-12 | 2011-12-22 | Probiodrug Ag | Transgenic mice comprising a DNA transgene encoding ABeta peptide |
| WO2009090190A1 (en) * | 2008-01-14 | 2009-07-23 | Probiodrug Ag | Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene |
| PT2365804E (pt) * | 2008-11-13 | 2015-09-16 | Modgene Llc | Redução da carga da beta-amiloide em tecido não cerebral |
| EP2475428B1 (en) | 2009-09-11 | 2015-07-01 | Probiodrug AG | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| US20110152341A1 (en) | 2009-12-22 | 2011-06-23 | Probiodrug Ag | Cleavage of b-amyloid precursor protein |
| JP5786020B2 (ja) * | 2010-04-16 | 2015-09-30 | アボットジャパン株式会社 | 関節リウマチを診断する方法および試薬 |
| EP2742062A2 (en) * | 2011-08-12 | 2014-06-18 | Probiodrug AG | In vivo screening models for treatment of qc-related disorders |
| CN104039324B (zh) | 2011-11-01 | 2017-03-15 | 莫德基因有限责任公司 | 减少β淀粉样蛋白负载的组合物和方法 |
| WO2016097305A1 (en) | 2014-12-19 | 2016-06-23 | Probiodrug Ag | Novel method for the detection of pglu-abeta peptides |
| CN106831532B (zh) * | 2017-01-24 | 2019-03-08 | 云南大学 | 全取代3-硝基吲哚化合物及其中间体化合物、制备方法和应用 |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
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| DE3044566A1 (de) * | 1980-11-26 | 1982-07-15 | Basf Ag, 6700 Ludwigshafen | N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung |
| WO2001070696A1 (en) | 2000-03-21 | 2001-09-27 | Ishihara Sangyo Kaisha, Ltd. | Nitroethenamine derivatives or salts thereof and pharmaceutical compositions containing the derivatives or the salts |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| DK2206496T3 (da) * | 2003-05-05 | 2014-12-15 | Probiodrug Ag | Screening af inhibitorer af pyroglutaminsyredannelse i amyloid beta-peptid |
| US8338120B2 (en) * | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| ZA200508439B (en) * | 2003-05-05 | 2007-03-28 | Probiodrug Ag | Medical use of inhibitors of glutaminyl and glutamate cyclases |
| DK1675578T3 (da) * | 2003-10-15 | 2013-08-26 | Probiodrug Ag | Inhibitorer af glutaminyl- og glutamatcyclaser til behandling af de neurodegenerative sygdomme FBD og FDD |
| NZ546887A (en) * | 2003-11-03 | 2009-04-30 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| US7667044B2 (en) * | 2003-11-03 | 2010-02-23 | Probiodrug Ag | Compounds for the treatment of neurological disorders |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| EP1713780B1 (en) * | 2004-02-05 | 2012-01-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| BRPI0718507A2 (pt) * | 2006-09-21 | 2013-11-12 | Probiodrug Ag | Genes relacionados à glutaminil ciclase |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| WO2008055950A1 (en) * | 2006-11-09 | 2008-05-15 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| WO2008065141A1 (en) * | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| US20080200567A1 (en) * | 2007-01-19 | 2008-08-21 | Probiodrug Ag | In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders |
| DK2118101T3 (da) * | 2007-03-09 | 2013-01-02 | Probiodrug Ag | IMIDAZO (1,5-A)-PYRIDinderivater som glutaminylcyclaseinhibitorer |
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2008
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| ES2473621T3 (es) | 2014-07-07 |
| US20080262065A1 (en) | 2008-10-23 |
| EP2142515B1 (en) | 2014-03-26 |
| WO2008128987A1 (en) | 2008-10-30 |
| DK2142515T3 (da) | 2014-06-23 |
| JP2010524899A (ja) | 2010-07-22 |
| US8202897B2 (en) | 2012-06-19 |
| EP2142515A1 (en) | 2010-01-13 |
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