JP5663309B2 - フッ素化ジヒドロテトラベナジンエーテルイメージング剤及びプローブ - Google Patents

フッ素化ジヒドロテトラベナジンエーテルイメージング剤及びプローブ Download PDF

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Publication number
JP5663309B2
JP5663309B2 JP2010531220A JP2010531220A JP5663309B2 JP 5663309 B2 JP5663309 B2 JP 5663309B2 JP 2010531220 A JP2010531220 A JP 2010531220A JP 2010531220 A JP2010531220 A JP 2010531220A JP 5663309 B2 JP5663309 B2 JP 5663309B2
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JP
Japan
Prior art keywords
group
compound
fluorinated
fluorinated ether
mixture
Prior art date
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Expired - Fee Related
Application number
JP2010531220A
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English (en)
Japanese (ja)
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JP2011500829A5 (zh
JP2011500829A (ja
Inventor
アマラシンゲ，カンデ・カンカナナマラゲ・ダヤラスナ
リシェル，マイケル・ジェームズ
ディン，ショーン・リチャード
ジョンソン，ブルース・フレッチャー
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General Electric Co
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General Electric Co
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Publication date
Priority claimed from US11/923,926 external-priority patent/US7897770B2/en
Priority claimed from US11/923,805 external-priority patent/US7897769B2/en
Application filed by General Electric Co filed Critical General Electric Co
Publication of JP2011500829A publication Critical patent/JP2011500829A/ja
Publication of JP2011500829A5 publication Critical patent/JP2011500829A5/ja
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Publication of JP5663309B2 publication Critical patent/JP5663309B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2010531220A 2007-10-25 2008-10-23 フッ素化ジヒドロテトラベナジンエーテルイメージング剤及びプローブ Expired - Fee Related JP5663309B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/923,926 US7897770B2 (en) 2007-10-25 2007-10-25 Fluorinated dihydrotetrabenazine ether imaging agents and probes
US11/923,926 2007-10-25
US11/923,805 US7897769B2 (en) 2007-10-25 2007-10-25 Intermediates for fluorinated dihydrotetrabenazine ether imaging agents and probes
US11/923,805 2007-10-25
PCT/US2008/080861 WO2009055520A2 (en) 2007-10-25 2008-10-23 Fluorinated dihydrotetrabenazine ether imaging agents and probes

Publications (3)

Publication Number Publication Date
JP2011500829A JP2011500829A (ja) 2011-01-06
JP2011500829A5 JP2011500829A5 (zh) 2013-11-07
JP5663309B2 true JP5663309B2 (ja) 2015-02-04

Family

ID=40525290

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010531220A Expired - Fee Related JP5663309B2 (ja) 2007-10-25 2008-10-23 フッ素化ジヒドロテトラベナジンエーテルイメージング剤及びプローブ

Country Status (4)

Country Link
EP (1) EP2214721A2 (zh)
JP (1) JP5663309B2 (zh)
CN (1) CN101998956B (zh)
WO (1) WO2009055520A2 (zh)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3053845A (en) * 1962-09-11 Benzofykedocolines
HU175890B (en) * 1977-06-15 1980-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 1,2,3,4,6,7-hexahydro-11-b-alpha-benzo-square bracket-a-square brecket closed-quinolyzine derivatives
US5278308A (en) * 1992-02-28 1994-01-11 The Trustees Of The University Of Pennsylvania Iodine derivatives of tetrabenazine
GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
AU2007248764B2 (en) * 2006-05-02 2013-08-01 Avid Radiopharmaceuticals, Inc. Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents

Also Published As

Publication number Publication date
EP2214721A2 (en) 2010-08-11
WO2009055520A3 (en) 2009-10-29
JP2011500829A (ja) 2011-01-06
WO2009055520A2 (en) 2009-04-30
CN101998956B (zh) 2014-10-22
CN101998956A (zh) 2011-03-30

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