JP5661994B2 - Composition or internal preparation with anti-stress / fatigue prevention, skin texture improvement or wrinkle improvement / prevention effect - Google Patents

Description

  The present invention has an anti-stress function and fatigue prevention function, and is effective in improving skin texture or preventing or improving wrinkles by suppressing skin troubles and skin aging caused by external or internal factors. It is about prescription.

Since it has been found that stress is a cause of various malfunctions and diseases, in recent medicine, medical care that focuses on mental and physical health by focusing on mental elements has attracted attention. In particular, the female body is based on a menstrual cycle and a delicate hormonal balance, and is susceptible to stress.
For this reason, a feeling of fatigue or a skin trouble is caused, and the influence on the comfortable life is disturbed by preventing QOL.

When stressed, the sympathetic excitement of the autonomic nervous system increases blood pressure and heart rate, decreases blood flow to the gastrointestinal tract, kidneys and skin, and increases blood supply to skeletal muscle.
The parasympathetic nerve, on the other hand, rests the body, restores physical strength, acquires new energy, lowers heart rate and blood pressure, increases blood to the skin and gastrointestinal tract, contracts the pupil and bronchioles, Stimulates salivary gland secretion and activates peristalsis of the digestive tract. Most organs in the whole body are controlled by both sympathetic and parasympathetic nerves, and the two nervous systems work well in balance, but when the sympathetic and parasympathetic nerves are unbalanced, fatigue and sweating Systemic symptoms such as appear.

  Fatigue is generally defined as “a specific pathological discomfort caused by excessive physical or mental activity and a state of reduced physical or mental function with the desire to rest.” Fatigue and chronic fatigue syndrome. Among them, in recent years, the number of people who are conscious of mental fatigue is increasing rapidly, and the development of preventive and therapeutic methods is required along with elucidating the causes. In addition, chronic fatigue syndrome is triggered by a person living in a healthy manner, and the symptoms such as intense fatigue, slight fever, headache, muscle pain, weakness, depression, etc. are reported over a long period of time. It is a disease that makes life impossible, and its cause has not been elucidated at all.

  Regarding the effect of stress on the skin, it has been empirically pointed out that stress is related to the worsening of acne onset and one of the causes of atopic dermatitis. The relationship between stress and skin diseases such as chronic urticaria is known.

  The skin covers the entire body and receives various stimuli from the outside world. Therefore, it goes without saying that the most important function of the skin is the barrier function. However, the skin is hurt by external factors such as ultraviolet rays and dryness, and internal factors such as aging, and the accumulated damage will surely fatigue and age. Skin aging results in rough skin, no firmness, increased wrinkles, yellowing of the skin and pigmentation. In addition, in women, the state of the skin changes due to disturbance of hormone balance accompanying menstruation, and in many cases, complainants of menstrual troubles cause skin troubles such as acne and pigmentation.

On the surface of the skin, there are thin grooves running in a mesh shape called skin grooves, and there are large and small squares, rhombuses, polygons, etc. surrounded by this, It is called a barn. When the skin groove is made of fine and shallow grooves, and the skin mound also has a smooth surface as a whole, it is called fine skin. On the other hand, the skin with deep and wide skin grooves and conspicuous clumps is called rough skin. The former is more common in the skin of children and young women, and the latter is more common in people after middle age. In addition, the more the skin is exposed, the more rough the skin.

  It is a natural providence that the fineness of the skin disappears and wrinkles increase with aging, but as a cosmetic problem, the desire to prevent skin aging and remain young forever is also natural. . However, in addition to such appearance problems, leaving the texture of the skin rough will cause the skin's function to deteriorate and even affect the original barrier function. Will cause damage.

  Many techniques have been developed in the form of cosmetics and foods in order to solve the problem of skin deterioration by improving the texture and wrinkles of the skin. For example, when skin care cosmetics are used to suppress rough skin caused by external factors and prepare skin texture, the cosmetics contain ingredients that are effective in promoting metabolism of the skin epidermis and ingredients that are effective in protecting the stratum corneum. In addition, components that promote the synthesis of hyaluronic acid and collagen, antioxidants, and the like have been proposed. From such a point of view, an anti-aging agent that stably contains linolenic acid that promotes metabolism (Patent Document 1), and a texture-improving cosmetic that contains sorbitol and / or mannitol and glycerin and / or diglycerin (Patent Document) 2), a texture-improving cosmetic composition containing an oily component characterized by having a skin penetration index of 2 or more (Patent Document 3), and a cosmetic composition excellent in the effect of preparing a texture containing ethyl oleate (Patent Document 4) ), Skin texture containing nonyl acid vanillylamide, a skin external preparation for improving wrinkles and sagging (Patent Document 5), and the like.

  As foods, beauty drinks made of rice extract that refines skin texture (Patent Document 6), wrinkles, sagging, dullness, and texture due to skin aging, 2 kinds of mucopolysaccharides and collagen, and coenzyme An oral skin aging preventive / improving agent containing Q10 as an active ingredient (Patent Document 7), an anti-aging composition containing a retinoid-related orphan receptor (ROR) activator (Patent Document 8), and the like are disclosed. Has been.

  However, it cannot be said that the conventional method is sufficiently satisfied with the skin texture improvement effect, and it suppresses skin troubles and skin aging caused by external factors such as ultraviolet rays and drying, and internal factors such as aging, There has been a demand for an agent for improving the texture of rough skin, or an agent for preventing or improving wrinkles.

  Further, for the purpose of improving wrinkles, collagen production promoters (Patent Document 9) and hyaluronic acid production promoters (Patent Document 10) have been disclosed, and cinnamon extract and glaze extract are each effective. These are symptomatic measures and do not provide a fundamental solution.

  As another proposal for preventing wrinkles, Yokuinin extract and the like have been disclosed as an anti-aging agent (Patent Document 11) by inhibiting neovascularization of vascular endothelial cells, such as Yokuinin for the purpose of improving rough skin caused by microcirculatory failure. Although an oral administration composition for stress relief containing herbal medicines (Patent Document 12) has been disclosed, the relationship with the wrinkle prevention effect is not clear, and it cannot be said that sufficient effects are obtained.

  On the other hand, regarding various troubles caused by stress, biocomfort-enhancing composition containing the essence of fungi such as spider (Patent Document 13) An anti-apoptotic agent containing Japanese herbal medicine as an active ingredient (Patent Document 14), an aging inhibitor containing an anti-progenitor granule as an active ingredient, and an oxidative stress inhibitor (Patent Document 15) are both disclosed. It is intended to improve the deterioration of the function on the living body caused by the cause, and has not yet completely removed the stress itself.

  For fatigue fatigue, Chinese medicines such as Hachimijiogan and Ginseng Nutrition are well known, but in addition to herbal medicines, new medicines that combine vitamins, amino acids, etc. with herbal medicines such as cinnamon, glaze, and salmon An internal preparation for improving fatigue (Patent Documents 16 and 17) has been proposed. Here, it is suggested that the use of crude drugs is only to promote the fatigue recovery effect by vitamins and amino acids, and the fatigue prevention effect of the crude drug itself is not shown.

As described above, conventional methods do not cure stress and fatigue, but symptomatically improve symptoms caused by stress and fatigue, and are sufficient to expect fundamental treatment for stress and fatigue. Could not be said to be satisfied.

JP 2002-80370 A JP 2004-51545 A JP 2004-51539 A JP 2006-273807 A JP 2007-261964 A JP-A-2005-177 JP 2006-143671 A JP 2007-238463 A JP 2008-105984 A JP 2008-105985 A Republished WO2003 / 084302 JP 2004-83449 A JP 2000-119126 A JP-A-9-30983 JP 2006-28155 A JP 2007-161675 A JP 2007-277207 A

An object of the present invention is to provide a composition or an internal preparation having an “anti-stress / fatigue-preventing action” and having an excellent effect of “improvement of skin texture” and “prevention or improvement of wrinkles”.

  As a result of intensive studies to solve the above-mentioned problems, the inventors of the present invention have the anti-stress / fatigue-preventing effect of Katsushido Karasuma-ryo-yokuinin to improve skin texture and promote skin exocrine secretion. As a result, the present invention was completed by finding that it can be moisturized and can be expected to be effective in preventing and improving wrinkles.

That is, the present invention is a composition for skin texture improvement or wrinkle prevention / improvement comprising a mixture of keihi (cinnamon), bukkaku (pepper), button pi (peony skin), tounin (pepper), peonies (glaze), and yakuinin. It is a product or an internal medicine. More specifically, 2 to 5 parts by weight of cinnamon, 2 to 5 parts by weight of peony, 2 to 5 parts by weight of peony, 2 to 5 parts by weight of peony, 2 to 5 parts by weight of glaze, and 5 to 20 parts by weight of yokuinin. A composition for improving skin texture or preventing or improving wrinkles, or an internal preparation. More specifically, the composition or the internal preparation is a Chinese herbal prescription called Keikine Karasuma Yokuinin.

So far, it has not been known that Katsushika Testicle Yokainin has effects such as anti-stress, fatigue prevention, and improvement of skin texture and wrinkles. In addition, as described in the background art, herbal medicines such as cinnamon bark, cocoon, glaze, and yokuinin that make up Keishi Karasuma Ryoka Yokuinin have been disclosed to symptomatically improve symptoms caused by stress and fatigue. However, the anti-stress action and the action to prevent fatigue itself have not been known.

  The oral preparation containing an extract extracted from a mixture of cinnamon, persimmon, peony skin, peach seed, glaze, and yokuinin of the present invention is known in addition to the conventionally known “problem eliminating effect caused by menstrual trouble” "Stress / fatigue prevention action" "Face skin texture improvement effect", and also "Effects to activate moisture secretion to the skin, moisturize the skin and prevent and improve wrinkles".

Hereinafter, the present invention will be described in more detail.
The crude drugs used in the present invention are as follows.
The cinnamon is obtained by removing a part of the bark or pericyte of Cinnamomum cassia Blue of the camphor family.
The cocoon is a mycorrhiza of the pine moss, Poria cocos Wolf, which is usually removed from the outer layer.
Peony skin is the root bark of the button department button Paeonia suffruticosa andrews.
Taojin is a peach of the Rosaceae, Prunus persica Batsch or Prunus persica Batsch var. It is the seed of davidiana maximowicz.
The glaze is a Peonyia patonia lactiflora Pallas
Is the root of
Yokuinin is a pearl barley of Coix lacryma-jobi Linene var. It is the seed excluding the seed coat of mayuen Stapf.

  Among these six kinds of herbal medicines, Kameda Karasuma is a Kampo prescription consisting of five kinds of herbal medicines such as cinnamon bark, persimmon, peony skin, peach seed and glaze. This katsura testicle is described in a Chinese book of the Chinese era, `` Kin Xin Summary ''. Prescribed for stiff shoulders and spots. This is a prescription that adds Yokuinin, which is often used for wart removal and skin as a folk medicine. Used for skin rashes and acne caused by the cause.

  An anti-stress / fatigue-preventing action comprising a mixture of cinnamon, cocoon, peony, peony, glaze, and yokuinin of the present invention, 2 to 5 parts by weight of cinnamon for skin texture improvement or wrinkle prevention / improvement, 2 to 5 parts by weight of cocoon, 2 to 5 parts by weight of peony skin, 2 to 5 parts by weight of peach seed, 2 to 5 parts by weight of glaze, 5 to 20 parts by weight of yokuinin, or preferably 4 parts by weight of cinnamon, A concentrated extract or dry extract powder obtained from a mixed herbal medicine consisting of 4 parts by weight, 4 parts by weight of peony skin, 4 parts by weight of peony, 4 parts by weight of glaze, and 10 parts by weight of yokuinin.

The extract is decocted by adding 5 to 25 times, preferably 8 to 20 times the amount of water with respect to the total weight of these six kinds of herbal medicines, and usually heating at 80 to 100 ° C. for 30 minutes to 2 hours. Next, the decoction is filtered while hot to remove the solid components, and this extract is concentrated to obtain a herbal extract. Furthermore, it can also be dried by ordinary drying methods such as spray drying, vacuum concentration drying, freeze drying and the like. Although the extract powder thus obtained can be used as it is, it is usually used as usual excipients for food and / or pharmaceuticals (for example, crystalline cellulose, sucrose fatty acid ester, sucrose, etc. ), For example, granulated by dry granulation method or wet granulation method, and such granulated products can be used as they are, but they are further compressed using a tableting machine. It can also be used as a molded product.

  In addition, since the Kampo extract has a peculiar taste, a masked preparation is preferable for taking, and a film coating agent coated with a coating agent can also be obtained. In addition, as a component stability point and a form that can be easily ingested, the pulverized product may be used as it is or filled with the above granulated product in a hard capsule or soft capsule.

  Alternatively, extracts obtained by individually extracting each herbal medicine can be mixed and used by the same method as described above.

  In addition, the extracted extract can be dissolved in a liquid form by adding excipients such as sweeteners, acidulants, emulsifiers, flavors, and dispersion aids that are usually used in liquid foods. .

As described above, not only in the form of internal solid granules, tablets, powders, and liquids, but also in semi-solid forms and powdered forms that can be dissolved and used in water or hot water. It can also be processed.

Hereinafter, the present invention will be described in detail with reference to test examples.
(Test Example 1)
It is known that women have periodic changes in mind and body due to significant changes in hormones associated with menstruation. Therefore, in order to confirm the effect of internal use on texture, after taking the skin measurement described in the test method in the luteal phase in consideration of the influence of menstrual cycle variation, 4 tablets of the formulation of Example 1 once from the first day of menstruation, 1 Taking twice a day, the same skin measurement was performed in each cycle until the next menstrual period.
(1) Test method For 12 healthy adult women aged 22 to 40 years old, the skin condition was evaluated by skin evaluation using a full-face image capturing and image analysis system (Robo Skin Analyzer) (manufactured by Inforward Co., Ltd.). The texture of the cheeks and the skin moisture were measured, and the dermis moisture in the cheeks and forehead was measured with a polarization ammeter. Note that the evaluation of the texture is such that the dark part in the monochrome image is a skin groove, the bright part is a skin hill, and the result of binarization by emphasizing the bright part dark part is close to a regular triangle texture model with a side of 0.4 mm. It is measured and evaluated so that the closer it is, the higher the score is out of 100 points.

(2) Test results The test results are shown in Tables 1 and 2. By taking the internal preparation of Example 1, the texture score was significantly improved. In addition, during the luteal phase, where the body easily retains water due to the effects of luteinizing hormone, epidermal moisture increased significantly by taking the internal preparation. In addition, dermal moisture was significantly reduced during the menstrual period, when the excretion of stored water was impaired and trouble was likely to occur. From this result, it was suggested that the secretion of water stagnated in the dermis layer was activated, the epidermal water increased, and the skin was moistened.

(Test Example 2)
In order to confirm the relationship between epidermal water and wrinkles, changes in the cheek and forehead due to the menstrual cycle were evaluated.

(1) Test method For all 13 healthy adult women aged 24 to 40 years old, the skin condition of the whole face imaging and image analysis system for each menstrual cycle (follicular phase, ovulation phase, luteal phase, menstrual phase) ( Using a Robo Skin Analyzer (manufactured by Inforward Co., Ltd.), wrinkles and skin moisture were measured.

(2) Test results The epidermal water content in the cheeks and forehead had individual differences in menstrual cycle changes, but on average, no significant variation was observed due to the cycle. As a result of evaluating the relationship between the epidermal water content and the wrinkle length of the corners of the eyes divided by period, as shown in FIGS. 1 to 3, a significant negative correlation was observed between the epidermal water content and the wrinkle. It was confirmed that there were few wrinkles. Therefore, the increase in epidermal water shown in Test Example 1 suggests the effect of preventing and improving wrinkles.

(Test Example 3)
In order to confirm the effect of internal use on fatigue and stress, after the fatigue evaluation described in the test method and the measurement of the level of sympathetic nerve activity were performed in the luteal phase, 4 tablets of the preparation of Example 1 once a day, 2 times a day The same measurement was performed at each cycle until the next menstrual period.

Test Method For 12 healthy adult women aged 22 to 40 years old, fatigue evaluation using POMS (Profile of Mood Status) and skin conductance measurement of the forehead using a polarization ammeter were performed.

(2) Test results The test results are shown in Tables 4 and 5. By dividing the high score group (n = 6) and the low score group (n = 6) according to the fatigue score before taking, and analyzing the change due to the internal use, as shown in Table 4, in the high fatigue score group The fatigue score decreased significantly with the internal use. In addition, as shown in Table 5, the AP value indicating the level of sympathetic nerve activity by measuring skin conductance significantly decreased as a result of internal use. As described above, it was confirmed that the sympathetic nervous system excitement was suppressed by taking the preparation of Example 1, and the fatigue feeling was also reduced. This result suggests anti-fatigue and anti-stress effects. .

Hereinafter, the present invention will be described more specifically with reference to examples and comparative examples.

Example 1
Keishi Karasuma Ryoko Yokuinin Film Coat Tablets

(Uncoated part)
Keishi Karasuma Yakuinin Extract Powder ^* 1800g
380 g of crystalline cellulose
Croscarmellose sodium 300g
Hydrous silicon dioxide 130g
Magnesium stearate 30g
Subtotal 2640g
(Skin part)
Hypromellose 82g
Titanium oxide 14g
Carnauba wax Subtotal 96g
Total 2736g

* 1800 mg of Keishibuchi Karasuma Yokuinin Extract Powder is obtained by extracting with hot water from a mixture of 2 g of cinnamon bark, 2 g of strawberry, 2 g of peony skin, 2 g of peach seed, 2 g of glaze and 5 g of yokuinin and drying.

(Production method)
Prepare tablets according to “JP” General Rules for Preparations, Tablets. That is, take the ingredients from katsushi testicles added Yokuinin extract powder to magnesium stearate as shown in the table above, and make a tablet with a tablet weight of 330 mg, and use carnauba wax from the skin part hypromellose in the table above The film-coated tablets of Example 1 (one tablet weight 342 mg)
And 225 mg of Yakuinin extract powder).

(Example 2)
Keishi Karasuma Ryoko Yokuinin Tablet

Katsushika Karasuma Yokuinin Extract Powder 1800g
380 g of crystalline cellulose
Croscarmellose sodium 300g
Hydrous silicon dioxide 130g
Magnesium stearate 30g
Total 2640g

(Production method)
Prepare tablets according to “JP” General Rules for Preparations, Tablets. That is, taking the ingredients from the Katsushido testicles added Yokuinin extract powder to magnesium stearate as shown in the above table to produce a tablet (one tablet weight 330 mg containing Keishibuchi testicles added Yokuinin extract powder 225 mg), The tablet of Example 2 was obtained.

Example 3
Keishi Karasuma Ryoko Yokuinin Tablet

(Uncoated part)
Keishi Testicle Extract Powder * 1150g
Yokuinin Extract Powder ** 390g
400g of crystalline cellulose
Croscarmellose sodium 300g
Hydrous silicon dioxide 130g
Magnesium stearate 30g
Total 2400g

* Keiseki Karasuma Yakuinin Extract Powder 1800 mg is obtained by extracting with hot water from a mixture of 2 g of cinnamon bark, 2 g of persimmon, 2 g of peony skin, 2 g of peach seed and 2 g of glaze and drying.
** Yokuinin extract powder is obtained by extracting from 5 g of Yokuinin with hot water and drying.

(Production method)
Prepare tablets according to “JP” General Rules for Preparations, Tablets. That is, the ingredients from Katsushido testicle extract powder to magnesium stearate described in the above table were taken to produce (tablet weight 300 mg) to obtain a tablet of Example 3 of the present invention.

Example 4
Keishi Karasuma Ryoko Yokuinin Granules

Katsushika Karasuma Yokuinin Extract Powder 1800g
Lactose 2550g
Hydroxypropylcellulose 150g
Total 4500g

(Production method)
Granules are prepared according to the “JP” general rules for preparations and tablets. That is, the ingredients described in the above table, from Katsushika testicle additive Yokuinin extract powder to hydroxypropyl cellulose, were used to obtain granules of Example 4.

Relationship between water content of right cheek epidermis in the follicular stage and wrinkle score (length) Relationship between water content of right cheek epidermis during ovulation and wrinkle score (length) of eye corner The relationship between the water content of the eyebrow during the luteal phase and the wrinkle score (length) of the outer corner of the eye

Claims (5)

Cinnamon (cinnamon),茯苓(Bukuryou), Mudanpi (moutan bark), MomoHitoshi (the person), peony (Paeonia), and preventing the Re turbulence of skin texture by menstrual cycle variations, characterized in that it contains a mixture of Coix Seed Composition to improve. The composition according to claim 1 comprises 2 to 5 parts by weight of cinnamon, 2 to 5 parts by weight of peony, 2 to 5 parts by weight of peony, 2 to 5 parts by weight of peony, 2 to 5 parts by weight of glaze, and 5 to 20 parts by weight of yokuinin. part composition for preventing and improving Re turbulence of skin texture by menstrual cycle fluctuation is. The composition of claim 1 or 2, wherein the, Keishi茯苓Maruryo turbulent Re composition for preventing and improving the skin texture menstrual period fluctuation is pressurized Coix. Agents for preventing and improving Re turbulence of skin texture by menstrual cycle variations containing any one of claims 1 to 3 composition. Oral agent for preventing and improving Re turbulence of skin texture by menstrual cycle variations containing any one of claims 1 to 3 composition.

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