JP5658688B2 - カルボキサミド化合物およびその使用方法 - Google Patents
カルボキサミド化合物およびその使用方法 Download PDFInfo
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- JP5658688B2 JP5658688B2 JP2011548297A JP2011548297A JP5658688B2 JP 5658688 B2 JP5658688 B2 JP 5658688B2 JP 2011548297 A JP2011548297 A JP 2011548297A JP 2011548297 A JP2011548297 A JP 2011548297A JP 5658688 B2 JP5658688 B2 JP 5658688B2
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- Prior art keywords
- alkyl
- haloalkyl
- substituted
- containing group
- heterocycloalkyl
- Prior art date
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
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- Obesity (AREA)
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- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US14798209P | 2009-01-28 | 2009-01-28 | |
| US61/147,982 | 2009-01-28 | ||
| PCT/US2010/022411 WO2010088392A1 (en) | 2009-01-28 | 2010-01-28 | Carboxamide compounds and methods for using the same |
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| JP2012516349A JP2012516349A (ja) | 2012-07-19 |
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| UA (1) | UA106600C2 (enExample) |
| WO (1) | WO2010088392A1 (enExample) |
| ZA (1) | ZA201105215B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013532692A (ja) * | 2010-07-29 | 2013-08-19 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｍｐｋ活性化複素環化合物およびその使用方法 |
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| CA2722139C (en) | 2008-04-23 | 2017-04-11 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds for the treatment of metabolic disorders |
| WO2011123681A1 (en) | 2010-03-31 | 2011-10-06 | Rigel Pharmaceuticals, Inc. | Methods for using carboxamide, sulfonamide and amine compounds |
| US9005909B2 (en) | 2011-01-06 | 2015-04-14 | Rigel Pharmaceuticals, Inc. | Whole blood assay for measuring AMPK activation |
| US9409884B2 (en) | 2012-02-01 | 2016-08-09 | Rigel Pharmaceuticals, Inc. | 5- or 6-substituted benzofuran-2-carboxamide compounds and methods for using them |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
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| WO2015046595A1 (ja) | 2013-09-30 | 2015-04-02 | 国立大学法人東京大学 | アディポネクチン受容体活性化化合物 |
| US11597715B2 (en) | 2018-01-11 | 2023-03-07 | Centaurus Therapeutics | Inhibitors of dihydroceramide desaturase for treating disease |
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| CA2634235A1 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Combination of an h3 antagonist/inverse agonist and an appetite suppressant |
| EP1932834B1 (en) | 2006-12-11 | 2011-04-27 | The Genetics Company, Inc. | Aromatic 1,4-DI-Carboxylamides and their use |
| EP2079694B1 (en) * | 2006-12-28 | 2017-03-01 | Rigel Pharmaceuticals, Inc. | N-substituted-heterocycloalkyloxybenzamide compounds and methods of use |
| GB0706793D0 (en) * | 2007-04-05 | 2007-05-16 | Evotec Ag | Compounds |
| KR101573091B1 (ko) | 2007-11-16 | 2015-11-30 | 리겔 파마슈티칼스, 인크. | 대사성 장애를 위한 카르복스아미드, 술폰아미드 및 아민 화합물 |
| CA2707047C (en) * | 2007-12-12 | 2017-11-28 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| CA2722139C (en) * | 2008-04-23 | 2017-04-11 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds for the treatment of metabolic disorders |
| WO2011123681A1 (en) | 2010-03-31 | 2011-10-06 | Rigel Pharmaceuticals, Inc. | Methods for using carboxamide, sulfonamide and amine compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013532692A (ja) * | 2010-07-29 | 2013-08-19 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｍｐｋ活性化複素環化合物およびその使用方法 |
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| UA106600C2 (uk) | 2014-09-25 |
| ZA201105215B (en) | 2012-09-26 |
| CN102365275B (zh) | 2014-09-24 |
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| BRPI1007287B1 (pt) | 2021-03-09 |
| US20130131078A1 (en) | 2013-05-23 |
| HK1164860A1 (zh) | 2012-09-28 |
| WO2010088392A1 (en) | 2010-08-05 |
| KR101693061B1 (ko) | 2017-01-04 |
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| MX2011007639A (es) | 2011-09-15 |
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| SG172974A1 (en) | 2011-08-29 |
| BRPI1007287B8 (pt) | 2021-05-25 |
| US8362235B2 (en) | 2013-01-29 |
| US8846600B2 (en) | 2014-09-30 |
| IL214203A (en) | 2015-01-29 |
| IL214203A0 (en) | 2011-08-31 |
| EA022083B1 (ru) | 2015-10-30 |
| EP2391616B1 (en) | 2016-03-30 |
| CN102365275A (zh) | 2012-02-29 |
| NZ594556A (en) | 2013-11-29 |
| JP2012516349A (ja) | 2012-07-19 |
| EP2391616A1 (en) | 2011-12-07 |
| CA2750835C (en) | 2018-09-04 |
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