JP5657862B2 - Ｍ−ｃｓｆに対する抗体の使用 - Google Patents

Ｍ−ｃｓｆに対する抗体の使用 Download PDF

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Publication number
JP5657862B2
JP5657862B2 JP2008524146A JP2008524146A JP5657862B2 JP 5657862 B2 JP5657862 B2 JP 5657862B2 JP 2008524146 A JP2008524146 A JP 2008524146A JP 2008524146 A JP2008524146 A JP 2008524146A JP 5657862 B2 JP5657862 B2 JP 5657862B2
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Prior art keywords
antibody
human
csf
antibodies
amino acid
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JP2008524146A
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Japanese (ja)
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JP2009502949A (ja
JP2009502949A5 (enExample
Inventor
ウィリアム マイケル カバナフ，
ウィリアム マイケル カバナフ，
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
ゾーマ テクノロジー リミテッド
ゾーマ テクノロジー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008524146A 2005-07-28 2006-07-27 Ｍ−ｃｓｆに対する抗体の使用 Expired - Fee Related JP5657862B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70319105P 2005-07-28 2005-07-28
US60/703,191 2005-07-28
PCT/US2006/029186 WO2007016240A2 (en) 2005-07-28 2006-07-27 Use of antibody to m-csf

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012126356A Division JP2012162572A (ja) 2005-07-28 2012-06-01 Ｍ−ｃｓｆに対する抗体の使用

Publications (3)

Publication Number Publication Date
JP2009502949A JP2009502949A (ja) 2009-01-29
JP2009502949A5 JP2009502949A5 (enExample) 2009-07-09
JP5657862B2 true JP5657862B2 (ja) 2015-01-21

Family

ID=37517276

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008524146A Expired - Fee Related JP5657862B2 (ja) 2005-07-28 2006-07-27 Ｍ−ｃｓｆに対する抗体の使用
JP2012126356A Withdrawn JP2012162572A (ja) 2005-07-28 2012-06-01 Ｍ−ｃｓｆに対する抗体の使用
JP2014157391A Withdrawn JP2014208703A (ja) 2005-07-28 2014-08-01 Ｍ−ｃｓｆに対する抗体の使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012126356A Withdrawn JP2012162572A (ja) 2005-07-28 2012-06-01 Ｍ−ｃｓｆに対する抗体の使用
JP2014157391A Withdrawn JP2014208703A (ja) 2005-07-28 2014-08-01 Ｍ−ｃｓｆに対する抗体の使用

Country Status (5)

Country Link
US (2) US20080233118A1 (enExample)
EP (2) EP2277916A3 (enExample)
JP (3) JP5657862B2 (enExample)
ES (1) ES2538036T3 (enExample)
WO (1) WO2007016240A2 (enExample)

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* Cited by examiner, † Cited by third party
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AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
US20100226884A1 (en) * 2009-01-20 2010-09-09 Immunomedics, Inc. Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R)
US8883162B2 (en) 2005-10-19 2014-11-11 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
US9862770B2 (en) 2005-10-19 2018-01-09 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
JP5786204B2 (ja) * 2010-01-19 2015-09-30 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． インスリン様増殖因子ｉ型受容体（ｉｇｆ−１ｒ）を標的とする新規クラスの単一特異性ヒト化抗体および二重特異性ヒト化抗体
WO2013011021A1 (en) 2011-07-18 2013-01-24 The University Of Melbourne Use of c-fms antagonists
SG11201507871XA (en) * 2013-04-12 2015-10-29 Morphosys Ag Antibodies targeting m-csf
EP3080161B1 (en) * 2013-12-09 2021-03-24 New York University Compositions and methods for phagocyte delivery of anti-staphylococcal agents
JP7704740B2 (ja) 2019-09-16 2025-07-08 アムジエン・インコーポレーテツド 薬物送達デバイスの外部滅菌の方法
CA3218564A1 (en) * 2021-05-05 2022-11-10 Leveragen, Inc. Engineered non-human animals for producing antibodies

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Also Published As

Publication number Publication date
US20150050280A1 (en) 2015-02-19
EP1913028A2 (en) 2008-04-23
EP1913028B1 (en) 2015-03-04
JP2012162572A (ja) 2012-08-30
JP2009502949A (ja) 2009-01-29
WO2007016240A2 (en) 2007-02-08
ES2538036T3 (es) 2015-06-16
EP2277916A2 (en) 2011-01-26
EP2277916A3 (en) 2011-04-27
WO2007016240A3 (en) 2007-04-12
JP2014208703A (ja) 2014-11-06
US20080233118A1 (en) 2008-09-25

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