JP5653438B2 - オルトミクソウイルス感染の治療方法 - Google Patents

オルトミクソウイルス感染の治療方法 Download PDF

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JP5653438B2
JP5653438B2 JP2012528002A JP2012528002A JP5653438B2 JP 5653438 B2 JP5653438 B2 JP 5653438B2 JP 2012528002 A JP2012528002 A JP 2012528002A JP 2012528002 A JP2012528002 A JP 2012528002A JP 5653438 B2 JP5653438 B2 JP 5653438B2
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influenza
virus
substituted
pharmaceutical composition
unsubstituted
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JP2013503880A (ja
JP2013503880A5 (enExample
Inventor
ラムステッド，アーバン
クロセ，ブレナン
ツィツマン，ニコール
ドウェック，レイモンド，エー．
バターズ，テリー，ディー．
Original Assignee
ユナイテッド セラピューティクス コーポレイション
ユナイテッド セラピューティクス コーポレイション
ザ チャンセラー，マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード
ザ チャンセラー，マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012528002A 2009-09-04 2010-09-01 オルトミクソウイルス感染の治療方法 Expired - Fee Related JP5653438B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US27225409P 2009-09-04 2009-09-04
US61/272,254 2009-09-04
US28250810P 2010-02-22 2010-02-22
US61/282,508 2010-02-22
US35393510P 2010-06-11 2010-06-11
US61/353,935 2010-06-11
PCT/US2010/047488 WO2011028775A1 (en) 2009-09-04 2010-09-01 Methods of treating orthomyxoviral infections

Publications (3)

Publication Number Publication Date
JP2013503880A JP2013503880A (ja) 2013-02-04
JP2013503880A5 JP2013503880A5 (enExample) 2014-03-20
JP5653438B2 true JP5653438B2 (ja) 2015-01-14

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JP2012528002A Expired - Fee Related JP5653438B2 (ja) 2009-09-04 2010-09-01 オルトミクソウイルス感染の治療方法

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US (2) US20110065752A1 (enExample)
EP (1) EP2473482B1 (enExample)
JP (1) JP5653438B2 (enExample)
KR (1) KR101497194B1 (enExample)
CN (1) CN102625796B (enExample)
BR (1) BR112012004676A2 (enExample)
CA (1) CA2772875A1 (enExample)
DK (1) DK2473482T3 (enExample)
ES (1) ES2466027T3 (enExample)
MX (1) MX2012002486A (enExample)
PL (1) PL2473482T3 (enExample)
WO (1) WO2011028775A1 (enExample)

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EP2398321B1 (en) 2009-02-23 2015-11-25 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
WO2013184780A1 (en) 2012-06-06 2013-12-12 Unither Virology, Llc Novel iminosugars and their applications
WO2015039010A2 (en) * 2013-09-16 2015-03-19 Unither Virology, Llc Deoxynojirimycin derivatives and methods of their using
WO2016073652A1 (en) 2014-11-05 2016-05-12 Unither Virology, Llc Iminosugars useful for the treatment of viral diseases
WO2017201030A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating viral infection
US20220257604A1 (en) * 2019-03-08 2022-08-18 University Of Virginia Patent Foundation Compositions and methods for modulating viral infections by regulating glucosylceramides
CN111904959A (zh) * 2020-08-21 2020-11-10 牡丹江医学院 α-L-岩藻糖苷酶抑制剂在制备治疗小儿肺炎的药物中的用途
IT202200007808A1 (it) * 2022-04-20 2023-10-20 Luigi Michele Pavone Composizioni terapeutiche per malattie causate da accumulo di eparan solfato
CN119841765B (zh) * 2025-01-09 2025-10-10 中南大学 Dnj衍生物、药物组合物及其应用

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JP2013503880A (ja) 2013-02-04
PL2473482T3 (pl) 2014-09-30
KR20120080584A (ko) 2012-07-17
DK2473482T3 (en) 2014-05-12
ES2466027T3 (es) 2014-06-09
BR112012004676A2 (pt) 2019-09-24
US20110065752A1 (en) 2011-03-17
CN102625796A (zh) 2012-08-01
EP2473482A1 (en) 2012-07-11
WO2011028775A1 (en) 2011-03-10
KR101497194B1 (ko) 2015-02-27
EP2473482B1 (en) 2014-03-05
EP2473482A4 (en) 2013-01-16
CN102625796B (zh) 2015-03-11
CA2772875A1 (en) 2011-03-10
MX2012002486A (es) 2012-09-07
US20160243096A1 (en) 2016-08-25

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