IT202200007808A1 - Composizioni terapeutiche per malattie causate da accumulo di eparan solfato - Google Patents

Composizioni terapeutiche per malattie causate da accumulo di eparan solfato Download PDF

Info

Publication number
IT202200007808A1
IT202200007808A1 IT102022000007808A IT202200007808A IT202200007808A1 IT 202200007808 A1 IT202200007808 A1 IT 202200007808A1 IT 102022000007808 A IT102022000007808 A IT 102022000007808A IT 202200007808 A IT202200007808 A IT 202200007808A IT 202200007808 A1 IT202200007808 A1 IT 202200007808A1
Authority
IT
Italy
Prior art keywords
eparan
accumulation
sulfate
diseases caused
therapeutic compositions
Prior art date
Application number
IT102022000007808A
Other languages
English (en)
Inventor
Luigi Michele Pavone
Annalisa Guaragna
Pasquale Valeria De
Anna Esposito
Massimo D'agostino
Original Assignee
Luigi Michele Pavone
Annalisa Guaragna
Pasquale Valeria De
Anna Esposito
D’Agostino Massimo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luigi Michele Pavone, Annalisa Guaragna, Pasquale Valeria De, Anna Esposito, D’Agostino Massimo filed Critical Luigi Michele Pavone
Priority to IT102022000007808A priority Critical patent/IT202200007808A1/it
Priority to US18/856,892 priority patent/US20250255856A1/en
Priority to JP2024561909A priority patent/JP2025513384A/ja
Priority to PCT/EP2023/059966 priority patent/WO2023203004A1/en
Priority to CN202380034938.2A priority patent/CN119136803A/zh
Priority to EP23720571.1A priority patent/EP4511032A1/en
Priority to AU2023257557A priority patent/AU2023257557A1/en
Publication of IT202200007808A1 publication Critical patent/IT202200007808A1/it
Priority to MX2024012934A priority patent/MX2024012934A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102022000007808A 2022-04-20 2022-04-20 Composizioni terapeutiche per malattie causate da accumulo di eparan solfato IT202200007808A1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT102022000007808A IT202200007808A1 (it) 2022-04-20 2022-04-20 Composizioni terapeutiche per malattie causate da accumulo di eparan solfato
US18/856,892 US20250255856A1 (en) 2022-04-20 2023-04-18 Therapeutic compositions with imino sugars for the treatment of diseases with accumulation of heparan sulfate
JP2024561909A JP2025513384A (ja) 2022-04-20 2023-04-18 ヘパラン硫酸の蓄積を伴う疾患の処置のためのイミノ糖を含む治療用組成物
PCT/EP2023/059966 WO2023203004A1 (en) 2022-04-20 2023-04-18 Therapeutic compositions with imino sugars for the treatment of diseases with accumulation of heparan sulfate
CN202380034938.2A CN119136803A (zh) 2022-04-20 2023-04-18 用于治疗硫酸乙酰肝素蓄积疾病的治疗组合物
EP23720571.1A EP4511032A1 (en) 2022-04-20 2023-04-18 Therapeutic compositions with imino sugars for the treatment of diseases with accumulation of heparan sulfate
AU2023257557A AU2023257557A1 (en) 2022-04-20 2023-04-18 Therapeutic compositions with imino sugars for the treatment of diseases with accumulation of heparan sulfate
MX2024012934A MX2024012934A (es) 2022-04-20 2024-10-18 Composiciones terapeuticas con iminoazucares para el tratamiento de enfermedades con acumulacion de heparan sulfato

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102022000007808A IT202200007808A1 (it) 2022-04-20 2022-04-20 Composizioni terapeutiche per malattie causate da accumulo di eparan solfato

Publications (1)

Publication Number Publication Date
IT202200007808A1 true IT202200007808A1 (it) 2023-10-20

Family

ID=82483266

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102022000007808A IT202200007808A1 (it) 2022-04-20 2022-04-20 Composizioni terapeutiche per malattie causate da accumulo di eparan solfato

Country Status (8)

Country Link
US (1) US20250255856A1 (it)
EP (1) EP4511032A1 (it)
JP (1) JP2025513384A (it)
CN (1) CN119136803A (it)
AU (1) AU2023257557A1 (it)
IT (1) IT202200007808A1 (it)
MX (1) MX2024012934A (it)
WO (1) WO2023203004A1 (it)

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2083205C1 (ru) 1994-01-19 1997-07-10 Товарищество с ограниченной ответственностью предприятие "БИОМ" Способ лечения мукополисахаридоза
WO2002055064A2 (en) 2001-01-12 2002-07-18 Oxford Glycosciences (Uk) Ltd. Mucopolysaccharidosis therapies
RU2196988C2 (ru) 2000-04-19 2003-01-20 Государственный новосибирский областной клинический диагностический центр Способ диагностики мукополисахаридозов
JP2003265196A (ja) 2002-03-15 2003-09-24 Seikagaku Kogyo Co Ltd ムコ多糖症のスクリーニング方法
KR20040084881A (ko) 2004-09-08 2004-10-06 진동규 동물 세포주를 이용한 이듀로네이트-설파타제의 발현 방법및 그 발현을 위한 세포주
US20040204379A1 (en) * 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
JP2008102114A (ja) 2005-12-27 2008-05-01 Dai Ichi Seiyaku Co Ltd ムコ多糖症の診断方法
US20090092996A1 (en) 2005-12-08 2009-04-09 Clarke Lorne A Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith
EP2081023A2 (en) 2002-06-14 2009-07-22 Women's And Children's Hospital Oligosaccharide biomarkers for mucopolysaccharidoses and other related disorders
WO2011028775A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating orthomyxoviral infections
US20120190642A1 (en) 2005-09-21 2012-07-26 Instytut Farmaceutyczny Isoflavones for treating mucopolysaccharidoses
WO2012177778A1 (en) 2011-06-20 2012-12-27 Mount Sinai School Of Medicine Anti-tnf- therapy for the mucopolysaccharidoses and other lysosomal disorders
US20130302308A1 (en) 2010-12-22 2013-11-14 Fondazione Telethon Therapeutic strategies to treat cns pathology in mucopolysaccharidoses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160094848A (ko) * 2013-05-02 2016-08-10 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 이미노당을 사용한 당지질 억제
WO2017201030A1 (en) * 2016-05-16 2017-11-23 Emergent Virology Llc Methods of treating viral infection

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2083205C1 (ru) 1994-01-19 1997-07-10 Товарищество с ограниченной ответственностью предприятие "БИОМ" Способ лечения мукополисахаридоза
RU2196988C2 (ru) 2000-04-19 2003-01-20 Государственный новосибирский областной клинический диагностический центр Способ диагностики мукополисахаридозов
US20040204379A1 (en) * 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
WO2002055064A2 (en) 2001-01-12 2002-07-18 Oxford Glycosciences (Uk) Ltd. Mucopolysaccharidosis therapies
JP2003265196A (ja) 2002-03-15 2003-09-24 Seikagaku Kogyo Co Ltd ムコ多糖症のスクリーニング方法
EP2081023A2 (en) 2002-06-14 2009-07-22 Women's And Children's Hospital Oligosaccharide biomarkers for mucopolysaccharidoses and other related disorders
KR20040084881A (ko) 2004-09-08 2004-10-06 진동규 동물 세포주를 이용한 이듀로네이트-설파타제의 발현 방법및 그 발현을 위한 세포주
KR100762945B1 (ko) 2004-09-08 2007-10-04 진동규 동물 세포주를 이용한 이듀로네이트-설파타제의 발현 방법및 그 발현을 위한 세포주
US20120190642A1 (en) 2005-09-21 2012-07-26 Instytut Farmaceutyczny Isoflavones for treating mucopolysaccharidoses
US8623910B2 (en) 2005-09-21 2014-01-07 Instytut Farmaceutyczny Isoflavones for treating mucopolysaccharidoses
US20090092996A1 (en) 2005-12-08 2009-04-09 Clarke Lorne A Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith
US8105788B2 (en) 2005-12-08 2012-01-31 The University Of British Columbia Mucopolysaccharidosis (MPS) diagnostic methods, systems, kits and assays associated therewith
JP4965999B2 (ja) 2005-12-27 2012-07-04 セント ルイス ユニバーシティ ムコ多糖症の診断方法
US20110008810A1 (en) 2005-12-27 2011-01-13 Saint Louis University, A Non-Profit Organization Diagnostic method of mucopolysaccharidoses
JP2008102114A (ja) 2005-12-27 2008-05-01 Dai Ichi Seiyaku Co Ltd ムコ多糖症の診断方法
WO2011028775A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating orthomyxoviral infections
US20130302308A1 (en) 2010-12-22 2013-11-14 Fondazione Telethon Therapeutic strategies to treat cns pathology in mucopolysaccharidoses
WO2012177778A1 (en) 2011-06-20 2012-12-27 Mount Sinai School Of Medicine Anti-tnf- therapy for the mucopolysaccharidoses and other lysosomal disorders

Non-Patent Citations (28)

* Cited by examiner, † Cited by third party
Title
ASANO N: "Sugar-mimicking glycosidase inhibitors: bioactivity and application", CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHÄUSER-VERLAG, BA, vol. 66, no. 9, 12 January 2009 (2009-01-12), pages 1479 - 1492, XP019700781, ISSN: 1420-9071 *
ATSUSHI KATO ET AL: "-1-Deoxyazasugars", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 6, 1 March 2005 (2005-03-01), pages 2036 - 2044, XP055091630, ISSN: 0022-2623, DOI: 10.1021/jm0495881 *
BENJAMIN, E.R. ET AL., J. INHERIT. METAB. OFF., vol. 32, 2009, pages 424
BUTTERS, T.D. ET AL., CURR. TOP. MED. CHEM., vol. 3, 2003, pages 561
COMPAZINE, P.MARTIN, O.: "Iminosugars: From Synthesis to therapeutic applications", 2008, JOHN WILEY & SONS, LTD, article "Medicinal use of Iminosugars", pages: 295 - 326
COX, T.M. ET AL., THE LANCET, vol. 355, 2000, pages 1481
D'ALONZO DANIELE ET AL: "Glycomimetics at the Mirror: Medicinal Chemistry of L-Iminosugars", CURRENT MEDICINAL CHEMISTRY, vol. 16, no. 4, 1 February 2009 (2009-02-01), NL, pages 473 - 505, XP055981378, ISSN: 0929-8673, DOI: 10.2174/092986709787315540 *
D'ALONZO, D. ET AL., J.MED CHEM., vol. 60, 2017, pages 9462
DE FENZA, M ET AL., EUR. J. MED. CHEM., vol. 175, 2019, pages 63
DE GREGORIO ELIANA ET AL: "N-Nonyloxypentyl-l-Deoxynojirimycin Inhibits Growth, Biofilm Formation and Virulence Factors Expression of Staphylococcus aureus", ANTIBIOTICS (BASEL, SWITZERLAND) 2015, vol. 9, no. 6, 26 June 2020 (2020-06-26), pages 362, XP055979603, ISSN: 2079-6382, DOI: 10.3390/antibiotics9060362 *
DE PASQUALE, V ET AL., INT J MOL SCI., vol. 22, 2021, pages 6574
ESPOSITO, A. ET AL., CHEM. - EUR. J., vol. 26, 2020, pages 2597
ESPOSITO, A. ET AL., MAR. DRUGS, vol. 18, 2020, pages 572
ESPOSITO, A. ET AL., RSC ADV, vol. 9, 2019, pages 21519
FANTUR, K. ET AL., MOL. GENET. METAB., vol. 100, 2010, pages 262
FECAROTTA, S. ET AL., ITAL. J. PEDIATRIC, vol. 44, 2018, pages 124
GUFFON, N. ET AL., J. PEDIATRIC, vol. 159, 2011, pages 838
HOLLAK CEMWIJBURG FA., J INHERIT METAB DIS, vol. 37, 2014, pages 587
JAKOBKIEWICZ-BANECKA, J ET AL., J. BIOMED. SCI., vol. 16, 2009, pages 26
KAIDONIS, X. ET AL., GEN MOL. METAB., vol. 118, 2016, pages 110
MARKHAM, A., DRUGS, vol. 76, 2016, pages 1147
NASH, R.J. ET AL., FUTURE MEAN. CHEM., vol. 3, 2011, pages 1513
PINEDA, M. ET AL., ORPHANET J. RARE DIS, vol. 13, 2018, pages 140
PLATT, F.M. ET AL., NAT. REV. OFF. PRIM., vol. 4, 2018, pages 27
PLATT, F.M.JEYAKUMAR, M., ACTA PAEDIATR, vol. 97, 2008, pages 88
POSWAR, F. ET AL., EXPERT OPIN. INVESTIG. DRUGS, vol. 26, 2017, pages 1331
SAACHEZ-FERNANDEZ, E.M. ET AL., CHEM. COMMUN., vol. 52, 2016, pages 5497
ZHU, S ET AL., CHEM. - EUR. J., vol. 27, 2021, pages 11291

Also Published As

Publication number Publication date
EP4511032A1 (en) 2025-02-26
US20250255856A1 (en) 2025-08-14
MX2024012934A (es) 2024-12-06
WO2023203004A1 (en) 2023-10-26
CN119136803A (zh) 2024-12-13
JP2025513384A (ja) 2025-04-24
AU2023257557A1 (en) 2024-12-05

Similar Documents

Publication Publication Date Title
EP4157338A4 (en) METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
CO6290683A2 (es) Compuestos de pirido imidazolinas heterociclicas y sus composiciones como inhibidores de c-met
UY29503A1 (es) Derivados de amida sustituida y metodos de uso
CU20200053A7 (es) Compuesto de pirimidina como inhibidor de las janocinasas, composición, forma cristalina y proceso de preparación
IL287522A (en) Useful preparations for the treatment of Pompe disease
EP4087568A4 (en) Treatment of pain by administration of sustained-release liposomal anesthetic compositions
AR122929A1 (es) Nuevos compuestos y sus composiciones farmacéuticas para el tratamiento de enfermedades
MX2022007171A (es) Compuestos cíclicos y métodos de uso de estos.
MX2021008984A (es) Inhibidor jak y metodo de preparacion del mismo.
PL3860998T3 (pl) Związki i kompozycje do leczenia schorzeń związanych z aktywnością receptora apj
MX2021011574A (es) Nuevos compuestos y composiciones farmaceuticas de los mismos para el tratamiento de trastornos inflamatorios.
EA201001566A1 (ru) Новый класс спиропиперидинов для лечения нейродегенеративных заболеваний
IT202200007808A1 (it) Composizioni terapeutiche per malattie causate da accumulo di eparan solfato
CR20240192A (es) Composiciones farmacéuticas de efruxifermina
CO2021001174A2 (es) Inhibidores de ckd8/19
EP3998086A4 (en) THERAPEUTIC AGENT FOR A DISEASE CAUSED BY A DOMINANT MUTED GENE
EP3924324A4 (en) L-PIPECOLIC ACID COCRYSTAL FROM CANNABIDIOL
EP4373522A4 (en) Engineered compositions for bone-targeted therapy
IL319571A (en) R-Trihexyphenidyl for the treatment of movement disorders
EP4405469A4 (en) COMPOSITIONS FOR THE TREATMENT OF CHARCOT-MARIE-TOOTH DISEASE
EP4216941A4 (en) METHODS OF FAT REDUCTION BY ADMINISTRATION OF BENZOLESULFONAMIDE COMPOSITIONS
IT202200002108A1 (it) Composizioni a base di quercetina per il trattamento e la prevenzione di affezioni oculari
PT4041186T (pt) Composição farmacêutica anidra para tratamento de manutenção da psoríase
EP4341271A4 (en) Compositions for treatment of neurodegenerative conditions
IL307342A (en) Formulations of apremilast