JP5643332B2 - ピロロピリジンまたはベンゾイミダゾールコアを含有する複素環化合物 - Google Patents

ピロロピリジンまたはベンゾイミダゾールコアを含有する複素環化合物 Download PDF

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JP5643332B2
JP5643332B2 JP2012543150A JP2012543150A JP5643332B2 JP 5643332 B2 JP5643332 B2 JP 5643332B2 JP 2012543150 A JP2012543150 A JP 2012543150A JP 2012543150 A JP2012543150 A JP 2012543150A JP 5643332 B2 JP5643332 B2 JP 5643332B2
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alkyl
oxo
pyrrolo
carboxamide
tetrahydro
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JP2013512953A (ja
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スティーブン ジェイムズ ボイヤー
スティーブン ジェイムズ ボイヤー
ジェニファー バーク
ジェニファー バーク
シン グオ
シン グオ
ジュニア トーマス マーティン カーレイン
ジュニア トーマス マーティン カーレイン
スノー　ロジャー　ジョン
ロジャー ジョン スノー
ユンロン チャン
ユンロン チャン
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2012543150A 2009-12-07 2010-12-01 ピロロピリジンまたはベンゾイミダゾールコアを含有する複素環化合物 Active JP5643332B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26718109P 2009-12-07 2009-12-07
US61/267,181 2009-12-07
PCT/US2010/058482 WO2011071725A1 (en) 2009-12-07 2010-12-01 Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core

Publications (3)

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JP2013512953A JP2013512953A (ja) 2013-04-18
JP2013512953A5 JP2013512953A5 (https=) 2014-01-23
JP5643332B2 true JP5643332B2 (ja) 2014-12-17

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JP2012543150A Active JP5643332B2 (ja) 2009-12-07 2010-12-01 ピロロピリジンまたはベンゾイミダゾールコアを含有する複素環化合物

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US (1) US9073926B2 (https=)
EP (1) EP2509979B1 (https=)
JP (1) JP5643332B2 (https=)
WO (1) WO2011071725A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9185916B2 (en) 2004-10-13 2015-11-17 Lotte Co., Ltd Method of processing wheat flour, processed wheat flour obtained by the method and food utilizing the processed wheat flour

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US9073926B2 (en) 2009-12-07 2015-07-07 Boehringer Ingelheim International Gmbh Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core
ES2607113T3 (es) 2012-03-16 2017-03-29 Vitae Pharmaceuticals, Inc. Moduladores de los receptores X del hígado
SI2825541T1 (sl) 2012-03-16 2016-10-28 Vitae Pharmaceuticals, Inc. Modulatorji jetrnega receptorja X
RU2015106013A (ru) * 2012-08-10 2016-10-10 Ф. Хоффманн-Ля Рош Аг Соединения пиразолкарбоксамида, композиции и способы применения
KR102343212B1 (ko) 2013-03-27 2021-12-23 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
PL3636649T3 (pl) 2014-01-24 2024-05-06 Turning Point Therapeutics, Inc. Diaryle makrocykliczne jako modulatory kinaz białkowych
CN104557666B (zh) * 2015-01-16 2017-01-18 烟台贝森医药科技有限公司 一种合成3‑酞酰亚胺‑2‑氧代丁醛‑1,2‑双缩氨基硫脲的方法
ES2864839T3 (es) 2015-07-02 2021-10-14 Turning Point Therapeutics Inc Macrociclos de diarilo quirales como moduladores de proteína quinasas
JP6917974B2 (ja) 2015-07-06 2021-08-11 ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ジアリール大環状多形
DK3416964T3 (da) * 2016-02-19 2021-02-22 Phoenix Molecular Designs 6-Oxo-N-(1-(benzyl)-1H-pyrazol-4-YL)-6,7,8,9-tetrahydropyrido[3',2':4,5]pyrrolo[1,2-A]pyrazin-2-carboxamid-derivater som P90 ribosomal S6 kinase- (RSK-) hæmmere til behandling af cancer
BR112019010511A2 (pt) 2016-11-23 2019-09-17 Bayer Ag derivados de heterociclo bicíclico fundido como pesticidas
US12378245B2 (en) 2019-02-11 2025-08-05 Phoenix Molecular Designs Crystalline forms of an RSK inhibitor
TW202307005A (zh) 2021-05-28 2023-02-16 美商邊際分析公司 以核醣體蛋白質S6激酶α-1 (RSK1)及核醣體蛋白質S6激酶α-3 (RSK2)之調節劑治療神經病症之方法
CN117186098A (zh) * 2022-06-07 2023-12-08 上海科恩泰生物医药科技有限公司 一种具有rsk抑制作用的羧酰胺衍生物、包含其的药物组合物及其用途
CN116396241A (zh) * 2023-04-12 2023-07-07 南京优氟医药科技有限公司 一种叔丁基（r）-4-乙基-2,2-二氧化物-1,2,3-氧杂噻唑烷-3-羧酸的制备方法
CN116396240A (zh) * 2023-04-12 2023-07-07 南京优氟医药科技有限公司 一种叔丁基（s）-4-乙基-2,2-二氧化物-1,2,3-氧杂噻唑 烷-3-羧酸的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6027A (en) * 1849-01-09 Rotary blacksmith s twyer
US7790712B2 (en) 2005-03-17 2010-09-07 Boehringer Ingelheim Pharmaceutical, Inc. Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors
GB0718870D0 (en) 2007-09-27 2007-11-07 Univ Dundee Modulation of RSK
US9073926B2 (en) 2009-12-07 2015-07-07 Boehringer Ingelheim International Gmbh Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core
EP2509980A1 (en) * 2009-12-07 2012-10-17 Boehringer Ingelheim International GmbH Heterocyclic compounds containing an indole core

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9185916B2 (en) 2004-10-13 2015-11-17 Lotte Co., Ltd Method of processing wheat flour, processed wheat flour obtained by the method and food utilizing the processed wheat flour

Also Published As

Publication number Publication date
WO2011071725A1 (en) 2011-06-16
JP2013512953A (ja) 2013-04-18
EP2509979B1 (en) 2016-05-25
EP2509979A1 (en) 2012-10-17
US20130137680A1 (en) 2013-05-30
US9073926B2 (en) 2015-07-07

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