JP5628839B2 - 眼球表面疾患を検出するシステムおよび眼球表面検査装置 - Google Patents

眼球表面疾患を検出するシステムおよび眼球表面検査装置 Download PDF

Info

Publication number
JP5628839B2
JP5628839B2 JP2011550224A JP2011550224A JP5628839B2 JP 5628839 B2 JP5628839 B2 JP 5628839B2 JP 2011550224 A JP2011550224 A JP 2011550224A JP 2011550224 A JP2011550224 A JP 2011550224A JP 5628839 B2 JP5628839 B2 JP 5628839B2
Authority
JP
Japan
Prior art keywords
filter
light
image
imaging
contrast agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011550224A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012517325A5 (enExample
JP2012517325A (ja
Inventor
リチャード エル． オーンバーグ，
リチャード エル． オーンバーグ，
ゲイリー ダブリュー． ウィリアムズ，
ゲイリー ダブリュー． ウィリアムズ，
Original Assignee
アルコン リサーチ， リミテッド
アルコン リサーチ， リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルコン リサーチ， リミテッド, アルコン リサーチ， リミテッド filed Critical アルコン リサーチ， リミテッド
Publication of JP2012517325A publication Critical patent/JP2012517325A/ja
Publication of JP2012517325A5 publication Critical patent/JP2012517325A5/ja
Application granted granted Critical
Publication of JP5628839B2 publication Critical patent/JP5628839B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/101—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the tear film
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/107—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/14—Arrangements specially adapted for eye photography
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10004—Still image; Photographic image
    • G06T2207/10012—Stereo images
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10064—Fluorescence image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30041—Eye; Retina; Ophthalmic

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Pathology (AREA)
  • Eye Examination Apparatus (AREA)
JP2011550224A 2009-02-12 2010-02-11 眼球表面疾患を検出するシステムおよび眼球表面検査装置 Expired - Fee Related JP5628839B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15188009P 2009-02-12 2009-02-12
US61/151,880 2009-02-12
PCT/US2010/023865 WO2010093772A1 (en) 2009-02-12 2010-02-11 Method and apparatus for ocular surface imaging

Publications (3)

Publication Number Publication Date
JP2012517325A JP2012517325A (ja) 2012-08-02
JP2012517325A5 JP2012517325A5 (enExample) 2013-03-07
JP5628839B2 true JP5628839B2 (ja) 2014-11-19

Family

ID=42540979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011550224A Expired - Fee Related JP5628839B2 (ja) 2009-02-12 2010-02-11 眼球表面疾患を検出するシステムおよび眼球表面検査装置

Country Status (4)

Country Link
US (1) US9232889B2 (enExample)
EP (1) EP2395906A4 (enExample)
JP (1) JP5628839B2 (enExample)
WO (1) WO2010093772A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9241622B2 (en) 2009-02-12 2016-01-26 Alcon Research, Ltd. Method for ocular surface imaging
WO2010093772A1 (en) 2009-02-12 2010-08-19 Alcon Research, Ltd. Method and apparatus for ocular surface imaging
US8574277B2 (en) * 2009-10-21 2013-11-05 Avedro Inc. Eye therapy
EP2547298B1 (en) 2010-03-19 2019-05-08 Avedro, Inc. Systems for applying and monitoring eye therapy
WO2011139827A1 (en) 2010-05-06 2011-11-10 Alcon Research, Ltd. Devices and methods for assessing changes in corneal health
US9044308B2 (en) 2011-05-24 2015-06-02 Avedro, Inc. Systems and methods for reshaping an eye feature
JP6122845B2 (ja) 2011-06-02 2017-04-26 アヴェドロ・インコーポレーテッドＡｖｅｄｒｏ，Ｉｎｃ． 時間ベースの光活性剤の送達又は光活性マーカの存在をモニターするシステム及び方法
WO2013126568A1 (en) 2012-02-21 2013-08-29 Massachusetts Eye & Ear Infirmary Calculating conjunctival redness
EP2872081B2 (en) 2012-07-16 2025-07-16 Avedro, Inc. Systems for corneal cross-linking with pulsed light
US9498122B2 (en) 2013-06-18 2016-11-22 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
US9498114B2 (en) 2013-06-18 2016-11-22 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
CA2947295C (en) 2014-05-02 2023-11-21 Massachusetts Eye And Ear Infirmary Grading corneal fluorescein staining
WO2016063345A1 (ja) * 2014-10-21 2016-04-28 パイオニア株式会社 観察装置
WO2016069628A1 (en) 2014-10-27 2016-05-06 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
WO2016077747A1 (en) 2014-11-13 2016-05-19 Avedro, Inc. Multipass virtually imaged phased array etalon
EP3285704B1 (en) 2015-04-24 2020-11-18 Avedro Inc. Systems for photoactivating a photosensitizer applied to an eye
WO2016191342A1 (en) 2015-05-22 2016-12-01 Avedro, Inc. Systems and methods for monitoring cross-linking activity for corneal treatments
WO2017009450A1 (en) * 2015-07-16 2017-01-19 Koninklijke Philips N.V. Digital pathology system
CN116832158A (zh) 2015-07-21 2023-10-03 艾维德洛公司 用光敏剂治疗眼睛的系统和方法
CN105662343B (zh) * 2016-01-05 2021-01-15 中国科学院苏州生物医学工程技术研究所 一种干眼检测手持成像装置及干眼检测设备
WO2018132563A1 (en) 2017-01-11 2018-07-19 Avedro, Inc. Systems and methods for determining cross-linking distribution in a cornea and/or structural characteristics of a cornea
KR102469720B1 (ko) * 2017-10-31 2022-11-23 삼성전자주식회사 전자 장치 및 이를 이용한 눈의 충혈도 판단 방법
CA3093065A1 (en) 2018-03-05 2019-09-12 Avedro, Inc. System for eye tracking during eye treatment
WO2019173762A1 (en) 2018-03-08 2019-09-12 Avedro, Inc. Micro-devices for treatment of an eye
CN109165569B (zh) * 2018-08-03 2022-05-13 南京理工大学 基于ba算法的被动毫米波图像极化信息显示方法
WO2020055272A1 (en) * 2018-09-12 2020-03-19 Auckland Uniservices Limited Methods and systems for ocular imaging, diagnosis and prognosis
JP7504083B2 (ja) 2018-09-19 2024-06-21 アヴェドロ・インコーポレーテッド 角膜拡張障害を治療するシステム及び方法
CN113316411B (zh) 2018-09-19 2025-01-17 艾维德洛公司 用于眼部治疗期间的眼部追踪的系统及方法
WO2020077015A1 (en) 2018-10-09 2020-04-16 Avedro, Inc. Photoactivation systems and methods for corneal cross-linking treatments
JP7571038B2 (ja) 2019-02-26 2024-10-22 アヴェドロ・インコーポレーテッド 眼の架橋処置のためのシステム及び方法
CN110458806A (zh) * 2019-07-05 2019-11-15 中山大学中山眼科中心 一种眼部图片和属性信息的分析方法和系统
WO2021026405A1 (en) 2019-08-06 2021-02-11 Avedro, Inc. Photoactivation systems and methods for corneal cross-linking treatments
FR3100703B1 (fr) * 2019-09-13 2025-04-25 E Swin Dev Dispositif et procede de detection de rupture de film lacrymal
AU2022232309A1 (en) 2021-03-08 2023-10-12 Avedro, Inc. Systems and methods for generating patient-specific corneal cross-linking treatment patterns
JP2024016406A (ja) * 2022-07-26 2024-02-07 株式会社トプコン 眼科装置、眼科装置の制御方法、及びプログラム
CN115868920B (zh) * 2022-08-18 2023-11-21 上海佰翊医疗科技有限公司 一种结膜充血的量化评估方法、装置和存储介质

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6002829A (en) * 1992-03-23 1999-12-14 Minnesota Mining And Manufacturing Company Luminaire device
JPH06277179A (ja) * 1993-01-28 1994-10-04 Kowa Co 眼科測定装置
JP3340805B2 (ja) 1993-07-27 2002-11-05 興和株式会社 眼科測定装置
US6049367A (en) * 1995-05-23 2000-04-11 Colorlink, Inc. Polarization manipulating device modulator with retarder stack which preconditions light for modulation and isotropic states
US6252979B1 (en) * 1995-06-07 2001-06-26 Tripath Imaging, Inc. Interactive method and apparatus for sorting biological specimens
US5924487A (en) 1997-01-31 1999-07-20 Halliburton Energy Services, Inc. Proppant slurry screen apparatus and methods of using same
US5852498A (en) * 1997-04-04 1998-12-22 Kairos Scientific Inc. Optical instrument having a variable optical filter
US5986271A (en) * 1997-07-03 1999-11-16 Lazarev; Victor Fluorescence imaging system
US6024449A (en) * 1998-07-13 2000-02-15 Smith; Robert F. High speed topography measurement of semi-diffuse objects
US6006756A (en) 1998-08-03 1999-12-28 Shadduck; John H. Non-contact magnetoresonant implant system and techniques for periodic corneal re-shaping
JP3699853B2 (ja) 1999-02-18 2005-09-28 株式会社ニデック 眼科装置
JP2000296109A (ja) 1999-04-15 2000-10-24 Canon Inc 検眼装置
GR1004180B (el) * 2000-03-28 2003-03-11 ����������� ����� ��������� (����) Μεθοδος και συστημα χαρακτηρισμου και χαρτογραφησης αλλοιωσεων των ιστων
WO2002069789A1 (en) * 2001-03-01 2002-09-12 University Of Massachusetts Ocular spectrometer and probe method for non-invasive spectral measurement
WO2004111621A1 (en) * 2003-06-19 2004-12-23 Koninklijke Philips Electronics N.V. Analysis apparatus and method comprising auto-focusing means
EP1642234A1 (en) 2003-07-09 2006-04-05 Humanitas Mirasole S.p.A. Method and apparatus for analyzing biological tissues
US7346203B2 (en) 2003-11-19 2008-03-18 General Electric Company Methods and apparatus for processing image data to aid in detecting disease
US7338167B2 (en) * 2003-12-10 2008-03-04 Joslin Diabetes Center, Inc. Retinal imaging system
US20060077581A1 (en) * 2004-08-31 2006-04-13 Jim Schwiegerling Multipurpose optical imaging device, system and method
WO2006047475A2 (en) * 2004-10-25 2006-05-04 Sytera, Inc. Detection and analysis of ophthalmically-relevant fluorescent molecules
DE102005026371B4 (de) 2005-06-07 2024-02-08 Oculus Optikgeräte GmbH Verfahren zum Betrieb eines ophthalmologischen Analysesystems
DE102005034332A1 (de) 2005-07-22 2007-01-25 Carl Zeiss Meditec Ag Einrichtung und Verfahren zur Beobachtung, Dokumentation und/oder Diagnose des Augenhintergrundes
JP5114024B2 (ja) 2005-08-31 2013-01-09 オリンパス株式会社 光イメージング装置
US7778491B2 (en) * 2006-04-10 2010-08-17 Microsoft Corporation Oblique image stitching
EP2656780B1 (en) 2006-05-26 2016-04-27 The Cleveland Clinic Foundation System for measuring biomechanical properties in an eye
WO2008039768A2 (en) 2006-09-25 2008-04-03 Careflash, Llc A system and method for providing medical disposition sensitive content
US7702139B2 (en) * 2006-10-13 2010-04-20 Carestream Health, Inc. Apparatus for caries detection
EP2094209B1 (en) 2006-11-10 2013-04-17 AMO Manufacturing USA, LLC System for operator-controlled scanning laser procedure designed for large-area epithelium removal
US8498695B2 (en) * 2006-12-22 2013-07-30 Novadaq Technologies Inc. Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy
JP2008264137A (ja) 2007-04-18 2008-11-06 Topcon Corp 角膜観察装置
US7860286B2 (en) * 2007-04-24 2010-12-28 Microsoft Corporation Medical image acquisition error detection
JP5160826B2 (ja) 2007-07-19 2013-03-13 株式会社トプコン 角膜観察装置
WO2009124271A1 (en) 2008-04-03 2009-10-08 Arcscan, Inc. Procedures for an ultrasonic arc scanning apparatus
WO2009146434A1 (en) 2008-05-29 2009-12-03 Arcscan, Inc. Compound scanning head for an ultrasonic scanning apparatus
US20100079580A1 (en) 2008-09-30 2010-04-01 Waring Iv George O Apparatus and method for biomedical imaging
EP2377917A1 (en) 2009-01-09 2011-10-19 NTN Corporation Microinjection apparatus and microinjection method
WO2010093772A1 (en) 2009-02-12 2010-08-19 Alcon Research, Ltd. Method and apparatus for ocular surface imaging
US9241622B2 (en) 2009-02-12 2016-01-26 Alcon Research, Ltd. Method for ocular surface imaging
JP5733962B2 (ja) 2010-02-17 2015-06-10 キヤノン株式会社 眼科装置、眼科装置の制御方法、及びプログラム
US8414564B2 (en) 2010-02-18 2013-04-09 Alcon Lensx, Inc. Optical coherence tomographic system for ophthalmic surgery
US20110271470A1 (en) 2010-05-04 2011-11-10 Baker Hughes Incorporated Brush Assembly with Non-Rotating Stabilizer and Brushes
WO2011139827A1 (en) 2010-05-06 2011-11-10 Alcon Research, Ltd. Devices and methods for assessing changes in corneal health

Also Published As

Publication number Publication date
US20100204584A1 (en) 2010-08-12
EP2395906A1 (en) 2011-12-21
EP2395906A4 (en) 2017-06-28
US9232889B2 (en) 2016-01-12
JP2012517325A (ja) 2012-08-02
WO2010093772A1 (en) 2010-08-19

Similar Documents

Publication Publication Date Title
JP5628839B2 (ja) 眼球表面疾患を検出するシステムおよび眼球表面検査装置
US9241622B2 (en) Method for ocular surface imaging
JP4624122B2 (ja) 眼科装置
JP6009935B2 (ja) 眼科装置
JP2022520708A (ja) 広角自発蛍光画像における加齢黄斑変性症患者の地図状委縮パターンのセグメントテーションおよび分類
JP2019518511A (ja) 傾斜照明による網膜の吸収、位相および暗視野撮像のためのシステム、方法、および装置
JP7384987B2 (ja) 眼科装置
Yang et al. Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues
US10111582B2 (en) Image processing device and method to identify disease in an ocular fundus image
WO2013187146A1 (ja) 眼科撮影装置及び眼科画像処理装置
EP3884843A1 (en) Multi-modal retinal imaging platform
JP2022075772A (ja) 眼科装置
JP6616673B2 (ja) 角膜検査装置
JP2017136212A (ja) 眼科装置
JP2016140428A (ja) 眼科装置、画像処理方法およびプログラム
JP5038925B2 (ja) 眼科測定装置
JP2019150486A (ja) 画像処理装置、画像処理方法及びプログラム
JP4751689B2 (ja) 眼球表面解析システム
Schramm et al. 3D retinal imaging and measurement using light field technology
WO2019102739A1 (ja) 眼科情報処理装置、眼科システム、眼科情報処理方法、及びプログラム
JP6664992B2 (ja) 眼科撮影装置
JP6503040B2 (ja) 眼科観察装置
JP7096391B2 (ja) 眼科装置
JP7643899B2 (ja) グレード評価装置、眼科撮影装置、プログラム、記録媒体、およびグレード評価方法
JP7774410B2 (ja) 眼科情報処理装置、眼科装置、眼科情報処理方法、及びプログラム

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130121

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130121

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131001

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20131004

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131210

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140313

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140515

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140926

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20141002

R150 Certificate of patent or registration of utility model

Ref document number: 5628839

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees