JP5620417B2 - アミノピラゾール誘導体を含む医薬 - Google Patents

アミノピラゾール誘導体を含む医薬 Download PDF

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Publication number
JP5620417B2
JP5620417B2 JP2012023811A JP2012023811A JP5620417B2 JP 5620417 B2 JP5620417 B2 JP 5620417B2 JP 2012023811 A JP2012023811 A JP 2012023811A JP 2012023811 A JP2012023811 A JP 2012023811A JP 5620417 B2 JP5620417 B2 JP 5620417B2
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JP
Japan
Prior art keywords
alkyl
amino
methyl
benzimidazol
pyrazol
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Expired - Fee Related
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JP2012023811A
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English (en)
Japanese (ja)
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JP2012180344A (ja
JP2012180344A5 (enExample
Inventor
高　直樹
直樹 高
正幸 大森
正幸 大森
京子 高見
京子 高見
松下正行
正行 松下
忠克 早瀬
忠克 早瀬
郁美 兵藤
郁美 兵藤
雅美 河内
雅美 河内
広樹 西井
広樹 西井
啓達 海老池
啓達 海老池
中西　義人
義人 中西
俊之 三尾
俊之 三尾
リーシャ ワン
リーシャ ワン
ウェイリィ チャオ
ウェイリィ チャオ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority to JP2012023811A priority Critical patent/JP5620417B2/ja
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Publication of JP2012180344A5 publication Critical patent/JP2012180344A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
JP2012023811A 2011-02-07 2012-02-07 アミノピラゾール誘導体を含む医薬 Expired - Fee Related JP5620417B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2012023811A JP5620417B2 (ja) 2011-02-07 2012-02-07 アミノピラゾール誘導体を含む医薬

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011024078 2011-02-07
JP2011024078 2011-02-07
JP2012023811A JP5620417B2 (ja) 2011-02-07 2012-02-07 アミノピラゾール誘導体を含む医薬

Publications (3)

Publication Number Publication Date
JP2012180344A JP2012180344A (ja) 2012-09-20
JP2012180344A5 JP2012180344A5 (enExample) 2014-10-02
JP5620417B2 true JP5620417B2 (ja) 2014-11-05

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JP2012023811A Expired - Fee Related JP5620417B2 (ja) 2011-02-07 2012-02-07 アミノピラゾール誘導体を含む医薬

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JP (1) JP5620417B2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3015953B1 (ja) 1998-10-06 2000-03-06 株式会社ワールド・ブリック れんが壁

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10689705B2 (en) * 2012-09-27 2020-06-23 Chugai Seiyaku Kabushiki Kaisha FGFR3 fusion gene and pharmaceutical drug targeting same
CN103224479B (zh) * 2013-04-26 2014-10-15 温州大学 一种2-芳基苯并呋喃类化合物的合成方法
TWI637744B (zh) * 2013-07-31 2018-10-11 中外製藥股份有限公司 含有胺基吡唑衍生物之醫藥製劑
KR101862493B1 (ko) 2013-10-25 2018-05-29 노파르티스 아게 Fgfr4 억제제로서의 고리-융합된 비시클릭 피리딜 유도체
MX374758B (es) 2013-12-13 2025-03-06 Hoffmann La Roche Inhibidores de tirosina cinasa de bruton.
CN105722834B (zh) 2013-12-13 2017-12-22 豪夫迈·罗氏有限公司 酪氨酸蛋白激酶抑制剂
DK3087986T3 (da) * 2013-12-27 2019-12-02 Chugai Pharmaceutical Co Ltd Mutant fgfr-gatekeepergen og aktivt stof rettet mod samme
KR20160138494A (ko) * 2014-03-31 2016-12-05 데비오팜 인터네셔날 에스 에이 Fgfr 융합물
ES2756748T3 (es) * 2014-10-03 2020-04-27 Novartis Ag Uso de derivados de piridilo bicíclicos de anillo fusionado como inhibidores de fgfr4
US9802917B2 (en) * 2015-03-25 2017-10-31 Novartis Ag Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
US10479780B2 (en) 2015-06-17 2019-11-19 Chugai Seiyaku Kabushiki Kaisha Aminopyrazole derivatives
JP6549311B2 (ja) * 2015-08-20 2019-07-24 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． インドール誘導体、その調製方法および医薬におけるその使用
CN110950848B (zh) * 2018-09-27 2024-03-26 徐诺药业 新型氨基吡唑类衍生物的合成与应用
JP2022515198A (ja) * 2018-12-19 2022-02-17 アレイ バイオファーマ インコーポレイテッド ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物
WO2020131674A1 (en) 2018-12-19 2020-06-25 Array Biopharma Inc. 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
CN112358435B (zh) * 2019-10-12 2023-01-10 中国医学科学院医药生物技术研究所 取代芳并杂环类化合物、制备方法和抑制ulk1及抗肿瘤用途
WO2023109776A1 (zh) * 2021-12-13 2023-06-22 上海和誉生物医药科技有限公司 一种fgfr4抑制剂酸式盐及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2329065A1 (en) * 1998-05-05 1999-11-11 Francisco Xavier Talamas Pyrazole derivatives as p-38 map kinase inhibitors
US6316466B1 (en) * 1998-05-05 2001-11-13 Syntex (U.S.A.) Llc Pyrazole derivatives P-38 MAP kinase inhibitors
ATE517872T1 (de) * 2003-06-26 2011-08-15 Novartis Ag Fünfgliedrige p38-kinaseinhibitoren auf heterocyclusbasis
KR20110033291A (ko) * 2008-07-23 2011-03-30 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3015953B1 (ja) 1998-10-06 2000-03-06 株式会社ワールド・ブリック れんが壁

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