JP5599406B2 - 薬剤送達デバイスのための駆動機構、及び、薬剤送達デバイス - Google Patents
薬剤送達デバイスのための駆動機構、及び、薬剤送達デバイス Download PDFInfo
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- JP5599406B2 JP5599406B2 JP2011540078A JP2011540078A JP5599406B2 JP 5599406 B2 JP5599406 B2 JP 5599406B2 JP 2011540078 A JP2011540078 A JP 2011540078A JP 2011540078 A JP2011540078 A JP 2011540078A JP 5599406 B2 JP5599406 B2 JP 5599406B2
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- drive
- housing
- dose
- drive mechanism
- piston rod
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H25/00—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms
- F16H25/18—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms for conveying or interconverting oscillating or reciprocating motions
- F16H25/20—Screw mechanisms
- F16H25/2015—Means specially adapted for stopping actuators in the end position; Position sensing means
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
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- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
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- A61M5/31581—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle
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- A—HUMAN NECESSITIES
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- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
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- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
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- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H25/00—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms
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- F16H25/12—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms for interconverting rotary motion and reciprocating motion with reciprocation along the axis of rotation, e.g. gearings with helical grooves and automatic reversal or cams
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H25/00—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms
- F16H25/18—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms for conveying or interconverting oscillating or reciprocating motions
- F16H25/20—Screw mechanisms
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
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- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
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- A—HUMAN NECESSITIES
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/18—Mechanical movements
- Y10T74/18568—Reciprocating or oscillating to or from alternating rotary
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/18—Mechanical movements
- Y10T74/18568—Reciprocating or oscillating to or from alternating rotary
- Y10T74/18576—Reciprocating or oscillating to or from alternating rotary including screw and nut
- Y10T74/18696—Reciprocating or oscillating to or from alternating rotary including screw and nut including means to selectively transmit power [e.g., clutch, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
部材21に連結される。
2 カートリッジ・ユニット
3 駆動ユニット
4 カートリッジ
5 薬剤
6 出口
7 デバイスの遠位端
8、デバイスの近位端
9 膜
10 ピストン
11 カートリッジ保持部材
12 ピストン・ロッド
13、ハウジング
14 カートリッジ・ユニットの近位端側
15 ハウジングの遠位端側
16 用量部分
17 ハウジング部分
18 ハウジング部分の近位端
19 ハウジング部分の遠位端
20 駆動部材
21 回転部材
22 歯部、
23 歯部
24、歯
25、歯
26、停止部材
27 歯部
28 歯部
29 ガイド機構
30 ガイド・スロット
31 弾性部材
32 支持部材
33 突起部材
34 用量部材
35 ガイド機構
36 ネジ山
37 係合トラック
38 係合機構
39 開口部
40 ハウジング部分
41 用量ノブ
42 係合部材
43,44,45,46,47 矢印
48 支持
49 ネジ山
50 軸部材
51 駆動部材の外側歯部
52 ピストン・ロッドの歯部
53 開口部
54 係合手段
55 レバー
56 開口部
57 ベアリング部材
58 クラッチ部材
59 丸で囲んだ部分
60 クラッチ弾性部材
61 突起
62 突起
63 クラッチ停止部材
64 固定エレメント
65 矢印
66 ベース部分
67 ブロック部材
68 停止機構
A 軸
Claims (17)
- 薬剤送達デバイス(1)のための駆動機構であって、
‐近位端、及び遠位端を有するハウジング(13,17,40)、
‐薬剤(5)の用量のセッティング中、ハウジングに対して第1の方向に回転し、用量の送達中、第1の方向と反対向きの、ハウジングに対して第2の方向に回転するように適合される回転部材(21)、
‐用量を送達するため、ハウジングに対して遠位方向に移動するように適合されるピストン・ロッド(12)、
‐用量の送達中の回転部材の第2の方向への回転運動に従うように適合される、駆動部材(20)、
‐用量のセッティング中の、第1の方向へのハウジングに対する、駆動部材の回転運動を防止するように適合される停止部材(26)を含んでなり、
ここで、
‐駆動部材(20)とピストンロッド(12)が、ピストンロッド(12)のハウジング(13、17、40)に対する回転運動に変換される、駆動部材(20)のハウジング(13、17、40)に対する回転運動のため構成され、
‐第2の方向への駆動部材の回転運動が、駆動部材(20)と回転部材(21)の機械的協働の手段によりハウジングに対して遠位方向へのピストン・ロッドの運動に変換される、
上記駆動機構。 - 駆動機構が、用量のセッティング中及び送達中、ハウジング(13,17,40)に対して可動である用量部材(16,34,41)を含み、そしてここでハウジングに対する用量部材の運動が、ハウジングに対する回転部材の回転運動に変換される、請求項1に記載の駆動機構。
- 用量部材(16,34,41)が、ハウジング(13,17,40)に対する回転運動に抗して固定される、請求項2に記載の駆動機構。
- 駆動部材(20)及び回転部材(21)が、共通回転軸周りに回転可能である、請求項1〜3のいずれか1項に記載の駆動機構。
- ピストン・ロッド(12)が、回転軸に沿って、ハウジング(13,17,40)に対して遠位方向に移動する、又はピストンロッド(12)が回転軸に対して横方向に、ハウジング(13,17,40)に対して遠位方向に移動する、請求項4に記載の駆動機構。
- 駆動部材(20)が、停止部材(26)と回転部材(21)の間に配置される、請求項1〜5のいずれか1項に記載の駆動機構。
- 用量部材(16,34,41)と回転部材(21)がネジ係合される、
請求項2に、又は請求項2に従属するいずれかの請求項に、記載の駆動機構。 - 用量部材(16,34,41)と回転部材(21)が、用量のセッティングと送達のた
め、用量部材の運動中、回転軸の周りに枢動する、レバー(55)により互いに連結される、請求項2に、又は請求項2に従属するいずれかの請求項に、記載の駆動機構。 - 駆動部材(20)と回転部材(21)が、用量のセッティングのため、第1の方向への回転部材の回転中、回転部材と駆動部材間の相対的回転運動を可能にし、そして用量の送達のため、第2の方向への回転部材の回転中、回転部材と駆動部材間の相対的回転運動を防止するように構成される、第1の一方向性摩擦クラッチ機構によって、互いに連結される、請求項1〜8のいずれか1項に記載の駆動機構。
- 駆動部材(20)と停止部材(26)が、用量のセッティングのため、第1の方向への、回転部材(21)の回転中、停止部材と駆動部材間の相対的回転運動を防止し、用量の送達のため、第2の方向への回転部材の回転中、停止部材と駆動部材間の相対的回転運動を可能にするように構成される、第2の一方向性摩擦クラッチ機構によって、互いに連結される、請求項1〜9のいずれか1項に記載の駆動機構。
- 停止部材(26)が、ハウジング(13,17,40)に対する回転運動に抗して固定される、請求項1〜10のいずれか1項に記載の駆動機構。
- 停止部材(26)が、ハウジング(13,17,40)に対して、軸方向に可動である、請求項1〜11のいずれか1項に記載の駆動機構。
- ‐回転部材(21)が、回転軸周りを第1の方向に回転するように適合され、
‐駆動部材が、複数の歯(24)が付いた歯部(22)を含み、回転部材が、複数の歯(25)が付いた歯部(23)を含み、ここで駆動部材の歯部が、回転部材の歯部と対になり、回転部材の歯部の歯と駆動部材の歯部の歯が、回転軸に沿って伸び、
‐駆動部材が、用量のセッティングと送達のため、回転部材の運動中停止部材と回転部材に隣接し、及び
‐回転部材と停止部材が、用量のセッティング中及び送達中、バネ部材(31)によって与えられる力によって、駆動部材と隣接して保持される、
請求項1〜12のいずれか1項に記載の駆動機構。 - 停止部材(26)が歯部(27)を有し、駆動部材(20)がさらなる歯部(28)を有し、駆動部材の歯部(22)と駆動部材のさらなる歯部が反対向きに配列される、請求項13に記載の駆動機構。
- それぞれの歯部の歯が斜面形状である、請求項13又は14に記載の駆動機構。
- 駆動部材(20)がピストン・ロッドにスプライン結合される、請求項1〜15のいずれか1項に記載の駆動機構。
- 請求項1〜16のいずれか1項に記載の駆動機構と、薬剤(5)の複数の用量を保持するカートリッジ(4)を含む、薬剤送達デバイス(1)。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/333,459 US8840591B2 (en) | 2008-12-12 | 2008-12-12 | Drive mechanism for a medication delivery device and medication delivery device |
US12/333,459 | 2008-12-12 | ||
EP08021628.6 | 2008-12-12 | ||
EP08021628A EP2196232A1 (en) | 2008-12-12 | 2008-12-12 | Drive mechanism for a medication delivery device and medication delivery device |
PCT/EP2009/066742 WO2010066796A1 (en) | 2008-12-12 | 2009-12-09 | Drive mechanism for a medication delivery device and medication delivery device |
Publications (3)
Publication Number | Publication Date |
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JP2012511358A JP2012511358A (ja) | 2012-05-24 |
JP2012511358A5 JP2012511358A5 (ja) | 2013-01-24 |
JP5599406B2 true JP5599406B2 (ja) | 2014-10-01 |
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JP2011540078A Active JP5599406B2 (ja) | 2008-12-12 | 2009-12-09 | 薬剤送達デバイスのための駆動機構、及び、薬剤送達デバイス |
Country Status (18)
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US (3) | US8840591B2 (ja) |
EP (3) | EP2196232A1 (ja) |
JP (1) | JP5599406B2 (ja) |
KR (1) | KR20110099030A (ja) |
CN (1) | CN102281910B (ja) |
AU (1) | AU2009324405B2 (ja) |
CA (1) | CA2746014A1 (ja) |
DE (1) | DE202009019077U1 (ja) |
DK (3) | DK3335749T3 (ja) |
IL (1) | IL213383A (ja) |
MX (1) | MX2011005879A (ja) |
MY (1) | MY155197A (ja) |
NZ (1) | NZ593301A (ja) |
RU (1) | RU2515867C2 (ja) |
SG (1) | SG172112A1 (ja) |
TR (2) | TR201810016T4 (ja) |
TW (1) | TW201026349A (ja) |
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