JP5587950B2 - 臓器線維形成に対するパラポックスウイルスovis株の使用 - Google Patents
臓器線維形成に対するパラポックスウイルスovis株の使用 Download PDFInfo
- Publication number
- JP5587950B2 JP5587950B2 JP2012145847A JP2012145847A JP5587950B2 JP 5587950 B2 JP5587950 B2 JP 5587950B2 JP 2012145847 A JP2012145847 A JP 2012145847A JP 2012145847 A JP2012145847 A JP 2012145847A JP 5587950 B2 JP5587950 B2 JP 5587950B2
- Authority
- JP
- Japan
- Prior art keywords
- parapoxvirus
- fibrosis
- cells
- liver
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24211—Parapoxvirus, e.g. Orf virus
- C12N2710/24232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24211—Parapoxvirus, e.g. Orf virus
- C12N2710/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24211—Parapoxvirus, e.g. Orf virus
- C12N2710/24261—Methods of inactivation or attenuation
- C12N2710/24264—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Addiction (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10033581.0 | 2000-07-11 | ||
DE10033581 | 2000-07-11 | ||
DE10122233A DE10122233A1 (de) | 2000-07-11 | 2001-05-08 | Verwendung von Stämmen des Parapoxvirus ovis gegen Organfibrosen |
DE10122233.5 | 2001-05-08 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002508473A Division JP5106736B2 (ja) | 2000-07-11 | 2001-07-11 | 臓器線維形成に対するパラポックスウイルスovis株の使用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014124405A Division JP5950964B2 (ja) | 2000-07-11 | 2014-06-17 | 臓器線維形成に対するパラポックスウイルスovis株の使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012214492A JP2012214492A (ja) | 2012-11-08 |
JP5587950B2 true JP5587950B2 (ja) | 2014-09-10 |
Family
ID=7648485
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012145847A Expired - Lifetime JP5587950B2 (ja) | 2000-07-11 | 2012-06-28 | 臓器線維形成に対するパラポックスウイルスovis株の使用 |
JP2014124405A Expired - Lifetime JP5950964B2 (ja) | 2000-07-11 | 2014-06-17 | 臓器線維形成に対するパラポックスウイルスovis株の使用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014124405A Expired - Lifetime JP5950964B2 (ja) | 2000-07-11 | 2014-06-17 | 臓器線維形成に対するパラポックスウイルスovis株の使用 |
Country Status (14)
Country | Link |
---|---|
JP (2) | JP5587950B2 (ko) |
KR (1) | KR100845643B1 (ko) |
CN (1) | CN101444539B (ko) |
AT (1) | ATE445413T1 (ko) |
BR (1) | BRPI0112411B8 (ko) |
DE (2) | DE10122233A1 (ko) |
DK (1) | DK1303302T3 (ko) |
DO (1) | DOP2001000210A (ko) |
EC (1) | ECSP034420A (ko) |
ES (1) | ES2332355T3 (ko) |
PE (1) | PE20020218A1 (ko) |
PT (1) | PT1303302E (ko) |
SV (1) | SV2002000527A (ko) |
ZA (1) | ZA200300276B (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102015111756A1 (de) * | 2015-07-20 | 2017-01-26 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Rekombinanter Orf-Virus-Vektor |
US11077157B2 (en) | 2016-02-16 | 2021-08-03 | Osaka University | Medicinal composition for treating fibrosis |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4405841C1 (de) * | 1994-02-23 | 1995-01-05 | Mayr Anton Prof Dr Med Vet Dr | Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
KR100302994B1 (ko) * | 1996-04-15 | 2001-11-30 | 안톤 마이어 | 약독화된비면역원성폭스바이러스또는파라폭스바이러스로부터멀티포텐트파라폭스면역유발인자의약제로서이용하는새로운적용 |
-
2001
- 2001-05-08 DE DE10122233A patent/DE10122233A1/de not_active Withdrawn
- 2001-07-10 PE PE2001000681A patent/PE20020218A1/es not_active Application Discontinuation
- 2001-07-11 BR BRPI0112411-0 patent/BRPI0112411B8/pt not_active IP Right Cessation
- 2001-07-11 DE DE50115181T patent/DE50115181D1/de not_active Expired - Lifetime
- 2001-07-11 ES ES01965110T patent/ES2332355T3/es not_active Expired - Lifetime
- 2001-07-11 CN CN200810149856.XA patent/CN101444539B/zh not_active Expired - Lifetime
- 2001-07-11 SV SV2001000527A patent/SV2002000527A/es not_active Application Discontinuation
- 2001-07-11 DO DO2001000210A patent/DOP2001000210A/es unknown
- 2001-07-11 KR KR1020037000310A patent/KR100845643B1/ko active IP Right Grant
- 2001-07-11 AT AT01965110T patent/ATE445413T1/de active
- 2001-07-11 PT PT01965110T patent/PT1303302E/pt unknown
- 2001-07-11 DK DK01965110.8T patent/DK1303302T3/da active
-
2003
- 2003-01-10 ZA ZA200300276A patent/ZA200300276B/en unknown
- 2003-01-10 EC EC2003004420A patent/ECSP034420A/es unknown
-
2012
- 2012-06-28 JP JP2012145847A patent/JP5587950B2/ja not_active Expired - Lifetime
-
2014
- 2014-06-17 JP JP2014124405A patent/JP5950964B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN101444539A (zh) | 2009-06-03 |
ZA200300276B (en) | 2004-04-13 |
DE50115181D1 (de) | 2009-11-26 |
BR0112411A (pt) | 2003-05-27 |
CN101444539B (zh) | 2016-07-06 |
ECSP034420A (es) | 2003-03-10 |
PE20020218A1 (es) | 2002-05-19 |
KR100845643B1 (ko) | 2008-07-10 |
BRPI0112411B8 (pt) | 2021-05-25 |
SV2002000527A (es) | 2002-10-24 |
DK1303302T3 (da) | 2010-02-08 |
JP2014196329A (ja) | 2014-10-16 |
DE10122233A1 (de) | 2002-01-24 |
DOP2001000210A (es) | 2002-12-15 |
ES2332355T3 (es) | 2010-02-03 |
ATE445413T1 (de) | 2009-10-15 |
KR20030019562A (ko) | 2003-03-06 |
JP5950964B2 (ja) | 2016-07-13 |
JP2012214492A (ja) | 2012-11-08 |
PT1303302E (pt) | 2009-11-11 |
BRPI0112411B1 (pt) | 2018-02-27 |
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