JP5586607B2 - 20個の遺伝子パネルを用いて潰瘍性大腸炎及び関連疾患を評価し治療するためのマーカー及び方法 - Google Patents
20個の遺伝子パネルを用いて潰瘍性大腸炎及び関連疾患を評価し治療するためのマーカー及び方法 Download PDFInfo
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- JP5586607B2 JP5586607B2 JP2011525223A JP2011525223A JP5586607B2 JP 5586607 B2 JP5586607 B2 JP 5586607B2 JP 2011525223 A JP2011525223 A JP 2011525223A JP 2011525223 A JP2011525223 A JP 2011525223A JP 5586607 B2 JP5586607 B2 JP 5586607B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9296608P | 2008-08-29 | 2008-08-29 | |
| US61/092,966 | 2008-08-29 | ||
| PCT/US2009/055323 WO2010025340A2 (en) | 2008-08-29 | 2009-08-28 | Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012501452A JP2012501452A (ja) | 2012-01-19 |
| JP2012501452A5 JP2012501452A5 (enExample) | 2012-06-28 |
| JP5586607B2 true JP5586607B2 (ja) | 2014-09-10 |
Family
ID=41722298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525223A Active JP5586607B2 (ja) | 2008-08-29 | 2009-08-28 | 20個の遺伝子パネルを用いて潰瘍性大腸炎及び関連疾患を評価し治療するためのマーカー及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100069256A1 (enExample) |
| EP (1) | EP2329259B1 (enExample) |
| JP (1) | JP5586607B2 (enExample) |
| CN (1) | CN102165315B (enExample) |
| AU (1) | AU2009285644B2 (enExample) |
| BR (1) | BRPI0917379A2 (enExample) |
| CA (1) | CA2734519C (enExample) |
| DK (1) | DK2329259T3 (enExample) |
| ES (1) | ES2581774T3 (enExample) |
| IL (1) | IL211154A0 (enExample) |
| RU (1) | RU2011111748A (enExample) |
| WO (1) | WO2010025340A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008028044A2 (en) * | 2006-08-30 | 2008-03-06 | Centocor, Inc. | Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel |
| WO2012154987A1 (en) | 2011-05-10 | 2012-11-15 | Nestec Sa | Methods of disease activity profiling for personalized therapy management |
| WO2016063204A1 (en) * | 2014-10-20 | 2016-04-28 | Nestec S.A. | Methods for prediction of anti-tnf alpha drug levels and autoantibody formation |
| WO2016092045A1 (en) * | 2014-12-11 | 2016-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting medically refractory acute severe colitis |
| GB2547406A (en) * | 2015-11-20 | 2017-08-23 | Folkersen Lasse | Apparatus and methods of using of biomarkers for predicting TNF-inhibitor response |
| WO2017175228A1 (en) | 2016-04-06 | 2017-10-12 | Technion Research & Development Foundation Limited | Infiltrating immune cell proportions predict anti-tnf response in colon biopsies |
| KR102481305B1 (ko) | 2016-05-20 | 2022-12-26 | 세다르스-신나이 메디칼 센터 | 유전자에 기반한 염증성 장 질환의 진단 |
| WO2017216206A1 (en) * | 2016-06-14 | 2017-12-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting acute severe colitis treatment response |
| CA3064529C (en) | 2017-05-31 | 2021-12-14 | Prometheus Biosciences, Inc. | Methods for assessing mucosal healing in crohn's disease patients |
| EP3821246A4 (en) * | 2018-07-15 | 2022-06-22 | Rambam Med-Tech Ltd. | Determining responders to inflammation treatment |
| US20210355538A1 (en) * | 2018-10-19 | 2021-11-18 | Children's Hospital Medical Center | Use of mucosal transcriptomes for assessing severity of ulcerative colitis and responsiveness to treatment |
| JP7657714B2 (ja) * | 2018-11-15 | 2025-04-07 | ヤンセン バイオテツク,インコーポレーテツド | 炎症性腸疾患の治療に対する応答を予測するための方法及び組成物 |
| CN114015689B (zh) * | 2021-10-26 | 2024-06-07 | 江苏大学 | 一种特异性抑制GOS2基因表达的shRNA序列及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5721098A (en) | 1986-01-16 | 1998-02-24 | The Regents Of The University Of California | Comparative genomic hybridization |
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| JP3645903B2 (ja) | 1992-03-04 | 2005-05-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 比較ゲノムハイブリダイゼーション(cgh) |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| CA2174140C (en) | 1993-10-28 | 2004-04-06 | Kenneth L. Beattie | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions |
| GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5723320A (en) | 1995-08-29 | 1998-03-03 | Dehlinger; Peter J. | Position-addressable polynucleotide arrays |
| US5843655A (en) | 1995-09-18 | 1998-12-01 | Affymetrix, Inc. | Methods for testing oligonucleotide arrays |
| US6022963A (en) | 1995-12-15 | 2000-02-08 | Affymetrix, Inc. | Synthesis of oligonucleotide arrays using photocleavable protecting groups |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US6013440A (en) | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
| AU3568897A (en) | 1996-06-07 | 1998-01-05 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
| ATE234674T1 (de) | 1996-11-14 | 2003-04-15 | Affymetrix Inc | Chemische amplifizierung zur synthese von musterordnungen |
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| US6197503B1 (en) | 1997-11-26 | 2001-03-06 | Ut-Battelle, Llc | Integrated circuit biochip microsystem containing lens |
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| EP1356088A2 (en) | 2000-06-07 | 2003-10-29 | Baylor College of Medicine | Compositions and methods for array-based nucleic acid hybridization |
| US20040077020A1 (en) * | 2001-11-30 | 2004-04-22 | Mannick Elizabeth E. | Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis |
| JP2006504406A (ja) | 2002-06-28 | 2006-02-09 | セントカー・インコーポレーテツド | 哺乳動物のch1欠失ミメティボディ、組成物、方法および使用 |
| AU2005300688B2 (en) * | 2004-11-03 | 2012-02-02 | Almac Diagnostics Limited | Transcriptome microarray technology and methods of using the same |
| WO2007103823A2 (en) | 2006-03-03 | 2007-09-13 | University Of Southern California | Genetic markers for predicting disease and treatment outcome |
| WO2008028044A2 (en) * | 2006-08-30 | 2008-03-06 | Centocor, Inc. | Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel |
| WO2008137383A2 (en) * | 2007-04-30 | 2008-11-13 | Centocor, Inc. | Markers and methods for assessing and treating ulcerative colitis and related disorders using a 19 gene panel |
| EP2326731B1 (en) * | 2008-08-25 | 2013-11-13 | Janssen Biotech, Inc. | Biomarkers for anti-tnf treatment in ulcerative colitis and related disorders |
-
2009
- 2009-08-28 CN CN200980134148.1A patent/CN102165315B/zh active Active
- 2009-08-28 DK DK09810643.8T patent/DK2329259T3/en active
- 2009-08-28 AU AU2009285644A patent/AU2009285644B2/en active Active
- 2009-08-28 RU RU2011111748/15A patent/RU2011111748A/ru unknown
- 2009-08-28 WO PCT/US2009/055323 patent/WO2010025340A2/en not_active Ceased
- 2009-08-28 JP JP2011525223A patent/JP5586607B2/ja active Active
- 2009-08-28 EP EP09810643.8A patent/EP2329259B1/en active Active
- 2009-08-28 ES ES09810643.8T patent/ES2581774T3/es active Active
- 2009-08-28 CA CA2734519A patent/CA2734519C/en active Active
- 2009-08-28 BR BRPI0917379A patent/BRPI0917379A2/pt not_active Application Discontinuation
- 2009-08-31 US US12/550,703 patent/US20100069256A1/en not_active Abandoned
-
2011
- 2011-02-10 IL IL211154A patent/IL211154A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2329259B1 (en) | 2016-04-20 |
| IL211154A0 (en) | 2011-04-28 |
| EP2329259A4 (en) | 2012-05-16 |
| CA2734519C (en) | 2018-11-13 |
| CN102165315A (zh) | 2011-08-24 |
| AU2009285644A1 (en) | 2010-03-04 |
| WO2010025340A3 (en) | 2010-04-22 |
| EP2329259A2 (en) | 2011-06-08 |
| RU2011111748A (ru) | 2012-10-10 |
| ES2581774T3 (es) | 2016-09-07 |
| AU2009285644B2 (en) | 2015-08-20 |
| CA2734519A1 (en) | 2010-03-04 |
| US20100069256A1 (en) | 2010-03-18 |
| BRPI0917379A2 (pt) | 2015-11-17 |
| DK2329259T3 (en) | 2016-05-09 |
| CN102165315B (zh) | 2014-06-18 |
| WO2010025340A2 (en) | 2010-03-04 |
| JP2012501452A (ja) | 2012-01-19 |
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