AU2009285644B2 - Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel - Google Patents

Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel Download PDF

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AU2009285644B2
AU2009285644B2 AU2009285644A AU2009285644A AU2009285644B2 AU 2009285644 B2 AU2009285644 B2 AU 2009285644B2 AU 2009285644 A AU2009285644 A AU 2009285644A AU 2009285644 A AU2009285644 A AU 2009285644A AU 2009285644 B2 AU2009285644 B2 AU 2009285644B2
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sample
patient
nucleic acid
ulcerative colitis
seq
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AU2009285644A1 (en
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Frederic Baribaud
Xilin Li
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Janssen Biotech Inc
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/065Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2009285644A 2008-08-29 2009-08-28 Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel Active AU2009285644B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9296608P 2008-08-29 2008-08-29
US61/092,966 2008-08-29
PCT/US2009/055323 WO2010025340A2 (en) 2008-08-29 2009-08-28 Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel

Publications (2)

Publication Number Publication Date
AU2009285644A1 AU2009285644A1 (en) 2010-03-04
AU2009285644B2 true AU2009285644B2 (en) 2015-08-20

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AU2009285644A Active AU2009285644B2 (en) 2008-08-29 2009-08-28 Markers and methods for assessing and treating ulcerative colitis and related disorders using a 20 gene panel

Country Status (12)

Country Link
US (1) US20100069256A1 (enExample)
EP (1) EP2329259B1 (enExample)
JP (1) JP5586607B2 (enExample)
CN (1) CN102165315B (enExample)
AU (1) AU2009285644B2 (enExample)
BR (1) BRPI0917379A2 (enExample)
CA (1) CA2734519C (enExample)
DK (1) DK2329259T3 (enExample)
ES (1) ES2581774T3 (enExample)
IL (1) IL211154A0 (enExample)
RU (1) RU2011111748A (enExample)
WO (1) WO2010025340A2 (enExample)

Families Citing this family (13)

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WO2008028044A2 (en) * 2006-08-30 2008-03-06 Centocor, Inc. Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel
WO2012154987A1 (en) 2011-05-10 2012-11-15 Nestec Sa Methods of disease activity profiling for personalized therapy management
WO2016063204A1 (en) * 2014-10-20 2016-04-28 Nestec S.A. Methods for prediction of anti-tnf alpha drug levels and autoantibody formation
WO2016092045A1 (en) * 2014-12-11 2016-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting medically refractory acute severe colitis
GB2547406A (en) * 2015-11-20 2017-08-23 Folkersen Lasse Apparatus and methods of using of biomarkers for predicting TNF-inhibitor response
WO2017175228A1 (en) 2016-04-06 2017-10-12 Technion Research & Development Foundation Limited Infiltrating immune cell proportions predict anti-tnf response in colon biopsies
KR102481305B1 (ko) 2016-05-20 2022-12-26 세다르스-신나이 메디칼 센터 유전자에 기반한 염증성 장 질환의 진단
WO2017216206A1 (en) * 2016-06-14 2017-12-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting acute severe colitis treatment response
CA3064529C (en) 2017-05-31 2021-12-14 Prometheus Biosciences, Inc. Methods for assessing mucosal healing in crohn's disease patients
EP3821246A4 (en) * 2018-07-15 2022-06-22 Rambam Med-Tech Ltd. Determining responders to inflammation treatment
US20210355538A1 (en) * 2018-10-19 2021-11-18 Children's Hospital Medical Center Use of mucosal transcriptomes for assessing severity of ulcerative colitis and responsiveness to treatment
JP7657714B2 (ja) * 2018-11-15 2025-04-07 ヤンセン バイオテツク,インコーポレーテツド 炎症性腸疾患の治療に対する応答を予測するための方法及び組成物
CN114015689B (zh) * 2021-10-26 2024-06-07 江苏大学 一种特异性抑制GOS2基因表达的shRNA序列及其应用

Citations (1)

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WO2008028044A2 (en) * 2006-08-30 2008-03-06 Centocor, Inc. Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel

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Also Published As

Publication number Publication date
EP2329259B1 (en) 2016-04-20
IL211154A0 (en) 2011-04-28
EP2329259A4 (en) 2012-05-16
CA2734519C (en) 2018-11-13
CN102165315A (zh) 2011-08-24
JP5586607B2 (ja) 2014-09-10
AU2009285644A1 (en) 2010-03-04
WO2010025340A3 (en) 2010-04-22
EP2329259A2 (en) 2011-06-08
RU2011111748A (ru) 2012-10-10
ES2581774T3 (es) 2016-09-07
CA2734519A1 (en) 2010-03-04
US20100069256A1 (en) 2010-03-18
BRPI0917379A2 (pt) 2015-11-17
DK2329259T3 (en) 2016-05-09
CN102165315B (zh) 2014-06-18
WO2010025340A2 (en) 2010-03-04
JP2012501452A (ja) 2012-01-19

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