JP5583366B2 - Manufacturing method of patch - Google Patents

Description

The present invention relates to the production how the patch such as a medical use by sticking to the skin.

  Although various forms exist for patches used by being attached to the skin, generally, a drug is applied on a support such as a resin sheet. Conventionally, such a patch is produced by spreading and applying a drug on a surface of a support (so-called solid coating), and a bar coater, a die coater, or the like is used for the coating process (for example, Patent Document 1). More specifically, the medicine is spread and applied on a belt-like support, and necessary parts are punched out therefrom, and unnecessary parts are removed to produce individual patches (for example, Patent Documents 2 and 3). reference).

JP 2009-108006 A JP 2006-223611 A JP-A-3-85160

  However, when a patch is produced by the above technique, an expensive drug applied to an unnecessary part is also removed, so that there is a problem that the use efficiency of the drug is poor and the manufacturing cost of the patch is hindered. It was happening.

The present invention has been made in view of the above problems, and an object thereof is to provide a manufacturing how excellent patch to drug use efficiency.

In order to solve the above-mentioned problems, the invention of claim 1 is directed to a method for producing a patch, in which a liquid containing a medicine is micronized by an application head using an inkjet head having a piezo drop-on-demand driving method. together to generate a droplet to form a drug layer is sprayed on one side of a part of the substrate sheet formed of a resin material having impermeability to the liquid drops with respect to the medicament from the nozzle of the application head, the The chemical liquid is fed to the nozzle by capillary action generated in the nozzle when the coating head ejects the chemical liquid, and the chemical liquid is micronized after adjusting the viscosity and surface tension of the chemical liquid .

  Further, the invention of claim 2 is the method for producing a patch according to the invention of claim 1, wherein the droplets of the chemical liquid sprayed on the base sheet spread so that the adjacent droplets overlap each other. It is characterized by spraying.

  The invention of claim 3 is characterized in that, in the method for producing a patch according to the invention of claim 1, a plurality of droplets of different chemicals are sprayed on the base sheet according to a preset application pattern. To do.

  According to a fourth aspect of the present invention, in the method for producing a patch according to the third aspect of the present invention, each of the plurality of different chemical solutions is sprayed onto different areas.

  Further, the invention of claim 5 is the method for producing a patch according to the invention of claim 4, wherein when the droplets of different chemicals sprayed across the boundary portion of the different regions spread, the boundary portion is sandwiched. The liquid droplets are sprayed so that adjacent liquid droplets do not overlap each other.

The invention of claim 6 is the method of manufacturing a patch according to claim 4 or claim 5 , wherein the first chemical liquid is applied in a first checkered pattern in the plurality of different chemical liquids. The second chemical solution is applied in a second checkered pattern that is black and white reversed from the first checkered pattern .

The invention of claim 7 is characterized in that, in the method for producing a patch according to the invention of claim 3 , each of the plurality of different chemical solutions is sprayed on the same region .

The invention of claim 8 is the method for producing a patch according to any of claims 3 to 7 , wherein the plurality of different chemical solutions contain the same type of drug at different concentrations. It is characterized by.

The invention of claim 9 is the method for producing a patch according to any one of claims 3 to 7 , wherein the plurality of different chemical solutions contain different types of drugs. .

The invention of claim 10 is the method for producing a patch according to any one of claims 1 to 9 , wherein the viscosity and surface tension of the drug solution are adjusted by adding a solvent of the drug. It is characterized by.

The invention of claim 11 is the method for producing a patch according to any one of claims 1 to 9 , wherein the temperature of the chemical solution is adjusted to adjust the viscosity and surface tension of the chemical solution. Features.

The invention of claim 12 is a method of manufacturing a patch according to any one of claims 1 to invention of claim 11, adjusting the viscosity and surface tension of the liquid medicine with the addition of a humectant to the chemical It is characterized by.

  The invention of claim 13 is the method for producing a patch of the invention of claim 1, further comprising a step of applying an adhesive to a partial region of the one side of the base sheet.

  According to a fourteenth aspect of the present invention, in the method for producing a patch according to the thirteenth aspect of the present invention, droplets generated by atomizing the adhesive solution are sprayed onto the base material sheet.

According to invention of Claim 1-14, the chemical | medical solution containing a chemical | medical agent is atomized, the droplet is produced | generated, the said droplet is sprayed on the partial area | region of the single side | surface of a base material sheet, and a chemical | medical agent layer is formed. Therefore, the chemical solution can be easily applied only to a partial region of the base sheet, and the use efficiency of the medicine can be improved by eliminating the medicine that is removed wastefully. Further, since the chemical liquid is micronized after adjusting the viscosity and surface tension of the chemical liquid, it is possible to reliably spray droplets obtained by micronizing the chemical liquid containing the chemical.

  In particular, according to the invention of claim 3, a plurality of different chemical solutions are sprayed onto the base sheet according to a preset application pattern for each of the plurality of different chemical solutions. Can be applied.

  In particular, according to the twelfth aspect of the present invention, the moisturizing agent is added to the chemical solution and the viscosity and surface tension of the chemical solution are adjusted, so that the chemical solution can be prevented from being dried and denatured. Can be sprayed stably.

  In particular, according to the invention of claim 13, since the adhesive is applied to a partial region of one side of the base sheet, the adhesive and the chemical solution can be applied on the same base sheet.

It is a figure which shows the outline of the principal part structure of the patch manufacturing apparatus which concerns on this invention. It is a top view which shows the internal structure of a coating unit. It is a figure which shows the outline of the internal structure of a coating head. It is a figure which shows the arrangement | positioning relationship of three application | coating heads which comprise a head group. It is a block diagram which shows the structure of a control part. It is a figure which shows an example of the manufacturing process of the patch in a patch manufacturing apparatus. It is a top view which shows the state by which the chemical | medical solution was apply | coated only to the partial area | region of the base material sheet. It is a figure which shows a mode that the droplet of the chemical | medical solution which landed on the base material sheet overlaps. It is a figure which shows the outline of the principal part structure of the patch manufacturing apparatus of 2nd Embodiment. It is a figure which shows an example of the coating of a chemical | medical solution separately. It is a figure which shows the other example of separate application of a chemical | medical solution. It is a figure which shows the other example of separate application of a chemical | medical solution. It is a figure which shows a mode that a chemical | medical solution is applied separately so that it may not mutually mix in a boundary part. It is a figure which shows the outline of the principal part structure of the patch manufacturing apparatus of 3rd Embodiment. It is a figure which shows an example of application | coating of an adhesive. It is a figure which shows an example of application | coating of an adhesive and a chemical | medical solution. It is a figure which shows application | coating by the nozzle of a dispenser system. It is a figure which shows the other example of the manufacturing process of a patch. It is a figure which shows the other example of the manufacturing process of a patch.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

<1. First Embodiment>
FIG. 1 is a diagram showing an outline of a main configuration of a patch manufacturing apparatus 1 according to the present invention. The patch manufacturing apparatus 1 is an apparatus that manufactures a patch by applying a medicine to one side of a base sheet. In 1st Embodiment, the circular base material sheet 90 is affixed on the strip | belt-shaped support body 92 with which the adhesive 91 was previously applied at fixed intervals (refer FIG. 7), and a chemical | medical agent is put on the base material sheet 90. Apply. The patch manufacturing apparatus 1 is applied by spraying a chemical solution containing a medicine onto a transport mechanism 20 that transports a belt-shaped support body 92 along the horizontal direction and a base sheet 90 that is pasted on the transported support body 92. A coating unit 10 that performs the coating, a chemical feeding unit 30 that feeds the chemical to the coating unit 10, and a drying unit 50 that dries the chemical applied to the base sheet 90. Moreover, the patch manufacturing apparatus 1 is provided with the control part 40 which controls said each element provided in the apparatus.

  The transport mechanism 20 includes a feed roller 21 around which a long belt-like support 92 is wound. The transport mechanism 20 also includes a tension roller and an auxiliary roller (not shown), and transports the support body 92 fed from the feed roller 21 along the horizontal direction. The support 92 plays a role of sequentially conveying and supplying the base sheet 90 to the coating unit 10 and can be formed of flannel cloth, woven cloth, knitted fabric, non-woven cloth, resin film, or the like. The width of the support 92 is 60 mm, for example. In the first embodiment, the adhesive 91 is previously laminated on the entire surface of one side of the support 92 wound around the feed roller 21 (FIG. 6). That is, the transport mechanism 20 feeds the support 92 on which the adhesive 91 layer has already been formed from the feed roller 21 and transports the support 92 so that the adhesive layer faces upward.

  In addition, the patch manufacturing apparatus 1 includes a sheet supply mechanism (not shown) in the vicinity of the feed roller 21, and a disk-shaped base sheet on the support 92 that is fed from the feed roller 21 by the sheet supply mechanism. 90 is supplied. The base material sheet 90 that directly carries the drug is formed of a resin material that is impermeable to the drug, and is formed of PET (polyethylene terephthalate) in the first embodiment. The substrate sheet 90 may be formed of PP (polypropylene) or PE (polyethylene).

  The coating unit 10 applies a chemical solution containing a drug to the base sheet 90 transported by the transport mechanism 20. FIG. 2 is a plan view showing the internal configuration of the coating unit 10. As shown in the figure, the coating unit 10 includes twelve coating heads 11. Each of the twelve coating heads 11 generates a fine droplet by atomizing a chemical solution containing a drug, and sprays the droplet onto the upper surface of the base sheet 90 conveyed by the conveyance mechanism 20. The coating head 11 is a droplet jet head that ejects a chemical solution by a droplet jet method. In this embodiment, the driving method is a multilayer piezo drop-on-demand inkjet head (for example, a product type name manufactured by Ricoh Printing Systems Co., Ltd.). "GEN3E2") is used.

  The internal structure of the coating head 11 is the same as that disclosed in, for example, Japanese Patent Application Laid-Open No. 2009-23334. FIG. 3 is a diagram showing an outline of the internal structure of the coating head 11. Each coating head 11 is provided with 128 nozzles 12 arranged in a line at a predetermined pitch. FIG. 3 is a cross-sectional view of the application head 11 taken along one of the nozzles 12. As described in JP 2009-23334 A, the coating head 11 includes a frame 61 in which a common liquid chamber 64 is formed, a flow path plate 66 in which a pressurized liquid chamber 65 and a communication port 68 are formed, and a nozzle. 12, a diaphragm 63 having a diaphragm portion 63 a, a laminated piezoelectric element 62 bonded to the diaphragm portion 63 a of the diaphragm 63, and a base 60 for fixing the laminated piezoelectric element 62. Yes.

  The base 60 is fixedly installed on the coating head 11, and the laminated piezoelectric element 62 is attached to the base 60. The laminated piezoelectric element 62 is formed by laminating a plurality of piezoelectric elements (piezo elements) of lead zirconate titanate (PZT). The diaphragm 63 has a diaphragm portion 63a, and the diaphragm portion 63a is joined to the laminated piezoelectric element 62 via an island-shaped convex portion.

  The frame 61 is made of a resin material and has a common liquid chamber 64. The common liquid chamber 64 is provided with a chemical supply port (not shown). The flow path plate 66 has a pressurized liquid chamber 65 and a communication port 68. The pressurized liquid chamber 65 is in communication with the common liquid chamber 64 through the opening of the diaphragm 63. A diaphragm portion 63 a of the diaphragm 63 faces the pressurized liquid chamber 65. The communication port 68 connects the pressurized liquid chamber 65 and the nozzle 12 in communication. The nozzle plate 67 is provided with a nozzle 12 that is a fine discharge port for discharging a droplet of a chemical solution. The internal shape of the nozzle 12 is a horn shape.

  In the coating head 11 having the configuration as shown in FIG. 3, a voltage having a predetermined waveform is applied to the piezoelectric element of the laminated piezoelectric element 62 while filling the pressurized liquid chamber 65 with the chemical liquid from the common liquid chamber 64. By causing the displacement, the chemical liquid in the pressurized liquid chamber 65 is pressurized through the diaphragm portion 63a to increase the liquid pressure, and as a result, a droplet of the chemical liquid is discharged from the nozzle 12. The timing and the applied voltage value for applying a voltage to the piezoelectric element of the laminated piezoelectric element 62 are controlled by the control unit 40. That is, the control unit 40 controls the spraying of the chemical solution from each coating head 11.

  Further, one head group is configured by the three coating heads 11 arranged along the conveying direction of the base sheet 90. As shown in FIG. 2, four rows of such head groups are arranged in the coating unit 10 to cover the entire width of the support 92. Note that it is not always necessary to arrange the coating heads 11 so as to cover the entire width of the support 92. For example, when the circular base sheet 90 is disposed only in the center of the support 92, 2 in the center in the width direction. Only the head group in the row may be arranged. Further, according to the arrangement state of the base sheet 90 on the support 92, for example, two rows of the head group shown in four rows in the width direction in FIG.

  FIG. 4 is a diagram showing the arrangement relationship of the three coating heads 11 constituting the head group. Each coating head 11 provided in the coating unit 10 is provided to be inclined by an angle α in the horizontal plane with respect to the transport direction TD of the base sheet 90. When the arrangement pitch of 128 nozzles 12 provided in each coating head 11 (distance between adjacent nozzles) is p, the direction is perpendicular to the transport direction TD (the width direction of the base sheet 90). The distance d between the nozzles is psinα. The three coating heads 11 constituting the head group are arranged so as to be shifted by d / 3 along a direction perpendicular to the transport direction TD. Specifically, the middle coating head 11 is arranged to be shifted by d / 3 in the direction perpendicular to the transport direction TD with respect to the most downstream (upper side in FIG. 4) coating head 11 along the transport direction TD. . Similarly, the coating head 11 on the most upstream side (lower side in FIG. 4) with respect to the middle coating head 11 is disposed by being shifted by d / 3 in a direction perpendicular to the transport direction TD.

  By arranging in this way, the apparent nozzle arrangement pitch in the width direction of the support 92 becomes d / 3, which can be significantly smaller than the original pitch p, and the accuracy of chemical application can be improved. . The inclination angle α and the original arrangement pitch p are set so that the apparent nozzle arrangement pitch falls within a range of, for example, 10 μm or more and 200 μm or less. Further, the amount of one droplet discharged from one nozzle 12 of the coating head 11 is, for example, in the range of 5 pl (picoliter) or more and 100 pl or less. In the first embodiment, the amount of one droplet discharged from one nozzle 12 is 25 pl, and the apparent nozzle arrangement pitch is 50 μm. In addition, each coating head 11 is arrange | positioned so that the nozzle 12 of the coating head 11 which comprises an adjacent head group may not mutually overlap.

  Returning to FIG. 1, the chemical liquid supply unit 30 that supplies the chemical liquid to the coating unit 10 includes a chemical liquid tank 31. The chemical tank 31 is connected to each application head 11 of the application unit 10 through a supply pipe 32. A foreign substance removal filter 36 and a deaeration filter 33 are inserted in the middle of the supply pipe 32. The chemical liquid tank 31 always stores a certain amount of chemical liquid, and the chemical liquid tank 31 is appropriately replenished with the chemical liquid from the preparation tank 331.

  Here, the chemical solution is a liquid containing a drug. The drug used in the patch according to the present invention is not particularly limited, but a drug that can be administered through the skin, that is, a drug that can be absorbed through the skin is preferable. More specifically, analgesic and anti-inflammatory agents such as indomethacin, ketoprofen, flurbiprofen, ibuprofen, viloxicam, methyl salicylate, glycol salicylate, l-menthol, dl-camphor, valinylyl nonylate, capsaicin, etc. can give. In addition, coronary vasodilators such as nitroglycerin, nifedipine, isosorbide nitrate, or asthma drugs such as procaterol and tulobuterol may be used as the drug. In addition to the above, the drugs include general anesthetics, hypnotics / sedatives, antiepileptics, antipruritics, psychoneurotics, skeletal muscle relaxants, autonomic nerves, antispasmodics, antiparkinson drugs, Antihistamine, cardiotonic, arrhythmic, diuretic, antihypertensive, vasoconstrictor, peripheral vasodilator, arteriosclerosis, cardiovascular, respiratory stimulant, antitussive expectorant, hormone, purulent disease Topical medicine, analgesic / antipruritic / astringent / anti-inflammatory medicine, parasitic skin disease medicine, hemostatic medicine, gout treatment medicine, diabetes medicine, anti-malignant tumor medicine, antibiotics, chemotherapeutic medicine, narcotic, anti Depressants, smoking cessation aids (nicotine), etc. can be used.

  Such a drug is dissolved in a solvent to form a drug solution. As the solvent, water or alcohol can be used depending on the properties of the drug. A chemical solution having a predetermined concentration in which a medicine is dissolved in a solvent is prepared in the preparation tank 331, and the chemical liquid is supplied from the preparation tank 331 and stored in the chemical liquid tank 31. The chemical solution stored in the chemical solution tank 31 is supplied to each nozzle 12 by capillary action generated in the nozzle when the application head 11 ejects the chemical solution. In the process of supplying the chemical liquid, foreign substances and bubbles are removed from the chemical liquid flowing through the supply pipe 32 by the foreign substance removal filter 36 and the degassing filter 33, respectively. In addition, the chemical | medical solution may further contain the binder and / or additive which improve the adhesiveness to the base material sheet 90. FIG.

  The chemical liquid feeding unit 30 of the first embodiment includes a solvent addition unit 34. The solvent addition unit 34 adjusts the viscosity and surface tension of the chemical solution by further adding a chemical solvent to the chemical solution in the preparation tank 331. That is, in the coating head 11 that adopts the droplet jet method, the chemical liquid droplets cannot be ejected from the nozzle 12 unless the viscosity and surface tension of the chemical liquid are within the appropriate ranges. Conventionally, the chemicals used for the manufacture of transdermal absorbents are often out of the proper range in which the viscosity and surface tension can be ejected from the droplet jet type nozzle 12 as they are, and should be ejected stably. Is difficult. For this reason, a solvent is further added to the chemical solution from the solvent addition unit 34 so that the viscosity and surface tension of the chemical solution are adjusted to be within an appropriate range that can be ejected from the droplet jet type nozzle 12. In addition, as the solvent addition part 34, what is necessary is just what can supply a predetermined amount of solvent to the preparation tank 331, For example, it can comprise using a weighing tank or a mass flow controller.

  Further, a temperature control unit 15 is attached to the coating unit 10. The temperature control unit 15 controls the temperature of the chemical solution by heating or cooling the 12 coating heads 11 provided in the coating unit 10. As the temperature control unit 15, temperature control piping for introducing temperature control water at a predetermined temperature or a heater can be used. The viscosity and surface tension of the chemical solution also depend on the temperature of the chemical solution. That is, the temperature control unit 15 also adjusts the temperature of the chemical solution so that the viscosity and surface tension of the chemical solution fall within an appropriate range that can be ejected from the droplet jet type nozzle 12. The temperature control unit 15 may be built in the coating head 11.

  Further, when the temperature of the chemical solution changes, the viscosity and surface tension of the chemical solution change, and the meniscus amount of the chemical solution formed near the tip of the nozzle 12 changes. This causes a problem that the amount of ejected liquid droplets changes. Therefore, the temperature adjustment unit 15 is provided in the coating unit 10 to keep the temperature of the chemical solution in the coating head 11 constant (for example, 30 ° C.). . As a result, the viscosity and surface tension of the chemical solution are also constant, and the amount of liquid droplets ejected can be constant. The temperature control unit 15 may be attached to the coating head 11 individually or may be attached to the supply pipe 32.

  The chemical solution feeding unit 30 includes a moisturizing agent adding unit 35. The humectant addition unit 35 adds 0.5 vol% to 10 vol% of the humectant to the chemical liquid in the preparation tank 331. A humectant is added to reduce the drying rate of the chemical solution. That is, in the coating head 11 employing the droplet jet method, if the drying speed of the chemical solution is high, the chemical solution is dried in the nozzle and its physical properties change rapidly. In the worst case, the chemical solution may solidify. When such a situation occurs, the chemical liquid cannot be stably ejected from the nozzle 12. For this reason, a moisturizing agent is added to the chemical liquid from the moisturizing agent adding section 35 to reduce the drying speed, and the chemical liquid is prevented from drying in the nozzle. As the humectant to be added, a polyhydric alcohol having little influence on the human body such as glycerin, propylene glycol, sorbitol and the like can be used. The moisturizing agent adding unit 35 may be any unit that can supply a predetermined amount of the moisturizing agent to the blending tank 331, and may be configured using, for example, a weighing tank or a mass flow controller. In addition, a stirrer 338 for sufficiently mixing the moisturizer supplied from the moisturizer addition unit 35 and the solvent supplied from the solvent addition unit 34 with the chemical solution in the preparation tank 331 is provided inside the preparation tank 331. Yes. A similar stirrer 38 is also provided inside the chemical liquid tank 31.

  Further, the chemical liquid feeding unit 30 includes a negative pressure pump 37. The negative pressure pump 37 applies a negative pressure from the chemical solution tank 31 to each application head 11 of the application unit 10 via the supply pipe 32. This negative pressure pump 37 is for forming a meniscus of a chemical solution near the tip of the nozzle 12 before the laminated piezoelectric element 62 pressurizes the chemical solution in the pressurized liquid chamber 65 in the nozzle 12. That is, since the chemical liquid supplied to the nozzle 12 from the communication port 68 is not weighted as it is, a meniscus suitable for the droplet jet method cannot be formed in the vicinity of the tip of the nozzle 12, so that the negative pressure pump 37 reverses the discharge direction. A negative pressure is applied to the chemical solution, and the chemical solution is slightly pulled back into the nozzle 12 to form an appropriate meniscus.

  Furthermore, a heater 340 and a heater 341 are attached to the lower part of the preparation tank 331 and the chemical liquid tank 31, respectively. The heaters 340 and 341 respectively adjust the temperature of the chemical solution in the preparation tank 331 and the chemical solution tank 31 to 30 ° C., for example. The temperature of the chemical solution is adjusted to 30 ° C. from the chemical solution supply unit 30 to the coating unit 10 by the heaters 340 and 341 and the temperature adjustment unit 15.

  The drying unit 50 is provided on the downstream side of the coating unit 10 in the conveyance direction of the base sheet 90. The drying unit 50 dries the chemical applied to the base sheet 90 that passes through the inside of the drying unit 50. As the drying unit 50, various known drying devices such as one that blows normal temperature dry air or heated dry air (hot air) onto the surface of the base sheet 90 can be used. Further, as the drying unit 50, a hot air drying furnace for supplying simple hot air (not performing special dehumidification) or a drying furnace using a far infrared heater may be used.

  As shown in FIG. 1, a position detection sensor 70 is provided on the upstream side of the coating unit 10 in the conveyance direction of the base sheet 90. The position detection sensor 70 detects the position of the base sheet 90 on the support 92 before spraying a liquid droplet of the chemical liquid from the application head 11. Based on the position information of the base sheet 90 detected by the position detection sensor 70, the control unit 40 controls the chemical liquid discharge position of the coating head 11 so that the liquid droplets of the chemical liquid are accurately sprayed on the base sheet 90. . As the position detection sensor 70, various sensors such as a reflection type or transmission type optical sensor or an ultrasonic sensor can be used. Further, an imaging camera may be provided in place of the position detection sensor 70, and the position of the base sheet 90 may be detected by processing image data obtained by imaging the upper surface of the support 92 with the imaging camera. .

  The control unit 40 controls the various operation mechanisms provided in the patch manufacturing apparatus 1. FIG. 5 is a block diagram illustrating a configuration of the control unit 40. The configuration of the control unit 40 as hardware is the same as that of a general computer. That is, the control unit 40 stores a CPU 41 that performs various arithmetic processes, a ROM 42 that is a read-only memory that stores basic programs, a RAM 43 that is a readable / writable memory that stores various information, a processing program 81, data, and the like. The fixed disk 44 to be placed is connected to the bus line 49. The RAM 43 stores a coating pattern 82 to be described later.

  Further, the above-described position detection sensor 70 and each coating head 11 of the coating unit 10 are connected to the bus line 49 via an interface (I / F) 45. Various operating mechanisms of the patch manufacturing apparatus 1 other than the position detection sensor 70 and the coating head 11 are also connected to the bus line 49 via an interface (not shown). The CPU 41 of the control unit 40 executes the processing program 81 stored in the fixed disk 44 to control each operation mechanism such as the coating head 11 and advance the patch manufacturing process.

  A display device 46 and an input device 47 are electrically connected to the bus line 49. The display device 46 is configured using, for example, a liquid crystal display and displays various information such as processing results and messages. The input device 47 is configured using, for example, a keyboard and a mouse, and receives input of commands, parameters, and the like. The operator of the device can input commands, parameters, and the like from the input device 47 while confirming the contents displayed on the display device 46. Note that the display device 46 and the input device 47 may be integrated to form a touch panel.

  Further, a reading device 48 that reads recorded contents from a recording medium RM such as a DVD or a CD is connected to the bus line 49. The processing program 81 may be read from the recording medium RM by the reading device 48 and stored in the fixed disk 44. Further, the coating pattern 82 may be read from the recording medium RM by the reading device 48 and stored in the RAM 43.

  In addition to the above configuration, the patch manufacturing apparatus 1 includes various mechanisms that omit detailed description. For example, on the further downstream side of the drying unit 50, a mechanism for attaching a release liner to the base sheet 90 coated with a chemical solution and a mechanism for cutting the support 92 are provided.

  When performing patch manufacturing processing in the patch manufacturing apparatus 1 having the above configuration, the CPU 41 of the control unit 40 executes a processing program 81 to control each operation mechanism of the patch manufacturing apparatus 1. FIG. 6 is a diagram illustrating an example of the manufacturing process of the patch in the patch manufacturing apparatus 1. Under the control of the control unit 40, the transport mechanism 20 transports the support body 92 along the horizontal direction, and a sheet supply mechanism (not shown) has a disk-shaped base sheet 90 on the upper surface of the support body 92 at regular intervals. Supply. A layer of an adhesive 91 is formed in advance on the upper surface of the support 92 that is fed from the feed roller 21 and conveyed in the horizontal direction, and the supplied base sheet 90 is stuck on the support 92 at regular intervals. Is done. The position of each base sheet 90 affixed on the support 92 is detected by the position detection sensor 70 and transmitted to the control unit 40, and the control unit 40 controls the coating head 11 based on the position information. A droplet of the chemical solution is sprayed onto the base material sheet 90 on the support 92.

  The chemical solution application to the base material sheet 90 by the application head 11 will be further described. Under the control of the control unit 40, the solvent addition unit 34 adds a solvent to the chemical solution in the preparation tank 331 and stirs it with the stirrer 338 to adjust the viscosity and surface tension of the chemical solution. Further, as necessary, the temperature adjustment unit 15 adjusts the temperature of the chemical solution to supplementarily adjust the viscosity and surface tension of the chemical solution. With these adjustments, the viscosity and surface tension of the chemical solution are adjusted to fall within an appropriate range that can be ejected from the droplet jet type nozzle 12. As described above, when the temperature of the chemical solution in the coating head 11 changes, the physical properties of the chemical solution change and the amount of liquid droplets to be ejected changes. Therefore, the temperature adjustment unit 15 adjusts the temperature of the chemical solution at a constant temperature. It is preferable to keep it. In addition, under the control of the control unit 40, the moisturizing agent adding unit 35 adds a moisturizing agent to the chemical solution in the blending tank 331 to reduce the drying rate of the chemical solution.

  The control unit 40 controls droplet spraying from each coating head 11 of the coating unit 10 according to the position information of the base sheet 90 transmitted from the position detection sensor 70 and the coating pattern 82 stored in the RAM 43. Specifically, the application pattern 82 describes a pattern of a region where the chemical solution is sprayed onto the base sheet 90. The controller 40 reads the pattern and controls the on / off timing for all the nozzles 12 provided in the twelve coating heads 11. That is, when a chemical solution is sprayed onto a certain region, a voltage is applied to the laminated piezoelectric element 62 of the nozzle 12 corresponding to that region, and the chemical solution is ejected from the nozzle 12. The application pattern 82 may be generated by calculation and stored in the RAM 43, or may be read from the recording medium RM and stored in the RAM 43 as described above. When the coating pattern 82 is generated by calculation, the size and shape of the base sheet 90, the resolution of the coating head 11 (the apparent nozzle arrangement pitch), and the pattern shape are input from the input device 47 as so-called recipe data. To do. Then, the CPU 41 performs a calculation based on the recipe data to calculate the application pattern 82, and the calculation result may be stored in the RAM 43.

  The application pattern 82 of the first embodiment is a simple pattern in which a chemical solution is applied to a partial region of the base sheet 90. The control unit 40 controls droplet spraying from the coating unit 10 according to such a coating pattern 82. Each coating head 11 of the coating unit 10 generates a fine droplet by atomizing a chemical solution containing a drug under the control of the control unit 40, and one side of the base sheet 90 that transports the droplet by the transport mechanism 20. Spray on some areas. As a result, as shown in FIG. 7, the drug solution 95 is formed by applying the chemical solution only to a partial region on one side of the base sheet 90 affixed on the support 92. The base material sheet 90 to which the chemical solution is applied is conveyed to the drying unit 50 and the chemical solution is dried. Thereafter, a release liner is bonded to the base sheet 90 on which the drug layer 95 is formed, and the support 92 is cut into a predetermined size to obtain a patch.

  In the first embodiment, a chemical liquid containing a medicine is made into fine droplets by a droplet jet application head 11 to generate droplets, and the droplets are sprayed only on a partial region of the base sheet 90. With the droplet jet type coating head 11, it is possible to switch on / off of the chemical spraying according to the coating pattern 82, and it is possible to easily apply the chemical to only a partial region of the base sheet 90. If the chemical solution can be applied only to a partial region of the base sheet 90, it is possible to eliminate a drug that is removed wastefully because it has been applied to an unnecessary part in a later process, and to improve the use efficiency of the drug. it can. In addition, the droplet jet type application head 11 is suitable for manufacturing a medical patch because it is excellent in quantitative accuracy of chemical solution application. Further, patterning can be freely performed by changing the setting of the coating pattern 82. Furthermore, it is possible to freely adjust the size of the application region by changing the size of the application pattern 82.

  Moreover, since the application unit 10 applies a chemical solution containing a medicine in a non-contact manner, contamination from the application unit 10 can be reliably prevented as compared with the conventional spread application method.

  In the first embodiment, the amount of one droplet discharged from one nozzle 12 is 25 pl, and the apparent nozzle arrangement pitch is 50 μm. Therefore, a droplet of 25 pl is landed on the base sheet 90 with an interval of 50 μm. FIG. 8A is a diagram showing a state immediately after the 25 pl droplet 99 of the chemical liquid sprayed from the coating head 11 has landed on the base sheet 90 with an interval of 50 μm. As shown in FIG. 8 (a), the droplets 99 do not overlap each other immediately after landing, but the droplet of 25 pl gradually spreads on the base sheet 90 and is adjacent to each other with an interval of 50 μm. Droplets 99 to overlap each other. As a result, as shown in FIG. 8 (b), the chemical solution is uniformly applied in the region on the base sheet 90 on which the droplets of the chemical solution are sprayed, and the efficacy of the drug can be made uniform. it can. In addition, the beauty of the area is also maintained. In order to set the amount of droplets to 25 pl, it may be discharged from a single nozzle 12 once, or it may be discharged from a multiple discharge type nozzle in multiple times at the same position. Also good. For example, a 5 pl droplet may be ejected five times from the multiple ejection type nozzle to the same position, and the amount of droplets may be 25 pl.

  Further, in the first embodiment, the solvent addition unit 34 and the temperature control unit 15 are adjusted so that the viscosity and surface tension of the chemical solution fall within an appropriate range that can be ejected from the droplet jet type nozzle 12. For this reason, the chemical | medical solution containing a medical chemical | medical agent can be reliably ejected from the application head 11 of a droplet jet system.

  Furthermore, in 1st Embodiment, the moisturizer is added to the chemical | medical solution from the moisturizer addition part 35, and the drying rate of a chemical | medical solution is reduced. Thereby, it can prevent that a chemical | medical solution dries and changes in quality in a nozzle, and can spray a chemical | medical solution from the application head 11 stably. That is, when the chemical liquid is dried in the nozzle, the physical properties (viscosity and surface tension) of the chemical liquid deviate from the droplet jet characteristics, the meniscus formed near the tip of the nozzle 12 is broken, and the droplets cannot be ejected. By adding a moisturizing agent to the chemical solution, such a phenomenon can be prevented and the chemical solution can be stably sprayed from the coating head 11. Further, it is possible to prevent the chemical liquid from drying in the nozzle even after the ejection of the chemical liquid is stopped, and it is possible to prevent so-called nozzle omission.

<2. Second Embodiment>
Next, a second embodiment of the present invention will be described. FIG. 9 is a diagram illustrating an outline of a main configuration of the patch manufacturing apparatus 1 according to the second embodiment. In the figure, the same elements as those in the first embodiment are denoted by the same reference numerals. The patch manufacturing apparatus 1 according to the second embodiment is an apparatus that manufactures a patch by applying a medicine to one side of a resin base sheet 90. The patch manufacturing apparatus 1 of the second embodiment is different from the first embodiment in that it includes two coating units 10a and 10b.

  Each of the two coating units 10a and 10b is the same as the coating unit 10 of the first embodiment. That is, each of the two coating units 10 a and 10 b includes twelve coating heads 11. The twelve coating heads 11 are disposed so as to be inclined with respect to the transport direction TD of the base sheet 90 as in the first embodiment. The coating unit 10a is provided upstream of the coating unit 10b in the transport direction of the base sheet 90.

  Moreover, a chemical solution is supplied to the coating units 10a and 10b from the chemical solution supply units 30a and 30b, respectively. The configuration of each of the two chemical liquid feeding units 30a and 30b is the same as that of the chemical liquid feeding unit 30 of the first embodiment. In the second embodiment, the chemical liquid supplied by the chemical liquid supply unit 30a and the chemical liquid supplied by the chemical liquid supply unit 30b have the same kind of chemicals but have different concentrations. In addition, as a kind of chemical | medical agent and solvent which comprise a chemical | medical solution, the thing similar to 1st Embodiment can be used.

  Although not shown in FIG. 9, the coating units 10a and 10b of the second embodiment are provided with temperature control units similar to those of the first embodiment, and the chemical solution feeding units 30a and 30b are provided with a first temperature control unit. The solvent addition part and moisturizing agent addition part similar to the embodiment are provided. The remaining configuration of the patch manufacturing apparatus 1 of the second embodiment is the same as that of the first embodiment.

  When performing the patch manufacturing process in the patch manufacturing apparatus 1 of the second embodiment, the circular base sheet 90 pasted on the support 92 by the transport mechanism 20 is controlled in the horizontal direction under the control of the control unit 40. The coating heads 11 of the two coating units 10 a and 10 b spray liquid chemical droplets onto the base sheet 90. The basic flow of the manufacturing process of the patch is the same as that of the first embodiment, but in the second embodiment, the application pattern for each of two chemical solutions having different concentrations, that is, for each of the application units 10a and 10b. 82 is preset. Here, it is assumed that a checkered coating pattern 82 is set for each of the coating units 10a and 10b.

  The control unit 40 controls the droplet spraying from the coating head 11 of the upstream coating unit 10a according to the first checkered coating pattern 82. Each coating head 11 of the coating unit 10 a generates a droplet by making the first concentration chemical liquid into fine droplets under the control of the control unit 40, and one side of the base sheet 90 that transports the droplet by the transport mechanism 20. Spray on some areas. As a result, when the application by the application unit 10a is completed, the first concentration of the chemical solution is applied in a checkered pattern to a partial region on one side of the base sheet 90, as indicated by the hatched portion in FIG. The Rukoto.

  Further, the control unit 40 controls the droplet spraying from the coating head 11 of the downstream coating unit 10b according to the second checkered coating pattern 82 which is black and white inverted from the first checkered pattern. Each coating head 11 of the coating unit 10b generates droplets by atomizing a chemical solution having a second concentration different from the first concentration under the control of the control unit 40, and the droplets are transported by the transport mechanism 20. It sprays on the partial area | region of the single side | surface of the base material sheet 90. FIG. The partial area itself for spraying the droplets is the same as the spray area by the coating unit 10a. As a result, as shown by the grid lines in FIG. 10B, the second concentration of the chemical solution is applied to the non-application portion of the checkered pattern drawn with the first concentration of the chemical solution. As shown in FIG. 10 (b), the base sheet 90 on which the chemical solutions having different concentrations are applied is conveyed to the drying unit 50, where the chemical solution is dried. Thereafter, a release liner is bonded to the base material sheet 90 on which the drug layer is formed, and the support 92 is cut into a predetermined size to obtain a patch.

  In the second embodiment, a coating pattern 82 is set in advance for each of two chemical solutions having different concentrations, and droplets of the two chemical solutions are sprayed onto the base sheet 90 according to the preset coating pattern 82 for each. Yes. And two chemical | medical solutions from which a density | concentration differs are sprayed on the base material sheet 90 according to the different application pattern 82, and these two chemical | medical solutions are sprayed on a mutually different area | region, and are applied separately.

  Since the application pattern 82 can be freely set, it is possible to apply two chemical solutions having different concentrations in a desired pattern. For example, as shown in FIG. 10, two chemical solutions having different concentrations may be applied separately in a checkered pattern, or may be applied separately in a stripe shape as shown in FIG. 11, or as shown in FIG. You may make it paint in concentric circles. In this manner, by spraying two different chemical solutions having different concentrations on different areas and coating them separately, it is possible to suppress a decrease in the absorption rate of the drug and to absorb the drug on the skin at a constant rate for a long time. . That is, it becomes possible to control the persistence of the medicine. In order to control the persistence of conventional patches, it is necessary to apply the iontophoresis principle to electrically adjust the absorption of the drug, and it is necessary to attach a battery to the patch. The process was complicated and the price was high. If this is made like 2nd Embodiment, since the sustainability of a chemical | medical agent is controlled by spraying and coating two chemical | medical solutions from which a density | concentration mutually differs on a different area | region, a manufacturing process is simple, An increase in unit price can also be suppressed. Moreover, if the price of the patch can be suppressed and the price can be reduced, a patch more suitable for disposable use can be produced.

  Further, since the two coating units 10a and 10b apply different chemical solutions to different regions in a non-contact manner, contamination from the coating units 10a and 10b can be prevented, and both chemical solutions are unnecessarily mixed. Can also be prevented. When different chemical liquids are applied to different areas, in order to prevent the two chemical liquids from being mixed with each other, it is possible to prevent the liquid droplets from spreading at the boundary between adjacent different areas. Specifically, as shown in FIG. 13 (a), on both sides of the boundary between different regions where different chemical solutions are applied, normally, 5 pl is ejected 5 times each to give a 25 pl amount of liquid droplets. For landing, for example, a droplet of 5 pl is discharged only once to land on the substrate sheet 90. In this way, as shown in FIG. 13B, even if a 5 pl amount of liquid droplets spread on the base sheet 90, adjacent liquids of different chemicals that land on different regions across the boundary portion. Drops can be prevented from overlapping each other. Further, instead of reducing the number of droplet ejections, the ejection from the nozzles corresponding to the boundary portions of the regions may be stopped.

  Further, in the second embodiment, the chemical solutions containing the same kind of medicines at different concentrations from the two coating units 10a and 10b are sprayed on different areas, but these are sprayed on the same area. You may do it. For example, the first concentration chemical solution is applied from the application unit 10a to the checkered pattern in FIG. 10A, and then the second concentration chemical solution is applied over the first concentration chemical solution from the application unit 10b. Also good. Even if it does in this way, it becomes possible to control the sustainability and absorption amount of a medicine suitably.

  In the second embodiment, the chemical solutions containing the same kind of medicines at different concentrations from the two coating units 10a and 10b are sprayed onto the base sheet 90, but the two coating units 10a and 10b are used. Alternatively, chemical solutions containing different types of chemicals may be sprayed onto the base sheet 90. In this case, chemical solutions containing different types of drugs may be sprayed on different areas and applied separately, or may be sprayed on the same area. New efficacy can be expected by combining different types of drugs with different efficacy.

  Further, the control unit 40 may control the weight ratio of the chemicals sprayed from the two coating units 10a and 10b to have variations.

  Further, in the second embodiment, the two application units 10a and 10b are provided in the patch manufacturing apparatus 1, but three or more application units may be provided and different chemicals may be sprayed from each. . That is, a plurality of different chemical liquids (including both chemical liquids containing the same type of chemicals at different concentrations and chemical liquids containing different types of chemicals) may be sprayed on the base sheet 90. In this case, an application pattern 82 set in advance for each of a plurality of different chemical solutions is held in the RAM 43, and a plurality of different chemical solution droplets are sprayed onto the base sheet 90 according to the application patterns 82. When the same application pattern 82 is set for a plurality of different chemical solutions, each of the plurality of different chemical solutions is sprayed over the same region. In addition, when different application patterns 82 are set for each of a plurality of different chemical solutions, each of the plurality of different chemical solutions is sprayed and applied separately to different areas.

<3. Third Embodiment>
Next, a third embodiment of the present invention will be described. FIG. 14: is a figure which shows the outline of a principal part structure of the patch manufacturing apparatus 1 of 3rd Embodiment. In the figure, the same elements as those in the first embodiment are denoted by the same reference numerals. The patch manufacturing apparatus 1 according to the third embodiment is an apparatus that manufactures a patch by applying a medicine to one side of a resin base sheet 90. The patch manufacturing apparatus 1 of the third embodiment is different from the first embodiment in that it includes two coating units 10c and 110. In the third embodiment, the belt-shaped base sheet 90 is directly wound around the feed roller 21.

  Each of the two coating units 10c and 110 is the same as the coating unit 10 of the first embodiment. That is, each of the two coating units 10 c and 110 includes twelve coating heads 11. The twelve coating heads 11 are disposed so as to be inclined with respect to the transport direction TD of the base sheet 90 as in the first embodiment. The coating unit 110 is provided on the upstream side in the transport direction of the base sheet 90 from the coating unit 10c.

  A chemical solution is supplied from the chemical solution supply unit 30c to the coating unit 10c. The configuration of the chemical liquid feeding unit 30c is exactly the same as that of the chemical liquid feeding unit 30 of the first embodiment. That is, although not shown in FIG. 14, the chemical solution feeding unit 30c is provided with a solvent addition unit and a humectant addition unit similar to those in the first embodiment. Moreover, the temperature control part similar to 1st Embodiment is attached to the coating unit 10c of 3rd Embodiment. In addition, as a kind of chemical | medical agent and solvent which comprise a chemical | medical solution, the thing similar to 1st Embodiment can be used.

  Further, an adhesive solution is supplied from the adhesive supply unit 130 to the coating unit 110. The adhesive feeding unit 130 feeds the adhesive solution stored in the adhesive tank 131 to the coating unit 110 via the supply pipe 132. As an adhesive, various well-known things can be employ | adopted in the transdermal absorption medicine field | areas, such as a rubber adhesive, a vinyl adhesive, and an acrylic adhesive. The adhesive tank 131 stores a solution obtained by dissolving such an adhesive in an organic solvent. The viscosity and surface tension of the pressure-sensitive adhesive solution are adjusted in advance so as to be within an appropriate range that can be ejected from the nozzle of the droplet jet type coating unit 110.

  In the third embodiment, the drying unit 50 is provided downstream of each of the coating unit 110 and the coating unit 10c. The remaining configuration of the patch manufacturing apparatus 1 of the third embodiment is the same as that of the first embodiment.

  When performing the patch manufacturing process in the patch manufacturing apparatus 1 of the third embodiment, the transport mechanism 20 transports the belt-shaped base sheet 90 along the horizontal direction under the control of the control unit 40. However, in the third embodiment, only the base sheet 90 is directly wound around the feed roller 21, and the transport mechanism 20 transports the base sheet 90 on which the adhesive layer is not formed along the horizontal direction. .

  In addition, under the control of the control unit 40, the coating head 11 of the coating unit 110 sprays droplets generated by atomizing the adhesive solution onto the substrate sheet 90, and then the coating head 11 of the coating unit 10c performs the chemical solution. The droplets generated by atomizing are sprayed onto the substrate sheet 90. That is, in the third embodiment, both the pressure-sensitive adhesive solution and the chemical solution are sprayed onto the base sheet 90 by the droplet jet method.

  In the third embodiment, the coating pattern 82 is set for each of the pressure-sensitive adhesive and the chemical solution, that is, for each of the coating units 110 and 10c. The control unit 40 controls droplet spraying from the coating head 11 of the coating unit 110 according to the coating pattern 82 set for the adhesive. Each coating head 11 of the coating unit 110 generates droplets by making the pressure-sensitive adhesive solution into fine droplets according to control by the control unit 40, and the liquid droplets are transported on one side of the base sheet 90 transported by the transport mechanism 20. Spray the area. As a result, when the application by the application unit 110 is completed, the adhesive solution is applied to the ring-shaped region on one side of the base sheet 90 as shown by the hatched portion in FIG. The base material sheet 90 to which the adhesive solution is applied is conveyed to the drying unit 50, and the adhesive solution is dried.

  Further, the control unit 40 controls the droplet spraying from the coating head 11 of the coating unit 10c according to the coating pattern 82 set for the chemical solution. Each coating head 11 of the coating unit 10 c generates a droplet by atomizing the chemical liquid under the control of the control unit 40, and a partial region on one side of the base sheet 90 that transports the droplet by the transport mechanism 20. Spray on. As a result, as shown by the vertical line in FIG. 16, the chemical solution is applied to the inside of the adhesive applied in a ring shape. The base material sheet 90 to which the chemical solution is applied is conveyed to the drying unit 50 and the chemical solution is dried. Thereafter, a release liner is bonded to the base sheet 90 on which the pressure-sensitive adhesive and the drug layer are formed, and cut into a predetermined size to obtain a patch.

  In the third embodiment, both the pressure-sensitive adhesive and the chemical liquid are sprayed and applied to the base material sheet 90 by the droplet jet type application head 11. For this reason, it is possible to accurately apply the adhesive and the chemical solution to a predetermined position without mixing them together. As a result, alignment at the time of applying the pressure-sensitive adhesive and the chemical solution becomes unnecessary, and cutting in a subsequent process can be easily performed.

  In the third embodiment, the chemical solution is applied to the inside of the pressure-sensitive adhesive applied in a ring shape. However, by freely setting the application pattern 82 for the pressure-sensitive adhesive and the chemical solution, both are formed into a desired pattern. Can be applied. For example, the adhesive application pattern 82 may be a pattern in which a plurality of islands are formed inside the ring shown in FIG. The adhesive force of the patch to the skin can be increased by applying an adhesive to a plurality of islands formed inside the ring in addition to the ring. Moreover, you may make it apply | coat both an adhesive and a chemical | medical solution separately by the checkered pattern shown in FIG. 10 of 2nd Embodiment, the stripe form shown in FIG. 11, and the concentric form shown in FIG.

  Further, the adhesive may be applied by a dispenser type application mechanism instead of the droplet jet type application head 11. FIG. 17 is a diagram showing application by a dispenser type nozzle. The dispenser nozzle 210 applies the adhesive in a linear manner while being scanned in the direction perpendicular to the conveyance direction of the base sheet 90 (the normal direction of the paper surface in FIG. 17). Then, by turning on / off the discharge of the adhesive from the dispenser nozzle 210, the adhesive can be applied to a desired shape such as a ring shape as shown in FIG. Such a dispenser-type application mechanism can apply the adhesive accurately and quantitatively. In addition, the range of physical properties of liquids (chemicals and the like) suitable for the droplet jet method is narrow, whereas the range of physical properties of liquids that can be handled by the dispenser method is wide. In general, since many adhesives have high viscosity, a dispenser method is suitable. However, it is preferable to use a droplet jet type coating head 11 that is excellent in positional accuracy of coating and can be freely coated in various patterns.

<4. Modification>
While the embodiments of the present invention have been described above, the present invention can be modified in various ways other than those described above without departing from the spirit of the present invention. For example, although the laminated piezo drop on demand type inkjet head is used as the coating head 11 in each of the above-described embodiments, the invention is not limited to this. Anything to do.

  In the first embodiment, the application pattern 82 is a simple pattern that only applies a chemical solution to a partial region of the base sheet 90. However, even if there is only one application unit, the application pattern 82 is Of course, it can be set freely, and can be any pattern such as a checkered pattern, a stripe pattern, or a concentric pattern.

  In the first and second embodiments, the support 92 on which the layer of the adhesive 91 has already been formed is conveyed along the horizontal direction, and the base sheet 90 is supplied to the upper surface of the support 92 and pasted. In addition, the liquid droplets of the chemical solution were sprayed on the upper surface of the base sheet 90. However, the types of chemicals and solvents contained in the chemical solution, or a plurality of different chemical solutions as in the second embodiment Depending on their combination, the form of spraying can be variously changed. For example, as shown in FIG. 18A, a belt-like base material sheet 90 is wound directly around the feed roller 21 as in the third embodiment, and the transport mechanism 20 causes the belt-like base material sheet 90 along the horizontal direction. The drug layer 95 is formed by spraying the chemical solution directly from the coating unit 10 onto a partial region of the upper surface. And the area | region in which the chemical | medical agent layer 95 was formed from the base material sheet 90 was cut out, and the support body 92 in which the layer of the adhesive 91 prepared separately was already formed as shown in FIG.18 (b). Affix to the top surface of. Thereby, the patch similar to 1st Embodiment (FIG. 6) can be manufactured.

  Further, as shown in FIG. 19, the base sheet 90 on which the layer of the adhesive 91 has already been formed is conveyed along the horizontal direction, and the coating unit 10 directly sprays the liquid droplets of the chemical solution from the adhesive 91. You may do it. In this case, the substrate sheet 90 itself also serves as a support. In the example of FIG. 19, a release liner is bonded to the base material sheet 90 on which the drug layer 95 is formed, and the release liner is cut into a predetermined size to obtain a patch.

  Further, in each of the above embodiments, the coating head 11 is provided so as to be inclined by the angle α with respect to the transport direction TD of the base sheet 90. However, the arrangement pitch p of the nozzles 12 is the apparent nozzle arrangement. When it is the same as the pitch, it is not always necessary to incline it. In other words, the inclination angle α of the coating head 11 and the nozzles 12 are overlapped so that the distance between adjacent droplets when they land on the substrate sheet 90 is 10 μm or more and 200 μm or less and the adjacent droplets spread. It is sufficient that the arrangement pitch p is set. Further, the amount of one droplet ejected from one nozzle 12 is in the range of 5 pl or more and 100 pl or less so that adjacent droplets landed on the base sheet 90 overlap each other. Since adjacent droplets only need to overlap, the larger the amount of one droplet discharged from one nozzle 12, the larger the interval between adjacent droplets.

  In addition, the second embodiment and the third embodiment are combined, and an adhesive application unit and a plurality of chemical solution application units are provided, and a plurality of adhesive units applied in a ring shape on the base sheet 90 are provided inside the adhesive. Different chemicals may be sprayed.

  In the second embodiment, after all different chemicals are applied to the base sheet 90, the drying unit 50 performs the drying process. However, as in the third embodiment, each downstream of the application unit. The drying unit 50 may be provided to perform a drying process each time one chemical solution is applied. If it does in this way, it can prevent more reliably that a different chemical | medical solution mixes.

DESCRIPTION OF SYMBOLS 1 Patch production apparatus 10, 10a, 10b, 10c, 110 Application | coating unit 11 Application | coating head 12 Nozzle 15 Temperature control part 20 Conveyance mechanism 21 Feed roller 30, 30a, 30b, 30c Chemical solution supply part 31 Chemical solution tank 34 Solvent addition part 35 Moisturizer addition part 37 Negative pressure pump 38,338 Stirrer 40 Control part 50 Drying unit 62 Multilayer piezoelectric element 70 Position detection sensor 82 Application pattern 90 Base sheet 92 Support body 95 Drug layer 130 Adhesive supply part 131 Adhesive tank 210 Dispenser nozzle 331 mixing tank

Claims (14)

Liquid droplets are generated by using a coating head that uses a multilayer piezo drop-on-demand ink jet head to generate a liquid droplet, and the liquid droplet is impermeable to the drug from the nozzle of the coating head . While spraying a partial region of one side of the base sheet formed of a resin material having a drug layer ,
The chemical solution is fed to the nozzle by capillary action generated in the nozzle when the coating head ejects the chemical solution,
A method for producing a patch, comprising adjusting the viscosity and surface tension of the chemical solution, and then micronizing the chemical solution . In the manufacturing method of the patch of Claim 1,
A method for producing a patch, wherein the droplets of the chemical sprayed on the base sheet spread and the droplets are sprayed so that adjacent droplets overlap each other. In the manufacturing method of the patch of Claim 1,
A method for producing a patch, which comprises spraying a plurality of droplets of different chemical solutions on the base sheet according to a coating pattern set in advance for each. In the manufacturing method of the patch of Claim 3,
A method for producing a patch, wherein each of the plurality of different chemical solutions is sprayed onto different areas. In the manufacturing method of the patch of Claim 4,
When the droplets of different chemicals sprayed across the boundary portion of the different regions spread, the droplets are sprayed so that adjacent droplets do not overlap each other across the boundary portion Production method. In the method for producing a patch according to claim 4 or 5 ,
The first chemical liquid is applied in a first checkered pattern application pattern among the plurality of different chemical liquids, and the second chemical liquid is applied to a second checkered pattern application pattern that is black and white inverted from the first checkered pattern. A method for producing a patch, characterized by being applied . The manufacturing method of claim 3 Symbol placement of the patch,
A method for producing a patch, wherein each of the plurality of different chemical solutions is sprayed on the same region . The method of manufacturing a patch according to claims 3 to claim 7,
The method for producing a patch, wherein the plurality of different chemical solutions contain the same type of drug at different concentrations . In the manufacturing method of the patch in any one of Claims 3-7,
The method for producing a patch, wherein the plurality of different chemical solutions contain different types of drugs . In the manufacturing method of the patch in any one of Claims 1-9,
A method for producing a patch, comprising adjusting the viscosity and surface tension of the drug solution by adding a solvent for the drug. In the manufacturing method of the patch in any one of Claims 1-9,
A method for producing a patch, comprising adjusting the viscosity and surface tension of the chemical solution by adjusting the temperature of the chemical solution. In the manufacturing method of the patch in any one of Claims 1-11,
A method for producing a patch comprising adding a humectant to the chemical solution and adjusting the viscosity and surface tension of the chemical solution. In the manufacturing method of the patch of Claim 1,
The method for producing a patch, further comprising a step of applying an adhesive to a partial region of the one side of the base sheet. In the manufacturing method of the patch of Claim 13,
A method for producing a patch, which comprises spraying droplets generated by atomizing the adhesive solution onto the substrate sheet.

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