JP2013173699A - Method of producing percutaneous absorption preparation and device for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method and a device for producing a percutaneous absorption preparation capable of excellently discharging nicotine from a coating head.SOLUTION: When pure water is added to a stock solution of nicotine in a preparation tank 31, viscosity of nicotine is increased to a target viscosity level higher than an initial level (6 mPas) of the stock solution. A coating head 10 generates microdroplets from the nicotine with viscosity increased to the target viscosity level, and blows them toward a base material sheet 90 conveyed horizontally by a conveying mechanism 20. The target viscosity level is 10-13 mPas suitable for generation and discharge of ink droplets by the coating head 10. Therefore, the nicotine with viscosity increased to a required proper value of the coating head 10 is discharged from a nozzle of the coating head 10, and the nicotine can be excellently discharged while preventing occurrence of split, satellite and mist of droplets.

Description

  The present invention relates to a method and apparatus for producing a transdermally absorbable preparation containing nicotine such as a nicotine patch.

  Percutaneous absorption preparations in which an active ingredient is taken into the systemic bloodstream through the skin by being attached to the skin are widely used. Generally, a transdermally absorbable preparation is produced by spreading and applying a drug on a base material (so-called solid coating), and a bar coater, a die coater or the like is used for the coating process (for example, Patent Document 1). In spread coating, since it is difficult to apply a drug only to a desired region on the substrate, Patent Document 2 discloses that only a part of the region on the substrate is used by using a droplet jet type coating head. Techniques for spraying fine droplets of drugs have been proposed.

  The droplet jet method as disclosed in Patent Document 2 has a feature that a medicine can be patterned in a necessary amount by a necessary amount. Patent Document 2 also discloses the use of nicotine as a drug, and transdermal preparations coated with nicotine are widely used as smoking cessation aids such as so-called nicotine patches.

JP 2009-108006 A JP2011-12010A

  In the technique of spraying a medicine on a substrate as fine droplets as disclosed in Patent Document 2, it is necessary to adjust the viscosity of the medicine so as to meet the specification of the application head. However, the viscosity of nicotine is 6 mPa · s at 20 ° C., which is lower than the specification of a general coating head. For this reason, when nicotine is ejected as it is from the coating head, there arises a problem that droplets are split or mist and satellite (satellite droplets) are likely to be generated.

  The viscosity of nicotine has temperature dependency, and the viscosity increases as the temperature decreases. If the temperature of nicotine is 10 degrees C or less, the viscosity will meet the specifications of a general coating head. Therefore, it is conceivable that the coating head discharges nicotine cooled to 10 ° C. or lower. In this case, however, the coating head and the entire nicotine feeding path must also be cooled to 10 ° C. or lower. Then, dew condensation occurs on the coating head and the like, causing a problem that the droplet meniscus in the droplet jet method collapses and discharge failure occurs.

  This invention is made | formed in view of the said subject, and it aims at providing the manufacturing method and manufacturing apparatus of a percutaneous absorption preparation which can discharge nicotine favorably from an application | coating head.

  In order to solve the above-mentioned problems, the invention of claim 1 is a method for producing a transdermally absorbable preparation containing nicotine, wherein the viscosity is increased to a target viscosity value larger than the initial value by adding pure water to nicotine. And a coating step of generating droplets of nicotine having a viscosity increased to a target viscosity value in the thickening step and spraying the droplets from the coating head to the substrate.

  The invention of claim 2 is the method for producing a transdermally absorbable preparation according to the invention of claim 1, wherein in the thickening step, when the amount of pure water added to nicotine is increased, the viscosity increases and becomes maximum. It is characterized by adding a small amount of pure water less than the critical water amount to increase the viscosity of nicotine from the initial value to the target viscosity value.

  The invention of claim 3 is the method for producing a transdermally absorbable preparation according to the invention of claim 1, wherein in the thickening step, when the amount of pure water added to nicotine is increased, the viscosity increases and becomes the highest. It is characterized in that a larger amount of pure water than the critical water amount is added, and the viscosity of nicotine is increased from the initial value to the maximum value and then decreased to the target viscosity value.

  Further, the invention of claim 4 is a percutaneous absorption preparation manufacturing apparatus for manufacturing a percutaneous absorption preparation containing nicotine, wherein the pure water is added to nicotine to increase the viscosity to a target viscosity value larger than the initial value. And a coating head for generating droplets of nicotine having a target viscosity value blended in the blending unit and spraying the droplets on the substrate.

  Further, the invention of claim 5 is the transdermally absorbable preparation manufacturing apparatus according to the invention of claim 4, wherein the target viscosity value is an appropriate value for the application head to generate and discharge droplets. .

  In addition, the invention of claim 6 is the transdermally absorbable preparation manufacturing apparatus according to claim 4 or 5, wherein the preparation section increases in viscosity when the amount of pure water added to nicotine is increased. And adding a small amount of pure water less than the maximum critical water amount to increase the viscosity of nicotine from the initial value to the target viscosity value.

  The invention according to claim 7 is the transdermal absorption preparation manufacturing apparatus according to claim 4 or claim 5, wherein the blending section increases in viscosity when the amount of pure water added to nicotine is increased. A quantity of pure water larger than the critical water amount that is the maximum value is added, and the viscosity of nicotine is increased from the initial value to the maximum value and then decreased to the target viscosity value.

  According to the first to third aspects of the present invention, pure water is added to nicotine to increase the viscosity to a target viscosity value larger than the initial value, and the thickened nicotine droplets are generated from the coating head. Since it sprays on a base material, nicotine can be discharged favorably from a coating head. Moreover, since pure water is added, there is no possibility of affecting the medicinal efficacy of nicotine.

  In addition, according to the inventions of claims 4 to 7, pure water is added to nicotine to increase the viscosity to a target viscosity value larger than the initial value, and the thickened nicotine droplets are generated and applied. Since it sprays on a base material from a head, nicotine can be discharged favorably from a coating head. Moreover, since pure water is added, there is no possibility of affecting the medicinal efficacy of nicotine.

It is a figure which shows the principal part schematic structure of the transdermally absorbable preparation manufacturing apparatus which concerns on this invention. It is a figure which shows the correlation of the density | concentration and viscosity of nicotine. It is a figure which shows the state by which nicotine was apply | coated to the base material sheet.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  FIG. 1 is a diagram showing a schematic configuration of a main part of a transdermally absorbable preparation manufacturing apparatus 1 according to the present invention. The transdermally absorbable preparation manufacturing apparatus 1 is an apparatus that manufactures a transdermally absorbable preparation (nicotine patch) containing nicotine by spraying nicotine droplets on a substrate. The transdermally absorbable preparation manufacturing apparatus 1 includes a transport mechanism 20 that transports a belt-shaped base sheet 90 along a horizontal direction, and an application head 10 that sprays and applies fine nicotine droplets to the transported base sheet 90. The nicotine feeding unit 30 that feeds nicotine to the coating head 10 and the drying unit 50 that dries the nicotine applied to the base sheet 90 are provided. The transdermally absorbable preparation manufacturing apparatus 1 includes a control unit 80 that controls each of the above elements provided in the apparatus.

  The transport mechanism 20 includes a feed roller 21 around which a long belt-like base sheet 90 is wound. The transport mechanism 20 also includes a tension roller and an auxiliary roller (not shown), and transports the base sheet 90 fed from the feed roller 21 along the horizontal direction. The base sheet 90 is a member that carries a drug (nicotine in the present embodiment) of a transdermal absorption preparation, and is a resin material that is impermeable to the drug (for example, PET (polyethylene terephthalate), PP (polypropylene)). , PE (polyethylene), etc.). In this embodiment, nicotine is applied to the base material sheet 90. In this case, a general material used for a transdermal drug can be used as the base material sheet 90. The width of the strip-shaped base sheet 90 is, for example, 60 mm. In this embodiment, the belt-like base sheet 90 is fed directly from the feed roller 21, but the present invention is not limited to this. For example, a belt-like support such as a nonwoven fabric laminated with an adhesive is fed. You may make it supply the base material sheet | seat sent out from the roller 21 and cut | judged to the predetermined shape beforehand on it. In this case, as the type of the pressure-sensitive adhesive, a pressure-sensitive adhesive generally used in the field of transdermal drug such as acrylic pressure-sensitive adhesive, silicone rubber-based pressure-sensitive adhesive, and vinyl-based pressure-sensitive adhesive can be used. The type of the support is not particularly limited, but the nicotine contained in the pressure-sensitive adhesive layer is not lost from the surface opposite to the pressure-sensitive adhesive layer forming surface through the support, that is, nicotine is impermeable. It is preferable that the material is. For example, polyester, nylon, Saran (registered trademark), polyethylene, ethylene-vinyl acetate copolymer, polyvinyl chloride, ethylene-ethyl acrylate copolymer, polytetrafluoroethylene, metal foil, single film such as polyethylene terephthalate, A film obtained by laminating these plural types of films can also be used.

  The coating head 10 applies the nicotine fed from the nicotine feeding unit 30 to the base sheet 90. The coating head 10 atomizes ink (nicotine in the present embodiment) to generate fine droplets, and sprays the droplets onto the upper surface of the base sheet 90 conveyed in the horizontal direction by the conveyance mechanism 20. The coating head 10 is a droplet jet head that ejects ink by a droplet jet method, and in this embodiment, the driving method is a multilayer piezo drop-on-demand inkjet head (for example, a product type name manufactured by Ricoh Printing Systems Co., Ltd.). “GEN4”) is used.

  For example, the coating head 10 is provided with two nozzle rows each having 192 nozzles in one row, for a total of 384 nozzles. The nozzle pitch in each nozzle row is about 0.17 mm, and the coating width of the entire coating head 10 is about 32 mm. The structure of each nozzle is the same as that disclosed in Patent Document 2. The controller 80 controls the application of voltage to the piezo elements of each nozzle, whereby the ejection of nicotine droplets is controlled for each of the 384 nozzles. The ejection of nicotine droplets from each nozzle is controlled in accordance with a coating pattern that is set in advance and stored in the memory or the like of the control unit 80, and nicotine is coated on the base sheet 90 from the coating head 10 with the coating pattern. Is done. In this embodiment, one coating head 10 is provided in the percutaneous absorption preparation manufacturing apparatus 1, but if two coating heads 10 are arranged side by side, the base sheet 90 having a width of 60 mm is formed. Application is possible over the entire width.

  The nicotine feeding unit 30 that feeds nicotine to the coating head 10 includes a preparation tank 31 and a feeding tank 43. In the blending tank 31, pure water is added to the nicotine stock solution for dilution, and nicotine (diluted nicotine) to be fed to the coating head 10 is blended. The mixing tank 31 is supplied with a nicotine stock solution from a nicotine supply unit 33 and pure water from a pure water supply unit 35.

  The input amount of the nicotine stock solution supplied from the nicotine supply unit 33 to the preparation tank 31 is adjusted by the weighing unit 34. The weighing unit 34 includes a flow rate adjusting mechanism such as a mass flow controller, for example, and adjusts the input amount to the blending tank 31 based on the flow rate and passage time of the nicotine stock solution. Similarly, the amount of pure water charged into the preparation tank 31 from the pure water supply unit 35 is adjusted by the weighing unit 36. Similar to the weighing unit 34, the weighing unit 36 includes a flow rate adjusting mechanism such as a mass flow controller, and adjusts the input amount to the preparation tank 31 based on the flow rate of pure water and the passage time. In this case, the adjustment of the nicotine stock solution input by the weighing unit 34 and the pure water input by the weighing unit 36 may be controlled by the control unit 80. Further, the weighing unit 34 and the weighing unit 36 may include a weighing tank for weighing a certain amount of liquid.

  A predetermined amount of nicotine stock solution weighed by the weighing unit 34 is introduced from the nicotine feeding unit 30 into the preparation tank 31, and a predetermined amount of pure water weighed by the weighing unit 36 is supplied from the pure water supply unit 35 to the preparation tank 31. It is thrown into. Thereby, in the preparation tank 31, the nicotine stock solution is diluted with pure water to obtain nicotine having a predetermined concentration. A stirrer 32 is provided inside the blending tank 31, and the nicotine stock solution and pure water are sufficiently mixed by the stirrer 32 to obtain nicotine having a uniform concentration.

Here, nicotine (C ₁₀ H ₁₄ N ₂ ) is a kind of pyridine alkaloid and is a colorless oily liquid. The stock solution of nicotine has a viscosity of 6 mPa · s at room temperature (about 20 ° C.). On the other hand, the viscosity of the ink suitable for the coating head 10 used in this embodiment is 10 to 13 mPa · s. That is, the viscosity of the nicotine stock solution is too low to be discharged from the coating head 10. If nicotine is discharged from the coating head 10 of this embodiment as a stock solution, the viscosity is too low, and there is a risk that droplets may break up or mist and satellites may be generated.

  Therefore, the present inventors conducted extensive studies on the viscosity of nicotine, and found that when water was added to nicotine, the viscosity increased up to a certain addition amount. FIG. 2 is a diagram showing the correlation between the concentration of nicotine and the viscosity (shear viscosity). In the figure, the change in viscosity when water is added to nicotine is indicated by a solid line, and the change in viscosity when ethanol is added is indicated by a dotted line. As shown in the figure, the viscosity of the nicotine stock solution (concentration: 100 vol%) is about 6 mPa · s. When water is added to the nicotine stock solution, the viscosity becomes higher than 6 mPa · s and the viscosity increases. The viscosity of nicotine increases as the amount of water added increases and reaches a maximum value of 34 mPa · s at a nicotine concentration of about 80 vol%. When the amount of water to be added is further increased and the nicotine concentration becomes smaller than 80 vol%, the viscosity of nicotine decreases as the amount of water to be added increases. The viscosity of pure water is about 0.8 mPa · s at 20 ° C.

  In general, when water or alcohol as a solvent is added to dilute a solute, the viscosity tends to decrease as the amount added increases. Also for nicotine, as shown by the dotted line in FIG. 2, when ethanol is added, the viscosity of nicotine decreases from the initial value of 6 mPa · s as the amount added increases. The viscosity of ethanol is about 1.0 mPa · s at 20 ° C. Up to the amount of water (critical water amount) where the nicotine concentration is 80 vol%, such as water, the nicotine viscosity increases as the added amount increases, and on the contrary, the viscosity decreases as the added amount increases. Is rather singular. As a result of intensive studies, the present inventors have found that when water is added to nicotine, a unique viscosity change as shown in FIG. 2 appears. The present invention has been completed based on such knowledge.

  Returning to FIG. 1, when nicotine is prepared in the preparation tank 31, the viscosity value of the nicotine conforms to the specification of the application head 10, that is, the appropriate value at which the application head 10 generates and discharges droplets. In this manner, the amounts of the nicotine stock solution and pure water charged into the preparation tank 31 are adjusted. In the present embodiment, the appropriate value that the coating head 10 generates and discharges droplets is 10 to 13 mPa · s. Therefore, the target viscosity value is set to 10 to 13 mPa · s, and the viscosity of nicotine is larger than the initial value. The input amounts of the nicotine stock solution and pure water to be added to the preparation tank 31 are adjusted so as to achieve the target viscosity value. As shown in FIG. 2, the viscosity of nicotine reaches a target viscosity value of 10 to 13 mPa · s when the pure water concentration is 2.5 vol% (nicotine concentration 97.5 vol%). On the other hand, the weighing unit 34 and the weighing unit 36 adjust the respective charging amounts so that the pure water 2.5 is charged.

  By adding and mixing pure water 2.5 to the nicotine stock solution 97.5 by volume in the mixing tank 31, the viscosity of nicotine increases to a target viscosity value larger than the initial value. At this time, the concentration and viscosity of nicotine in the preparation tank 31 become uniform by sufficiently stirring the nicotine stock solution and the pure water by the stirrer 32.

  Nicotine having a target viscosity value of 10 to 13 mPa · s prepared in the preparation tank 31 is transferred to the supply tank 43. The feed tank 43 is connected to the coating head 10 through a feed pipe 44. A foreign substance removal filter 45 and a deaeration filter 46 are inserted in the middle of the route of the feed pipe 44. The feed tank 43 always stores a certain amount or more of diluted nicotine transferred from the preparation tank 31. Nicotine stored in the feed tank 43 is fed to each nozzle by capillary action that occurs in the nozzle when the coating head 10 ejects nicotine. In the nicotine feeding process, foreign matter and bubbles are removed from the nicotine flowing through the feeding pipe 44 by the foreign matter removing filter 45 and the degassing filter 46, respectively.

  The nicotine feeding unit 30 includes a negative pressure pump 47. The negative pressure pump 47 applies a negative pressure from the feed tank 43 to the coating head 10 via the feed pipe 44. The negative pressure pump 47 is for forming a meniscus of nicotine near the tip of the nozzle before the piezo element pressurizes nicotine in each nozzle of the coating head 10. That is, the nicotine supplied from the feed tank 43 to the nozzle of the coating head 10 as it is cannot directly form a meniscus suitable for the droplet jet method near the tip of the nozzle. By applying a negative pressure in the opposite direction, the nicotine is slightly pulled back into the nozzle to form an appropriate meniscus.

  Nicotine fed from the nicotine feeding unit 30 is made into fine droplets by the coating head 10 and is sprayed from the coating head 10 onto the base sheet 90 under the control of the control unit 80. The control unit 80 controls the on / off timing for all the nozzles of the coating head 10 according to the coating pattern stored in a memory or the like. Specifically, a voltage is applied to a piezo element of a nozzle corresponding to a region where nicotine is sprayed in the coating pattern, and nicotine droplets are generated and discharged from the nozzle. Since the viscosity of nicotine is adjusted to 10 to 13 mPa · s, which is a required appropriate value of the coating head 10, an appropriate meniscus is formed in the nozzle without causing clogging or droplet breakup, The fine droplets of nicotine fly stably from the nozzle toward the base sheet 90.

  FIG. 3 is a diagram illustrating a state in which nicotine is applied to the base sheet 90. In the present embodiment, nicotine is applied from the application head 10 to the base sheet 90 according to a circular application pattern. On the base sheet 90, circular nicotine application regions 95 are repeatedly formed at predetermined intervals. The diameter of the nicotine application region 95 is, for example, about φ20 mm.

  The nicotine application region 95 formed on the base material sheet 90 by spraying from the application head 10 is dried by a drying unit 50 provided downstream of the application head 10 in the transport direction of the base material sheet 90 as necessary. You may be made to do. Nicotine itself does not need to be dried, but when pure water is added as in the present embodiment, there is a possibility that a drying step may be performed as necessary to evaporate the water. As the drying unit 50, various known drying devices such as those that blow normal temperature dry air or heated dry air (warm air) onto the surface of the substrate sheet 90 can be applied. Further, as the drying unit 50, a hot air drying furnace for supplying simple hot air (not performing special dehumidification) or a drying furnace using an infrared heater may be used.

  An adhesive layer for sticking is formed on the base material sheet 90 after the drying process, and a release liner is stuck together. And the base material sheet 90 is cut | judged to predetermined size, and it is set as the percutaneous absorption preparation containing nicotine.

  In this embodiment, the viscosity is increased to a target viscosity value larger than the initial value (6 mPa · s) by adding pure water to the nicotine stock solution in the preparation tank 31. The coating head 10 generates droplets from nicotine that has been thickened to the target viscosity value and sprays the droplets onto the base sheet 90. The target viscosity value is 10 to 13 mPa · s appropriate for the application head 10 to generate and discharge ink droplets. Therefore, the nicotine thickened to the required appropriate value of the coating head 10 is discharged well from the nozzle of the coating head 10, and more stable nicotine liquid by suppressing droplet breakup and generation of satellites and mists. Drops can fly.

  In this embodiment, the additive used to adjust the viscosity of nicotine to an appropriate value for the coating head 10 is pure water. Therefore, there is no possibility that the additive affects the efficacy of nicotine in the transdermal absorption preparation. Further, the added pure water evaporates by a drying process in the drying unit 50.

  While the embodiments of the present invention have been described above, the present invention can be modified in various ways other than those described above without departing from the spirit of the present invention. For example, in the above-described embodiment, when the amount of pure water added to nicotine is increased, the viscosity increases and the amount is smaller than the critical water amount corresponding to the nicotine concentration (80 vol%) at which the maximum value (34 mPa · s) is obtained. Pure water was added to increase the viscosity of nicotine from the initial value to the target viscosity value. However, as shown in FIG. 2, the viscosity of nicotine has a target viscosity value of 10 to 13 mPa · s even when the pure water concentration is 50 vol% (nicotine concentration 50 vol%). Even with this nicotine having a pure water concentration of 50 vol%, the viscosity is an appropriate value for the coating head 10, so that droplets can be stably ejected from the nozzles of the coating head 10. That is, in view of the peculiarity of the nicotine viscosity change as shown in FIG. 2, when the amount of pure water added to nicotine is increased, a larger amount of pure water is added than the critical water amount that increases the viscosity to the maximum value. Then, the viscosity of nicotine may be increased from the initial value to the maximum value and then decreased to the target viscosity value.

  In short, as long as the viscosity is increased to a target viscosity value larger than the initial value (6 mPa · s) by adding pure water to the nicotine stock solution, the amount added may be larger or smaller than the critical water amount. . However, when the amount of pure water to be added is larger than the critical water amount and the pure water concentration reaches 50 vol%, a larger amount of coating is required to apply the same amount of nicotine, and further, drying in the drying unit 50 is performed. In addition, since it takes a long time, it is preferable that the amount of pure water added as in the above embodiment is smaller than the critical water amount.

  In the above embodiment, the appropriate value of the viscosity for the application head 10 to generate and discharge ink droplets is 10 to 13 mPa · s. This appropriate value depends on the type of the application head 10. Are individually defined. For this reason, what is necessary is just to determine so that the target viscosity value at the time of mix | blending nicotine with the preparation tank 31 may correspond with the appropriate value of the application head 10 integrated in the transdermal absorption preparation manufacturing apparatus 1. FIG. The coating head 10 is not limited to a laminated piezo drop-on-demand inkjet head, and any coating head that generates and ejects fine droplets by a so-called droplet jet method may be used. Of course, when the target viscosity value is changed, the volume ratio of the nicotine stock solution to be added to the preparation tank 31 and the pure water is increased or decreased accordingly.

  The pure water added to nicotine does not necessarily have to be so-called ultrapure water, and may be of a purity that does not mix impurities into the transdermally absorbable preparation as a product, for example, distilled water. good.

  Moreover, when the viscosity change curve when pure water is added to nicotine as shown in FIG. 2 is stored as a table in the memory or the like of the control unit 80 and the target viscosity value is input from the outside of the apparatus, the control unit 80 detects the target viscosity. The nicotine concentration corresponding to the value may be acquired from the table, and the weighing unit 34 and the weighing unit 36 may be controlled based on the obtained nicotine concentration to adjust the input amounts of the nicotine stock solution and pure water.

  The method for producing a percutaneous absorption preparation and the device for producing a percutaneous absorption preparation according to the present invention can be suitably used for the production of a percutaneous absorption preparation containing nicotine such as a nicotine patch.

DESCRIPTION OF SYMBOLS 1 Percutaneous absorption preparation manufacturing apparatus 10 Application head 20 Conveyance mechanism 30 Nicotine feeding part 31 Preparation tank 33 Nicotine supply part 35 Pure water supply part 34,36 Weighing part 43 Feeding tank 50 Drying unit 80 Control part 90 Base material sheet

Claims (7)

A method for producing a transdermally absorbable preparation containing nicotine,
A thickening step of adding pure water to nicotine to increase the viscosity to a target viscosity value larger than the initial value;
A coating step of generating droplets of nicotine having a viscosity increased to a target viscosity value in the thickening step and spraying the droplets from the coating head to the substrate;
A method for producing a transdermally absorbable preparation, comprising: In the manufacturing method of the transdermal absorption preparation of Claim 1,
In the thickening step, when the amount of pure water added to nicotine is increased, the viscosity increases and a smaller amount of pure water is added than the critical water amount which becomes the maximum value, and the viscosity of nicotine is changed from the initial value to the target viscosity value. A method for producing a transdermally absorbable preparation, characterized by In the manufacturing method of the transdermal absorption preparation of Claim 1,
In the thickening step, when the amount of pure water added to nicotine is increased, the viscosity increases and a larger amount of pure water is added than the critical water amount, which reaches the maximum value, and the viscosity of nicotine is increased from the initial value to the maximum value. A method for producing a transdermally absorbable preparation, which comprises increasing the viscosity to a target viscosity value. A transdermal absorption preparation manufacturing apparatus for manufacturing a transdermal absorption preparation containing nicotine,
A preparation unit that adds pure water to nicotine to increase the viscosity to a target viscosity value larger than the initial value;
An application head for generating droplets of nicotine having a target viscosity value prepared in the preparation unit and spraying the droplets on the substrate;
An apparatus for producing a transdermally absorbable preparation, comprising: In the percutaneous absorption preparation manufacturing apparatus according to claim 4,
The percutaneous absorption preparation manufacturing apparatus, wherein the target viscosity value is an appropriate value for the application head to generate and discharge droplets. In the percutaneous absorption preparation manufacturing apparatus according to claim 4 or 5,
When the amount of pure water to be added to nicotine is increased, the blending part adds a smaller amount of pure water than the critical water amount at which the viscosity increases and reaches the maximum value, and the viscosity of nicotine is changed from the initial value to the target viscosity value. An apparatus for producing a transdermally absorbable preparation characterized by increasing. In the percutaneous absorption preparation manufacturing apparatus according to claim 4 or 5,
The blending unit increases the viscosity of nicotine from the initial value to the maximum value by adding a larger amount of pure water than the critical water amount, which increases the viscosity when the amount of pure water added to nicotine is increased. An apparatus for producing a percutaneous absorption preparation, wherein the target viscosity value is reduced to the target viscosity value.

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