JP5576869B2 - パルスepr検出 - Google Patents
パルスepr検出 Download PDFInfo
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- JP5576869B2 JP5576869B2 JP2011529548A JP2011529548A JP5576869B2 JP 5576869 B2 JP5576869 B2 JP 5576869B2 JP 2011529548 A JP2011529548 A JP 2011529548A JP 2011529548 A JP2011529548 A JP 2011529548A JP 5576869 B2 JP5576869 B2 JP 5576869B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/10—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/60—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using electron paramagnetic resonance
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
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Description
Claims (13)
- パルス電子常磁性共鳴を実施する方法であって、
初期のスピン配列を付与するために、スピンを有するプローブを備える物体に印加するための静磁場を発生させることと、
スピンを有するプローブを備える物体に印加するための励起磁気パルス列を発生させることであって、励起磁気パルス列は、静磁場とは実質的に異なる向きを有する励起磁気パルスを含むようにしたことと、
励起磁気パルス列によって誘導されるエコー応答を、スピンを有するプローブから検出することとを含み、
スピンを有するプローブは、3MHz以上の線幅を有する広帯域プローブであって、
励起磁気パルス列を発生させることは、プローブの所定の周波数を選択的に励起することを含み、
エコー応答を検出することは、リフェーズパルスを印加せずに実施する方法。 - 励起パルスを発生させることは、エコー応答を形成するために、選択的に励起された個々の周波数の間でスピンの正の干渉を誘導する励起パルスを発生させることを含む請求項1記載の方法。
- エコー応答を検出することは、物体内で分布したプローブからのエコー応答を位相幾何学的に画像化することを含む請求項1または2記載の方法。
- 対象とする広帯域プローブの所定の周波数を励起することは、プローブの広帯域共鳴の限られた数の周波数を励起することを含む請求項1〜3のいずれかに記載の方法。
- エコー応答を検出することは、単磁区粒子からのエコー応答を検出することを含む請求項1〜4のいずれかに記載の方法。
- エコー応答を検出することは、広帯域共鳴超常磁性粒子からのエコー応答を検出することを含む、請求項5記載の方法。
- 励起パルス列を発生させることは、EPRパルスシーケンスを発生させることを含み、
EPRパルスシーケンスにおける異なるEPRパルスの形状は、物体中のプローブのスピン共鳴の周波数依存性を少なくとも部分的に補償するように適合した請求項1〜6のいずれかに記載の方法。 - 励起パルス列を発生させることは、EPRパルスシーケンスを発生させることを含み、 EPRパルスシーケンス中の異なるEPR周波数の強度は、物体中のスピンプローブの共鳴または検出システムの電力依存性を少なくとも部分的に補償するように適合した請求項1〜7のいずれかに記載の方法。
- パルス電子常磁性共鳴を実施するシステム(900)であって、
初期のスピン配列を付与するために、スピンを有するプローブを備える物体に静磁場を印加するための静磁場発生器(902)と、
スピンを有するプローブを備える物体に印加するための励起磁気パルス列であって、静磁場とは実質的に異なる向きを有する励起磁気パルスを含む励起磁気パルス列を発生させるための励起磁気パルス列発生器(904)と、
励起磁気パルス列によって誘導されるエコー応答を、スピンを有するプローブから検出するための検出手段(908)とを備え、
励起磁気パルス列発生器(904)は、プローブの所定の周波数を選択的に励起するように適合したコントローラ(906)を備え、
システム(900)は、リフェーズパルスを印加せずにエコー応答を検出するように適合したシステム。 - コントローラ(906)は、エコー応答を形成するために、選択的に励起された個々の周波数の間でスピンの正の干渉を発生させるように適合した請求項9記載のシステム。
- 検出手段は、物体内で分布したプローブからのエコー応答を位相幾何学的に画像化するように適合した請求項9または10記載のシステム(900)。
- 請求項9〜11のいずれかに記載のシステムを制御するためのコントローラ内で実行した場合に、請求項1〜8のいずれかに記載の方法を実施するためのコンピュータプログラム。
- 請求項12記載のコンピュータプログラムを備えるデータ記録媒体。
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10137408P | 2008-09-30 | 2008-09-30 | |
US61/101,374 | 2008-09-30 | ||
GBGB0906644.0A GB0906644D0 (en) | 2009-04-17 | 2009-04-17 | Magnetic resonance imaging of single domain nano-particles |
GB0906644.0 | 2009-04-17 | ||
EP09165120A EP2273280A1 (en) | 2009-07-10 | 2009-07-10 | Pulsed EPR detection |
EP09165120.8 | 2009-07-10 | ||
US22542409P | 2009-07-14 | 2009-07-14 | |
US61/225,424 | 2009-07-14 | ||
PCT/EP2009/062723 WO2010037801A1 (en) | 2008-09-30 | 2009-09-30 | Pulsed epr detection |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012504247A JP2012504247A (ja) | 2012-02-16 |
JP5576869B2 true JP5576869B2 (ja) | 2014-08-20 |
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JP2011529548A Active JP5576869B2 (ja) | 2008-09-30 | 2009-09-30 | パルスepr検出 |
Country Status (4)
Country | Link |
---|---|
US (1) | US8816685B2 (ja) |
EP (1) | EP2331982B1 (ja) |
JP (1) | JP5576869B2 (ja) |
WO (1) | WO2010037801A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0906644D0 (en) * | 2009-04-17 | 2009-06-03 | Imec Inter Uni Micro Electr | Magnetic resonance imaging of single domain nano-particles |
GB2489403A (en) * | 2011-03-22 | 2012-10-03 | Pepric Nv | Isolating active electron spin signals in EPR by changing field direction |
PL219169B1 (pl) * | 2011-03-24 | 2015-03-31 | Mikołaj Baranowski | Sposób wyznaczania elektronowych czasów relaksacji T₁ w tomografii EPR |
GB201217228D0 (en) | 2012-09-26 | 2012-11-07 | Pepric Nv | Methods and systems for determining a particle distribution |
US10605751B2 (en) | 2015-02-09 | 2020-03-31 | Pepric Nv | System and method for determining a quantity of magnetic particles |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8713353D0 (en) | 1987-06-08 | 1987-07-15 | Scient Generics Ltd | Magnetic article surveillance systems |
US5387867A (en) * | 1993-07-26 | 1995-02-07 | The United States Of America As Represented By The Dept. Of Health And Human Services | Pulsed low frequency EPR spectrometer and imager |
JP3345527B2 (ja) * | 1995-05-16 | 2002-11-18 | 株式会社日立製作所 | 核磁気共鳴装置 |
US5678548A (en) * | 1995-07-20 | 1997-10-21 | The United States Of America As Represented By The Department Of Health And Human Services | System and method for performing in vivo imaging and oxymetry and FT microscopy by pulsed radiofrequency electron paramagnetic resonance |
DE10037883A1 (de) | 2000-08-03 | 2002-02-14 | Henkel Kgaa | Ferromagnetische Resonanzanregung und ihre Verwendung zur Erwärmung teilchengefüllter Substrate |
US6693426B1 (en) * | 2002-02-09 | 2004-02-17 | Intematix Corporation | Spatially resolved spin resonance detection |
JP4330009B2 (ja) | 2002-09-30 | 2009-09-09 | 古河電気工業株式会社 | Rfidタグ及びその製造方法 |
US7289839B2 (en) | 2002-12-30 | 2007-10-30 | Calypso Medical Technologies, Inc. | Implantable marker with a leadless signal transmitter compatible for use in magnetic resonance devices |
US20050118102A1 (en) * | 2003-04-28 | 2005-06-02 | Intematix Corporation | Spin resonance heating and/or imaging in medical applications |
JP4810368B2 (ja) * | 2006-09-11 | 2011-11-09 | 株式会社日立製作所 | 電子スピン共鳴ct装置 |
JP2008212505A (ja) * | 2007-03-07 | 2008-09-18 | Hitachi Ltd | Mri装置 |
GB0906644D0 (en) * | 2009-04-17 | 2009-06-03 | Imec Inter Uni Micro Electr | Magnetic resonance imaging of single domain nano-particles |
-
2009
- 2009-09-30 EP EP09744097.8A patent/EP2331982B1/en active Active
- 2009-09-30 JP JP2011529548A patent/JP5576869B2/ja active Active
- 2009-09-30 WO PCT/EP2009/062723 patent/WO2010037801A1/en active Application Filing
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2011
- 2011-03-29 US US13/075,087 patent/US8816685B2/en active Active
Also Published As
Publication number | Publication date |
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WO2010037801A1 (en) | 2010-04-08 |
US20120049847A1 (en) | 2012-03-01 |
JP2012504247A (ja) | 2012-02-16 |
EP2331982A1 (en) | 2011-06-15 |
US8816685B2 (en) | 2014-08-26 |
EP2331982B1 (en) | 2018-11-14 |
WO2010037801A9 (en) | 2010-05-27 |
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