JP5566577B2 - 二次代謝産物の異種発現方法 - Google Patents

二次代謝産物の異種発現方法 Download PDF

Info

Publication number
JP5566577B2
JP5566577B2 JP2007538549A JP2007538549A JP5566577B2 JP 5566577 B2 JP5566577 B2 JP 5566577B2 JP 2007538549 A JP2007538549 A JP 2007538549A JP 2007538549 A JP2007538549 A JP 2007538549A JP 5566577 B2 JP5566577 B2 JP 5566577B2
Authority
JP
Japan
Prior art keywords
gene
host cell
pseudomonas
vector
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2007538549A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008517996A5 (enExample
JP2008517996A (ja
Inventor
ヨウミン ザン
ロルフ ミューラー
フランシス ステュアート
フランク グロス
ジルケ ツェー ヴェンツェル
ジュン フ
Original Assignee
ジーン ブリッジス ゲゼルシャフト ミット ベシュレンクテル ハフツング
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジーン ブリッジス ゲゼルシャフト ミット ベシュレンクテル ハフツング filed Critical ジーン ブリッジス ゲゼルシャフト ミット ベシュレンクテル ハフツング
Publication of JP2008517996A publication Critical patent/JP2008517996A/ja
Publication of JP2008517996A5 publication Critical patent/JP2008517996A5/ja
Application granted granted Critical
Publication of JP5566577B2 publication Critical patent/JP5566577B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
JP2007538549A 2004-10-26 2005-10-26 二次代謝産物の異種発現方法 Expired - Fee Related JP5566577B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0423755.8A GB0423755D0 (en) 2004-10-26 2004-10-26 Methods for heterologus expression of secondary metabolites
GB0423755.8 2004-10-26
PCT/IB2005/003650 WO2006046152A2 (en) 2004-10-26 2005-10-26 Methods for heterologous expression of secondary metabolites

Publications (3)

Publication Number Publication Date
JP2008517996A JP2008517996A (ja) 2008-05-29
JP2008517996A5 JP2008517996A5 (enExample) 2008-12-11
JP5566577B2 true JP5566577B2 (ja) 2014-08-06

Family

ID=33485231

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007538549A Expired - Fee Related JP5566577B2 (ja) 2004-10-26 2005-10-26 二次代謝産物の異種発現方法

Country Status (9)

Country Link
US (1) US20090298117A1 (enExample)
EP (1) EP1809749B1 (enExample)
JP (1) JP5566577B2 (enExample)
AT (1) ATE422547T1 (enExample)
AU (1) AU2005298341B2 (enExample)
CA (1) CA2584777A1 (enExample)
DE (1) DE602005012718D1 (enExample)
GB (1) GB0423755D0 (enExample)
WO (1) WO2006046152A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0605166A (pt) * 2006-11-03 2008-07-01 Inst Fleury método de determinação de ácido metilmalÈnico baseado na extração alquilativa associada à cromatografia lìquida acoplada à espectrometria de massas
GB0922108D0 (en) 2009-12-17 2010-02-03 Gene Bridges Gmbh Heterologous hosts
EP3027754B1 (en) 2013-08-02 2022-03-02 enEvolv, Inc. Processes and host cells for genome, pathway, and biomolecular engineering
WO2017151059A1 (en) * 2016-02-29 2017-09-08 Agency For Science, Technology And Research Multiplexable activation of silent biosynthetic clusters in native actinomycete hosts for natural product discovery
EP3938518A4 (en) 2019-03-12 2023-01-11 Terra Bioworks, Inc. EXPRESSION VECTOR

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1291420B1 (en) * 1997-12-05 2009-11-25 Europäisches Laboratorium Für Molekularbiologie (Embl) Novel DNA cloning method relying on the E.coli RECE/RECT recombination system
US6355412B1 (en) * 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
JP2004508810A (ja) * 2000-04-28 2004-03-25 コーサン バイオサイエンシーズ, インコーポレイテッド ポリケチドの生成
WO2003044186A2 (en) * 2001-11-22 2003-05-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Novel gene cluster of pederin biosynthesis genes
US20040005672A1 (en) * 2002-02-22 2004-01-08 Santi Daniel V. Heterologous production of polyketides

Also Published As

Publication number Publication date
WO2006046152A2 (en) 2006-05-04
AU2005298341A1 (en) 2006-05-04
EP1809749A2 (en) 2007-07-25
EP1809749B1 (en) 2009-02-11
CA2584777A1 (en) 2006-05-04
US20090298117A1 (en) 2009-12-03
DE602005012718D1 (de) 2009-03-26
WO2006046152A3 (en) 2006-11-16
AU2005298341B2 (en) 2011-06-23
GB0423755D0 (en) 2004-11-24
JP2008517996A (ja) 2008-05-29
ATE422547T1 (de) 2009-02-15

Similar Documents

Publication Publication Date Title
Phelan et al. Development of next generation synthetic biology tools for use in Streptomyces venezuelae
Song et al. Enhanced heterologous spinosad production from a 79-kb synthetic multioperon assembly
CN102015756B (zh) Nrps-pks基因簇及其操纵和应用
Bian et al. Heterologous production and yield improvement of epothilones in Burkholderiales strain DSM 7029
CN101490260A (zh) 使用遗传工程化的微生物菌株的改进的鞘氨醇类碱的生产
Liu et al. High GC content Cas9-mediated genome-editing and biosynthetic gene cluster activation in Saccharopolyspora erythraea
Basitta et al. AGOS: a plug-and-play method for the assembly of artificial gene operons into functional biosynthetic gene clusters
Gao et al. Mutations in genes encoding antibiotic substances increase the synthesis of poly‐γ‐glutamic acid in Bacillus amyloliquefaciens LL3
WO2017176347A9 (en) Pathway integration and expression in host cells
CN111117942B (zh) 一种产林可霉素的基因工程菌及其构建方法和应用
Zhang et al. A permissive medium chain acyl-CoA carboxylase enables the efficient biosynthesis of extender units for engineering polyketide carbon scaffolds
JP5566577B2 (ja) 二次代謝産物の異種発現方法
Watanabe et al. Robust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli
Jagadeesh et al. Simple and Rapid Non-ribosomal Peptide Synthetase Gene Assembly Using the SEAM–OGAB Method
Zhang et al. Simultaneous multiplex genome loci editing of Halomonas bluephagenesis using an engineered CRISPR-guided base editor
CN105176899A (zh) 构建生产或高产目的基因产物重组菌的方法及构建的重组菌与应用
JP7086984B2 (ja) Streptomyces fungicidicusの遺伝子組換え株におけるエンデュラシジンの産生を増強するための組成物及び方法
HUP0104772A2 (hu) Szubsztituált fenolok előállítására alkalmazható, termelő törzsek létrehozása az eugenol- és ferulasav-katabolizmusgénjeinek specifikus inaktiválásával
Desai et al. Combining classical, genetic, and process strategies for improved precursor‐directed production of 6‐deoxyerythronolide B analogues
WO2004015088A2 (en) Transposon-based transformation system
Qi et al. Consolidated plasmid Design for Stabilized Heterologous Production of the complex natural product Siderophore Yersiniabactin
CA2354030A1 (en) Micromonospora echinospora genes encoding for biosynthesis of calicheamicin and self-resistance thereto
Pistorius et al. Genetic engineering of Chromobacterium vaccinii DSM 25150 for improved production of FR900359
US7033818B2 (en) Recombinant polyketide synthase genes
Qi E. Coli Engineering for Diverse Biotechnology Application Spanning Natural Product Formation and Mammalian Cell Gene Delivery

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081024

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20081024

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110411

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110708

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110715

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120705

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121003

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121011

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130104

RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20130131

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20130130

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20130208

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20131015

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140217

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20140224

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20140328

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140515

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140618

R150 Certificate of patent or registration of utility model

Ref document number: 5566577

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees