JP5565906B2 - スカベンジャー受容体−aを抑制する方法および抗原への免疫応答を増大する方法 - Google Patents

スカベンジャー受容体−aを抑制する方法および抗原への免疫応答を増大する方法 Download PDF

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JP5565906B2
JP5565906B2 JP2010504215A JP2010504215A JP5565906B2 JP 5565906 B2 JP5565906 B2 JP 5565906B2 JP 2010504215 A JP2010504215 A JP 2010504215A JP 2010504215 A JP2010504215 A JP 2010504215A JP 5565906 B2 JP5565906 B2 JP 5565906B2
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cells
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mice
individual
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JP2010526034A5 (enExample
JP2010526034A (ja
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ワン,シャン‐ヤン
サブジェック,ジョン
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Health Research Inc
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/19Dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
    • C12N2310/531Stem-loop; Hairpin

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  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010504215A 2007-04-16 2008-04-16 スカベンジャー受容体−aを抑制する方法および抗原への免疫応答を増大する方法 Expired - Fee Related JP5565906B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92362807P 2007-04-16 2007-04-16
US60/923,628 2007-04-16
PCT/US2008/060479 WO2008131006A2 (en) 2007-04-16 2008-04-16 Method for inhibiting scavenger receptor-a and increasing immune response to antigens

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JP2010526034A JP2010526034A (ja) 2010-07-29
JP2010526034A5 JP2010526034A5 (enExample) 2011-05-19
JP5565906B2 true JP5565906B2 (ja) 2014-08-06

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JP2010504215A Expired - Fee Related JP5565906B2 (ja) 2007-04-16 2008-04-16 スカベンジャー受容体−aを抑制する方法および抗原への免疫応答を増大する方法

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US (2) US8133875B2 (enExample)
EP (1) EP2147011A4 (enExample)
JP (1) JP5565906B2 (enExample)
CN (1) CN101675066A (enExample)
CA (1) CA2684278C (enExample)
WO (1) WO2008131006A2 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2790203C (en) * 2010-02-19 2019-05-14 Norman Latov Inhibitor of macrophage scavenger receptor 1 (msr1) for the treatment of autoimmune demyelinating diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5881000A (en) 1999-06-24 2001-01-09 Smithkline Beecham Corporation Macrophage scavenger receptor antagonists
GB9927328D0 (en) * 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
WO2003042246A2 (en) * 2001-11-14 2003-05-22 Lorantis Limited Inhibitors of the notch signalling pathway for use in the treatment of cancer
EP1601374B2 (en) * 2003-03-12 2012-05-23 Rappaport Family Institute for Research in the Medical Sciences Compositions and methods for diagnosing and treating an inflammation

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Publication number Publication date
CA2684278A1 (en) 2008-10-30
US8133875B2 (en) 2012-03-13
EP2147011A4 (en) 2012-07-18
JP2010526034A (ja) 2010-07-29
CN101675066A (zh) 2010-03-17
US20120156223A1 (en) 2012-06-21
WO2008131006A3 (en) 2008-12-24
US20080254072A1 (en) 2008-10-16
WO2008131006A2 (en) 2008-10-30
US8314076B2 (en) 2012-11-20
CA2684278C (en) 2018-06-12
EP2147011A2 (en) 2010-01-27

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