JP5563299B2 - リンパ系撮像方法 - Google Patents

リンパ系撮像方法 Download PDF

Info

Publication number
JP5563299B2
JP5563299B2 JP2009524805A JP2009524805A JP5563299B2 JP 5563299 B2 JP5563299 B2 JP 5563299B2 JP 2009524805 A JP2009524805 A JP 2009524805A JP 2009524805 A JP2009524805 A JP 2009524805A JP 5563299 B2 JP5563299 B2 JP 5563299B2
Authority
JP
Japan
Prior art keywords
region
lymph nodes
image
mammal
contrast agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009524805A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010501009A5 (https=
JP2010501009A (ja
Inventor
ジャック,バンサン
デー. キャラバン,ピーター
ミゼルビッツ,ベルント
バインマン,ハンス−ヨアヒム
Original Assignee
エピックス ファーマシューティカルズ,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エピックス ファーマシューティカルズ,インコーポレイテッド filed Critical エピックス ファーマシューティカルズ,インコーポレイテッド
Publication of JP2010501009A publication Critical patent/JP2010501009A/ja
Publication of JP2010501009A5 publication Critical patent/JP2010501009A5/ja
Application granted granted Critical
Publication of JP5563299B2 publication Critical patent/JP5563299B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Signal Processing (AREA)
  • Endocrinology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2009524805A 2006-08-17 2007-08-16 リンパ系撮像方法 Expired - Fee Related JP5563299B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83848806P 2006-08-17 2006-08-17
US60/838,488 2006-08-17
PCT/US2007/076109 WO2008022263A2 (en) 2006-08-17 2007-08-16 Methods for lymph system imaging

Publications (3)

Publication Number Publication Date
JP2010501009A JP2010501009A (ja) 2010-01-14
JP2010501009A5 JP2010501009A5 (https=) 2010-09-30
JP5563299B2 true JP5563299B2 (ja) 2014-07-30

Family

ID=39083140

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009524805A Expired - Fee Related JP5563299B2 (ja) 2006-08-17 2007-08-16 リンパ系撮像方法

Country Status (7)

Country Link
US (1) US20080044358A1 (https=)
EP (1) EP2053968A4 (https=)
JP (1) JP5563299B2 (https=)
KR (1) KR101336505B1 (https=)
CN (1) CN101528124A (https=)
CA (1) CA2660717A1 (https=)
WO (1) WO2008022263A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090024022A1 (en) * 2006-10-25 2009-01-22 Siemens Corporate Research, Inc. System and method for lymph node imaging using co-registration of ct and mr imagery
US9747789B2 (en) 2013-03-31 2017-08-29 Case Western Reserve University Magnetic resonance imaging with switched-mode current-source amplifier having gallium nitride field effect transistors for parallel transmission in MRI
US10076264B2 (en) 2013-03-31 2018-09-18 Case Western Reserve University System and method for quantitative magnetic resonance (MR) analysis using T1 mapping
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法
EP3920775A1 (en) * 2019-02-04 2021-12-15 Massachusetts Institute of Technology Systems and methods for lymph nodes and vessels imaging
WO2023177683A1 (en) * 2022-03-14 2023-09-21 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems, and methods for treating volume overload

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0289304A (ja) * 1988-09-27 1990-03-29 Kitamura Kiden Kk 巻鉄心用帯材の切抜方法
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
AU4778893A (en) * 1992-07-21 1994-02-14 General Hospital Corporation, The System of drug delivery to the lymphatic tissues
GB9216082D0 (en) * 1992-07-28 1992-09-09 Univ Nottingham Lymphatic delivery composition
TW319763B (https=) * 1995-02-01 1997-11-11 Epix Medical Inc
DE19525924A1 (de) * 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
JPH10120597A (ja) * 1996-10-22 1998-05-12 Eiken Chem Co Ltd リンパ節高集積性コロイド粒子
KR20010030854A (ko) * 1997-10-02 2001-04-16 로퍼, 랜달 비. 인터벤셔날 요법을 모니터하기 위한 콘트라스트 강화된진단 영상화 방법
US6444192B1 (en) * 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
ES2228536T3 (es) * 1999-05-14 2005-04-16 The Regents Of The University Of California Soporte macromolecular a base de dextrano para un farmaco y suministro de un agente de diagnosotico.
BR0013171A (pt) * 1999-07-29 2002-05-28 Epix Medical Inc Agentes multimericos para formação de imagem de objetivação através de ligação multi-local
DE19948651B4 (de) 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US6818203B2 (en) * 2000-08-11 2004-11-16 Schering Aktiengesellschaft Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
US7160535B2 (en) * 2001-10-31 2007-01-09 Bracco International Bv Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
US6549798B2 (en) * 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
US6705476B2 (en) * 2001-08-22 2004-03-16 Central Metal Products, Inc. Shipping rack with torsionally loaded shelf
US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
US8097283B2 (en) * 2004-01-15 2012-01-17 Mount Sinai School Of Medicine Methods and compositions for imaging

Also Published As

Publication number Publication date
EP2053968A2 (en) 2009-05-06
EP2053968A4 (en) 2015-10-21
WO2008022263A2 (en) 2008-02-21
KR20090045343A (ko) 2009-05-07
WO2008022263A3 (en) 2008-12-11
JP2010501009A (ja) 2010-01-14
US20080044358A1 (en) 2008-02-21
KR101336505B1 (ko) 2013-12-05
CN101528124A (zh) 2009-09-09
CA2660717A1 (en) 2008-02-21

Similar Documents

Publication Publication Date Title
JP5563299B2 (ja) リンパ系撮像方法
CA2303426C (en) Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
Wu et al. Synthesis and evaluation of a peptide targeted small molecular Gd-DOTA monoamide conjugate for MR molecular imaging of prostate cancer
Wu et al. Peptide targeted high-resolution molecular imaging of prostate cancer with MRI
JP6145612B2 (ja) 高分子ナノ粒子複合体、及びそれを含むmri造影用組成物
Galisova et al. Frontiers in 19 F-MR imaging: nanofluorides and 19 F-CEST as novel extensions to the 19 F-MRI toolbox
US20050171424A1 (en) Methods for imaging the lymphatic system using dendrimer-based contrast agents
CA2271735C (en) Magnetic resonance blood pool agents
Wu et al. MR molecular imaging of prostate cancer with a small molecular CLT1 peptide targeted contrast agent
HK1131533A (en) Methods for lymph system imaging
KR20250158760A (ko) 콜라겐 및 피브린 영상화를 위한 조영제
You et al. A new magnetic resonance imaging probe specifically targeting vascular endothelial growth factor receptor 2: synthesis, characterization and biological evaluation
AU3138702A (en) Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
MXPA00002869A (en) Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
CZ20001189A3 (cs) Diagnostické činidlo pro monitorování intervenčních terapií

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100813

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100813

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20100902

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20100902

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120828

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121127

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130228

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130618

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130917

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130925

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131218

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140328

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140513

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140612

R150 Certificate of patent or registration of utility model

Ref document number: 5563299

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees