JP5547067B2 - 治療組成物およびその使用 - Google Patents

治療組成物およびその使用 Download PDF

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Publication number
JP5547067B2
JP5547067B2 JP2010515115A JP2010515115A JP5547067B2 JP 5547067 B2 JP5547067 B2 JP 5547067B2 JP 2010515115 A JP2010515115 A JP 2010515115A JP 2010515115 A JP2010515115 A JP 2010515115A JP 5547067 B2 JP5547067 B2 JP 5547067B2
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JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
lopinavir
per day
oxo
Prior art date
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Expired - Fee Related
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JP2010515115A
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English (en)
Japanese (ja)
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JP2010532373A5 (enExample
JP2010532373A (ja
Inventor
ブライアン ピー. ケアニー,
アニータ エー. マティアス,
Original Assignee
ギリアード サイエンシーズ, インコーポレイテッド
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Publication of JP2010532373A publication Critical patent/JP2010532373A/ja
Publication of JP2010532373A5 publication Critical patent/JP2010532373A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010515115A 2007-06-29 2008-06-26 治療組成物およびその使用 Expired - Fee Related JP5547067B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94732507P 2007-06-29 2007-06-29
US60/947,325 2007-06-29
PCT/US2008/068351 WO2009006203A1 (en) 2007-06-29 2008-06-26 Therapeutic compositions and the use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013142320A Division JP5769762B2 (ja) 2007-06-29 2013-07-08 治療組成物およびその使用

Publications (3)

Publication Number Publication Date
JP2010532373A JP2010532373A (ja) 2010-10-07
JP2010532373A5 JP2010532373A5 (enExample) 2011-07-21
JP5547067B2 true JP5547067B2 (ja) 2014-07-09

Family

ID=39817166

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010515115A Expired - Fee Related JP5547067B2 (ja) 2007-06-29 2008-06-26 治療組成物およびその使用
JP2013142320A Expired - Fee Related JP5769762B2 (ja) 2007-06-29 2013-07-08 治療組成物およびその使用
JP2015094705A Withdrawn JP2015143277A (ja) 2007-06-29 2015-05-07 治療組成物およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013142320A Expired - Fee Related JP5769762B2 (ja) 2007-06-29 2013-07-08 治療組成物およびその使用
JP2015094705A Withdrawn JP2015143277A (ja) 2007-06-29 2015-05-07 治療組成物およびその使用

Country Status (21)

Country Link
US (4) US20110009411A1 (enExample)
EP (1) EP2167089A1 (enExample)
JP (3) JP5547067B2 (enExample)
KR (1) KR20100028656A (enExample)
CN (2) CN103356622A (enExample)
AP (1) AP2490A (enExample)
AR (1) AR067184A1 (enExample)
AU (1) AU2008270634B2 (enExample)
BR (1) BRPI0813955A2 (enExample)
CA (1) CA2691736A1 (enExample)
CO (1) CO6251236A2 (enExample)
EA (1) EA200971096A1 (enExample)
EC (1) ECSP109889A (enExample)
IL (1) IL202745A0 (enExample)
MX (1) MX2009013828A (enExample)
NZ (1) NZ582089A (enExample)
SG (1) SG182228A1 (enExample)
TW (1) TW200916103A (enExample)
UA (1) UA103881C2 (enExample)
WO (1) WO2009006203A1 (enExample)
ZA (1) ZA201000468B (enExample)

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* Cited by examiner, † Cited by third party
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JP4676536B2 (ja) * 2005-12-30 2011-04-27 ギリアド サイエンシズ, インコーポレイテッド Hivインテグラーゼ阻害剤の薬物動態の改善方法
PL2049506T5 (pl) 2006-07-07 2024-09-09 Gilead Sciences, Inc. Modulatory farmakokinetycznych właściwości leków
EP2644587A3 (en) 2006-09-12 2013-10-23 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
EP3150586B1 (en) * 2007-02-23 2020-01-08 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
NZ582086A (en) * 2007-06-29 2012-07-27 Gilead Sciences Inc Therapeutic compositions and the use thereof
AR068403A1 (es) 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa
EP2296633B1 (en) 2008-05-02 2015-09-30 Gilead Sciences, Inc. The use of solid carrier particles to improve the processability of a pharmaceutical agent
WO2011127244A2 (en) * 2010-04-09 2011-10-13 Bristol-Myers Squibb Company ATAZANAVIR SULFATE FORMULATIONS WITH IMPROVED pH EFFECT
WO2012088178A1 (en) * 2010-12-21 2012-06-28 Gilead Sciences, Inc. Inhibitors of cytochrome p450 (cyp3a4)
EP4556010A3 (en) 2011-11-30 2025-07-23 Emory University Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
WO2013130766A1 (en) * 2012-03-01 2013-09-06 Gilead Sciences, Inc. Spray dried formulations
CA2878699C (en) 2012-08-03 2018-09-11 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
NZ709260A (en) 2012-12-21 2016-07-29 Gilead Sciences Inc Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
NO2865735T3 (enExample) 2013-07-12 2018-07-21
ES2859102T3 (es) 2013-07-12 2021-10-01 Gilead Sciences Inc Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH
NO2717902T3 (enExample) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
CN118286245A (zh) 2014-12-26 2024-07-05 埃莫里大学 N4-羟基胞苷和衍生物及与其相关的抗病毒用途
SI3466490T1 (sl) 2015-04-02 2020-12-31 Gilead Sciences, Inc. Policiklične spojine karbamoilpiridona in njihova farmacevtska uporaba
RS66222B1 (sr) 2017-12-07 2024-12-31 Univ Emory N4-hidroksicitidin i derivati i antivirusne upotrebe povezane sa njim

Family Cites Families (21)

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US5552558A (en) * 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5914332A (en) * 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5849911A (en) * 1996-04-22 1998-12-15 Novartis Finance Corporation Antivirally active heterocyclic azahexane derivatives
US6087383A (en) * 1998-01-20 2000-07-11 Bristol-Myers Squibb Company Bisulfate salt of HIV protease inhibitor
DE60329318D1 (de) * 2002-11-20 2009-10-29 Japan Tobacco Inc 4-oxochinolinverbindungen und deren verwendung als hiv-integrase-inhibitoren
US20060111933A1 (en) * 2003-10-09 2006-05-25 Steven Wheeler Adaptive medical decision support system
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US20090233964A1 (en) * 2005-12-30 2009-09-17 Gilead Sciences, Inc. Methods for improving the pharmacokinetics of hiv integrase inhibitors
JP4676536B2 (ja) * 2005-12-30 2011-04-27 ギリアド サイエンシズ, インコーポレイテッド Hivインテグラーゼ阻害剤の薬物動態の改善方法
WO2007092802A1 (en) * 2006-02-09 2007-08-16 Boehringer Ingelheim International Gmbh Method for treating hiv infection through co-administration of tipranavir and gs 9137
PL2049506T5 (pl) * 2006-07-07 2024-09-09 Gilead Sciences, Inc. Modulatory farmakokinetycznych właściwości leków
EP2644587A3 (en) * 2006-09-12 2013-10-23 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
NZ582086A (en) * 2007-06-29 2012-07-27 Gilead Sciences Inc Therapeutic compositions and the use thereof
AR068403A1 (es) * 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa
EP2296633B1 (en) * 2008-05-02 2015-09-30 Gilead Sciences, Inc. The use of solid carrier particles to improve the processability of a pharmaceutical agent
US20110000941A1 (en) * 2009-07-06 2011-01-06 Volk J Patrick Apparatus and System for Carrying a Digital Media Player

Also Published As

Publication number Publication date
WO2009006203A1 (en) 2009-01-08
JP2015143277A (ja) 2015-08-06
UA103881C2 (ru) 2013-12-10
AP2490A (en) 2012-10-04
US20140343062A1 (en) 2014-11-20
EA200971096A1 (ru) 2010-08-30
AU2008270634A1 (en) 2009-01-08
KR20100028656A (ko) 2010-03-12
SG182228A1 (en) 2012-07-30
AP2009005083A0 (en) 2009-12-31
CA2691736A1 (en) 2009-01-08
JP2010532373A (ja) 2010-10-07
IL202745A0 (en) 2010-06-30
ECSP109889A (es) 2010-03-31
ZA201000468B (en) 2011-06-29
MX2009013828A (es) 2010-03-10
EP2167089A1 (en) 2010-03-31
AR067184A1 (es) 2009-09-30
CO6251236A2 (es) 2011-02-21
JP2013199494A (ja) 2013-10-03
US20090093482A1 (en) 2009-04-09
CN103356622A (zh) 2013-10-23
NZ582089A (en) 2013-01-25
BRPI0813955A2 (pt) 2017-05-09
JP5769762B2 (ja) 2015-08-26
US20110009411A1 (en) 2011-01-13
US20170136000A1 (en) 2017-05-18
AU2008270634B2 (en) 2014-01-16
TW200916103A (en) 2009-04-16
CN101743004A (zh) 2010-06-16

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