JP5544671B1 - One-part skin external preparation - Google Patents

Abstract

[PROBLEMS] To provide a one-pack type skin for external use that is low in cost, easy to be handled by a user, has a good feeling of use without rough feeling or sagging, has a high carbon dioxide retention, and has an excellent blood circulation promoting action. To provide an agent.
At least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide gas, and a thickening agent. It is a dosage form external preparation for skin, wherein the thickener is contained in 12 to 45% by mass in all external preparations for skin.
[Selection figure] None

Description

  The present invention does not contain water, and contains at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener, and contains moisture. The present invention relates to a one-part skin external preparation used by mixing with a liquid.

  Conventionally, an external preparation for skin containing a synthetic or natural extract having a blood circulation promoting action on the skin has been used.

  These extracts are not effective in a small amount of formulation, and if a large amount of formulation is too irritating to the skin, a topical skin preparation that enhances blood circulation by containing carbon dioxide is proposed. Has been made. Many of these substances generate carbon dioxide by the reaction between an acidic substance and a carbon dioxide generating substance. Therefore, at least one of the two preparations is viscous from the viewpoint of maintaining the carbon dioxide generating ability of the external preparation for a long period of time. A method of mixing and foaming these at the time of use was used. As the form of the two agents, for example, it has been proposed to use an aqueous solution and a solid (Patent Document 1), both of which are viscous substances (Patent Document 2), and a solid and a viscous substance (Patent Document 3).

  The two-part skin external preparation is excellent in terms of ease of manufacture and preservability, but all components are required from the viewpoint of cost reduction and easy handling because the manufacturing cost such as packaging cost is excessive. One-pack type external preparation for skin containing 1 in an agent has been desired.

  By the way, since acidic substances and carbon dioxide generating substances such as carbonates generate carbon dioxide upon contact in the presence of water, in two-part skin external preparations, acidic substances and carbonates are blended into separate agents. , Water can be contained in either one agent or two agents. On the other hand, the one-pack type external preparation for skin is provided as a solid product because it cannot contain moisture from the viewpoint of enhancing the storage stability. For this reason, it is necessary to cause foaming of carbon dioxide gas by mixing the one-part skin external preparation and a liquid containing moisture in a container or the like when used.

  In addition, as a skin external preparation that generates carbon dioxide gas, a type that retains carbon dioxide gas in the preparation by giving the agent a viscosity is well known. In one agent, the thickener can be prepared in a pre-thickened state in water. However, in the case of a one-part skin external preparation, the agent cannot contain moisture as described above. Cannot be prepared in a pre-thickened state in water. And since there are many things that need to be performed under certain conditions when dissolving the thickener, there are two-part skin external preparations in which the supplier of external preparations prepared moisture and thickener under certain conditions in advance. It was adopted. On the other hand, in the case of a one-part skin external preparation, the user mixes moisture during use, so it dissolves instantly in water under various conditions and retains carbon dioxide to obtain a sufficient effect of carbon dioxide or dripping. There has been a demand for the realization of an external preparation for skin that produces a viscosity necessary for preventing water immediately after mixing with moisture.

  Furthermore, the amount of thickening agent used in the two-part skin external preparation is blended as it is to produce a one-part skin external preparation. When mixed, the skin external preparation is difficult to dissolve in water-containing liquids and is likely to cause lumps. In addition, it has been found that problems such as a feeling of roughness when applied to the skin, sagging without obtaining sufficient viscosity, loss of adhesion, and impaired blood circulation promoting effects are caused.

JP-A-63-310807 JP 05-229933 A WO99 / 24043

  The present invention was made in view of the above circumstances, is low in cost, easy to handle by the user, and even when the user mixes the one-part skin external preparation with moisture under various conditions, An object of the present invention is to provide a one-part skin external preparation that has a high carbon dioxide retention amount, does not feel rough or sag, has a good feeling of use, and has an excellent blood circulation promoting action.

  In the one-part skin external preparation containing a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide, and a thickener, the thickener Was found to be easy to handle and have a good feeling when used, so that the present invention was completed.

  The present invention is a one-part skin external preparation containing at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide and a thickener, and does not contain water. In addition, the above-mentioned thickener is contained in 12 to 45% by mass in the whole skin external preparation, and is mixed with a liquid containing moisture at the time of use.

  According to the present invention, it is possible to provide a one-part skin external preparation that is low in cost, easy for a user to handle, has a good feeling of use and an excellent blood circulation promoting action. Furthermore, the one-part skin external preparation of the present invention has an increased amount of thickening agent, contrary to previous knowledge, which can eliminate the feeling of roughness when applied to the skin, and bubbles caused by carbon dioxide generation are less likely to collapse. The amount of gas retained is high, and there is no dripping when applied to the skin, and the effect of promoting the absorption of the active ingredient can be continuously obtained.

It is a figure which shows the time-dependent change of the volume increase rate by foaming of the external preparation of this invention.

  The one-part skin external preparation of the present invention contains at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide and a thickener, and does not contain water. It is a one-part skin external preparation, and the thickener is contained in 12 to 45% by mass in the whole skin external preparation.

  In the one-part skin external preparation of the present invention, the user mixes the one-part skin external preparation and a liquid containing water at the time of use, thereby causing foaming due to the generation of carbon dioxide gas. It is applied and used. Since the external preparation for skin of the present invention is made into one agent, it has a feature that the user can easily handle it at a lower cost than the two-component type. Hereinafter, each component contained in the one-pack type external preparation for skin and a production method thereof will be described.

<Solid acidic substance>
The solid acidic substance used in the present invention may be either an organic acid or an inorganic acid, and one or more of these are used. Moreover, any dosage form may be used as long as it is solid, but powders such as granules and powders are preferable, and powders are particularly preferable.

  Organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid Acids, dicarboxylic acids such as terephthalic acid, acidic amino acids such as glutamic acid and aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid And oxyacids such as tropic acid, ascorbic acid and gluconic acid. Of these, citric acid, ascorbic acid, malic acid, and succinic acid are preferable from the viewpoints of safety and solubility in water.

<Solid carbon dioxide generator>
As the solid carbon dioxide gas generating substance that generates carbon dioxide by reacting with the acidic substance used in the present invention, various substances can be used without any particular limitation. Moreover, any dosage form may be used as long as it is solid, but powders such as granules and powders are preferable, and powders are particularly preferable.

  Examples of the carbon dioxide generating substance include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogen carbonate, potassium hydrogen carbonate, sodium hydrogen carbonate, lithium hydrogen carbonate, cesium hydrogen carbonate, magnesium hydrogen carbonate And hydrogen carbonates such as calcium hydrogen carbonate, and one or more of these are used. Among these, hydrogen carbonate is preferably used, and sodium hydrogen carbonate is more preferable in that a moderate foaming power can be realized.

  The solid acidic substance and the solid carbon dioxide generating substance may be a single powder or granular substance, or a powder or granule comprising a mixture with other components such as excipients and granulating agents. It may be.

  Examples of other components that can be contained in the powder or granule are, for example, powders such as lactose, powdered sugar, starch, dextrin, xylitol, D-sorbitol, glucose, D-mannitol, fructose, sucrose, sucrose, urea, etc. It can be used alone or in combination of two or more.

  Here, by obtaining a granule of the acidic substance and / or the carbon dioxide generating substance and other components to obtain granules of the solid acidic substance and / or the solid carbon dioxide generating substance, Although there is no restriction | limiting in particular as content of another component, It is preferable to set it as less than 80 mass% in the said granule. When other components are present in a content exceeding 80% by mass, foaming properties are lowered, which is not preferable.

  The method for producing the powder or granule is not limited to this example, and includes dry crushing granulation method, wet crushing granulation method, fluidized bed granulation method, high-speed stirring granulation method, extrusion granulation method and the like. It can be produced according to a conventional method.

  For example, when a low melting point compound is used as a granulating agent as a matrix base, the acidic substance and / or the carbon dioxide generating substance is added to the low melting point granulating agent melted by heating in a container such as a beaker. Stir and mix thoroughly. You may add an appropriate additive to this as needed. The mixture is further stirred while being cooled at room temperature, and left to solidify. Once it has solidified to some extent, it may be rapidly cooled in a refrigerator or the like.

  Further, for example, the above materials may be put into a fluidized bed granulator, mixed by airflow for several minutes, and then granulated by spraying water.

  When a low melting point compound is not used for the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker to generate the acidic substance and / or the carbon dioxide gas. The substance is dissolved or dispersed and sufficiently mixed, and then heated in an oven or the like to remove the solvent and dried. When it is completely hardened, it is pulverized and sieved to make the size of the granules, and then granulated.

  As the shape of the solid acidic substance or solid carbon dioxide generating substance, for example, irregular shape, planar shape, polyhedron shape, spherical shape, drop shape, fibrous shape, cylindrical shape, fine powder shape, etc. are particularly limited. Can be adopted without any problem. Moreover, the thing of the wide range can be used without a restriction | limiting especially as the particle size. In particular, those having a particle size distribution of about 1,000 μm are more preferable from the viewpoint of ease of handling and ease of mixing with the viscous composition. The particle size distribution in the present invention can be determined by a normal laser diffraction / scattering method.

<Thickener>
The thickener used in the present invention is not particularly limited as long as it is a water-soluble component that can be used in the cosmetics and pharmaceutical fields. Polyvinyl alcohol, hydroxyethyl cellulose, hydroxypropyl methylcellulose, sulfonated cellulose derivatives, Hydrophilic synthetic polymers such as acrylates / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethylcellulose, cationized cellulose, pluronic, starch, xanthan gum, sodium alginate, sac In addition to hydrophilic natural polymers such as sinoglycan, carrageenan, guar gum, locust bean gum and celluloses, chondroitin sulfate, casein, co- Gen, gelatin, hydrophilic protein compounds such as albumin, laponite, bentonite, hydrophilic thickening compound such as a hydrophilic clay minerals such as smectite are exemplified.

  Among the above thickeners, the use of one having high solubility in water makes it possible to uniformly dissolve the one-part skin external preparation of the present invention without causing lumps, and the skin caused by undissolved components This is preferable because the rough feeling can be reduced. Here, the solubility in water is determined by the fact that when the water is added at room temperature and stirred, the skin external preparation instantly dissolves in water and dissolves uniformly so that carbon dioxide gas can be retained. It can be determined from the fact that it has, or does not cause lumps during dissolution.

  Examples of such thickeners include starch, xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, gum arabic, tragacanth gum, mannan, hyaluronic acid, curdlan, albumin, alginates, Examples thereof include carboxyvinyl polymer, polyvinyl alcohol, sodium polyacrylate, acrylic acid / alkyl methacrylate copolymer, and the like.

  A thickener can be used by selecting 1 type from among the above, or using 2 or more types together, but it is preferable to use 2 or more types in combination. In particular, it is preferable to contain a hydrophilic protein compound as an essential component of the thickener. Especially, it is preferable to contain at least albumin as a thickener. Albumin also has a role as a foaming aid, and in particular has a function of increasing the strength of bubbles to keep the foam stable for a long period of time. Therefore, albumin is an essential thickener and can be used alone or in combination with other thickeners to improve the ease of viscosity adjustment and solubility in water for topical skin preparations. A skin conditioning effect can also be provided.

  The thickener used in the present invention is preferably contained at 10 to 50% by mass, more preferably 12 to 45% by mass in the whole skin external preparation. When the content is small, a feeling of roughness is likely to occur due to undissolved components when the skin preparation for external use and a liquid containing water are mixed. In addition to being prone to sagging, the ability to retain the generated carbon dioxide gas is inferior, making it impossible to obtain a sufficient blood circulation promoting effect. On the other hand, if the content of the thickener exceeds the above range, the solubility in water is inferior, causing lumps and causing discomfort when applied to the skin, and the ability to retain the generated carbon dioxide gas is not very high. Therefore, it becomes impossible to obtain a sufficient blood circulation promoting action.

  Among the above thickeners, the content of the hydrophilic protein compound or albumin is preferably 0.1 to 50% by mass, and preferably 0.5 to 45% by mass in the whole skin external preparation. Is more preferable. Furthermore, it is desirable to contain 1-30 mass%.

  In the technical field of cosmetics (packs, etc.), increasing the amount of thickener is said to cause problems such as elongation, a decrease in solubility, and generation of residue, and the thickener is used at less than 1% by mass. It was common in this field. For this reason, even in the conventional carbonic acid pack, the amount used was limited to about 2 to 3% by mass. On the other hand, in the present invention, contrary to the previous knowledge possessed by those skilled in the art, by adding a lot of thickeners to the one-part skin external preparation, the rough feeling when applied to the skin unexpectedly is obtained. In addition, it is difficult to collapse the bubbles due to the generation of carbon dioxide, the amount of carbon dioxide retained is increased, and no dripping occurs when applied to the skin, and the effect of promoting the absorption of active ingredients can be obtained continuously. It was possible.

<External preparation for skin>
The one-part skin external preparation of the present invention comprises, in addition to the solid acidic substance, the solid carbon dioxide generating substance and the thickener, other active ingredients, pH adjusting agents, fats and oils, depending on the application and purpose. , Colorants, antioxidants, fungicides, fungicides, alcohols, polyhydric alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, inorganic salts, lubricants, solvents, etc. It can be mixed with at least one of the components usually used in external preparations for skin.

  Hereinafter, representative components other than the solid acidic substance, the solid carbon dioxide generating substance and the thickener contained in the external preparation for skin of the present invention will be further described.

  The active ingredient used in the present invention is not particularly limited, and drugs, plants, and the like that are usually used in cosmetics, external medicines, quasi drugs, and the like can be used according to the purpose. Typical examples include, for example, glycyrrhizic acid or derivatives thereof, whitening agents such as placenta extract, moisturizing ingredients such as propylene glycol, polyethylene glycol, sorbitol, sodium lactate, sodium pyrrolidonecarboxylate, and plant components such as licorice. It is done. As plant components, the whole plant, leaves (leaf blades, petiole, etc.), fruits (mature, immature, etc.), seeds, flowers (petals, ovary, etc.), stems, rhizomes, roots, tuberous roots, etc. are used as they are. These can be used after being cut, crushed, crushed or exploited, or dried or powdered.

<Usage form of external preparation for skin>
The one-part skin external preparation of the present invention does not contain moisture in the preparation, and in use, foaming is caused by mixing with a liquid containing moisture on the palm or in a container.

  As the liquid containing water used in the present invention, any liquid can be used without particular limitation as long as it is a liquid containing water in addition to water used in cosmetics, pharmaceuticals, etc., water used in general households. Can do. For example, tap water, distilled water, membrane filtered water, ion exchange water, deep ocean water, sake, wine such as sake, soy milk, drink yogurt, acerola juice, sports drink, carbonated water drink, rice tofu, etc. Is mentioned. These may be used alone or in combination of two or more.

  The amount of water-containing liquid to be used is not particularly limited and can be used in a wide range. It is more preferable to add the amount. By adding more than 1 times the amount of liquid, the external preparation for skin can be quickly dissolved, and a sufficient amount of carbon dioxide gas can be generated. On the other hand, dripping due to a decrease in viscosity of the external preparation for skin can be prevented by adding the liquid within 5 times the amount.

  The temperature of the liquid containing water is not particularly limited and can be used in a wide range. However, since the action of the active ingredient of the one-part skin external preparation is increased, it is particularly useful to cool it in advance. preferable. The usable temperature range is preferably water at about room temperature or tap water from the viewpoint of usability during application and user convenience.

  The method for preserving the external preparation for skin is not particularly limited as long as it is stored in a state where it blocks moisture and does not come into contact. The shape of the storage container to be used can be appropriately selected according to the purpose, and examples thereof include cup shape, tube shape, bag shape, bottle shape, stick shape, pump shape, jar shape, and canned shape. Moreover, the material which comprises a storage container can use plastics, glass, aluminum, paper, various polymers, etc. individually or in combination of 2 or more types, for example, It is not limited to these.

  Specific examples of containers include: aluminum sticks laminated with polyethylene terephthalate on the inner surface, storage bags such as aluminum bags, stand pouch with chuck, polyethylene terephthalate on the inner surface in terms of hermeticity, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate in which the lid is heat-sealed with an aluminum film or the like laminated with is preferable.

<Uses of external preparations for skin>
The external preparation for skin according to the present invention promotes an increase in skin blood flow, and is intended for whitening, improving skin quality, improving freckles, rejuvenating skin, tightening skin, and partially thinning cosmetics, emulsions, creams, packs. It can be suitably used not only for cosmetics such as pills and peeling agents, but also for quasi-drugs and pharmaceuticals such as drugs.

  Prior to obtaining the optimum thickener amount range, Reference Example 1 shown in Table 1 below was first prepared, and the state of foam was confirmed. Various thickeners and other components were added to this, and the state of foaming was observed. When albumin was selected as the thickener to be added, the strength of the bubbles was particularly high as described in Reference Example 2 in Table 1. A phenomenon was observed in which the bubbles became harder to collapse. Even when other thickeners that are not albumin are added, the evaluation results of solubility, sagging, and the amount of carbon dioxide that can be retained other than the strength of the bubbles are considered not to be significantly different from the case of adding albumin.

  EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated further more concretely, the scope of the present invention is not limited to these Examples.

<Examples 1-5, Comparative Examples 1-4>
According to the composition shown in Table 2, 12, 15, 20, 25, 45% by mass of a thickener, Examples 1-5 external preparations for skin and thickeners 5, 6, 10 , 55% by mass, a one-part skin external preparation for Comparative Examples 1 to 4 was produced.

According to the following procedure, the properties of the one-part skin external preparations of the above Examples and Comparative Examples were evaluated.
<Roughness evaluation>
A powdery one-part skin external preparation sample and water are mixed at 1: 3 (weight ratio) in a container, and the feel is evaluated based on the following criteria.
○ No rough or uncomfortable feeling during application or use.
△ Although slightly rough at the time of application, there is no discomfort during use.
× There is a feeling of roughness and discomfort during application and use.

<Evaluation of solubility>
A powdery one-part skin external preparation sample and water are mixed in a container at a ratio of 1: 3 (weight ratio), visually observed during stirring, and evaluated based on the following criteria.
○ Immediately after mixing, the powder dissolves uniformly and does not cause lumps.
Δ Immediately after mixing, the powder absorbs water and gels, producing some lumps.
X Immediately after mixing, the powder absorbs water and gels, resulting in a lumpy shape.

<Evaluation of sagging>
The powdered one-part skin external preparation sample and water were mixed in a container at a ratio of 1: 3 (weight ratio), and the mixture was applied to a person's arm standing vertically to prevent the mixture from dripping. Observe and evaluate based on the following criteria.
○ After application, no dripping occurs even after a certain period of time, and the mixture stays on the skin.
△ One minute after application, dripping occurs and a part of the mixture does not stay on the skin.
× Dripping immediately after application, hardly stays on the skin.

<Evaluation of the amount of carbon dioxide foaming of a one-part skin external preparation>
21 g of water was put into a bottle having a diameter of about 4.8 cm and a height of about 10.5 cm, and 7 g of a powdery one-part skin external preparation sample was added thereto and stirred 20 times for 10 seconds. Immediately after stirring, the volume after 1 minute, 10 minutes, and 20 minutes was measured, and the volume increase rate relative to the volume before stirring was measured. The result is shown in FIG. Moreover, let the volume increase rate of the carbon dioxide gas after 20 minutes be a holdable carbonic acid amount.

In Table 3, each evaluation result of said roughness, solubility, sagging, and the amount of carbonic acid which can be hold | maintained, and the comprehensive evaluation result of the one agent type skin external preparation which can be judged from these results are shown.

  The external preparation for skin of Comparative Example 1 containing 5% of the thickener and Comparative Example 2 containing 6% had a rough feeling, dripping occurred, and the amount of carbon dioxide gas that could be retained in the mixture was remarkably small. Moreover, even if it was the skin external preparation of the comparative example 3 which contains 10% of thickeners, dripping occurred. On the other hand, the external preparation for skin of Comparative Example 4 containing 55% of a thickener was remarkably inferior in solubility, generation of gelation and lumps was observed, and the amount of carbon dioxide gas that could be retained in the mixture was not very large. The amount of carbon dioxide gas that can be held in the mixture was excellent in the order of Example 4> Example 2, 3≈Comparative Example 3> Example 5≈Comparative Example 4> Comparative Examples 1 and 2 as seen from FIG. When the above results are comprehensively evaluated, the skin external preparations of Examples 1 to 4 which are embodiments of the present invention containing 12 to 45% by mass of the thickener are superior as the skin external preparations compared to the comparative examples. I understood that.

  As is clear from the above examination, the skin external preparation of the present invention contains a thickener in a higher composition than conventional external preparations, in addition to improving the retention of carbon dioxide gas and the dripping property, it is rough. It has the effect of preventing feeling.

[Prescription example of one-part skin external preparation]
The specific formulation example of the one-part skin external preparation of this invention is shown below further.
<Example 6>
Each component was mix | blended with the compounding ratio of Table 4, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 7>
Each component was mix | blended with the mixture ratio of Table 5, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 8>
Each component was mix | blended with the mixture ratio of Table 6, and it was set as the powdery one-pack type skin external preparation. When this one-part type skin external preparation powder was placed in a container and 1 weight of water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 9>
Each component was mix | blended with the compounding ratio of Table 7, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was placed in a container and 10 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 10>
Each component was mix | blended with the mixture ratio of Table 8, and it was set as the powdery one-pack type skin external preparation. When this one-part type skin external preparation powder was put in a container and 5 weight-percent water was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

<Example 11>
Each component was mix | blended with the mixture ratio of Table 9, and it was set as the powdery one-part type skin external preparation. When this one-part type skin external preparation powder was put in a container, and water of 3 by weight was added to the powder 1 and stirred, a foamy pack cosmetic was obtained.

  All of the one-part skin external preparations according to the above formulations showed good solubility in water, and each produced fine bubbles due to the generation of carbon dioxide. When the foam-like pack cosmetic obtained from the one-pack type external preparation for each formulation was applied to the face, there was no dripping or the like for several minutes, and the blood circulation promoting action was continuously obtained. In particular, even in the formulation of Example 9 in which 10 times the amount of water was added to the one-pack type external skin preparation, no dripping or the like was observed, and it was confirmed that it functions well as a pack agent.

Claims (1)

A one-part skin external preparation containing at least a solid acidic substance, a solid carbon dioxide generating substance that reacts with the acidic substance to generate carbon dioxide and a thickener, and does not contain water. In the external preparation for skin, the thickener is contained in an amount of 12 to 45% by mass. The thickener is used in combination with albumin and other thickeners, and mixed with a liquid containing moisture when the external preparation for skin is used. One-part skin external preparation.

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