JP5537033B2 - 無痛覚 - Google Patents

無痛覚 Download PDF

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Publication number
JP5537033B2
JP5537033B2 JP2008546592A JP2008546592A JP5537033B2 JP 5537033 B2 JP5537033 B2 JP 5537033B2 JP 2008546592 A JP2008546592 A JP 2008546592A JP 2008546592 A JP2008546592 A JP 2008546592A JP 5537033 B2 JP5537033 B2 JP 5537033B2
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JP
Japan
Prior art keywords
glycine
receptor
effect
compounds
compound
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Expired - Fee Related
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JP2008546592A
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English (en)
Japanese (ja)
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JP2009520010A5 (US07981874-20110719-C00313.png
JP2009520010A (ja
Inventor
マルティン ロイヴァー
ゲルトルート ヘゼラー
ジェレミー ランバート
デリア ベレリ
Original Assignee
ザ ユニヴァーシティー オブ リヴァプール
ザ ユニヴァーシティー オブ ダンディー
メディツィニシェ ホッホシューレ ハノーヴァー
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Publication of JP2009520010A publication Critical patent/JP2009520010A/ja
Publication of JP2009520010A5 publication Critical patent/JP2009520010A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2008546592A 2005-12-19 2006-12-19 無痛覚 Expired - Fee Related JP5537033B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75155905P 2005-12-19 2005-12-19
US60/751,559 2005-12-19
US79627006P 2006-04-27 2006-04-27
US60/796,270 2006-04-27
PCT/GB2006/004762 WO2007071967A2 (en) 2005-12-19 2006-12-19 Substituted phenol derivatives as analgesics

Publications (3)

Publication Number Publication Date
JP2009520010A JP2009520010A (ja) 2009-05-21
JP2009520010A5 JP2009520010A5 (US07981874-20110719-C00313.png) 2010-02-12
JP5537033B2 true JP5537033B2 (ja) 2014-07-02

Family

ID=37909696

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008546592A Expired - Fee Related JP5537033B2 (ja) 2005-12-19 2006-12-19 無痛覚

Country Status (6)

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US (2) US20070142477A1 (US07981874-20110719-C00313.png)
EP (1) EP1965780B1 (US07981874-20110719-C00313.png)
JP (1) JP5537033B2 (US07981874-20110719-C00313.png)
AU (1) AU2006328198B2 (US07981874-20110719-C00313.png)
CA (1) CA2632561C (US07981874-20110719-C00313.png)
WO (1) WO2007071967A2 (US07981874-20110719-C00313.png)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007071967A2 (en) * 2005-12-19 2007-06-28 The University Of Liverpool Substituted phenol derivatives as analgesics
CA2685570A1 (en) 2007-05-09 2008-11-20 Pharmacofore, Inc. Therapeutic compounds
AU2008251484A1 (en) * 2007-05-09 2008-11-20 Pharmacofore, Inc. Therapeutic compounds
GB0822486D0 (en) 2008-12-10 2009-01-14 Univ Liverpool Compounds for use in the treatment of pain
US20130005718A1 (en) * 2009-08-11 2013-01-03 Tibbs Gareth R Compositions and methods of treating chronic pain by administering propofol derivatives
CN103896743B (zh) * 2012-12-28 2017-04-05 四川海思科制药有限公司 一种2，6‑二异丙基‑4‑氟苯酚的制备方法
GB201322905D0 (en) 2013-12-23 2014-02-12 Univ Liverpool Pharmacologically active compounds
US10449198B2 (en) 2016-07-01 2019-10-22 The University Of Liverpool Method for treating pain

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2087019B1 (es) * 1994-02-08 1997-03-16 Bobel246 S L Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
US6518315B1 (en) * 1997-10-21 2003-02-11 The University Of Sydney Medicinal uses of phenylaikanols and derivatives
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
WO2000054588A1 (en) * 1999-03-15 2000-09-21 John Claude Krusz Treatment of acute headaches and chronic pain using rapidly-cleared anesthetic drug at sub-anesthetic dosages
HUP0400570A3 (en) * 2000-12-04 2004-09-28 Hoffmann La Roche Phenylethenyl or phenylethinyl heteroaril derivatives as glutamate receptor antagonists, their use, process for their preparation and pharmaceutical compositions containing them
US20030055023A1 (en) * 2001-03-20 2003-03-20 Rajewski Roger A. Formulations containing etomidate and a sulfoalkyl ether cyclodextrin
US20040038874A1 (en) * 2002-08-22 2004-02-26 Osemwota Omoigui Method of treatment of persistent pain
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US7261882B2 (en) * 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US20070043121A1 (en) * 2003-09-29 2007-02-22 Brown Milton L Discovery of novel soluble crystalline anesthetics
DE102005033496A1 (de) * 2005-07-19 2007-01-25 Bayer Healthcare Ag Desinfektionsmittel
WO2007071967A2 (en) * 2005-12-19 2007-06-28 The University Of Liverpool Substituted phenol derivatives as analgesics

Also Published As

Publication number Publication date
CA2632561A1 (en) 2007-06-28
AU2006328198B2 (en) 2013-07-18
AU2006328198A1 (en) 2007-06-28
EP1965780B1 (en) 2017-03-08
JP2009520010A (ja) 2009-05-21
WO2007071967A2 (en) 2007-06-28
WO2007071967A3 (en) 2007-10-11
EP1965780A2 (en) 2008-09-10
US20070142477A1 (en) 2007-06-21
US20160095823A1 (en) 2016-04-07
CA2632561C (en) 2015-01-27

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