JP5467997B2 - 生体吸収性材料およびそれを用いた生体内留置物 - Google Patents
生体吸収性材料およびそれを用いた生体内留置物 Download PDFInfo
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- JP5467997B2 JP5467997B2 JP2010505484A JP2010505484A JP5467997B2 JP 5467997 B2 JP5467997 B2 JP 5467997B2 JP 2010505484 A JP2010505484 A JP 2010505484A JP 2010505484 A JP2010505484 A JP 2010505484A JP 5467997 B2 JP5467997 B2 JP 5467997B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
- C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L69/00—Compositions of polycarbonates; Compositions of derivatives of polycarbonates
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- Materials For Medical Uses (AREA)
- Polyesters Or Polycarbonates (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
Description
下記一般式1で示されることを特徴とする生体吸収性材料。
下記一般式2で示されることを特徴とする生体吸収性材料。
本発明の生体吸収性材料の第1実施形態は、芳香環にα,β−不飽和カルボキシル基、および、1以上の水酸基が置換した芳香族化合物成分と、ポリカーボネート成分あるいはポリカーボネートを構成するモノマー成分との共重合体である。したがって、柔軟性を有しかつ分解速度を制御することが可能である。
本発明の生体吸収性材料の第2実施形態は、芳香環にα,β−不飽和カルボキシル基、および、1以上の水酸基が置換した第1の芳香族化合物成分と、芳香環にα,β−不飽和カルボキシル基、および、2以上の水酸基が置換した第2の芳香族化合物成分と、ポリカーボネート成分あるいはポリカーボネートを構成するモノマー成分との共重合体である。したがって、柔軟性を有しかつ分解速度を制御することが可能である。
4−ヒドロキシ桂皮酸(4HCA)0.066gとトリメチレンカーボネートモノマー(TMC)8.16gを混合し、オクチルスズ20μLを加えて3回窒素置換し、窒素気流下で150℃のオイルバスに6時間撹拌させた。得られた析出物をクロロホルムに溶解し、メタノール中で再沈殿させた。吸引ろ過後、室温で二昼夜真空乾燥させ、数平均分子量Mn=21,800のOligo−TMCを得た。
そして、4−ヒドロキシ桂皮酸(4HCA)2.05gと上記Oligo−TMC5.45gと触媒である酢酸ナトリウム0.05gとエステル交換剤である無水酢酸50mLを三口フラスコに入れて10分間窒素バブリングさせ、窒素気流下で180℃のオイルバスに6時間撹拌させ縮重合した。得られた析出物をジメチルホルムアミドに溶解し、メタノール中で再沈殿させた。吸引ろ過後、室温で二昼夜真空乾燥させ、ポリ(4HCA−TMC)共重合体を得た。
4−ヒドロキシ桂皮酸(4HCA)0.066gとトリメチレンカーボネートモノマー(TMC)8.16gを混合し、オクチルスズ20μLを加えて3回窒素置換し、窒素気流下で150℃のオイルバスに6時間撹拌させた。得られた析出物をクロロホルムに溶解し、メタノール中で再沈殿させた。吸引ろ過後、室温で二昼夜真空乾燥させ、数平均分子量Mn=21,800のOligo−TMCを得た。
そして、3,4−ジヒドロキシ桂皮酸(カフェ酸)(DHCA)2.52gと上記Oligo−TMC5.45gと4−ヒドロキシ桂皮酸(4HCA)2.05gと触媒である酢酸ナトリウム0.05gとエステル交換剤である無水酢酸50mLを三口フラスコに入れて10分間窒素バブリングさせ、窒素気流下で180℃のオイルバスに6時間撹拌させ縮重合した。得られた析出物をジメチルホルムアミドに溶解し、メタノール中で再沈殿させた。吸引ろ過後、室温で二昼夜真空乾燥させ、ポリ(DHCA−4HCA−TMC)共重合体を得た。
4−ヒドロキシ桂皮酸(4HCA)9.00gと触媒である酢酸ナトリウム0.05gとエステル交換剤である無水酢酸50mLを三口フラスコに入れて10分間窒素バブリングさせ、窒素気流下で200℃のオイルバスに6時間撹拌させ縮重合した。得られた析出物をジメチルホルムアミドに溶解し、メタノール中で再沈殿させた。吸引ろ過後、室温で二昼夜真空乾燥させ、ポリ4HCAを得た。
3,4−ジヒドロキシ桂皮酸(カフェ酸)(DHCA)5.4gと4−ヒドロキシ桂皮酸(4HCA)4.9gと触媒である酢酸ナトリウム0.05gとエステル交換剤である無水酢酸50mLを三口フラスコに入れて10分間窒素バブリングさせ、窒素気流下で200℃のオイルバスに6時間撹拌させ縮重合した。得られた析出物をジメチルホルムアミドに溶解し、メタノール中で再沈殿させた。吸引ろ過後、室温で二昼夜真空乾燥させ、ポリ(DHCA−4HCA)共重合体を得た。
Claims (4)
- 請求項1に記載の生体吸収性材料により形成されたことを特徴とする生体内留置物。
- 請求項3に記載の生体吸収性材料により形成されたことを特徴とする生体内留置物。
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JP2010505484A JP5467997B2 (ja) | 2008-03-27 | 2009-03-03 | 生体吸収性材料およびそれを用いた生体内留置物 |
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JP2008084376 | 2008-03-27 | ||
JP2008084376 | 2008-03-27 | ||
PCT/JP2009/053929 WO2009119258A1 (ja) | 2008-03-27 | 2009-03-03 | 生体吸収性材料およびそれを用いた生体内留置物 |
JP2010505484A JP5467997B2 (ja) | 2008-03-27 | 2009-03-03 | 生体吸収性材料およびそれを用いた生体内留置物 |
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JP5467997B2 true JP5467997B2 (ja) | 2014-04-09 |
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US (1) | US8222349B2 (ja) |
EP (1) | EP2243797B1 (ja) |
JP (1) | JP5467997B2 (ja) |
CN (1) | CN101959929B (ja) |
WO (1) | WO2009119258A1 (ja) |
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EP2532372B1 (en) * | 2010-02-02 | 2015-02-25 | Terumo Kabushiki Kaisha | Bioabsorbable stent |
US9493566B2 (en) | 2012-02-17 | 2016-11-15 | Seattle Genetics, Inc. | Antibodies to integrin AVB6 and use of same to treat cancer |
CN104419001A (zh) * | 2013-09-06 | 2015-03-18 | 常州化学研究所 | 一种新型可生物降解聚碳酸酯共聚物及其制备方法 |
AU2020397070A1 (en) | 2019-12-05 | 2022-07-14 | Seagen Inc. | Anti-avb6 antibodies and antibody-drug conjugates |
JP7414594B2 (ja) | 2020-03-11 | 2024-01-16 | 帝人株式会社 | 生体吸収性接着剤 |
CN114426660A (zh) * | 2020-10-29 | 2022-05-03 | 常州化学研究所 | 一种光敏无规共聚酯及其制备方法 |
Citations (4)
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JP2004250700A (ja) * | 2003-01-30 | 2004-09-09 | Mitsuru Akashi | バイオ液晶ポリマーおよび成形体 |
JP2006063316A (ja) * | 2004-07-29 | 2006-03-09 | Mitsuru Akashi | 剛直ポリマーおよびその製造方法 |
JP2009233166A (ja) * | 2008-03-27 | 2009-10-15 | Terumo Corp | 生体吸収性材料およびそれを用いた生体内留置物 |
JP2009233165A (ja) * | 2008-03-27 | 2009-10-15 | Terumo Corp | 生体吸収性材料およびそれを用いた生体内留置物 |
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US5587507A (en) * | 1995-03-31 | 1996-12-24 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
DE4132079A1 (de) * | 1991-09-26 | 1993-04-01 | Bayer Ag | Polyester mit phenolischen oh-gruppen, ihre herstellung und verwendung zur herstellung von polyesterpolycarbonaten |
US5614599A (en) * | 1994-10-31 | 1997-03-25 | The Dow Chemical Company | Stilbene-based polyester and polycarbonate compositions |
US6206883B1 (en) * | 1999-03-05 | 2001-03-27 | Stryker Technologies Corporation | Bioabsorbable materials and medical devices made therefrom |
US6747119B2 (en) * | 2002-03-28 | 2004-06-08 | General Electric Company | Method and system for preparing a polycarbonate, copolymerization reagent and polycarbonate |
US7182884B2 (en) | 2003-01-30 | 2007-02-27 | Mitsuru Akashi | Bio-liquid crystal polymer and shaped material using same |
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JP2004250700A (ja) * | 2003-01-30 | 2004-09-09 | Mitsuru Akashi | バイオ液晶ポリマーおよび成形体 |
JP2006063316A (ja) * | 2004-07-29 | 2006-03-09 | Mitsuru Akashi | 剛直ポリマーおよびその製造方法 |
JP2009233166A (ja) * | 2008-03-27 | 2009-10-15 | Terumo Corp | 生体吸収性材料およびそれを用いた生体内留置物 |
JP2009233165A (ja) * | 2008-03-27 | 2009-10-15 | Terumo Corp | 生体吸収性材料およびそれを用いた生体内留置物 |
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JPWO2009119258A1 (ja) | 2011-07-21 |
CN101959929B (zh) | 2013-05-01 |
US8222349B2 (en) | 2012-07-17 |
WO2009119258A1 (ja) | 2009-10-01 |
US20110046309A1 (en) | 2011-02-24 |
EP2243797A1 (en) | 2010-10-27 |
EP2243797A4 (en) | 2013-05-01 |
EP2243797B1 (en) | 2016-04-27 |
CN101959929A (zh) | 2011-01-26 |
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