JP5427891B2 - 電界紡糸によって得られる多層プリフォーム及びプリフォームの製造方法 - Google Patents
電界紡糸によって得られる多層プリフォーム及びプリフォームの製造方法 Download PDFInfo
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Classifications
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- D—TEXTILES; PAPER
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- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
- D04H1/43838—Ultrafine fibres, e.g. microfibres
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
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- D—TEXTILES; PAPER
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- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4374—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece using different kinds of webs, e.g. by layering webs
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H13/00—Other non-woven fabrics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
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- Y10T428/2913—Rod, strand, filament or fiber
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- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Manufacturing & Machinery (AREA)
- Prostheses (AREA)
- Nonwoven Fabrics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Description
a)実質的に凸面のみを含む少なくとも2つのサブ型からなる型を用意する工程と、
b)前記工程a)の前記サブ型の少なくとも1つの表面に少なくとも1つのナノファイバー層又はマイクロファイバー層を電界紡糸する工程と、
c)前記工程a)の前記サブ型及び前記工程b)の前記サブ型から選択される少なくとも2つのサブ型を組み合わせる工程と、
d)前記c)のアセンブリの表面に少なくとも1つのナノファイバー層又はマイクロファイバー層を電界紡糸してプリフォームを得る工程と、を含み、
前記プリフォームは、少なくとも1つのナノファイバー層と、少なくとも1つのマイクロファイバー層と、を含み、前記少なくとも1つのマイクロファイバー層の細孔径が1〜300μmであり、前記少なくとも1つのナノファイバー層の細孔径が1〜300μmである方法に関する。
Claims (10)
- 電界紡糸によって得られ、プロテーゼのスキャフォールド用の多層プリフォームであって、少なくとも1つのマイクロファイバー層と、少なくとも1つのナノファイバー層と、を含み、
前記マイクロファイバーの直径は、5〜18μmであり、
前記ナノファイバーの直径は、50〜800nmであり、
前記プリフォームの全ての層の細孔径は、5〜100μmであることを特徴とする多層プリフォーム。 - 請求項1において、前記マイクロファイバーの直径が8〜14μmであることを特徴とする多層プリフォーム。
- 請求項1または2において、前記ナノファイバーの直径が200nm〜800nmであることを特徴とする多層プリフォーム。
- 請求項1または2において、前記ナノファイバーの直径が400nm〜800nmであることを特徴とする多層プリフォーム。
- 請求項1または2において、前記ナノファイバーの直径が700nmを超えないことを特徴とする多層プリフォーム。
- 請求項1または2において、前記ナノファイバーの直径が600nmを超えないことを特徴とする多層プリフォーム。
- 請求項1乃至6のいずれか1項において、前記マイクロファイバー層及び/又はナノファイバー層の気孔率が70〜95%である多層プリフォーム。
- 請求項1乃至7のいずれか1項において、直径勾配を有する無数の層を有する多層プリフォーム。
- プロテーゼのスキャフォールド用の多層プリフォームを電界紡糸するプリフォームの製造方法であって、
前記多層プリフォームは、少なくとも1つのマイクロファイバー層と、少なくとも1つのナノファイバー層と、を含み、
前記マイクロファイバーの直径が5〜18μmであり、前記ナノファイバーの直径が50〜800μmであり、
前記プリフォームの全ての層の細孔径が5〜100μmであることを特徴とする、プリフォームの製造方法。 - 請求項9において、
前記少なくとも1つのナノファイバー層は220K未満の温度で電界紡糸して得られる、プリフォームの製造方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1036038A NL1036038C (en) | 2008-10-09 | 2008-10-09 | Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof. |
NL1036038 | 2008-10-09 | ||
PCT/NL2009/050611 WO2010041944A1 (en) | 2008-10-09 | 2009-10-09 | Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof. |
Publications (2)
Publication Number | Publication Date |
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JP2012505320A JP2012505320A (ja) | 2012-03-01 |
JP5427891B2 true JP5427891B2 (ja) | 2014-02-26 |
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Application Number | Title | Priority Date | Filing Date |
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JP2011530974A Active JP5427891B2 (ja) | 2008-10-09 | 2009-10-09 | 電界紡糸によって得られる多層プリフォーム及びプリフォームの製造方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9109310B2 (ja) |
EP (1) | EP2334857B1 (ja) |
JP (1) | JP5427891B2 (ja) |
ES (1) | ES2527447T3 (ja) |
NL (1) | NL1036038C (ja) |
WO (1) | WO2010041944A1 (ja) |
Families Citing this family (55)
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ES2645920T3 (es) * | 2008-06-06 | 2017-12-11 | Edwards Lifesciences Corporation | Válvula cardíaca transcatéter de perfil bajo |
US20150265744A1 (en) * | 2008-10-09 | 2015-09-24 | Technische Universiteit Eindhoven | Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
KR101703095B1 (ko) | 2010-06-17 | 2017-02-06 | 워싱톤 유니버시티 | 정렬된 섬유를 포함하는 생의학용 패치 |
EP2458042A1 (en) * | 2010-11-24 | 2012-05-30 | SpinPlant GmbH | Sheet material, method for producing the same and device for carrying out the method |
US9744033B2 (en) | 2011-04-01 | 2017-08-29 | W.L. Gore & Associates, Inc. | Elastomeric leaflet for prosthetic heart valves |
US9554900B2 (en) * | 2011-04-01 | 2017-01-31 | W. L. Gore & Associates, Inc. | Durable high strength polymer composites suitable for implant and articles produced therefrom |
US8945212B2 (en) | 2011-04-01 | 2015-02-03 | W. L. Gore & Associates, Inc. | Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom |
US8961599B2 (en) | 2011-04-01 | 2015-02-24 | W. L. Gore & Associates, Inc. | Durable high strength polymer composite suitable for implant and articles produced therefrom |
US9801712B2 (en) * | 2011-04-01 | 2017-10-31 | W. L. Gore & Associates, Inc. | Coherent single layer high strength synthetic polymer composites for prosthetic valves |
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