JP5412293B2 - ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 - Google Patents

ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 Download PDF

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JP5412293B2
JP5412293B2 JP2009544928A JP2009544928A JP5412293B2 JP 5412293 B2 JP5412293 B2 JP 5412293B2 JP 2009544928 A JP2009544928 A JP 2009544928A JP 2009544928 A JP2009544928 A JP 2009544928A JP 5412293 B2 JP5412293 B2 JP 5412293B2
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antibody
antigen
sequence
seb
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JP2010514459A5 (https=
JP2010514459A (ja
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サス、フィリップ、エム．
ニコライデス、ニコラス、シー．
グラッソ、ルイージ
バーガー、マーク
サイ、タオ
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モルフォテック、インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2009544928A 2007-01-03 2008-01-03 ブドウ球菌エンテロトキシンｂを中和する高親和性抗体 Active JP5412293B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88327107P 2007-01-03 2007-01-03
US60/883,271 2007-01-03
US88840507P 2007-02-06 2007-02-06
US60/888,405 2007-02-06
PCT/US2008/000104 WO2008085878A2 (en) 2007-01-03 2008-01-03 High affinity antibodies that neutralize staphylcoccus enterotoxin b

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013126119A Division JP5881646B2 (ja) 2007-01-03 2013-06-14 ブドウ球菌エンテロトキシンｂを中和する高親和性抗体

Publications (3)

Publication Number Publication Date
JP2010514459A JP2010514459A (ja) 2010-05-06
JP2010514459A5 JP2010514459A5 (https=) 2011-02-24
JP5412293B2 true JP5412293B2 (ja) 2014-02-12

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ID=39529113

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009544928A Active JP5412293B2 (ja) 2007-01-03 2008-01-03 ブドウ球菌エンテロトキシンｂを中和する高親和性抗体
JP2013126119A Active JP5881646B2 (ja) 2007-01-03 2013-06-14 ブドウ球菌エンテロトキシンｂを中和する高親和性抗体
JP2016017809A Active JP6195946B2 (ja) 2007-01-03 2016-02-02 ブドウ球菌エンテロトキシンｂを中和する高親和性抗体

Family Applications After (2)

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JP2013126119A Active JP5881646B2 (ja) 2007-01-03 2013-06-14 ブドウ球菌エンテロトキシンｂを中和する高親和性抗体
JP2016017809A Active JP6195946B2 (ja) 2007-01-03 2016-02-02 ブドウ球菌エンテロトキシンｂを中和する高親和性抗体

Country Status (9)

Country Link
US (6) US8236932B2 (https=)
EP (2) EP2109622B1 (https=)
JP (3) JP5412293B2 (https=)
AU (1) AU2008205376B2 (https=)
CA (2) CA2924155C (https=)
DK (1) DK2109622T3 (https=)
ES (1) ES2619943T3 (https=)
PL (1) PL2109622T3 (https=)
WO (1) WO2008085878A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8236932B2 (en) 2007-01-03 2012-08-07 Morphotek, Inc. High affinity antibodies that neutralize Staphylococcus enterotoxin B
US20110166076A1 (en) * 2008-09-10 2011-07-07 Bac Ip B.V. Antigen-binding proteins that inhibit superantigens for the treatment of skin diseases
WO2013089877A2 (en) * 2011-09-27 2013-06-20 Albert Einstein College Of Medicine Of Yeshiva University Adjuvant therapy for staphylococcal infection with enterotoxin specific mabs
CN103946236B (zh) * 2011-11-23 2018-02-16 弗·哈夫曼-拉罗切有限公司 表达cd40l的哺乳动物细胞及其用途
US20160039914A1 (en) * 2013-03-14 2016-02-11 Albert Einstein College Of Medicine Of Yeshiva University Humanized antibodies specific for staphylococcal enterotoxin b
EP3532497B1 (en) * 2016-10-26 2024-07-24 The Board of Trustees of the Leland Stanford Junior University Modified immunoglobulin hinge regions to reduce hemagglutination
US20230192896A1 (en) * 2016-11-23 2023-06-22 Bioverativ Therapeutics Inc. Bispecific antibodies binding to coagulation factor ix and coagulation factor x
KR102124258B1 (ko) * 2018-10-19 2020-06-26 대한민국(관리부서 질병관리본부장) 신속 면역크로마토그래피법을 이용한 황색 포도알균 장독소 b 진단·탐지 키트 및 이를 위한 특이항체와 항체생산세포주
EP4051711A4 (en) * 2019-11-01 2024-02-21 Magenta Therapeutics, Inc. ANTI-CD45 ANTIBODIES AND THEIR CONJUGATES
KR102274759B1 (ko) * 2020-01-16 2021-07-09 대한민국(질병관리청장) 황색포도알균 장독소 b에 특이적인 항체 및 이의 용도
CN119101153B (zh) * 2024-04-30 2025-07-08 中国人民解放军军事科学院军事医学研究院 一种葡萄球菌肠毒素b纳米抗体及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2574089A (en) 1948-06-08 1951-11-06 Cochran Jacqueline Luggage case having a removable lining
US4854432A (en) 1988-07-06 1989-08-08 American Tourister, Inc. Suitcase having removable divider with clothing pockets
US6713610B1 (en) * 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
CA2194450A1 (en) 1994-07-06 1996-01-18 Truckin' Movers Corporation Convertible carrying case and work platform
US6036697A (en) 1998-07-09 2000-03-14 Scimed Life Systems, Inc. Balloon catheter with balloon inflation at distal end of balloon
CA2345023A1 (en) 1998-10-07 2000-04-13 The Rockefeller University Peptides useful for reducing symptoms of toxic shock syndrome and septic shock
EP1532175B1 (en) 2002-03-22 2012-10-17 Aprogen, Inc. Humanized antibody and process for preparing the same
US20050240009A1 (en) 2002-08-21 2005-10-27 Carr Francis J T-cell epitopes in staphylococcal enterotoxin b
WO2005023853A1 (ja) * 2003-09-05 2005-03-17 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute プロテアーゼ耐性ｓｅｂ改変体およびそれを含むワクチン
CA2596925C (en) 2005-02-08 2017-07-04 Km Biologics Co., Ltd. Method for improving expression level and stability of antibody
WO2007141274A2 (en) * 2006-06-06 2007-12-13 Crucell Holland B.V. Human binding molecules having killing activity against staphylococci and uses thereof
US8236932B2 (en) * 2007-01-03 2012-08-07 Morphotek, Inc. High affinity antibodies that neutralize Staphylococcus enterotoxin B

Also Published As

Publication number Publication date
CA2924155A1 (en) 2008-07-17
EP3138852A1 (en) 2017-03-08
PL2109622T3 (pl) 2017-06-30
WO2008085878A2 (en) 2008-07-17
AU2008205376A1 (en) 2008-07-17
CA2674382C (en) 2016-05-31
US20170121396A1 (en) 2017-05-04
EP2109622A2 (en) 2009-10-21
US9868780B2 (en) 2018-01-16
DK2109622T3 (en) 2017-02-13
US8236932B2 (en) 2012-08-07
US8895704B2 (en) 2014-11-25
AU2008205376B2 (en) 2012-07-12
US20150050276A1 (en) 2015-02-19
JP2013216673A (ja) 2013-10-24
US20180094048A1 (en) 2018-04-05
US8889846B2 (en) 2014-11-18
US20130183314A1 (en) 2013-07-18
WO2008085878A3 (en) 2009-02-26
CA2674382A1 (en) 2008-07-17
JP5881646B2 (ja) 2016-03-09
JP2016146824A (ja) 2016-08-18
US20120171223A1 (en) 2012-07-05
EP2109622B1 (en) 2016-11-09
US9359428B2 (en) 2016-06-07
JP6195946B2 (ja) 2017-09-13
US10364284B2 (en) 2019-07-30
JP2010514459A (ja) 2010-05-06
CA2924155C (en) 2020-02-11
ES2619943T3 (es) 2017-06-27
US20140072553A1 (en) 2014-03-13

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