JP5411847B2 - Ｗｅｅｌキナーゼインヒビターとしてのジヒドロピラゾロピリミジノン誘導体の多形 - Google Patents

Ｗｅｅｌキナーゼインヒビターとしてのジヒドロピラゾロピリミジノン誘導体の多形 Download PDF

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JP5411847B2
JP5411847B2 JP2010506227A JP2010506227A JP5411847B2 JP 5411847 B2 JP5411847 B2 JP 5411847B2 JP 2010506227 A JP2010506227 A JP 2010506227A JP 2010506227 A JP2010506227 A JP 2010506227A JP 5411847 B2 JP5411847 B2 JP 5411847B2
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anticancer
compound
cancer
salt
agent
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JP2010525057A (ja
JP2010525057A5 (enExample
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雅史 川崎
裕夫 水野
俊浩 坂本
公正 鈴木
マキューン，アーリーン，イー
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010506227A 2007-04-25 2008-04-22 Ｗｅｅｌキナーゼインヒビターとしてのジヒドロピラゾロピリミジノン誘導体の多形 Active JP5411847B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010506227A JP5411847B2 (ja) 2007-04-25 2008-04-22 Ｗｅｅｌキナーゼインヒビターとしてのジヒドロピラゾロピリミジノン誘導体の多形

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007115448 2007-04-25
JP2007115448 2007-04-25
US18507P 2007-10-24 2007-10-24
US61/000,185 2007-10-24
PCT/US2008/005155 WO2008133866A1 (en) 2007-04-25 2008-04-22 Polymorph of dihydropyrazolopyrimidinone derivative as weel kinase.inhibitor
JP2010506227A JP5411847B2 (ja) 2007-04-25 2008-04-22 Ｗｅｅｌキナーゼインヒビターとしてのジヒドロピラゾロピリミジノン誘導体の多形

Publications (3)

Publication Number Publication Date
JP2010525057A JP2010525057A (ja) 2010-07-22
JP2010525057A5 JP2010525057A5 (enExample) 2011-06-30
JP5411847B2 true JP5411847B2 (ja) 2014-02-12

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JP2010506227A Active JP5411847B2 (ja) 2007-04-25 2008-04-22 Ｗｅｅｌキナーゼインヒビターとしてのジヒドロピラゾロピリミジノン誘導体の多形

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Country Link
US (1) US8198281B2 (enExample)
EP (1) EP2155752B1 (enExample)
JP (1) JP5411847B2 (enExample)
WO (1) WO2008133866A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2477628B1 (en) 2009-09-15 2014-08-20 Merck Sharp & Dohme Corp. Preparation of crystalline hemihydrate forms of dihydropyrazolopyrimidinone
CN102311443B (zh) * 2011-08-24 2014-07-16 上海北卡医药技术有限公司 盐酸伊立替康的新晶型及其制备方法
WO2013039854A1 (en) 2011-09-15 2013-03-21 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
RS56680B1 (sr) 2012-11-28 2018-03-30 Merck Sharp & Dohme Kompozicije i postupci za lečenje kancera
GB201322602D0 (en) 2013-12-19 2014-02-05 Almac Discovery Ltd Pharmaceutical compounds
JP2015214524A (ja) * 2014-05-13 2015-12-03 国立大学法人鳥取大学 増感剤、抗がん剤、および超音波を用いたがん治療
ES2851499T3 (es) * 2015-12-30 2021-09-07 Synthon Bv Proceso para fabricar una forma cristalina de gefitinib
EP3411039B1 (en) 2016-02-02 2020-06-24 The Regents of The University of Michigan Mercaptopurine hemihydrate
GB201612092D0 (en) 2016-07-12 2016-08-24 Almac Discovery Ltd Pharmaceutical compounds
JP6717457B2 (ja) 2017-01-23 2020-07-01 シージャーズォアン サガシティ ニュー ドラッグ デベロップメント カンパニー リミテッド Ｗｅｅ１阻害剤としての１，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン誘導体
SG11202003974XA (en) 2017-11-01 2020-05-28 Shijiazhuang Sagacity New Drug Development Co Ltd Macrocyclic compound serving as weel inhibitor and applications thereof
WO2019165204A1 (en) 2018-02-23 2019-08-29 Newave Pharmaceutical Inc. 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidine-3-one compounds as inhibitors of wee-1 kinase
US12318452B2 (en) 2018-09-27 2025-06-03 Dana-Farber Cancer Institute, Inc. Degraders of WEE1 kinase
US12180184B2 (en) 2018-10-26 2024-12-31 Wuxi Biocity Biopharmaceutics Co., Ltd. Pyrimidopyrazolone derivative as Wee1 inhibitor and use thereof
KR102697799B1 (ko) * 2019-03-22 2024-08-23 쇼우야오 홀딩스 (베이징) 코., 엘티디. Wee1 억제제 및 이의 제조 및 용도
SI3964510T1 (sl) 2019-04-30 2024-10-30 Wuxi Biocity Biopharmaceutics Co., Ltd. Kristalna oblika WEE1 inhibitorske spojine in njena uporaba
EP4048277A1 (en) 2019-10-25 2022-08-31 Astrazeneca AB Methods of treating cancer
CA3165477A1 (en) * 2019-12-20 2021-06-24 Recurium Ip Holdings, Llc Combinations
US20230065577A1 (en) * 2019-12-20 2023-03-02 Recurium Ip Holdings, Llc Combinations
CA3180664A1 (en) 2020-06-17 2021-12-23 Yuli Xie Pyrazolo[3,4-d]pyrimidine-3-one derivative as wee-1 inhibitor
JP7805372B2 (ja) * 2021-03-26 2026-01-23 オルファゲン ファーマシューティカルズ，インク． ピラゾロピリミジノン化合物
KR20240004539A (ko) 2021-04-30 2024-01-11 위겐 바이오메더슨 테크널러지 (상하이) 컴퍼니 리미티드 Wee-1 억제제로서의 축합 고리 화합물, 그를 위한 제조 방법 및 그의 용도
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
CN116462687B (zh) 2022-01-18 2025-01-07 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
CN117402162A (zh) 2022-07-13 2024-01-16 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091255A1 (en) * 2002-04-26 2003-11-06 Warner-Lambert Company Llc Inhibitors of checkpoint kinases (wee1 and chk1)
PE20080695A1 (es) * 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel

Also Published As

Publication number Publication date
JP2010525057A (ja) 2010-07-22
WO2008133866A1 (en) 2008-11-06
US20100124544A1 (en) 2010-05-20
US8198281B2 (en) 2012-06-12
EP2155752A1 (en) 2010-02-24
EP2155752B1 (en) 2018-09-19

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