JP5373381B2 - Cosmetic composition and cosmetic treatment method using the cosmetic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oleosome-blended cosmetic capable of stably dispersing fine oil droplets in an aqueous phase for a long period of time even in the case that ascorbic acid or its derivative exists in the aqueous phase. <P>SOLUTION: This cosmetic composition having an oil in water type emulsion form having an oil phase dispersing in an aqueous phase is provided by containing (a) the oil, (b) water, (c) at least one lipophilic surfactant, (d) at least one ether type nonionic hydrophilic surfactant, (e) at least one alkali 10C-22C acyl glutamate and (f) ascorbic acid or its derivative, wherein, the oil phase is covered by at least one layer consisting of (c) the lipophilic surfactant, (d) an ether type nonionic hydrophilic surfactant and (e) alkali 10C-22C acyl glutamate, and the component (f) exists in the aqueous phase. <P>COPYRIGHT: (C)2010,JPO&amp;INPIT

Description

  The present invention relates to a cosmetic composition in the form of an oil-in-water emulsion with improved stability, and a cosmetic treatment method using the cosmetic composition.

  An oleosome means an oil droplet covered with a mono- or oligolamellar liquid crystal layer, and cosmetic products having the form of an oil-in-water emulsion in which the oleosome is dispersed in an aqueous phase are known. And as a substance which comprises the said liquid-crystal layer, the combination of a lipophilic surfactant, a hydrophilic surfactant, and another component is mentioned, for example.

  Oleosome has a barrier function, a moistening effect, and a penetration-promoting effect, and cosmetics that exhibit an excellent cosmetic effect using these functions and effects have been proposed.

  For example, JP-A-7-165530 discloses an oil containing a lipophilic surfactant, a hydrophilic surfactant, and a lipophilic active ingredient such as vitamin E coated with a monolamellar layer or an oligolamellar layer made of a fatty acid. Cosmetics in the form of an oil-in-water emulsion in which the drops are dispersed in the aqueous phase are disclosed.

  JP-A-8-127526 discloses oil droplets coated with a monolamellar layer or an oligolamellar layer composed of a lipophilic surfactant, a hydrophilic surfactant, and an ionic amphiphilic lipid in an aqueous phase. Cosmetics in the form of dispersed oil-in-water emulsions are disclosed.

Each of the above publications describes that a hydrophilic active ingredient can be contained in the aqueous phase, but there is a description or suggestion about the use of a whitening ingredient such as ascorbic acid. Absent.
JP-A-7-165530 JP-A-8-127526

  By the way, pigmentation of skin spots, freckles, etc. is caused by abnormal secretion of hormones, ultraviolet rays, inflammation, etc., which activates the melanin production signal transmission circuit in the epidermis pigment cells and produces tyrosinase, which is the main enzyme producing melanin. This occurs because melanin is excessively deposited in the epidermis due to the increased expression.

  Conventionally, ascorbic acid, ascorbic acid glucoside and other ascorbic acid derivatives, kojic acid, ellagic acid, resorcin and its derivatives, and other whitening components are applied to the skin as a countermeasure against such pigmentation. Used as an active ingredient in cosmetics.

Therefore, the present inventors have intensively studied cosmetics containing oleosomes together with whitening components such as ascorbic acid or ascorbic acid derivatives, but when using ascorbic acid or ascorbic acid derivatives as whitening components, the lipophilic interface as an oleosome constituent component with those ester type together with the active agent and C ₁₀ -C ₂₂ acyl glutamic acid alkali salt as a hydrophilic surfactant, not able to fine oil droplets dispersed stably in the aqueous phase for a long period of time, It was found that the oil droplets coalesce and become unstable.

  Therefore, an object of the present invention is to provide an oleosome-containing cosmetic that allows fine oil droplets to be stably dispersed in an aqueous phase over a long period of time even when ascorbic acid or a derivative thereof is added. There is.

The objects of the present invention are achieved by constructing oleosomes using a new surfactant system. That is, an object of the present invention is a cosmetic composition in the form of an oil-in-water emulsion having an oil phase dispersed in an aqueous phase,
(A) oil;
(B) water;
(C) at least one lipophilic surfactant;
(D) at least one ether-type nonionic hydrophilic surfactant;
(E) at least one C ₁₀ -C ₂₂ acyl glutamic acid alkali salt; and (f) ascorbic acid or a derivative thereof,
The oil phase is coated with at least one layer comprising (c) a lipophilic surfactant, (d) an ether type nonionic hydrophilic surfactant, and (e) an alkali salt of C ₁₀ -C ₂₂ acyl glutamate. ,
This is achieved by a cosmetic composition in which the component (f) is present in the aqueous phase.

  The (c) lipophilic surfactant preferably has 2-5 HLB. Said (c) lipophilic surfactant having an HLB of 2-5 is preferably sucrose distearate, sucrose tristearate, diglyceryl distearate, tetraglyceryl tristearate, decaglyceryl decastearate , Diglyceryl monostearate, hexaglyceryl tristearate, decaglyceryl pentastearate, sorbitan monostearate, sorbitan tristearate, diethylene glycol monostearate, glyceryl ester of palmitic acid and stearic acid, polyoxyethylene monostearate 2EO (having two ethylene oxide units), mono- and glyceryl dibehenate, and pentaerythritol tetrastearate.

The (d) ether type nonionic hydrophilic surfactant preferably has 8 to 13 HLB. Said (d) ether type nonionic hydrophilic surfactant having 8-13 HLB is preferably polyethylene glycol and optionally propylene glycol and mono- or poly (C ₁₂ -C ₂₂ ) saturated or unsaturated alcohols An ether of 2 to 20 ethylene oxide units and optionally 1 to 10 propylene oxide units; an ether of beeswax and ethoxylated sorbitan having 5 to 25 ethylene oxide units; 5 to 30 ethylene oxides An ether of polyethylene glycol and cholesterol having units; and an alkylpolyglucoside having an alkyl group containing 12 to 20 carbon atoms.

The (e) at least one C ₁₀ -C ₂₂ acyl glutamic acid alkali salt is preferably an alkali salt of stearoyl glutamate.

The total amount of (c) lipophilic surfactant, (d) ether type nonionic hydrophilic surfactant, and (e) alkali salt of C ₁₀ -C ₂₂ acyl glutamate is based on the total weight of the composition. 1 to 6% by weight is preferable.

Wherein (c) a lipophilic surfactant, the (d) ether type non-ionic hydrophilic surfactant, and the ratio of the amount of said (e) C ₁₀ -C ₂₂ acyl glutamic acid alkali salt, the (c 35) to 70% by weight based on the total weight of the lipophilic surfactant, (d) the ether type nonionic hydrophilic surfactant, and (e) the alkali salt of C ₁₀ -C ₂₂ acyl glutamate It is preferably 25 to 40% by weight / 5 to 35% by weight.

  The amount of the (a) oil is preferably 5 to 50% by weight based on the total weight of the composition.

  The weight ratio of (a) oil / (b) water is preferably 1 or less.

  The amount of the component (f) is preferably 0.01 to 20% by weight based on the total weight of the composition.

  The diameter of the oil droplets composed of the oil phase is preferably less than 1000 nm. Moreover, it is preferable that the oil droplet which consists of the said oil phase is coat | covered with two or more layers.

  The cosmetic composition can be suitably used for whitening. Accordingly, the present invention also relates to a method for cosmetic treatment of keratin materials comprising applying the above cosmetic composition to keratin materials. The keratin material is preferably skin.

  In the cosmetic composition of the present invention, even though ascorbic acid or a derivative thereof is blended in the aqueous phase, the oil droplets do not coalesce and become unstable, and fine oil droplets remain for a long time. Can exist stably. Therefore, according to the present invention, a cosmetic in which a fine oil phase is uniformly dispersed in an aqueous phase can be obtained.

  Further, in the cosmetic composition of the present invention and the cosmetic treatment method using the cosmetic composition, in addition to the whitening effect possessed by ascorbic acid or a derivative thereof, the barrier function, the wetting effect, and the penetration promoting effect possessed by the oleosome are utilized. And effective cosmetic treatment.

In the oleosome-containing oil-in-water emulsion, when ascorbic acid or a derivative thereof is present in the aqueous phase, the present invention provides a lipophilic surfactant, an ether-type nonionic hydrophilic surfactant, and C ₁₀ −. When constituting the lamellar layer of oleosomes using a combination of C ₂₂ acyl glutamic acid alkali salts, oleosomes are present in stable aqueous, based on a novel finding that a fine oil phase is maintained over a long term.

Therefore, the cosmetic composition of the present invention comprises a lamella comprising a combination of a lipophilic surfactant, an ether type nonionic hydrophilic surfactant, and a C ₁₀ -C ₂₂ acyl glutamic acid alkali salt together with the ascorbic acid or a derivative thereof. An oleosome having a layer is essential. In addition, when an ester type nonionic hydrophilic surfactant is used instead of an ether type nonionic hydrophilic surfactant, the oleosome is destabilized. Therefore, the cosmetic composition of the present invention does not use an ester-type nonionic hydrophilic surfactant.

  The oleosome blended in the cosmetic composition of the present invention includes an oil phase (oil droplets) covered with a lamellar or thin-film liquid crystal layer, and has a monolamellar liquid crystal layer or an oligolamellar liquid crystal layer. The monolamella layer means one lamella layer, and the oligolamella layer means two or more, preferably 2 to 5 lamella layers.

  The average diameter of the oil droplets composed of the oil phase is less than 1000 nm, preferably less than 800 nm, more preferably less than 500 nm. The gap between internal keratinocytes in the skin is relatively large, whereas oleosomes are small in size, so that oleosomes can penetrate the skin well.

The liquid crystal layer (liquid crystal film) comprises a combination of at least one lipophilic surfactant, at least one ether type nonionic hydrophilic surfactant, and at least one C ₁₀ -C ₂₂ acyl glutamic acid alkali salt.

  As the lipophilic surfactant, any surfactant can be used as long as it is lipophilic, but preferably has an HLB (hydrophilic-lipophilic balance) of 2 to 5. Examples of lipophilic surfactants having an HLB of 2 to 5 include sucrose distearate, sucrose tristearate, diglyceryl distearate, tetraglyceryl tristearate, decaglyceryl decastearate, monostearic acid Diglyceryl, hexaglyceryl tristearate, decaglyceryl pentastearate, sorbitan monostearate, sorbitan tristearate, diethylene glycol monostearate, glyceryl ester of palmitic acid and stearic acid, polyoxyethylene 2EO monostearate (ethylene oxide unit) 1 or 2 selected from the group consisting of mono- and glyceryl dibehenate and pentaerythritol tetrastearate. As the lipophilic surfactant, sucrose tristearate is particularly preferable. The said lipophilic surfactant may be used independently and may be used as a 2 or more types of mixture.

The ether type nonionic hydrophilic surfactant used in the present invention is a nonionic and hydrophilic surfactant having an ether moiety. As the ether type nonionic hydrophilic surfactant, those having an HLB of 8 to 13 are preferable. Examples of ether type nonionic hydrophilic surfactants having an HLB of 8 to 13 include ethers of polyethylene glycol and optionally propylene glycol and mono- or poly (C ₁₂ -C ₂₂ ) saturated or unsaturated alcohols. An ether having 2 to 20 ethylene oxide units and optionally 1 to 10 propylene oxide units; an ether of beeswax and ethoxylated sorbitan having 5 to 25 ethylene oxide units; having 5 to 30 ethylene oxide units; And one or more selected from the group consisting of an ether of polyethylene glycol and cholesterol; and an alkyl polyglucoside having an alkyl group containing 12 to 20 carbon atoms. The ether type nonionic hydrophilic surfactant may be used alone or as a mixture of two or more.

Propylene glycol and monomethyl polyethylene glycol and optionally - or poly A ether with (C _{12 -C 22)} saturated or unsaturated alcohols, ethers having ethylene oxide units and optionally 1 to 10 propylene oxide units having 2 to 20 For example,
Polyethylene glycol ether of stearyl alcohol (INCI name; steareth-8 or steareth-10) having 8 or 10 ethylene oxide units, commercially available as EMALEX 608 from Nippon Emulsion Co., Ltd. or BRIJ 76 from Croda.
Polyethylene glycol ether of cetyl alcohol (INCI name: ceteth-7) having 7 ethylene oxide units commercially available as NIKKOL BC-7 manufactured by Nikko Chemicals Co., Ltd. or EMALEX107 manufactured by Nihon Emulsion Co., Ltd .:
Polyethylene glycol ether of cetyl alcohol having 10 ethylene oxide units (INCI name: ceteth-10), commercially available as Croda BRIJ 56 or NIKKOL BC-10 manufactured by Nikko Chemicals Corporation:
It is commercially available as EMALEX703 manufactured by Japan Emulsion Co., Ltd. or Dehydol LS3DEON manufactured by Cognis,
Polyethylene glycol ether of lauryl alcohol having 3 ethylene oxide units (INCI name: Laureth-3):
Polyethylene glycol ether of tridecyl alcohol having 6 ethylene oxide units (INCI name: Trideceth-6), commercially available as RENEX 36 from ICI Surfactant:
Polyethylene glycol ether of oleyl alcohol having 10 ethylene oxide units (INCI name; Ores-10), commercially available as Croda VOLPO 10 or Nikkol BO-10 from Nikko Chemicals:
Polyethylene glycol ether of behenyl alcohol having 10 ethylene oxide units (INCI name; Behenes-10), commercially available as NIKKOL BB-10 manufactured by Nikko Chemicals Co., Ltd .:
Polyethylene glycol / polypropylene glycol ether of cetyl alcohol having one ethylene oxide unit and four propylene oxide units (INCI name; PPG-4-ceteth-1), which is commercially available as NIKKOL PBC-31 manufactured by Nikko Chemicals Co., Ltd. :
Polyethylene glycol ether of cetylstearyl alcohol having 5 ethylene oxide units (INCI name; ceteares-5), commercially available as VOLPO CS 5 from Croda or Jeecol CS-5 from Jeen International Corporation: and Nikko Chemicals ( Polyethylene glycol / polypropylene glycol ether of cetyl alcohol having 10 ethylene oxide units and 4 propylene oxide units (INCI name; PPG-4-ceteth-10) commercially available as NIKKOL PBC-33 manufactured by
Etc.

Examples of ethers of beeswax and ethoxylated sorbitan having 5 to 25 ethylene oxide units include:
Solves-6 bead wax marketed as GBW-25 manufactured by Nikko Chemicals Co., Ltd., and Solves-20 bees wax marketed as GBW-125 manufactured by Nikko Chemicals Co., Ltd.

Examples of ethers of polyethylene glycol and cholesterol having 5 to 30 ethylene oxide units include:
One having 10 ethylene oxide units (INCI name; Cores-10), commercially available as EMALEX CS-10 manufactured by Nippon Emulsion Co., Ltd .:
A product having 15 ethylene oxide units (INCI name; Cores-15) commercially available as EMALEX CS-15 manufactured by Nippon Emulsion Co., Ltd .:
A product having 20 ethylene oxide units (INCI name; Cores-20) commercially available as EMALEX CS-20 manufactured by Nippon Emulsion Co., Ltd .:
A product having 24 ethylene oxide units (INCI name: Cores-24), commercially available as EMALEX CS-24 manufactured by Nippon Emulsion Co., Ltd.
Etc.

Alkyl polyglucosides having alkyl groups containing 12 to 20 carbon atoms are obtained by condensation of C _{12 to} C ₂₀ alcohols with glucose. As said alkyl polyglucoside, what has 12-18 carbon atoms is preferable, and what has 1-3 glucoside parts which are hydrophilic groups is preferable. Examples of the alkyl polyglucoside include Montanov L (mixture of C ₁₂ -C ₂₀ alkyl glucoside and C ₁₄ -C ₂₂ alcohol 20/80) manufactured by Seppic. Another example is caprylyl / capryl glucoside, which is commercially available as Oramix CG100 manufactured by Seppic. As yet another example, Montanov 68 manufactured by Seppic (a mixture of cetyl stearyl glucoside, cetyl alcohol and stearyl alcohol (12/46/42)) or Tegocare CG90 manufactured by Degusaa Care & Surface Specialities is commercially available. And cetearyl glucoside. Still another example is myristyl glucoside which is commercially available as Montanov 14 (mixture of myristyl glucoside and myristyl alcohol) manufactured by Seppic. Yet another example is lauryl glucoside, which is commercially available as Plantaren 1200N from Cognis. Still other examples include stearyl glucoside and cetyl glucoside manufactured by Aldrich.

Ether type nonionic hydrophilic surfactants are ethers of polyethylene glycol and optionally propylene glycol and mono- or poly (C ₁₂ -C ₂₂ ) saturated or unsaturated alcohols, 2 to 20 ethylene oxide units And optionally ethers having 1 to 10 propylene oxide units are preferred, and polyethylene glycol ethers of stearyl alcohol having 8 or 10 ethylene oxide units are more preferred.

Examples of the C ₁₀ -C ₂₂ acyl glutamic acid alkali salt include sodium salt, potassium salt and lithium salt of C ₁₀ -C ₂₂ acyl glutamic acid, and sodium salt is preferable. Examples of the C ₁₀ -C ₂₂ acyl glutamic acid include stearoyl glutamate, lauroyl glutamate, palmitoyl glutamate, cocoyl glutamate, and hydrogenated beef tallow. Preferable C ₁₀ -C ₂₂ acyl glutamic acid alkali salt is sodium salt of stearoyl glutamate, disodium salt of stearoyl glutamate, potassium salt of stearoyl glutamate, sodium salt of lauroyl glutamate, disodium salt of lauroyl glutamate, potassium salt of lauroyl glutamate, A sodium salt of glutamic acid cocoyl, a sodium salt of glutamic acid hydrogenated beef tallow, and a mixture thereof. The sodium salt of stearoyl glutamate is more preferred. The sodium salt of stearoyl glutamate is commercially available, for example, under the name Amisoft HS11P from Ajinomoto Co., Inc., and the disodium salt of stearoyl glutamate is commercially available, for example, under the name Amisoft HS21 (P) from Ajinomoto Co., Inc. ing. The C ₁₀ -C ₂₂ acyl glutamic acid alkali salts may be used alone or may be used as a mixture of two or more.

The total amount of (c) lipophilic surfactant, (d) ether type nonionic hydrophilic surfactant, and (e) alkali salt of C ₁₀ -C ₂₂ acyl glutamate is based on the total weight of the composition. 1 to 6% by weight is preferable, and 2 to 4% by weight is more preferable.

Wherein (c) a lipophilic surfactant, the (d) ether type non-ionic hydrophilic surfactant, and the ratio of the amount of said (e) C ₁₀ -C ₂₂ acyl glutamic acid alkali salt, the (c 35) to 70% by weight based on the total weight of the lipophilic surfactant, (d) the ether type nonionic hydrophilic surfactant, and (e) the alkali salt of C ₁₀ -C ₂₂ acyl glutamate It is preferably 25 to 40% by weight / 5 to 35% by weight.

  Arbitrary oil can be used as said (a) oil. The oil is preferably liquid. Here, “liquid” means liquid or paste (non-solid) at room temperature (25 ° C.) and atmospheric pressure (760 mmHg). As the liquid oil, generally, oils used in cosmetics can be used alone or in combination.

  The oil may be a non-polar oil such as a hydrocarbon oil or silicone oil; a polar oil such as a vegetable oil or an ester oil; or a mixture thereof.

  Hydrocarbon oils include, for example, mineral oil (liquid paraffin), straight chain or branched hydrocarbons such as liquid petrolatum, liquid naphthalene, hydrogenated polyisobutene, isoeicosane, squalane, squalene, and decene / butene copolymer, and , And mixtures thereof.

  Examples of silicone oils include, for example, chain organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, dimethicone, diphenylsiloxyphenyltrimethicone, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, Examples thereof include cyclic organopolysiloxanes such as dodecamethylcyclohexasiloxane and cyclohexasiloxane, and mixtures thereof.

  Examples of vegetable oils include linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil, sesame oil, Examples include soybean oil, peanut oil, meadow foam oil, and mixtures thereof.

  Examples of ester oils include diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octoate, octyldodecyl octoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2-ethylhexanoate. , 2-ethylhexyl octanoate, 2-ethylhexyl caprylate / caprate, methyl palmitate, ethyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isodecyl oleate, tri-2-ethylhexanoic acid Glyceryl, pentaerythrityl tetra-2-ethylhexanoate, 2-ethylhexyl succinate, diethyl sebacate, isopropyl myristate, isopyl palmitate Pills, dicaprylyl carbonate, isononyl isononanoate, octyl isononanoate, and tridecyl isononanoate and the like. Examples include isopropyl myristate, triethylhexanoin, diisostearyl maleate, glyceryl palmitate, glyceryl stearate, glyceryl diisostearate, glyceryl tri (capryl / capric acid), sorbitan isostearate, sorbitan stearate, sorbitan oleate, etc. . Examples include triethylhexanoin and diisostearyl maleate, neopentylene glycol dicaprate, and mixtures thereof.

  As said oil, what has polarity as a whole is preferable. Therefore, polar oils or mixtures of polar and nonpolar oils are preferred. In particular, polar oils such as tri (capryl / capric acid) glyceryl are preferred.

  The amount of the oil is preferably 5 to 50% by weight, more preferably 10 to 40% by weight, based on the total weight of the composition.

  In addition to the oil (a), the oil phase constituting the cosmetic composition of the present invention further includes fatty acids such as stearic acid and myristic acid, higher alcohols such as cetyl alcohol, stearyl alcohol, and octyldodecanol. An oily component may be included.

  The oil phase contains 0.01 to 15% by weight, preferably 0.1 to 10% by weight, more preferably 0.5 to 5% by weight, based on the total weight of the composition, of the other oil components. But you can.

  1-15 are preferable and, as for the weight ratio of the oil phase with respect to the component which comprises the coating layer of an oil phase, 5-15 are more preferable.

  Arbitrary water can be used as said (b) water. The water may be aromatic distilled water such as cornflower water and / or mineral water such as Vittel water, Lucas water, La Roche Posay water, and / or Seawater such as hot spring water and / or deep seawater may be used.

  The amount of water is preferably 50 to 95% by weight, more preferably 60 to 90% by weight, based on the total weight of the composition. The weight ratio of (a) oil / (b) water is preferably 1 or less.

  The aqueous phase constituting the cosmetic composition of the present invention may further contain a water-miscible medium in addition to the water (b). As the water-miscible medium, an organic solvent miscible with water (water-miscible organic solvent) at room temperature (25 ° C.) can be used.

Examples of the organic solvent miscible with water at room temperature (25 ° C.) include the following.
Monoalcohols having 2 to 6 carbon atoms such as ethanol and isopropanol;
Polyols having 2 to 20 carbon atoms, preferably 2 to 10 carbon atoms, more preferably 2 to 6 carbon atoms, such as glycerin, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, di- Propylene glycol and diethylene glycol;
Glycol ethers (especially those having carbon atoms of 3 to 16), (e.g., mono -, di -, (C ₁ -C ₄₎ alkyl ethers of tripropylene glycol, and mono -, di -, tri (C ₁ -C ₄ ) alkyl ethers of ethylene glycol); and mixtures thereof.

  The aqueous phase may contain the water-miscible organic solvent in an amount of 0.1 to 30% by weight, preferably 5 to 25% by weight, more preferably 10 to 20% by weight, based on the total weight of the composition.

  Said (f) ascorbic acid or its derivative exists in the said water phase which comprises the cosmetic composition of this invention. Therefore, the component (f) in the present invention is a water-soluble whitening component. Here, the “whitening component” means a component that effectively decolorizes and / or whitens human skin. In particular, human skin that has a stain due to brown pigment due to external factors, or a stain due to internal factors such as aging, or a human who intends to counter the onset of brown coloring due to melanin production after UV irradiation, etc. Applied to the skin. Ascorbic acid or its derivatives have the common property of being water-soluble and show similar behavior. As ascorbic acid or a derivative thereof, a single type may be used, or a mixture of two or more types may be used.

  Ascorbic acid has D or L form, and L form is used preferably. Ascorbic acid is also called vitamin C, and has a melanin production inhibitory action due to its strong reducing action. The derivative of ascorbic acid may be a salt of ascorbic acid, and the salt of ascorbic acid is preferably selected from sodium ascorbate, magnesium ascorbyl phosphate, and sodium ascorbyl phosphate. The derivative of ascorbic acid may be a glycoside of ascorbic acid or an ester of ascorbic acid. Examples of the glycoside of ascorbic acid include ascorbyl glucoside. Examples of the ester of ascorbic acid include silyl ester of ascorbic acid, tocopheryl ester of ascorbic acid, and alkyl ester of ascorbic acid. As an alkyl ester of ascorbic acid, preferably, ascorbic acid methyl ester or ascorbic acid ethyl ester can be used. In particular, ascorbic acid or ascorbyl glucoside is preferred.

Ascorbic acid includes Ascorbic Acid Fine Powder (\ t “new” DSM Nutritional Products, Inc. ). As a derivative of ascorbic acid, specifically, for example, 5,6-di-O-dimethylsilylascorbate commercially available under the name PRO-AA from Exsymol; commercially available under the name SEPIVITAL EPC from Senju Pharmaceutical Co., Ltd. Dl-α-tocopheryl-2-l-ascorbyl phosphate; sodium ascorbyl phosphate commercially available under the name Stay-C50 from Roche; ascorbyl glucoside commercially available from Hayashibara Biochemical Research Institute; Nippon Fine Chemical Co., Ltd. Examples include 3-O-ethylascorbic acid manufactured by the company.

  Ascorbic acid or a derivative thereof is preferably used in combination with a copolymer of maleic anhydride and styrene. In particular, it is preferable that at least a part of the maleic anhydride unit of the copolymer is hydrolyzed. The hydrolyzed maleic anhydride unit may be in the form of an alkali salt such as sodium salt, potassium salt or lithium salt. The maleic anhydride unit preferably occupies 0.4 to 0.9 mole of the entire copolymer as 1 mole, and the maleic anhydride unit and the styrene unit are preferably in a ratio of 50:50. . In particular, the maleic anhydride unit and the styrene unit are preferably 50:50 and are in the form of ammonium salt or sodium salt. By using in combination with the copolymer, the stability of ascorbic acid or a derivative thereof is improved. The copolymer may be, for example, a copolymer of styrene / maleic anhydride (50/50) in the form of 30% ammonium salt in water, commercially available as part number SMA1000H® from Clay Valley, or part number SMA1000HNa from Clay Valley. A commercially available styrene / maleic anhydride (50/50) copolymer in the form of a 40% sodium salt in water can be used. The copolymer is preferably used at a concentration of 0.1 to 20% by weight, preferably 0.1 to 10% by weight, based on the total weight of the cosmetic composition.

  The blending amount of the component (f) in the cosmetic composition of the present invention is not particularly limited, but is usually 0.01 to 20% by weight, preferably 0. 0% based on the total weight of the composition. 5 to 15% by weight, more preferably 1 to 10% by weight.

  The cosmetic composition of the present invention may or may not contain a water-soluble polymer compound. Water-soluble polymers here include natural polymer compounds (polysaccharides, proteins, etc.) derived from plants, microorganisms, animals, semi-synthetic polymer compounds (cellulose-based, starch-based, alginic acid-based, etc.) and synthetic polymers. Classified into compounds (acrylic, vinyl, etc.). Furthermore, it can be divided into anionic, cationic, amphoteric and nonionic according to electrical properties. These water-soluble polymer compounds have various functions such as improvement of rheological properties (thickening action and the like), surface active action, film forming action, moisturizing action and inclusion action. Examples of natural polymer compounds include gum arabic, carrageenan, guar gum, roast bean gum, pectin, tragacanth, starch, xanthan gum, dextrin, fructan, pullulan, sodium hyaluronate, sodium chondroitin sulfate, gelatin, casein, etc. Protein. Examples of the cellulose semisynthetic polymer compound include ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, nitrocellulose, and cationized cellulose. Examples of the alginic acid semisynthetic polymer compound include sodium alginate and propylene glycol alginate. Examples of the acrylic synthetic polymer compound include sodium polyacrylate, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyacrylic acid amide, acrylamide / acrylic acid copolymer, and the like. Examples of vinyl-based synthetic polymer compounds include polyvinyl pyrrolidone and polyvinyl alcohol. Other examples include polyethylene glycol, polyglycerin, cationized guar gum, and polymethacryloyloxyethyl phosphorylcholine. Furthermore, derivatives of these polymer compounds, or copolymers of these polymer compounds and appropriate monomers, such as water-soluble ones can be mentioned. Among these compounds, taking into account the skin protective effect, skin flesh, transparency and smoothness, polysaccharide compounds, polymethacryloyloxyethyl phosphorylcholine and polymethacryloyloxyethyl phosphorylcholine and other monomers Coalescence is preferred. Moreover, as a thickener, a carboxy vinyl polymer is preferable.

  When the cosmetic composition of the present invention contains a water-soluble polymer compound, the blending amount thereof is 0.1 wt% to 3 wt%, 0.2 wt% to 2 wt%, 0.3 wt% to 1 wt%. Is more preferable.

Furthermore, the cosmetic composition of the present invention can comprise a lipophilic active ingredient. The lipophilic active ingredient can be present in the oil phase. Examples of lipophilic active ingredients include:
D-α-tocopherol, DL-α-tocopherol, D-α-tocopherol acetate, DL-α-tocopherol acetate, ascorbyl palmitate, glycerides of vitamin F;
Vitamins D, especially vitamin D2 and vitamin D3;
Retinol, retinol esters (palmitic acid retinol ester and propionic acid retinol ester), β-carotene, D-panthenol, farnesol, farnesyl acetate;
Oils rich in essential fatty acids, especially jojoba oil and black cassis oil;
5-n-octanoylsalicylic acid, salicylic acid;
α-hydroxy acids such as alkyl esters of citric acid, lactic acid and glycolic acid;
Asian acid, Madagascar acid (acide madecassique), Asiaticoside, Centellaasiatica total extract, β-glycyrrhetinic acid, α-bisabolol;
Ceramides, especially 2-oleamide-1,3-octadecanediol;
Phytanetriol, sphingomyelin from milk, phospholipids derived from marine products rich in polyunsaturated essential fatty acids, ethoxyquin, mannen wax extract, perfume oil extract, quercetin, dried microalgal extract (Algatec) algoxan red), bergamot essential oil, octyl methoxycinnamate (Parsol MCX from Givauden-Roure), butylmethoxydibenzoylmethane (Parsol 1789 from Givauden-Roure), octyl triazone (Uvinul T150 from BASF) , Yellow iron oxide, brown iron oxide, black iron oxide, red iron oxide, oxidation that may be provided in micrometer or nanometer size form or may be provided as a coated (perfluorooctylalkyl) form Titanium, 3,5-di-tert-butyl-4-hydroxybenzylidene-3-camphor, 2-benzotriazol-2-yl-4-methyl-6 -{3- [1,3,3,3-Tetramethyl-1- (trimethylsilyloxy) disiloxanyl] -2-methylpropyl} phenol, perfluoro oil (perfluorodecalin and perfluorobromide) and super corn oil (from Carilene) And commercially available Epaline 100).

  The amount of the lipophilic active ingredient is not particularly limited, but is usually 0.01 to 10% by weight, preferably 0.01 to 5% by weight, more preferably based on the total weight of the cosmetic composition. 0.01 to 3% by weight.

  In addition, the present inventors incorporated nanometer-size pigments, particularly nanotitaniums, into the composition of the present invention, and the unindice de protection of the composition not containing oil droplets of the present invention. It has been found that it is possible to obtain a sun protection composition having a higher protection index than (SPF). The term tailor nanometriqe should be taken to mean a particle size smaller than 200 nanometers, in particular on the order of 10-50 nanometers.

  The cosmetic composition of the present invention has, as an additional component, one of one of the cosmetically or dermatologically active hydrophilic active ingredients in a free state or encapsulated state, other than ascorbic acid or a derivative thereof, in the aqueous phase. It can contain more.

  Examples of the additional hydrophilic active ingredient include conventional hydrophilic active ingredients such as antioxidants, free radical scavengers, moisturizers, melanin regulators, sunburn accelerators, decolorizers, skin colorants, lipids. Modifiers, diluents (amincissants), anti-acne agents, antiseborrheic agents, anti-aging agents, anti-wrinkle agents, UV inhibitors (benzene-1,4-di (3-methylidenecamphor-10-sulfonic acid) ), Keratolytic agent, anti-inflammatory agent, refraichissants, anti-scarring agent, vascular protective agent, antimicrobial agent, antibacterial agent, antiperspirant, deodorant, skin condition agent, hair condition agent, It is possible to use immunomodulators, nutrients, antidandruff agents, hair loss inhibitors, hair dyes, hair bleaches, permanent wave reducing agents, essential oils and perfumes.

  When these compounds are provided in an encapsulated form, these compounds can be incorporated into lipid vesicles obtained from ionic lipids or nonionic lipids or mixtures of both. These compounds can also be incorporated into lipid nanoparticles such as nanospheres, nanosponges or nanocapsules.

  It is particularly advantageous to incorporate lipid vesicles in the cosmetic composition of the present invention. The reason is that these two vesicles, one of which is an oil droplet containing a lipophilic active ingredient, has a preferred average dimension around 200 nm defined by a lamellar liquid crystal coating. Lipid vesicules with droplets and, on the other hand, an aqueous core containing a hydrophilic active ingredient, with a preferred average size around 200 nm delimited by their lamellae or thin film walls This is because lipid vesicles have complementary properties and good compatibility.

  The amount of the additional hydrophilic active ingredient is not particularly limited, but is usually 0.01 to 20% by weight, preferably 0.01 to 15% by weight, based on the total weight of the cosmetic composition. More preferably, it is 0.01 to 10 weight%.

  The cosmetic composition of the present invention may also contain various supplemental additives such as preservatives, metal sequestering agents and gelling agents in the aqueous phase. Depending on the viscosity desired for the final composition, one or more gelling agents may or may not be added.

  The cosmetic composition of the present invention may contain various supplemental additives in the oil phase, for example, oils and waxes having emollient or lubricating properties. The cosmetic compositions of the invention are most often provided in the form of an emulsion, cream or gel, and other provided forms are also encompassed. The composition is transparent or translucent when the oil phase particle size is less than 80 nm.

  The cosmetic composition of the present invention has the form of an oil-in-water emulsion. The cosmetic composition of the present invention may be either a skin cosmetic or a hair cosmetic, but is preferably a skin cosmetic. The cosmetic composition of the present invention is particularly suitable as a lotion or cosmetic liquid, emulsion, or cream.

  The cosmetic composition of the present invention is preferably used for whitening. Whitening cosmetics are topical compositions that are applied to the surface of the human body for whitening and are preferably applied on the skin. Here, “whitening” means any action that inhibits the production / deposition of melanin, and includes, for example, suppressing the production of melanin or reducing the produced melanin.

  When the cosmetic composition of the present invention is a lotion, the lotion is preferably transparent or uniform in appearance. Here, “transparent” means passing light without causing deflection due to refraction or reflection. The transparency of a composition such as lotion can be measured using a turbidimeter. The Hach portable turbidimeter model 2100P® can be used, for example, to measure the transparency limit of the composition. A composition is considered transparent when the measured turbidity is between 0 and 250 NTU.

  In the cosmetic composition of the present invention, the components (a), (c), (d) and (e) are mixed and stirred to form a coated oil phase, and the coated oil phase is mixed with the component (b). It can be produced by stirring to form an oil-in-water emulsion in which the oil phase is coated and dispersed in the water phase. The component (f) may be added to the component (b) from the beginning, or may be added to the aqueous phase after forming the oil-in-water emulsion.

  For example, a water-miscible organic solvent such as polyol and / or any other hydrophilic component such as a preservative is dissolved in water at a high temperature (preferably 80 ° C.) to form an aqueous phase. Meanwhile, until any lipophilic active ingredient, the components (c), (d) and (e), and oil are mixed at a slightly high temperature (preferably 75 ° C.) to form a uniform oil phase Stir. Next, the water phase is rapidly added to the oil phase at a slightly low temperature (preferably 70 ° C.), and the mixture is emulsified by stirring at high speed (preferably 10,000 rpm) using a mixer (eg, TK Robomix manufactured by PRIMIX). Preferably, the temperature is maintained for 10 minutes and emulsification is continued. The emulsified particles (oil phase) are preferably measured with a particle analyzer (such as NICOMP 380ZLS manufactured by Partial Sizing System) and checked to be 1000 nm or less. And the temperature of an emulsion is returned to room temperature. This produces an oil-in-water emulsion. If necessary, a water-soluble polymer compound or a gelling agent may be added to the aqueous phase and mixed by mixing at a medium speed (preferably 500 rpm) using a mixer (Rayneri VMI manufactured by Rayneri, etc.). . Finally, ascorbic acid or a derivative thereof is preferably mixed with a water-miscible organic solvent such as a lower alcohol, if necessary, at room temperature, using a mixer (such as TK Robomix manufactured by PRIMIX) at high speed (preferably 5000 rpm). Stir for 3 minutes and mix with aqueous phase. As a result, the cosmetic composition of the present invention in the form of an oil-in-water emulsion in which ascorbic acid or a derivative thereof is present in the aqueous phase and the oil phase coated with the liquid crystal layer is dispersed in the aqueous phase can be obtained. .

  The cosmetic composition of the present invention is used in a cosmetic treatment method of a keratin material including a step of applying to the keratin material. Preferably, the keratin substance is skin. The cosmetic treatment method is preferably a skin whitening method. This method is particularly suitable for removing stains due to brown pigments due to external factors and / or stains due to internal factors such as aging and / or for whitening brown skin.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to an Example.

[Examples 1-4 and Comparative Examples 1-3]
The oil-in-water emulsions of Examples 1 to 4 and Comparative Examples 1 to 3 comprising the components shown in Table 1 below were prepared by the following method. All numbers in the table are weight percent.

Sucrose tristearate: Ryoto sugar ester S370 (manufactured by Mitsubishi Chemical Foods)
Steareth-10 (oxyethylenated stearyl alcohol having 10 units of ethylene oxide): BRIJ76 (Croda)
CETES-10 (polyethylene glycol ether of cetyl alcohol): NIKKOL BC-10 (manufactured by Nikko Chemicals)
Colles-20 (polyethylene glycol and cholesterol ether having 20 ethylene oxide units): EMALEX CS-20 (manufactured by Nippon Emulsion Co., Ltd.)
Colles-24 (Ethylethylene glycol and cholesterol ether having 24 ethylene oxide units): EMALEX CS-24 (manufactured by Nippon Emulsion Co., Ltd.)
PEG-8 stearate: Polyethylene glycol (8EO) ester of monostearic acid: MYRJ45V (Croda)
Mixture of sucrose stearate and sucrose distearate (50/50): CRODESTA F110 (Croda)
Polysorbate 61: Oxyethylenated (4EO) sorbitan monostearate: TWEEN61V (Croda)
Sodium stearoyl glutamate: Amisoft HS11P (Ajinomoto Co., Inc.)

Diphenylsiloxyphenyl trimethicone: KF-56A (manufactured by Shin-Etsu Chemical Co., Ltd.)
Carbomer (carboxy vinyl polymer): Carbopol 980 (manufactured by Lubrizol)
(Styrene / MA) Copolymer Na: Sodium salt of styrene / maleic acid copolymer (40% aqueous solution) SMA1000HNa (manufactured by CRAY VALLEY)

(1) Heat phase A and phase B to about 70 ° C., respectively.
(2) Rapidly inject phase A into phase B.
(3) Homogenize at 10000 rpm for 10 minutes to obtain a uniform mixture.
(4) Cool and add other phases.

[Stability evaluation]
The oil-in-water emulsions of Examples 1 to 4 and Comparative Examples 1 to 3 obtained as described above were maintained at 45 ° C. for 1 month, and the stability was evaluated from the micrographs of each emulsion.

  1 to 7 are photomicrographs of Examples 1 to 4 and Comparative Examples 1 to 3, respectively. As is clear from FIGS. 1 to 7, fine oil droplets are stably present in the emulsions of Examples 1 to 4, whereas in the emulsions of Comparative Examples 1 to 3, fine oil droplets are united. Large oil droplets are generated, and fine oil droplets cannot exist stably. Therefore, the oil-in-water emulsions of Examples 1 to 4 are more stable than the oil-in-water emulsions of Comparative Examples 1 to 3. These results are also shown in Table 1.

[Example 5 and Comparative Examples 4 to 5]
The oil-in-water emulsions of Example 5 and Comparative Examples 4 to 5 having the components shown in Table 2 below were prepared by the following method. All numbers in the table are weight percent.

Sucrose tristearate: Ryoto sugar ester S370 (manufactured by Mitsubishi Chemical Foods)
Sodium stearoyl glutamate: Amisoft HS11P (Ajinomoto Co., Inc.)
Steareth-10 (oxyethylenated stearyl alcohol having 10 units of ethylene oxide): BRIJ76 (Croda)
PEG-8 stearate: Polyethylene glycol (8EO) ester of monostearic acid: MYRJ45V (Croda)
Mixture of sucrose stearate and sucrose distearate (50/50): CRODESTA F110 (Croda)
Polysorbate 61: Oxyethylenated (4EO) sorbitan monostearate: TWEEN61V (Croda)

Diphenylsiloxyphenyl trimethicone: KF-56A (manufactured by Shin-Etsu Chemical Co., Ltd.)
Carbomer (carboxy vinyl polymer): Carbopol 980 (manufactured by Lubrizol)

(1) Heat phase A and phase B to about 70 ° C., respectively.
(2) Rapidly inject phase A into phase B.
(3) Homogenize at 10000 rpm for 10 minutes to obtain a uniform mixture.
(4) Cool and add other phases.

[Stability evaluation]
The oil-in-water emulsions of Example 5 and Comparative Examples 4 to 5 obtained as described above were maintained at 45 ° C. for 1 month, and the stability was evaluated from micrographs of each emulsion.

  In the emulsion of Example 5, fine oil droplets existed stably, but in the emulsions of Comparative Examples 4 to 5, fine oil droplets merged to generate large oil droplets. It could not exist stably. Therefore, the oil-in-water emulsion of Example 5 is more stable than the oil-in-water emulsions of Comparative Examples 4-5. These results are also shown in Table 2.

Micrograph (400 times) of oil-in-water emulsion of Example 1 Taken with Olympus BX-51 Micrograph (400 times) of oil-in-water emulsion of Example 2 Taken with Olympus BX-51 Micrograph (400 times) of oil-in-water emulsion of Example 3 Taken with Olympus BX-51 Micrograph (400 times) of oil-in-water emulsion of Example 4 Taken with Olympus BX-51 Micrograph (400 times) of oil-in-water emulsion of Comparative Example 1 Taken with Olympus BX-51 Micrograph (400 times) of oil-in-water emulsion of Comparative Example 2 Taken with Olympus BX-51 Micrograph (400 times) of oil-in-water emulsion of Comparative Example 3 Taken with Olympus BX-51

Claims (16)

A cosmetic composition in the form of an oil-in-water emulsion having an oil phase dispersed in an aqueous phase,
(A) oil;
(B) water;
(C) at least one lipophilic surfactant;
(D) at least one ether-type nonionic hydrophilic surfactant;
(E) at least one C ₁₀ -C ₂₂ acyl glutamic acid alkali salt; and
(F) including ascorbic acid or a derivative thereof,
The oil phase is coated with at least one layer comprising (c) a lipophilic surfactant, (d) an ether type nonionic hydrophilic surfactant, and (e) an alkali salt of C ₁₀ -C ₂₂ acyl glutamate. As well as
A cosmetic composition, wherein the component (f) is present in the aqueous phase. The cosmetic composition according to claim 1, wherein the (c) lipophilic surfactant has 2 to 5 HLB. The lipophilic surfactant (c) having an HLB of 2 to 5 is sucrose distearate, sucrose tristearate, diglyceryl distearate, tetraglyceryl tristearate, decaglyceryl decastearate, monostearate Diglyceryl acid, hexaglyceryl tristearate, decaglyceryl pentastearate, sorbitan monostearate, sorbitan tristearate, diethylene glycol monostearate, glyceryl ester of palmitic acid and stearic acid, polyoxyethylene 2EO monostearate (ethylene oxide) 3. A cosmetic composition according to claim 2 selected from the group consisting of 2 units), glyceryl mono- and dibehenate, and pentaerythritol tetrastearate. The cosmetic composition according to any one of claims 1 to 3, wherein (d) the ether type nonionic hydrophilic surfactant has 8 to 13 HLB. Said (d) ether type nonionic hydrophilic surfactant having an HLB of 8 to 13 is an ether of polyethylene glycol and optionally propylene glycol and mono- or poly (C ₁₂ -C ₂₂ ) saturated or unsaturated alcohol An ether having 2 to 20 ethylene oxide units and optionally 1 to 10 propylene oxide units; an ether of beeswax and ethoxylated sorbitan having 5 to 25 ethylene oxide units; 5 to 30 ethylene oxide units 5. A cosmetic composition according to claim 4, selected from the group consisting of: an ether of polyethylene glycol and cholesterol; and an alkyl polyglucoside having an alkyl group containing from 12 to 20 carbon atoms. The cosmetic composition according to any one of claims 1 to 5, wherein (e) the at least one C ₁₀ -C ₂₂ acyl glutamic acid alkali salt is an alkali salt of stearoyl glutamate. The total amount of (c) lipophilic surfactant, (d) ether type nonionic hydrophilic surfactant, and (e) alkali salt of C ₁₀ -C ₂₂ acyl glutamate is based on the total weight of the composition The cosmetic composition according to any one of claims 1 to 6, wherein the cosmetic composition is 1 to 6% by weight. Wherein (c) a lipophilic surfactant, the (d) ether type non-ionic hydrophilic surfactant, and the ratio of the amount of said (e) C ₁₀ -C ₂₂ acyl glutamic acid alkali salt, wherein (c 35) to 70% by weight based on the total weight of the lipophilic surfactant, (d) the ether type nonionic hydrophilic surfactant, and (e) the alkali salt of C ₁₀ -C ₂₂ acyl glutamate The cosmetic composition according to any one of claims 1 to 7, which is 25 to 40% by weight / 5 to 35% by weight. The cosmetic composition according to any one of claims 1 to 8, wherein the amount of the (a) oil is 5 to 50% by weight based on the total weight of the composition. The cosmetic composition according to any one of claims 1 to 9, wherein a weight ratio of (a) oil / (b) water is 1 or less. The cosmetic composition according to any one of claims 1 to 10, wherein the amount of the component (f) is 0.01 to 20% by weight based on the total weight of the composition. The cosmetic composition according to any one of claims 1 to 11, wherein the diameter of oil droplets comprising the oil phase is less than 1000 nm. The cosmetic composition according to any one of claims 1 to 12, wherein an oil droplet comprising the oil phase is coated with two or more layers. The cosmetic composition according to any one of claims 1 to 13, which is used for whitening. A cosmetic treatment method for a keratin substance, comprising applying the cosmetic composition according to any one of claims 1 to 14 to the keratin substance. The cosmetic treatment method according to claim 15, wherein the keratin substance is skin.