JP6138725B2 - Dispersion composition and cosmetics - Google Patents

Description

  The present invention relates to a dispersion composition and a cosmetic.

Amino acids such as L-cystine and tyrosine are components that can be expected to have effects such as prevention of skin aging, but are hardly soluble in any of water, alcohol, organic solvents, and oils. For this reason, when using hardly soluble amino acids, such as L-cystine and tyrosine, in various compositions, there exists a problem that the addition amount of a hardly soluble amino acid is restrict | limited.
As a method for easily blending these hardly soluble amino acids into cosmetics, Patent Document 1 discloses a method of preparing fine particles having an average particle diameter of 1.0 μm or less by wet-grinding crystals of hardly soluble amino acids. Have been described.

  Patent Document 2 describes an oil agent containing a diester capable of dissolving a hardly soluble substance, and describes a cosmetic containing an oily base material such as an aluminum salt or a thickener in addition to the oil agent containing a diester. ing.

JP 2009-286755 A JP 2005-206573 A

However, as described above, hardly soluble amino acids are difficult to dissolve in any of organic solvents such as water and alcohol, and oils, for example, a foundation that can be blended in a solid state without dissolving hardly soluble amino acids, or Only the formulation of sparingly soluble amino acids in limited dosage forms, such as powder-containing lotions that are shaken and dispersed for use, has been studied.
For this reason, development of the further technique which can mix | blend a poorly soluble amino acid with cosmetics stably and can improve the permeability | transmittance of a poorly soluble amino acid to the skin was awaited.

  An object of the present invention is to provide a dispersion composition containing a sparingly soluble amino acid and having fine dispersed particles stably, and a cosmetic comprising the dispersion composition.

Means for solving the above-mentioned problems include the following aspects .
<1> A sparingly soluble amino acid, a fatty acid that is liquid at room temperature, a nonionic surfactant, and an aqueous medium, wherein the nonionic surfactant is a polyglycerin fatty acid ester and a polyoxyethylene hydrogenated castor oil A dispersion composition comprising at least one selected from the group consisting of:
<2> The dispersion composition according to <1>, wherein the hardly soluble amino acid includes at least one selected from cystine and tyrosine.
<3> The dispersion composition according to <1> or <2>, wherein the fatty acid that is liquid at room temperature includes at least one selected from isostearic acid and oleic acid.
Containing polysaccharide having a substituent containing an aliphatic group in <4> is found, <1> to dispersion composition according to any one of <3>.
< 5 > The dispersion composition according to < 4 >, wherein the polysaccharide having a substituent containing an aliphatic group is inulin laurylcarbamate.
< 6 > Furthermore, the dispersion composition as described in any one of <1>-< 5 > containing the oil agent different from a liquid fatty acid at room temperature.
< 7 > The dispersion composition according to < 6 >, wherein the ratio of the inorganic value / organic value of the oil different from the liquid fatty acid at room temperature is 0.3 or less.
< 8 > The ratio of the total content of the fatty acid that is liquid at room temperature and the oil different from the fatty acid that is liquid at room temperature to the total content of the sparingly soluble amino acid is 5 or less, < 6 > or < 7 > The dispersion composition as described in>.
< 9 > Cosmetics containing the dispersion composition according to any one of <1> to < 8 >.

  According to the present invention, it is possible to provide a dispersion composition containing a sparingly soluble amino acid and containing fine dispersed particles stably, and a cosmetic comprising the dispersion composition.

Hereinafter, the composition of the present invention and the cosmetics containing the composition will be described in detail.
In the present specification, a numerical range indicated using “to” indicates a range including the numerical values described before and after “to” as the minimum value and the maximum value, respectively.
In the present specification, the amount of each component in the composition is the total amount of the plurality of substances present in the composition unless there is a specific indication when there are a plurality of substances corresponding to each component in the composition. means.
In this specification, the term “process” is not limited to an independent process, and is included in this term if the intended purpose of this process is achieved even when it cannot be clearly distinguished from other processes.
In this specification, unless otherwise specified, room temperature means 23 ° C.

<Dispersion composition>
The dispersion composition of the present invention contains a hardly soluble amino acid, a fatty acid that is liquid at room temperature, a nonionic surfactant, and an aqueous medium.
The dispersion composition of the present invention may further contain other components as necessary.

Since the dispersion composition of the present invention contains a fatty acid that is liquid at room temperature (hereinafter sometimes referred to as a liquid fatty acid) and a nonionic surfactant, It becomes a dispersion composition which is contained as dispersed particles and has excellent storage stability including thermal stability.
Moreover, the cosmetics containing the dispersion composition containing the hardly soluble amino acid of the present invention as dispersed particles are expected to improve the penetration of the hardly soluble amino acid into the skin.

The dispersion composition of the present invention is obtained by dissolving a sparingly soluble amino acid and a fatty acid liquid at room temperature in an alkaline aqueous solution to obtain a liquid containing the sparingly soluble amino acid and the fatty acid, and the obtained sparingly soluble amino acid and the fatty acid. It is preferable to prepare by the method including neutralizing the liquid containing the acid aqueous solution to co-precipitate the hardly soluble amino acid and the fatty acid.
By allowing a nonionic surfactant to coexist, a co-precipitate of a hardly soluble amino acid and a fatty acid can be finely dispersed in an aqueous medium. Thereby, the dispersion composition containing the fine dispersion particle containing a sparingly soluble amino acid can be obtained.

The operation of the present invention is not clear, but is considered as follows.
When a hardly soluble amino acid and a fatty acid dissolved in an alkaline aqueous solution are co-precipitated by neutralization using an acidic aqueous solution, the hardly soluble amino acid and the fatty acid are coexisting with a certain complex or complex ( In the following, it is presumed that such a hardly soluble amino acid and a fatty acid coexist without being separated are simply referred to as “complex”.
In order to efficiently form a complex of a hardly soluble amino acid and a fatty acid, the fatty acid to be used needs to be liquid at room temperature.
Fatty acids that are solid at room temperature have the property that the fatty acids tend to aggregate. For this reason, at the time of preparing a liquid containing a hardly soluble amino acid and a fatty acid, even if the temperature of the liquid is increased and the solid fatty acid is dissolved, complex formation between the hardly soluble amino acid and the dissolved fatty acid does not proceed. During the neutralization, the hardly soluble amino acid and the solid fatty acid are each precipitated alone, and a stable dispersion composition containing fine dispersed particles containing the hardly soluble amino acid cannot be obtained.
On the other hand, when liquid fatty acids are used at room temperature, it is considered that the formation of a complex of a sparingly soluble amino acid and a liquid fatty acid proceeds promptly without aggregation of fatty acids.

  A complex of a sparingly soluble amino acid and a liquid fatty acid exhibits an oily property due to the presence of a hydrophobic group of the liquid fatty acid. Therefore, a dispersion composition containing fine dispersed particles containing a hardly soluble amino acid can be easily obtained by a commonly used emulsification and dispersion means.

Hereinafter, each component contained in the dispersion composition of the present invention will be described.
[Slightly soluble amino acids]
The poorly soluble amino acid in the present invention has a solubility in water of 20 ° C. pH = 5-7, ethanol at 20 ° C., and tri (caprylic acid / capric acid) glyceride at 20 ° C., 0.5 g / 100 g or less. Any amino acid can be used as long as it has this physical property.

Examples of the hardly soluble amino acids include cystine, cystine derivatives, cystine salts, tyrosine, tyrosine derivatives, tyrosine salts, aspartic acid, aspartic acid derivatives, aspartic acid salts, and the like.
Preferably, cystine, tyrosine, aspartic acid, etc. are mentioned, More preferably, L-cystine, L-tyrosine, L-aspartic acid, etc. are mentioned.

Any of the hardly soluble amino acids may be used alone or in combination of two or more.
The content of the hardly soluble amino acid is preferably 0.1% by mass to 5% by mass with respect to the total mass of the dispersion composition. The content of the hardly soluble amino acid is preferably 0.1% by mass or more with respect to the total mass of the dispersion composition, so that the effect of blending the hardly soluble amino acid is sufficiently obtained. This is preferable because precipitation of sparingly soluble amino acids in the dispersion composition is suppressed.
Further, the content of the hardly soluble amino acid is more preferably 0.5% by mass to 3.0% by mass with respect to the total mass of the dispersion composition, and 1.0% by mass to 2.0% by mass. More preferably it is.

[Fatty acid liquid at room temperature (23 ° C) (liquid fatty acid)]
The liquid fatty acid contained in the dispersion composition of the present invention can be used without particular limitation as long as it is a fatty acid that is liquid at 23 ° C.
In order for the fatty acid to be liquid at room temperature, it satisfies at least one of the short chain length of the hydrophobic group, the unsaturated group in the hydrophobic group, and the branched hydrophobic group. Is preferred.
The chain length of the hydrophobic group is preferably 8 or more, more preferably 12 or more, and most preferably 18 or more. By setting the chain length of the hydrophobic group to 8 or more, the oil solubility of the complex containing the hardly soluble amino acid and the liquid fatty acid is suitably maintained, and the preparation of the dispersion composition becomes easy. On the other hand, when the hydrophobic group is a straight chain saturated hydrocarbon group, if it has 10 or more carbon atoms, it may become a solid fatty acid at room temperature, so if the chain length of the hydrophobic group has 10 or more carbon atoms, The fatty acid is preferably a fatty acid having a branched hydrophobic group or an unsaturated fatty acid.
When the chain length of the hydrophobic group is 10 or more, the hydrophobic group is preferably unsaturated, and more preferably the hydrophobic group is branched. In addition, since it may become unstable with respect to oxidation if it has an unsaturated bond in the hydrophobic group, from the viewpoint of the stability of the dispersion composition, the hydrophobic group may be a saturated fatty acid having a branch. Most preferred.

  More specifically, examples of the liquid fatty acid used in the present invention include caprylic acid, palmitoleic acid, isostearic acid, oleic acid, linoleic acid, and the like, and isostearic acid, oleic acid, and the like are more preferable.

One type of liquid fatty acid may be used alone, or two or more types may be used in combination.
The content of the liquid fatty acid is preferably 10: 1 to 1:10 in terms of molar ratio of liquid fatty acid to hardly soluble amino acid with respect to the content of the hardly soluble amino acid, and 5: 1 to 1: 2. More preferably, it is more preferably 2: 1 to 1: 1.
When the content ratio of the liquid fatty acid and the hardly soluble amino acid is within the above range, the effectiveness of the hardly soluble amino acid can be sufficiently obtained, and the dispersion stability of the dispersion composition can be maintained well.
Further, the content of the liquid fatty acid is preferably 0.1% by mass to 20% by mass, more preferably 0.2% by mass to 10% by mass with respect to the total mass of the dispersion composition. More preferably, it is 0.5 mass%-5 mass%.

(Nonionic surfactant)
The dispersion composition of the present invention contains a nonionic surfactant. By containing a nonionic surfactant, a hardly soluble amino acid can be more stably blended with cosmetics, and the permeability of the hardly soluble amino acid to the skin can be further improved.

  The nonionic surfactant is not particularly limited as long as it is a nonionic surfactant that dissolves in an aqueous medium. For example, it is preferable to use a nonionic surfactant having an HLB of 8 or more because dispersibility of fine particles containing a hardly soluble amino acid can be improved. More preferably, it is a nonionic surfactant having an HLB of 9 to 18, and a nonionic surfactant having an HLB of 10 to 12 is more preferable.

Here, HLB is a hydrophilic-hydrophobic balance that is usually used in the field of surfactants, and a commonly used calculation formula such as the Kawakami formula can be used. Kawakami's formula is shown below.
HLB = 7 + 11.7 log (M _w / M _o )
Here, _Mw is the molecular weight of the hydrophilic group, and _Mo is the molecular weight of the hydrophobic group.
Moreover, you may use the numerical value of HLB described in the catalog etc.
Further, as can be seen from the above formula, a nonionic surfactant having an arbitrary HLB value can be obtained by utilizing the additivity of HLB.

Examples of nonionic surfactants include polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil Fatty acid ester, polyoxyethylene cholesterol, polyoxyethylene phytosterol, polyoxyethylene phytostanol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene trimethylolpropane fatty acid ester, Examples include sugar fatty acid esters.
Preferred are polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene cholesterol, polyoxyethylene phytosterol, and polyoxyethylene phytostanol. More preferably, polyglycerin fatty acid ester and polyoxyethylene hydrogenated castor oil are used.
Further, the nonionic surfactant is not necessarily highly purified by distillation or the like, and may be a reaction mixture.

As the polyglycerol fatty acid ester, the average degree of polymerization is 2 or more, preferably 6 to 15, more preferably 8 to 10 and fatty acid having 8 to 18 carbon atoms, such as caprylic acid, capric acid, lauric acid, An ester of myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, and linoleic acid is preferred.
Preferred examples of the polyglycerol fatty acid ester include hexaglycerol monooleate, hexaglycerol monostearate, hexaglycerol monoisostearate, hexaglycerol monopalmitate, hexaglycerol monomyristate, hexaglycerol monolaurate. , Decaglycerol monooleate, decaglycerol monostearate, decaglycerol monoisostearate, decaglycerol monopalmitate, decaglycerol monomyristate, decaglycerol monolaurate, decaglycerol dioleate, deca Glycerin distearate, decaglycerin diisostearate, decagli Rinjiparumichin esters, decaglycerol di myristate, decaglycerol dilaurate ester.
These polyglycerol fatty acid esters may be used alone or in combination of two or more.

  As the polyglycerol fatty acid ester, a commercially available product may be used. Commercially available products include, for example, NIKKOL Hexaglyn 1-L, Hexaglyn 1-M, Hexaglyn 1-SV, Hexalyn 1-OV, Decaglyn 1-L, Decaglyn 1-M, Decaglin 1-M, Dec, manufactured by Nikko Chemicals Co., Ltd. Decaglyn 1-50SV, Decaglyn 1-ISV, Decaglyn 1-OV, Decaglyn 1-LN, Decaglyn 2-SV, Decaglyn 2-ISV, Sunsoft Q-10Q-C, manufactured by Taiyo Kagaku Co., Ltd. 12D-C, Sunsoft Q-12S-C, Sunsoft Q-14S-C, Sunsoft Q-17S-C, Sunsoft Q-18S-C, Sunsoft A-121E-C, Sunsoft A-141E- C, Sunsoft A-17 1E-C, Sunsoft A-173E-C, Sunsoft A-181E-C, YS Grister MSW-7S, YS Grister TS-7S, YS Grister MS-5S, YS Grister SS- manufactured by Sakamoto Pharmaceutical Co., Ltd. 5S, YS glister MS-3S, YS glister MO-7S, YS glister MO-5S, YS glister MO-3S, YS glister MCA-750, YS glister ML-750, YS glister ML-500, YS glister ML-310, Poem J-0021, Poem J-0081HV, Poem J-0381V manufactured by Riken Vitamin Co., Ltd., Ryoto Polyglyceride CD-19D, Ryoto Polyglycerester L-10D, Ryoto Polyglycerester manufactured by Mitsubishi Chemical Foods Co., Ltd. L-7D, Ryoto-Polyglieste M-10D, Ryoto-polyglycerester M-7D, Ryoto-polyglycerester S-28D, Ryoto-polyglycerester S-24D, Ryoto-polyglycerester SWA-20D, Ryoto-polyglycerester SWA-15D, Ryoto-polyglycerester SWA- 10D, Ryoto polyglycerester SFS-10DB, Ryoto polyglycerester O-15D, etc. are mentioned.

The polyoxyethylene hydrogenated castor oil is a compound having an ethylene oxide chain having an average degree of polymerization of 20 or more, preferably 40 or more, more preferably 60 or more.
Polyoxyethylene hydrogenated castor oil can be used alone or in combination of two or more.
A commercially available polyoxyethylene hydrogenated castor oil may be used. Examples of commercially available products include Nikko Chemicals Corporation, NIKKOL HCO-20, NIKKOL HCO-30, NIKKOL HCO-40, NIKKOL HCO-50, NIKKOL HCO-60, NIKKOL HCO-80, NIKKOL HCO-100, Japan. Emulex Co., Ltd., EMALEX HC-20, EMALEX HC-30, EMALEX HC-40, EMALEX HC-50, EMALEX HC-60, EMALEX HC-80, EMALEX HC-100, Kao Co., Ltd., Emanon CH- 25, Emanon CH-40, Emanon CH-60, manufactured by NOF Corporation, UNIOX HC-20, UNIOX HC-40, UNIOX HC-60, UNIOX HC-100, Daiichi Kogyo Seiyaku Co., Ltd. Manufactured by Neugen HC-400 Gen HC-600 and the like.

As polyoxyethylene cholesterol, an ether of an ethylene oxide chain having an average degree of polymerization of 10 to 30 and cholesterol is preferable.
Polyoxyethylene cholesterol can be used alone or in combination of two or more.
As the polyoxyethylene cholesterol, a commercially available product may be used. As a commercial item, Nikko Chemicals Co., Ltd. product, EMALEX CS-10, EMALEX CS-15, EMALEX CS-20, EMALEX CS-24, EMALEX CS-30 etc. are mentioned, for example.

The polyoxyethylene phytosterol is preferably an ether of an ethylene oxide chain having an average degree of polymerization of 10 to 30 and phytosterol.
Polyoxyethylene cholesterol can be used alone or in combination of two or more.
As the polyoxyethylene phytosterol, a commercially available product may be used. As a commercial item, Nikko Chemicals Co., Ltd. product, NIKKOL BPS-10, NIKKOL BPS-20, NIKKOL BPS-30 etc. are mentioned, for example.

The polyoxyethylene phytostanol is preferably an ether of an ethylene oxide chain having an average degree of polymerization of 10 to 30 and phytostanol.
Polyoxyethylene cholesterol can be used alone or in combination of two or more.
As the polyoxyethylene cholesterol, a commercially available product may be used. As a commercial item, Nikko Chemicals Co., Ltd. product, NIKKOL BPSH-25, etc. are mentioned, for example.

  Among these, from the viewpoint of better dispersion stability, polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil and the like are preferable, and polyglycerin fatty acid ester is more preferable.

In the dispersion composition, one kind of nonionic surfactant may be used alone, or two or more kinds may be used in combination.
The content of the nonionic surfactant is preferably 0.1% by mass to 10% by mass and more preferably 0.5% by mass to 5% by mass with respect to the total amount of the dispersion composition. More preferably, it is 1 mass%-2 mass%.
When the content of the nonionic surfactant is within the above range, the particle diameter of the dispersed particles containing the hardly soluble amino acid becomes smaller, and the stability of the dispersed particles becomes better.

[Aqueous medium]
Examples of the aqueous medium that is a dispersion medium for dispersing dispersed particles containing a hardly soluble amino acid, a liquid fatty acid, a nonionic surfactant, and the like include water, a polyhydric alcohol, or a mixture of water and a polyhydric alcohol. From the viewpoint of dispersion stability of the composition, a mixture of water and a polyhydric alcohol is preferable. Examples of the polyhydric alcohol used in the aqueous medium include glycerin, diglycerin, 1,3-butylene glycol, propylene glycol, 1,2-pentanediol, dipropylene glycol and the like.
In the case where the aqueous medium contains a polyhydric alcohol, the content of the polyhydric alcohol is preferably 10% by mass to 90% by mass and more preferably 30% by mass to 80% by mass with respect to the aqueous medium. Preferably, it is 50 mass%-70 mass%.
In the dispersion composition of the present invention, the content ratio of the dispersed particles as the dispersoid and the aqueous medium as the dispersion medium is, for example, in the range of 0.1: 99.9 to 50:50 on a mass basis. 0.5: 99.5 to 20:80 is preferable, and 1.0: 99 to 10:90 is more preferable.

[Other ingredients]
The dispersion composition of the present invention contains various components as necessary within the range not impairing the effects of the present invention, in addition to the hardly soluble amino acid, liquid fatty acid, nonionic surfactant, and aqueous medium as the dispersion medium. Can be included.

(Polysaccharides having a substituent containing an aliphatic group)
The dispersion composition of the present invention can contain a polysaccharide having a substituent containing an aliphatic group. By containing a polysaccharide having a substituent containing an aliphatic group, the thermal stability of the dispersion composition is improved.
The “polysaccharide having a substituent containing an aliphatic group” used in the present invention is a compound having a structure in which a substituent containing an aliphatic group is linked to a sugar chain of a polysaccharide in a graft shape (hereinafter referred to as “fatty acid”). Group substituent-linked polysaccharide "). This aliphatic substituent-linked polysaccharide generally has a surface activity, and can also be classified as a kind of high molecular surfactant having an aliphatic group as a hydrophobic group and a sugar chain portion as a hydrophilic group. This aliphatic substituent-linked polysaccharide is present on the surface of oil droplets by inserting or adsorbing aliphatic groups, which are hydrophobic groups, into the oil droplets of the emulsion, and the sugar chain portions, which are hydrophilic groups, being greatly expanded in water. Therefore, it is considered that the dispersed particles in the dispersion composition can be prevented from coming close to each other and agglomerating and coalescing. In addition, the presence of large sugar chains in the aliphatic substituent-linked polysaccharide on the surface of the dispersed particles results in the formation of a thick hydrated layer around the dispersed particles, thus suppressing the Ostwald growth of the dispersed particles. It is considered to be done. As a result, the thermal stability of the dispersion composition is improved.

Examples of the polysaccharide skeleton of the aliphatic substituent-linked polysaccharide include dextrin having glucose as a unit sugar, starch, cellulose, glucan, glycogen pullulan, etc .; inulin, levan, or fructooligosaccharide having fructose as a unit sugar And the like; chitin having N-acetylglucosamine as a unit sugar; galactooligosaccharide having galactose as a unit sugar; and mannan oligosaccharide having a saccharide as a unit sugar. Further, raffinose, stachyose (galactose / fructose / glucose) and the like are known as polysaccharides composed of two or more kinds of unit sugars.
The average degree of polymerization (number of sugar units) of the polysaccharide in the aliphatic substituent-linked polysaccharide is generally 2 to 100, and more preferably 5 to 50 from the viewpoint of the stabilizing effect and solubility.

  Among the polysaccharides in the aliphatic substituent-linked polysaccharide, a polysaccharide containing fructose is preferable and inulin is particularly preferable from the viewpoint of improving the thermal stability in the dispersion composition. Inulin is an oligosaccharide composed mainly of D-fructose. The number of furanoid fructose units having a structure having β-1,2 linked furanoid fructose and α-D-glucose linked to sucrose at the reducing end in inulin is generally about 2-60.

The aliphatic substituent-linked polysaccharide is obtained by substituting a part of a hydrophilic group such as a hydroxyl group possessed by a polysaccharide with a hydrophobic group mainly composed of an aliphatic group.
Examples of the aliphatic group include alkyl groups, alkenyl groups, alkoxy groups, hydroxyalkyl groups, carboxylalkyl groups, alkylcarbonyl groups, alkoxycarbonyl groups, and alkylcarbonyloxy groups having 4 to 20 carbon atoms. Further, the group may contain one or more substituents such as an aromatic ring or an aliphatic ring. Examples of the aromatic ring or aliphatic ring as a substituent include a cyclohexyl group, a phenyl group, a phenoxy group, a phenylcarbamyl group, a cholesteryl group, and a phytosteryl group. The aliphatic group is preferably a fatty acid group having 12 to 18 carbon atoms from the viewpoint of improving thermal stability.

  Specific examples of the aliphatic group possessed by the aliphatic substituent-linked polysaccharide include higher fatty acid esters such as stearic acid, oleic acid, palmitic acid, myristic acid, lauric acid; alkyl succinic acid, alkyl tartaric acid, alkenyl succinic acid, etc. Dicarboxylic acid monoesters; alkyl carbamic acid amides, higher fatty acid amides, alkyl glyceryl esters, alkyl glyceryl ethers, cholesterol, phytosterols and the like.

Specific examples of polysaccharides having a substituent containing these fatty acid groups include Colloid and Interface Science Series, Vol. 4, Colloids in Cosmetics and Personal Care, WILEY-VCH Verlag GmbH & Co. Edited by T.M. F. Inulin laurylcarbamate (Inutec SP1; DKSH Japan Co., Ltd.), dextrin myristate (Leopard MKL2; Chiba Milling), inulin stearate (Leopard ISL2; Chiba Milling), starch octenyl succinate described in Tadros, 1 (2008) (Emulstar A1; Matsutani Chemical), hydroxypropylmethylcellulose stearoxy ether (Sangelose; Daido Kasei), various emulsification technology know-how / example collection, Information Organization Co., Ltd., 23 (2009), etc. Can be mentioned. In addition, emulsan made by Acinetobacter calcoaceticus as a kind of biosurfactant is also included as an example of an aliphatic substituent-linked polysaccharide.
Of these, inulin lauryl carbamate is most preferred.

The aliphatic substituent-linked polysaccharide typified by inulin laurylcarbamate is preferably contained in an amount of 0.05% by mass to 10% by mass with respect to the total mass of the dispersion composition from the viewpoint of improving thermal stability. More preferably, it is 0.5 mass%-3.0 mass%.
In the present invention, the above-mentioned “nonionic surfactant” does not include this aliphatic substituent-linked polysaccharide.

(Oil agent different from liquid fatty acid)
The dispersion composition of the present invention can contain an oil agent different from the liquid fatty acid described above. The oil different from the liquid fatty acid may be liquid or solid, but is preferably a liquid oil from the viewpoint of improving the stability of the dispersed particles.
Hereinafter, the oil agent different from the liquid fatty acid may be referred to as “other oil agent”.
Liquid oils suitable as other oils can be selected from those generally used in cosmetics as long as the stability of the dispersion composition is not impaired.
Desirable liquid oils include, for example, polar oils such as hydrocarbon oils and ester oils, silicone oils, liquid oils that are liquid at room temperature, and the like.
As the hydrocarbon oil, for example, liquid paraffin, squalane, squalene, paraffin, isoparaffin, ceresin and the like can be used.

  Examples of polar oils such as ester oils include pentaerythrityl tetraethylhexanoate, cetyl ethylhexanoate, jojoba oil, dilauroyl glutamate (phytosteryl / octyldodecyl), triisostearin, glyceryl diisostearate, triethylhexanoin, dimerlinol Acid (phytosteryl / behenyl), dimer linoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), isopropyl palmitate, macadamia nut fatty acid phytosteryl, tetra (behenic acid / benzoic acid / ethylhexanoic acid) pentaerythrityl, palmitic acid Ethylhexyl, myristyl myristate, tripropylene glycol dipivalate, etc. can be used.

  Examples of the silicone oil include chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, and cyclic silicones such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane. Can be mentioned.

  Examples of liquid oils include linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, sunflower oil, almond oil, rapeseed oil, sesame oil, soybean oil. , Peanut oil, triglycerin, glycerin trioctanoate, glycerin triisopalmitate, tri (caprylic acid / capric acid) and the like.

Among these, as the oil agent different from the liquid fatty acid, an oil agent having an inorganic value / organic value ratio of 0.3 or less is preferable.
The inorganic value / organic value is a parameter indicating an index of hydrophilicity / hydrophobicity exhibited by a compound based on the ratio between the organic group and the inorganic group, and is called IOB (Inorganic Organic Balance). Hereinafter, it may be referred to as “I / O value”. The I / O value is well known as a ratio of an inorganic value and an organic value determined based on an organic conceptual diagram, and represents the degree of polarity of an oily base.
The I / O value is represented by the following formula (I). “I” represents inorganicity, “O” represents organicity, and the larger the I / O value, the higher the inorganicity. I / O values are described in detail in “Organic Conceptual Diagram” (Yoshio Koda, Sankyo Publishing, 1984). Specifically, “Prediction of Organic Compounds and Organic Conceptual Diagram”, Fujita (Chemicals) Region 11-10), 1957, p. 719-725, “Emulsion prescription design based on organic conceptual diagram”, Nippon Emulsion Co., Ltd., Yaguchi, 1985, p. 98].
IO value = inorganic value (IV) / organic value (OV) (I)

The concept of the I / O value is that the properties of a compound are divided into an organic group that represents covalent bonding and an inorganic group that represents ionic bonding, and all organic compounds are orthogonal coordinates named organic and inorganic axes. Each of the above points is shown.
The inorganic value is obtained by quantifying the magnitude of the influence on the boiling point of various substituents and bonds of an organic compound, based on the hydroxyl group. The organic value is determined based on the influence on the boiling point of the carbon atom representing the methylene group with the methylene group in the molecule as a unit.

The I / O value indicates that the closer the value is to 0, the more non-polar (hydrophobic and organic) organic compound, and the higher the value, the more polar (hydrophilic and inorganic) organic compounds. Indicates that there is.
Table 1 below shows the reference values of organicity (O value) and inorganicity (I value) used for calculating the I / O value in the present invention.

  The I / O value of the other oil used in the present invention is preferably 0 or more and 0.3 or less, preferably 0 or more and 0.15 or less, and more preferably 0 or more and 0.11 or less.

  In the present invention, the term “oil agent” means that the amount dissolved in water is 0.1% by mass or less at 25 ° C. and 1 atm, the molecule contains an alkyl group having 4 or more carbon atoms, a hydroxyl group or a polyether group. It refers to a compound that does not have such a hydrophilic group.

Other oil agents having an I / O value of 0.3 or less include, for example, squalane (I / O value = 0), isopropyl myristate (I / O value = 0.26), octyldodecyl myristate (I / O value = 0.13), cetyl ethylhexanoate (I / O value = 0.18), isopropyl isostearate (I / O value = 0.21), isostearyl isostearate (I / O value = 0.0). 12), dialkyl carbonate (C14,15) (I / O value = 0.18), liquid paraffin (I / O value = 0), and the like, but are not limited thereto.
You may use a commercial item as another oil agent.

When the dispersion composition of this invention contains the oil agent (other oil agent) different from a liquid fatty acid, it may contain only 1 type and may contain 2 or more types.
As the content when the dispersion composition of the present invention contains other oil agent, the content ratio of the combined content of the liquid fatty acid and the other oil agent to the total content of the hardly soluble amino acids described above is The mass ratio is preferably 5 or less, and preferably 3.5 or less.
Moreover, it is preferable that content in the case of containing the oil agent different from a liquid fatty acid is 0.05 mass%-5.0 mass% with respect to the whole quantity of a dispersion composition, 0.1 mass%- The content is more preferably 2.0% by mass, and further preferably 0.5% by mass to 1.0% by mass.

Various components other than the above-mentioned preferred other components, such as aliphatic substituent-linked polysaccharides and other oil agents, can be included in the dispersion composition of the present invention as necessary.
Examples of various components include preservatives, antioxidants, pH adjusters and the like.

[PH]
The pH of the dispersion composition at 25 ° C. is preferably pH 3.5 to pH 8.5. Moreover, it is more preferable that it is pH 4.0-pH 8.0, and it is further more preferable that it is pH 5.0-pH 7.0.
The pH can be measured, for example, with a pH meter (model number: HM-30V, manufactured by Toa DKK Corporation).

(Dispersed particles)
In the dispersion composition of the present invention, a dispersoid containing a hardly soluble amino acid, a liquid fatty acid, and a nonionic surfactant can be dispersed in an aqueous medium such as water or a polyhydric alcohol to form dispersed particles.

  The dispersed particles in the dispersion composition of the present invention are not particularly limited, but the transparency of the obtained dispersion composition, or when the dispersion composition is used for cosmetics, the dispersed particles containing a sparingly soluble amino acid to the skin. In view of the permeability, the average particle size is preferably 5 nm or more and 500 nm or less, more preferably 5 nm or more and 200 nm or less, and further preferably 5 nm or more and 100 nm or less.

In this specification, the average particle size of the dispersed particles means the volume average particle size of the dispersed particles present in the composition.
In the present specification, the average particle size of the dispersed particles contained in the dispersion composition is determined by a known method such as an electron microscope, a centrifugal sedimentation method, a liquid exclusion chromatography method, a laser scattering diffraction method, or a dynamic light scattering method. There is no particular limitation. From the viewpoint of accuracy and ease of measurement, it is preferable to perform measurement using a dynamic light scattering method.

Examples of commercially available measuring apparatuses using the dynamic light scattering method include a concentrated particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.), Nanotrack UPA (Nikkiso Co., Ltd.), Nanosizer (Malvern Co., Ltd.), and the like. However, the particle diameter in this specification employs a value measured at 25 ° C. using FPAR-1000.
Specifically, the dispersion composition is diluted 100 times (mass) with water to obtain the median diameter (d = 50).
The average particle size of the dispersed particles is not limited to the type and amount of components contained in the dispersion composition, but the stirring conditions during preparation of the dispersion composition, for example, the shearing force during stirring, the temperature of the dispersion medium, It can also be adjusted as appropriate depending on factors such as pressure.

[Turbidity]
When the dispersion composition of the present invention is used in cosmetics, it is required to have transparency depending on the dosage form, such as lotion and cosmetic liquid, and further, it is required to maintain transparency even after aging.
For this reason, it is preferable that the dispersion composition of this invention has transparency. In the present specification, “transparency” refers to turbidity described in detail below, and is defined by absorbance measured at 25 ° C. using light having a wavelength of 650 nm. Absorbance (turbidity), which is an index of “transparency” in the dispersion composition of the present invention, is measured using a spectrophotometer (U-3310, Hitachi High-Technology Corporation).

  The relationship between the dispersion composition and the turbidity τ can be expressed by the following formula A when the particle diameter d of the dispersion composition is smaller than the visible light wavelength λ.

  As shown in Formula A, the particle diameter d of the dispersion composition, the number n of particles of the dispersion composition, and the relative refractive index m of the oil agent contribute to the turbidity τ. Here, the number n of particles of the dispersion composition is defined by the amount of oil in the dispersion composition. If it is cosmetics containing the dispersion composition of this invention, the turbidity is prescribed | regulated by the compounding quantity of the dispersion composition in cosmetics.

In a preferred embodiment of the dispersion composition of the present invention, the absorbance (turbidity) measured using light having a wavelength of 650 nm is preferably 0.15 or less, and more preferably 0.1 or less.
Moreover, when applying the dispersion composition of this invention to the cosmetics mentioned later, it is preferable that it is 0.001-0.15 as turbidity of the cosmetics from which transparency is calculated | required. The absorbance (turbidity) in cosmetics that require transparency is more preferably 0.001 to 0.125, and still more preferably 0.001 to 0.1.

<Method for producing dispersion composition>
The method for producing the dispersion composition of the present invention is not particularly limited. From the viewpoint of making the resulting dispersion composition more transparent, an alkaline aqueous solution containing a sparingly soluble amino acid and a fatty acid liquid at room temperature. To obtain a liquid containing a sparingly soluble amino acid and a fatty acid, and neutralizing the liquid containing the sparingly soluble amino acid and the fatty acid with an acidic aqueous solution to co-precipitate the sparingly soluble amino acid and the fatty acid. The manufacturing method prepared by the method including this is mentioned.

  According to this production method, a dispersion composition in which dispersed particles containing a hardly soluble amino acid and a liquid fatty acid are stably dispersed can be obtained. This is because when a liquid containing a sparingly soluble amino acid dissolved in an alkaline aqueous solution and a liquid fatty acid is neutralized using an acidic aqueous solution, the sparingly soluble amino acid and the liquid fatty acid are co-precipitated. This is considered to form a complex containing At this time, the coexistence of the hydrophobic coprecipitate resulting from the fatty acid and the nonionic surfactant coexists, thereby strengthening the interface between the dispersed particles, which are hydrophobic components, and the aqueous medium. It can be presumed that fine dispersed particles of precipitated particles containing glycine and liquid fatty acid can be obtained, and the obtained dispersed particles have good dispersion stability.

  Although the manufacturing method of the dispersion composition of this invention is shown more concretely below, the manufacturing method of a dispersion composition is not limited to the following method. The matters described in the section of the dispersion composition are applied as they are to the hardly soluble amino acid, liquid fatty acid, nonionic surfactant, aqueous medium, and other components contained as required.

First, a sparingly soluble amino acid and a fatty acid which is liquid at room temperature are dispersed and dissolved in an alkaline aqueous solution to obtain a liquid containing a sparingly soluble amino acid and a liquid fatty acid (hereinafter sometimes referred to as an amino acid-containing liquid).
As for the temperature at the time of melt | dissolving a sparingly soluble amino acid and a fatty acid liquid at room temperature in alkaline aqueous solution, 1 to 80 degreeC is mentioned, Preferably 10 to 70 degreeC is mentioned.
The pH of the alkaline aqueous solution is not particularly limited as long as it is higher than 7, but the pH of the alkaline aqueous solution is preferably 8.5 or more, and more preferably 10 or more, because the solubility of the hardly soluble amino acid can be improved.

Alkaline aqueous solutions are 0.1 mol / L to 6.0 mol / L sodium hydroxide, 0.1 mol / L to 6.0 mol / L potassium hydroxide, 0.1 mol / L to 6.0 mol / L hydroxide. It can be prepared using lithium or the like.
The amount of the poorly soluble amino acid added to the alkaline aqueous solution is preferably 1.0% by mass to 20% by mass, and 2.0% by mass to 15% by mass with respect to the total mass of the obtained amino acid-containing liquid. More preferably, the content is 4.0% by mass to 10% by mass. Moreover, it is preferable that it is 1 mass%-40 mass% with respect to the total mass of the amino acid containing liquid obtained, and, as for the quantity of the liquid fatty acid added to alkaline aqueous solution, it is more preferable that it is 2 mass%-30 mass%. Preferably, it is 4 mass%-20 mass%.
The amino acid-containing solution may be prepared by stirring until all of the added poorly soluble amino acid is dissolved. The stirring method and stirring time are not particularly limited.
Moreover, the amino acid-containing liquid may contain other components as required in addition to the hardly soluble amino acid and the liquid fatty acid.

Next, an acidic aqueous solution prepared separately from the alkaline aqueous solution is added to the prepared amino acid-containing solution to neutralize the amino acid-containing solution.
The acidic aqueous solution uses 0.1 mol / L to 6.0 mol / L hydrochloric acid, 0.1 mol / L to 6.0 mol / L sulfuric acid, 0.1 mol / L to 6.0 mol / L citric acid, and the like. Can be prepared.
The acidic aqueous solution may contain a nonionic surfactant and other components in addition to the acid.
As for the temperature at the time of preparing acidic aqueous solution, 1 to 30 degreeC is mentioned, Preferably 15 to 25 degreeC is mentioned.
The stirring method and stirring time in preparation of acidic aqueous solution are not specifically limited.
The pH of the acidic aqueous solution is not particularly limited as long as it is less than 7, but the pH of the acidic aqueous solution is preferably 6.0 or less in order to neutralize the alkaline aqueous solution containing the hardly soluble amino acid and the liquid fatty acid. The following is more preferable.
The nonionic surfactant may be contained in any of an alkaline aqueous solution, an amino acid-containing solution, or an acidic aqueous solution, or may be added to the solution after neutralizing the amino acid-containing solution. It is preferable to add after neutralizing the containing liquid.

When a nonionic surfactant is added after neutralization of the amino acid-containing solution, a surfactant solution containing the nonionic surfactant and the aqueous medium is prepared, and the neutralized amino acid is prepared. It can be added to the containing liquid.
The content of the nonionic surfactant in the surfactant solution is preferably 0.2% by mass to 15% by mass, more preferably 1% by mass to 10% by mass, and 1.5% by mass. It is more preferable that it is% -5 mass%.

  When the nonionic surfactant solution is added after neutralization of the amino acid-containing liquid, the content of the nonionic surfactant is within a preferable content range with respect to the total amount of the dispersion composition described above. The range is preferably 1% by mass to 10% by mass, more preferably 0.5% by mass to 5% by mass, and still more preferably 1% by mass to 2% by mass.

When preparing the dispersion composition of the present invention, while stirring the neutralized amino acid-containing liquid, a surfactant solution containing a nonionic surfactant and an aqueous medium is added and mixed thoroughly with stirring. Thereafter, a dispersion composition may be prepared using a known dispersion apparatus such as a homogenizer.
There is no restriction | limiting in particular in the preparation method of a dispersion composition, A well-known method is applicable. When preparing a dispersion composition, it can be performed by a method including the steps described below. In addition, the method described below is an example of the preparation method of a dispersion composition, It is not limited to this.

(Mixing process)
In preparing the dispersion composition, an oil phase component containing a complex of a sparingly soluble amino acid and a liquid fatty acid is converted into an aqueous phase component containing a nonionic surfactant and an aqueous medium at 40 ° C to 90 ° C. A mixing step of adding and mixing while stirring under a temperature condition can be included.
In the mixing step, any commercially available mixing means may be used. That is, while stirring an aqueous medium containing a nonionic surfactant using an apparatus such as a magnetic stirrer, a home mixer, a paddle mixer, an impeller mixer, etc., an amino acid-containing liquid is added, and the amino acid-containing liquid and the aqueous medium Can be mixed and stirred to prepare a dispersion composition that is a uniform suspension.

(Dispersion process)
In addition, stirring means having a stronger shearing force than the above-described mixing means, that is, a high-speed stirring method using a homomixer, a disper mixer, an ultramixer, etc., an ultrasonic method using an ultrasonic homogenizer, and a high shear using a high-pressure homogenizer It is preferable to prepare a dispersion composition by refining using a refining means such as a high-pressure homogenizer method that applies force, and in particular, a dispersion step using a high-pressure dispersing means is preferable.
Examples of ultrasonic homogenizers include ultrasonic homogenizer US-600, US-1200T, US-1200T, US-1200T, US-MUS-1200T (above, manufactured by Nippon Seiki Seisakusho Co., Ltd.), ultrasonic processor UIP2000, UIP-4000. , UIP-8000, UIP-16000 (above, manufactured by Heelscher) and the like. These high-power ultrasonic irradiation devices can be used at a frequency of 25 kHz or less, preferably 15 to 20 kHz.

Examples of the high-pressure homogenizer include microfluidizer (manufactured by Microfluidics), nanomizer (manufactured by Yoshida Kikai Kogyo Co., Ltd.), starburst (manufactured by Sugino Machine Co., Ltd.), gorin type homogenizer (manufactured by APV), and Ranier. Type homogenizer (manufactured by Lanier), high-pressure homogenizer (manufactured by Niro Soabi), homogenizer (manufactured by Sanwa Kikai Co., Ltd.), high-pressure homogenizer (manufactured by Izumi Food Machinery Co., Ltd.), ultra-high pressure homogenizer (manufactured by Ika) Is mentioned.
The operating pressure of the high-pressure homogenizer is 50 MPa or more, more preferably 150 MPa or more, from the viewpoint of miniaturization. Further, the number of passes of the high-pressure treatment may be one, but in order to improve the uniformity of the entire liquid, it is preferably 2 times or more, more preferably 2 to 5 times. The temperature before the high-pressure dispersion treatment is set to 20 ° C to 80 ° C, more preferably 40 ° C to 70 ° C. Immediately after the high-pressure dispersion treatment, it is preferable to quickly cool using a cooling means and lower the temperature to a predetermined temperature. Any commercially available heat exchanger can be used as the cooling device.

(Other processes)
When preparing the dispersion composition of this invention, it can have other processes other than the above-mentioned process if necessary. Examples of other processes include a sterilization process, a pH adjustment process, and a concentration adjustment process.
As other steps, the method for preparing the dispersion composition may have a sterilization step if necessary.
(Sterilization process)
The sterilization step may be performed at any stage in each step of preparing the dispersion composition of the present invention. However, when performing the sterilization step, as soon as possible after the stirring and mixing step or the dispersion step such as high-pressure dispersion. It is preferable to carry out.

  Examples of the sterilization method in the sterilization process include heating methods such as dry heat sterilization and steam sterilization, electron beam sterilization, ionizing radiation sterilization, electromagnetic wave methods such as high frequency sterilization, and gases such as ethylene oxide gas (EOG) sterilization Examples thereof include sterilization, hydrogen peroxide low temperature plasma sterilization, chemical sterilization methods, chemical sterilization methods, and filtration sterilization methods such as separation and removal. As the sterilization step performed when preparing the dispersion composition of the present invention, dry sterilization, heat sterilization such as steam sterilization, and filter sterilization are preferable.

<Cosmetics>
The cosmetic of the present invention contains a dispersion composition containing a hardly soluble amino acid, a liquid fatty acid, a nonionic surfactant and an aqueous medium.
Thereby, a hardly soluble amino acid can be stably blended in cosmetics, and the permeability of the hardly soluble amino acid to the skin can be improved.

The details described above are applied as they are for the details of the dispersion composition.
In addition to the components described in the section of the dispersion composition, the cosmetics appropriately contain additive components that are usually used in the field of cosmetics and the like (hereinafter also referred to as “other additive components”) depending on the form. You may let them.

Examples of other additive components include pH adjusters, antioxidants, preservatives, ultraviolet absorbers, fragrances, colorants, excipients, viscosity modifiers, radical scavengers, etc. These additives can be used in combination.
Moreover, various components can be mix | blended based on the function. For example, emollient, treatment agent, lubricant, moisturizer, hair restorer, hair nourishing agent, hair growth agent, anti-whitening agent, anti-aging agent, perfume, coloring agent, antiperspirant, cooling agent, cooling agent, warming agent Etc.

As the pH adjuster, a base solution such as sodium hydroxide, an acid such as hydrochloric acid, a buffer solution such as a phosphate buffer or a citrate buffer can be used.
Examples of the antioxidant include ascorbic acid, ascorbic acid derivatives, and citric acid monoglyceride.
Examples of the preservative include methyl paraben, ethyl paraben, propyl paraben, isopropyl paraben, phenoxyethanol, pentylene glycol, dipropylene glycol, 1,3-butylene glycol, 3-iodo-2-propynyl N-butyl carbamate and the like.

The cosmetics of the present invention can be used as facial cosmetics, scalp cosmetics, and hair growth cosmetics.
There is no restriction | limiting in particular in the form of cosmetics, Cosmetics, such as lotion (lotion), a cosmetic liquid (essence), cream, milky lotion, powder foundation (solid cosmetics), can be illustrated.
The form of the cosmetic composition of the present invention containing the dispersion composition of the present invention is not particularly limited. However, since the dispersion composition of the present invention has high transparency, lotions and beauty products that require transparency. By applying to liquid (essence) etc., the effect can be exhibited more notably.

  The cosmetic of the present invention can be produced according to a known method. For example, the dispersion composition of the present invention is obtained by diluting with a purified water or the like so that the content concentration of the hardly soluble amino acid is 0.00001% by mass to 10% by mass or the like with respect to the total mass of the cosmetic. be able to.

  The present invention will be described more specifically with reference to the following examples. The embodiment described below is an example of the configuration of the present invention, and the present invention is not limited to the following embodiment. In the following description, “parts” or “%” are based on mass unless otherwise specified.

[Examples 1-7, Comparative Examples 1-4]
<Preparation of dispersion composition>
(Preparation of amino acid-containing liquid)
The following components were stirred and dissolved at 70 ° C. for 1 hour to obtain an alkaline amino acid-containing liquid containing L-cystine and isostearic acid.
L-cystine [slightly soluble amino acid] 1.00 g
Isostearic acid [liquid fatty acid] 2.37g
1 mol / L NaOH [alkaline aqueous solution] 8.33 g
8.33g of pure water

(Neutralization)
While stirring the alkaline amino acid-containing liquid obtained above, 8.33 g [acidic aqueous solution] of 1 mol / L HCl was added to neutralize the amino acid-containing liquid. Hereinafter, the neutralized amino acid-containing liquid is referred to as L-cystine-containing liquid.

(Preparation of aqueous surfactant solution)
The following components were stirred at 70 ° C. for 1 hour and dissolved to obtain an aqueous surfactant solution.
Isostearic acid decaglycerin ester [nonionic surfactant] 2.00 g
Glycerin 56.40g
Pure water 13.24g

While stirring the L-cystine-containing liquid, an aqueous surfactant solution was added, and stirring was continued until it was sufficiently mixed.
Furthermore, using a homogenizer (model name: HP93, manufactured by SMT Co., Ltd.), the mixture was stirred at 10,000 rpm for 1 minute to perform preliminary dispersion to obtain a preliminary dispersion.
Subsequently, the obtained preliminary dispersion was subjected to high-pressure dispersion at a pressure of 200 MPa using a dispersion apparatus: Starburst Mini HJP-25001 (trade name, manufactured by Sugino Machine Co., Ltd.). A product (D-01) was obtained.
Further, dispersion compositions (D-02 to D-11) were obtained in the same manner as in Example 1 except that the composition was changed as shown in Tables 2 and 3 below. The dispersion compositions (D-02 to D-07) are dispersion compositions of Examples 2 to 7, and the dispersion compositions (D-08 to D-11) are those of Comparative Examples 1 to 4. It is a dispersion composition.
"-" In the composition of Table 2 and Table 3 shows unblended.

Details of the components used in Tables 2 and 3 are as follows.
L-cystine and tyrosine (reagent manufactured by Wako Pure Chemical Industries, Ltd.)
Isostearic acid (made by Higher Alcohol Industry Co., Ltd., isostearic acid EX)
Oleic acid (manufactured by Kao Corporation, LUNAC OA: trade name)
Lauric acid (manufactured by Kao Corporation, LUNAC L-98: trade name)
Squalane (manufactured by Nikko Chemicals Co., Ltd., NIKKOL refined olive squalane: trade name)
Isostearic acid decaglycerin ester (Nikko Chemicals, NIKKOL Decaglyn 1-ISV: trade name)
Polyoxyethylene 60 hydrogenated castor oil (Nikko Chemicals Co., Ltd., NIKKOL HCO-60: trade name)
Cocoyl glutamate Na (Ajinomoto Co., Amisoft CS-11, trade name)
Inulin lauryl carbamate (manufactured by DKSH Japan, Inutech SP1: trade name)

<Evaluation of dispersion composition>
Add 0.1 ml of the obtained dispersion composition (D-01 to D-08) to 9.9 ml of pure water, and stir for 10 minutes using a stirrer. Obtained.
(Average particle size measurement)
Using the diluted solution of the obtained dispersion composition, the average particle size of the dispersed particles was measured using a dynamic light scattering particle size measuring device FPAR-1000 (trade name, manufactured by Otsuka Electronics Co., Ltd.).

(Turbidity measurement)
Turbidity measurement of the diluted solution of the dispersion composition was measured using a spectrophotometer U-3310 (trade name, manufactured by Hitachi High-Technology Corporation).
Absorbance at a wavelength of 650 nm was defined as turbidity using a cell having an optical path length of 10 mm.

(Thermal stability evaluation)
The dispersion composition (D-01 to D-08) was heated at 80 ° C. for 30 minutes, and then the average particle size was measured under the same conditions as described above. Thermal stability evaluation was performed by the change of the average particle diameter before and after heating the dispersion composition.
The criteria for thermal stability evaluation are as follows. In the following criteria, A to C are determined that the dispersion composition exhibits thermal stability.
A: Ratio of average particle diameter after heating / average particle diameter before heating ≦ 1.5
B: 1.5 <ratio of average particle diameter after heating / average particle diameter before heating ≦ 3.0
C: 3.0 <ratio of average particle diameter after heating / average particle diameter before heating D: The results of the dispersion being broken by heating are shown in Tables 2 and 3. "-" In the evaluation results of Tables 2 and 3 indicates that the test was not performed.

As is clear from the results shown in Tables 2 and 3, the average particle size of the dispersed particles contained in the dispersion compositions (D-01 to D-07) of Examples 1 to 7 is 100 nm or less. It became clear that it was excellent in transparency from the turbidity of a dispersion composition.
Therefore, if cosmetics are prepared using these dispersion compositions, it is expected that L-cystine and tyrosine are stably blended in the cosmetics. It is also expected to improve the penetration of L-cystine and tyrosine into the skin.

[Example 8: Toner 1]
(1) 1,3-butanediol 60 g
(2) Glycerin 40g
(3) 1g oleyl alcohol
(4) Polyoxyethylene (20) sorbitan monolaurate 5g
(5) Polyoxyethylene (15) lauryl alcohol ether 5g
(6) Ethanol 100g
(7) Methylparaben 2g
(8) L-ascorbic acid Na 10 g
(9) Dispersion composition D-01 10 g
(10) 767 g of purified water
Total 1000g

  The above (1) was added to and dissolved in (10) to obtain an aqueous phase. Next, (2) to (5) and (7) to (8) were dissolved in (6) and stirred and mixed with the previous aqueous phase. Furthermore, (9) was added and mixed with stirring to obtain a skin lotion. The obtained lotion was excellent in transparency, and no turbidity was observed even after standing at 50 ° C. for 1 month.

  From these facts, it was found that the dispersion composition of this example exhibited very excellent transparency and dispersion stability even when blended in cosmetics.

<Preparation of an astaxanthin-containing emulsion composition>
The following components were dissolved for 1 hour while heating at 70 ° C. to obtain an aqueous phase composition A.
・ Sucrose stearate (HLB = 16) 33.0 g
・ Decaglyceryl monooleate (HLB = 12) 67.0 g
・ Glycerin 450.0g
・ Pure water 300.0g

The following components were dissolved for 1 hour while heating at 70 ° C. to obtain an oil phase composition A.
・ Krill extract 15.0 g
・ Mix tocopherol (Riken Vitamin, Riken E Oil 800) 32.0g
・ Medium chain fatty acid glyceride (Kao Coconard MT) 93.0g
・ Lecithin (manufactured by Riken Vitamin, Recion P, derived from soybean) 10.0 g

The aqueous phase composition A obtained above was stirred with a homogenizer (model name: HP93, manufactured by SMT Co., Ltd.) while maintaining the temperature at 70 ° C. (10000 rpm), and the oil phase composition A was added to the aqueous phase composition A. Thus, a preliminary emulsion was obtained.
Subsequently, the obtained preliminary emulsified product was cooled to about 40 ° C., and high pressure emulsification was performed at 200 MPa using an optimizer HJP-25005 (manufactured by Sugino Machine Co., Ltd.). Then, it filtered with the micro filter with an average hole diameter of 1 micrometer, and prepared the astaxanthin containing emulsion composition (astaxanthin content rate: 0.3 mass%).

  The obtained astaxanthin-containing emulsion composition was diluted to 1% by mass with milli-Q water, and the particle size of the dispersed particles was measured using a particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.). there were.

  Even if the above krill extract is replaced with product name: Astax-ST Marine Daio Co., Ltd. or product name: ASTOTS-S Takeda Paper Co., Ltd. (Hematococcus alga extract), an equivalent emulsion composition is obtained. I can do it.

<Preparation of lycopene-containing emulsion composition>
[Oil phase composition B]
・ Tomato oleoresin 1.14g
(Sunbright, Lyc-O-Mato 15% (containing 15% by mass of lycopene))
・ Lecithin (manufactured by Riken Vitamin, Recion P, derived from soybean) 1.0g
・ Medium chain fatty acid glyceride (Kao Coconard MT) 12.8g

[Aqueous composition B]
・ Decaglyceryl oleate-10 8.0 g
(HLB = 12.0, manufactured by Nikko Chemicals, Decaglyn 1-OV)
・ Sucrose stearate 2.0g
(Mitsubishi Chemical Foods, Ryoto Sugar Ester S-1670)
・ Glycerin 45.0g
・ Remaining amount up to 100g of purified water

Each component used in the aqueous phase composition B is weighed in a container according to the above composition, heated and mixed with stirring in a constant temperature bath at 70 ° C., confirmed to be well mixed, held at 70 ° C., An aqueous phase composition B was obtained.
In addition, each component used in the oil phase composition B is weighed in a container according to the above composition, heated and mixed on a hot plate at 150 ° C. for 5 minutes, and confirmed to be well mixed. Phase composition B was obtained.
The obtained aqueous phase composition B was added to the oil phase composition B, mixed with stirring, and dispersed using an ultrasonic homogenizer to obtain a coarse dispersion.
Thereafter, the obtained coarse dispersion was further emulsified at a high pressure of 200 MPa using an ultrahigh pressure emulsifier (Altimizer, manufactured by Sugino Machine Co., Ltd.), and a lycopene-containing composition (lycopene content: 0.17% by mass) ) Was prepared.

The obtained lycopene-containing emulsion composition was diluted by 1% by mass with milliQ water, and the particle size of the dispersed particles was measured using a particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.). It was.
A cosmetic was prepared as follows using the astaxanthin-containing emulsion composition and the lycopene emulsion composition prepared by the above method as appropriate.

[Example 9: Lotion 2]
A lotion having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Dispersion composition D-01 1.0
Arbutin 2.0
Dipotassium glycyrrhetinate 1.0
Dipropylene glycol 4.0
Polyoxyethylene methyl glucoside 1.0
1,3-butylene glycol 4.0
Polyethylene glycol 1.0
Ethanol 2.0
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Phenoxyethanol 0.3
Glycerin mono-2-ethylhexyl ether 0.2
Oryzanol 0.01
Polyoxyethylene phytosterol (NIKKOL BPS-20: manufactured by Nikko Chemicals Co., Ltd.) 0.03
N-acetyl-L-hydroxyproline 1.0
Water-soluble collagen 1.0
Hydrolyzed collagen 1.0
Seaweed extract (1) 1.0
Astaxanthin-containing emulsion composition (krill extract) 0.2
[Composition prepared by the method described above]
Lycopene-containing emulsion composition [composition prepared by the above-described method] 0.1
Phosphoric acid-L-ascorbyl magnesium 1.0
Sodium hyaluronate 0.2
Citric acid 1.0
Sodium citrate Suitable amount Purified water Remaining

[Example 10: Cosmetic liquid]
A serum having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Dispersion composition D-05 1.0
Phosphoric acid-L-ascorbyl magnesium 2.0
Dipotassium glycyrrhetinate 1.0
Dipropylene glycol 4.0
Glycerin 5.0
Diglycerin 2.0
1,2-pentanediol 2.0
Phenoxyethanol 0.5
Methyl paraoxybenzoate 0.1
Alkali Neges Relatus B-16 Polymer 0.05
Oryzanol 0.01
Polyoxyethylene phytosterol (NIKKOL BPS-20: manufactured by Nikko Chemicals Co., Ltd.) 0.03
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Camellia extract 0.01
Lecithin 0.05
Citric acid 0.7
Sodium citrate appropriate amount N-acetyl-L-hydroxyproline 1.0
Water-soluble collagen 1.0
Hydrolyzed collagen 1.0
Yeast extract (1) 1.0
Astaxanthin-containing emulsion composition (krill extract)
[Composition prepared by the method described above] 0.2
Lycopene-containing emulsion composition [composition prepared by the above-described method] 0.2
Purified water remaining

[Example 11: Cream]
A cream having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Dispersion composition D-01 1.0
Arbutin 2.0
Dipotassium glycyrrhetinate 1.0
Phosphoric acid-L-ascorbyl magnesium 0.1
1,2-pentanediol 3.0
Dipropylene glycol 7.0
Concentrated glycerin 5.0
Polyethylene glycol 6000 [Molecular weight: 6000] 1.0
Sodium hyaluronate 0.5
Trimethylglycine 0.5
1,3-butylene glycol 3.0
Xanthan gum 0.5
Acrylic acid / alkyl methacrylate copolymer 0.7
Squalane 0.5
Shea fat 1.0
Sara honey bee 1.0
Behenyl alcohol 1.0
Glyceryl monostearate 2.0
Polyoxyethylene glyceryl isostearate 1.0
Tocopherol 0.5
Astaxanthin 0.2
Water-soluble collagen 1.0
Hydrolyzed collagen solution (from fish) 1.0
N-acetyl-L-hydroxyproline 1.0
Oryzanol 0.01
Polyoxyethylene phytosterol (NIKKOL BPS-20: manufactured by Nikko Chemicals Co., Ltd.) 0.03
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Camellia extract 0.01
Lecithin 0.1
Sucrose fatty acid ester 0.1
Polyglyceryl monooleate 0.1
Citric acid 0.7
Sodium citrate appropriate amount phenoxyethanol 0.3
Purified water remaining

[Example 12: Sunscreen agent]
A sunscreen agent having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Dispersion composition D-01 1.0
Cyclopentasiloxane 20.0
Dimethicone 10.0
Titanium oxide 5.0
t-Butylmethoxybenzoylmethane 1.0
HXMT-100ZA (Taika, average primary particle size 15 nm) 6.0
Aluminum hydroxide 1.0
Isostearic acid 0.5
Sorbitan sesquioleate 1.0
Dipotassium glycyrrhetinate 0.5
Phosphoric acid-L-ascorbyl magnesium 0.1
Krill extract 0.5
Water-soluble collagen 1.0
Citric acid 0.7
Sodium citrate appropriate amount Tocopherol 0.5
Oryzanol 0.01
Polyoxyethylene phytosterol (NIKKOL BPS-20: manufactured by Nikko Chemicals Co., Ltd.) 0.03
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Camellia extract 0.01
Lecithin 0.1
Perfume Trace amount of methyl paraoxybenzoate 0.15
Purified water remaining

[Example 13: Latex]
An emulsion having the following composition was prepared by heating the oil phase and the aqueous phase to 70 ° C. and stirring them while emulsifying (total amount: 100% by mass).
[Composition] [Content (% by mass)]
≪Oil phase component≫
Dispersion composition D-01 1.0
Haematococcus alga extract 0.2
Astaxanthin-containing emulsion composition (krill extract)
[Composition prepared by the method described above] 0.4
Squalane 8.0
Jojoba oil 7.0
Cetyl alcohol 1.5
≪Water phase ingredient≫
Glycerol monostearate 2.0
Polyoxyethylene cetyl ether 3.0
Polyoxyethylene soorbitan monooleate 2.0
1,3-butylene glycol 1.0
Glycerin 2.0
Sucrose stearate 0.1
Polyglyceryl oleate-10 0.1
Polyglyceryl stearate-2 0.1
Phenoxyethanol 0.2
Collagen 1.0
Oryzanol 0.01
Polyoxyethylene phytosterol (NIKKOL BPS-20: manufactured by Nikko Chemicals Co., Ltd.) 0.03
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Camellia extract 0.01
Lecithin 0.05
Arbutin 0.5
Dipotassium glycyrrhetinate 0.5
Citric acid 1.0
Sodium citrate Appropriate perfume Amount of purified water Remaining amount

[Example 14: Jerry-like serum]
A jelly-like serum having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Dispersion composition D-03 1.0
Haematococcus alga extract 0.1
Astaxanthin-containing emulsion composition (krill extract)
[Composition prepared by the method described above] 0.2
Ceramide III, VI mixture 1.0
Hydrolyzed collagen 1.0
Acetylhydroxyproline 1.0
Ethylhexyl glycerin 0.1
Oleic acid 0.5
1,3-butylene glycol 1.0
Glycerin 2.0
Sucrose 0.1
Polyglyceryl oleate-10 0.1
Polyglyceryl stearate-2 0.1
Phenoxyethanol 0.2
Collagen 1.0
Oryzanol 0.01
Polyoxyethylene phytosterol (NIKKOL BPS-20: manufactured by Nikko Chemicals Co., Ltd.) 0.03
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Camellia extract 0.01
Lecithin 0.1
Citric acid 1.0
Sodium citrate appropriate amount (PEG-240 / decyltetradeceth-20 / HDI) copolymer 0.3
Damask rose flower oil Trace fragrance Trace purified water Remaining

[Example 15: Wet foundation]
A slurry having the following composition was prepared, filled in a predetermined container, and dried to prepare a solid powder cosmetic (wet foundation) (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Dispersion composition D-01 0.1
Talc (OTS-2 TALK JA-46R: manufactured by Daito Kasei Kogyo Co., Ltd. 18
Titanium oxide (OTS-2 TiO2 CR-5: manufactured by Daito Kasei Kogyo Co., Ltd.) 9.0
Iron oxide yellow (OTS-2 YELLOW LLXLO: manufactured by Daito Kasei Kogyo Co., Ltd.) 2.3
Iron oxide red (OTS-2 RED R-516L: manufactured by Daito Kasei Kogyo Co., Ltd.) 0.15
Iron oxide black (OTS-2 BLACK BL-100: manufactured by Daito Kasei Kogyo Co., Ltd.) 0.3
Pearl pigment (gold) (Rona Flare Balance Gold: Merck) 13
Pearl pigment (red) (Transprismer Red: manufactured by Merck) 7.0
Composite powder pigment (HNB RED7: manufactured by Daito Kasei Kogyo Co., Ltd.) 1.0
Dimethicone trimethylsiloxysilicate (DC593:
Toray Dow Corning Co., Ltd.) 3.0
Dimethicone (SH200C-20cs: manufactured by Toray Dow Corning Co., Ltd.) 7.0
Phenoxyethanol 0.5
Sericite (OTS-2 SERICITE FSE: manufactured by Daito Kasei Kogyo Co., Ltd.)

[Example 16: Liquid foundation]
A liquid foundation (W / O emulsion) having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Dispersion composition D-05 1.0
Dipotassium glycyrrhizinate 0.2
Specific red composite pigment * 1 0.5
Extender * 2 15.0
Colorant pigment * 3 2.0
Pearl pigment * 4 3.0
Cyclomethicone 25.0
Dimethicone polyol 5.0
Lauryl PEG-9 polydimethylsiloxyethyl dimethicone 3.0
PEG-9 polydimethylsiloxyethyl dimethicone 1.2
Squalane 0.1
Sorbitan sesquiisostearate 1.0
Distemalimonium Hectorite 0.8
Ethyl hexyl methoxycinnamate 2.5
Hematococcus prubiaris oil 0.1
Tocopherol 0.1
Damask rose flower oil Trace amount fragrance Appropriate amount Phenoxyethanol 0.3
Glycerin 10.0
Dipropylene glycol 4.0
1,3-butylene glycol 3.0
Water-soluble collagen 0.1
Royal Jelly Extract 0.1
Oryzanol 0.01
Polyoxyethylene phytosterol (NIKKOL BPS-20: manufactured by Nikko Chemicals Co., Ltd.) 0.03
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Camellia extract 0.01
Lecithin 0.1
Ca chloride 1.0
Citric acid 1.0
Sodium citrate Appropriate amount of ion-exchanged water Remaining amount The following pigments * 1 to * 4 were used.
* 1 HNB RED7 (Daito Kasei Kogyo Co., Ltd.)
* 2 OTS-2 SERICITE PSE and OTS-2 TALK JA-46R (both manufactured by Daito Kasei Kogyo Co., Ltd.) mixed at a ratio of 7: 3 * 3 OTS-2 TiO2 CR-50 and OTS-2 YELLOW LLXLO, OTS-2 RED R-516L and OTS-2 BLACK BL-100 (both manufactured by Daito Kasei Kogyo Co., Ltd.) in a ratio of 78: 19: 1: 2 * 4 Lona Flare Balance Gold and Transformer Prisma-red (both manufactured by MERCK) mixed at a ratio of 7: 3

[Example 17: Face wash]
A face wash having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Dispersion composition D-05 1.0
Myristic acid K 2.0
Palmitic acid K 0.5
Stearic acid K 0.5
(Lauramide / Myristamide) DEA 1.0
Cocoylglycine Na 10.0
Lauro Anjo Na 13.0
PEG-32 3.0
Butylene glycol 15.0
Glycerin 10.0
Sorbitol 5.0
Potassium hydroxide appropriate amount Glyceryl stearate 1.5
Hematococcus spurbiaris oil 0.05
Astaxanthin-containing emulsion composition (krill extract) 0.05
[Composition prepared by the method described above]
Lycopene-containing emulsion composition [composition prepared by the above-described method] 0.1
Water-soluble collagen 1.0
Tocopherol 0.5
Citric acid 1.0
Sodium citrate appropriate amount shea fat 1.0
Polyquaternium-7 0.5
Polyquaternium-39 0.5
Sodium lauroyl glutamate 1.0
Oryzanol 0.01
Polyoxyethylene phytosterol (NIKKOL BPS-20: manufactured by Nikko Chemicals Co., Ltd.) 0.03
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Camellia extract 0.01
Phenoxyethanol 0.5
Damask rose flower oil appropriate amount perfume appropriate amount

Claims (9)

Contains a sparingly soluble amino acid, a fatty acid that is liquid at room temperature, a nonionic surfactant, and an aqueous medium ,
The dispersion composition in which a nonionic surfactant contains at least 1 sort (s) chosen from polyglyceryl fatty acid ester and polyoxyethylene hydrogenated castor oil .   The dispersion composition according to claim 1, wherein the hardly soluble amino acid comprises at least one selected from cystine and tyrosine.   The dispersion composition according to claim 1 or 2, wherein the fatty acid liquid at room temperature contains at least one selected from isostearic acid and oleic acid. Furthermore, the dispersion composition of any one of Claims 1-3 containing the polysaccharide which has a substituent containing an aliphatic group. The dispersion composition according to claim 4 , wherein the polysaccharide having a substituent containing an aliphatic group is inulin laurylcarbamate. Furthermore, the dispersion composition of any one of Claims 1-5 containing the oil agent different from a liquid fatty acid at room temperature. The dispersion composition according to claim 6 , wherein the ratio of the inorganic value / organic value of the oil different from the liquid fatty acid at room temperature is 0.3 or less. A liquid fatty acid at room temperature, the total content of different oils and fatty acids that are liquid at room temperature, the ratio of the total content of sparingly soluble amino acid is 5 or less in mass ratio to claim 6 or claim 7 The dispersion composition described. Cosmetics containing the dispersion composition of any one of Claims 1-8 .