JP5362203B2 - Stress relieving agent - Google Patents

Description

  The present invention relates to relieving stress caused by tea leaf components.

  Modern people are exposed to various stresses everywhere. If stress continues, you may not be able to sleep due to psychological tension anxiety, and this temporary psychological insomnia triggers insomnia phobias, causing psychiatric insomnia that the more you become conscious of sleep, the more you become sleepless May end up. Studies have shown that 1 in 5 modern people have sleep problems, and stress is one of the causes of various lifestyle-related diseases.

  Against this background, various ideas for relieving stress have been made. The relaxation of the spirit using a fragrance is a typical example, and aromatherapy using an essential oil is becoming common (see, for example, Patent Document 1 [0002]).

  As the fragrance, lavender, orange, camomil, etc. are common, and green leaf aldehyde (trans-2-hexenal: hereinafter referred to as hexenal) or green leaf alcohol (cis-3-hexenol), which is also called green fragrance contained in the green leaf. : Hereinafter referred to as hexenol) is also said to be effective (see, for example, Patent Document 2 [0003] [0006], Non-Patent Document 1).

  Further, it has been disclosed by the present inventor that a component extracted from tea leaves has a relaxation effect (see, for example, Patent Document 3). However, the ingredients extracted from tea leaves may have some effects that the relaxation effect obtained by mixing many ingredients may be masked by some ingredients, and some people may feel ineffective.

On the other hand, when Aoba aldehyde (trans-2-hexenal) or Aoba alcohol (cis-3-hexenol) is used alone, the initial effect is remarkable, but the depth of the effect and the sustainability of the effect are not. I sometimes felt it.
JP 2004-244756 A Japanese Patent Laying-Open No. 2005-299066 JP 2007-176857 A http: // kaihatsu. okomari. net / midori-no-kaori / Physiology & Behavior80 (2004) 481-488

  An object of this invention is to provide the stress reduction agent with a reliable effect and the effect lasting.

The gist of the invention is that an extract (A) obtained by cooling water generated by heating water mixed with fresh tea leaves at a temperature lower than the temperature at which the water boils,
Extract (B) obtained by cooling the gas generated by heating fresh tea leaves at a temperature lower than the temperature at which water contained in the fresh tea leaves boils,
A mixed extract in which the extract (A) and the extract (B) are mixed;
A stress reducing agent comprising 10 parts by weight of a liquid selected from 1 and 1 to 100 parts by weight of green leaf alcohol in addition to the liquid.

  The green leaf alcohol may include 3-hexenol (Z).

  The 3-hexenol (Z) may be extracted from peppermint.

  Moreover, the gist of the present invention is that it is a stress reducing agent in which the stress reducing agent is supported on a carrier.

Further, the gist of the present invention is the step of preparing the stress reducing agent,
Mixing the stress relieving agent and cyclodextrin to obtain a mixture;
And a step of drying the mixture.

Still further, the gist of the present invention is the step of preparing the stress reducing agent,
Mixing the stress relieving agent and water to obtain a mixture;
Mixing the mixture and cyclodextrin to obtain a mixture;
And a step of drying the mixture.

  ADVANTAGE OF THE INVENTION According to this invention, the stress reduction agent with a reliable effect and a durable effect is provided.

  The stress reducing agent of the present invention is obtained by adding a green leaf alcohol component, which is an essential oil component derived from plant green leaves, to an extract obtained by extraction from fresh tea leaves.

  In the stress reducing agent of the present invention, the mixing ratio of the extract obtained by extracting from raw tea leaves and the components of green leaf alcohol is the components of green leaf alcohol with respect to 10 parts by weight of the extract obtained by extracting from raw tea leaves. Is preferably 1 to 100 parts by weight. The stress relieving agent of the present invention formulated at such a ratio has a certain effect of reducing the stress and the effect is sustained. When the ratio of the green leaf alcohol component is reduced beyond this range, the effect of reducing stress may be insufficient for some people. If the ratio of the green leaf alcohol component exceeds this range, the sustainability of the stress reduction effect may be impaired.

  In the present invention, components are extracted from fresh tea leaves within one day after picking. Tea extracted more than one day after plucking, or an extract extracted from tea that has undergone a steaming process or a subsequent process has few or little components that provide a stress-reducing effect, and has little effect of the present invention. .

  The fresh tea leaves may be frozen tea within one day after picking. The frozen product can be used in the present invention even if the time elapses beyond one day after picking. Therefore, in the present invention, fresh tea leaves mean teas that have been frozen within 1 day after picking and those that have been frozen within 1 day after picking.

  Extraction of components from fresh tea leaves can be carried out by heating the water mixed with fresh tea leaves at a temperature lower than the temperature at which the water boils and cooling and trapping the steam generated. Or it can be performed by cooling and trapping steam generated by heating fresh tea leaves at a temperature lower than the temperature at which water contained in the fresh tea leaves boils. In the present invention, an extract liquid trapped by any of these methods or a mixed extract liquid obtained by mixing the extract liquids trapped by the respective methods can be used.

  When such distillation or heating is performed at the temperature of the boiling point of water, in addition to components that are effective as stress reducing agents, high-boiling components such as polyphenols and extras such as miscellaneous substances are also extracted at the same time. A lot of this extra component is contained in the extracted component. These extra components are not preferable because they mask or prevent the effects of the stress reducing agent.

  Furthermore, in the present invention, such distillation or heating for extracting components from fresh tea leaves is preferably performed under reduced pressure. In the distillation under reduced pressure, the extract used in the present invention is obtained by heating at a temperature below the boiling point of water at that pressure. The efficiency of extraction can be increased by distillation under reduced pressure. The pressure of the reduced pressure is preferably 380 mmHg or less in order to increase the extraction efficiency and extract only the components effective for the stress reduction effect as much as possible.

  FIG. 1 is a chart obtained by measuring an extract extracted from tea leaves according to the present invention with a gas chromatograph mass spectrometer (GCMS). The extract contains hexenal represented by the peak indicated by arrow A in the figure and hexenol represented by the peak indicated by arrow B, and further contains extraction components such as benzaldehyde and benzyl alcohol peculiar to tea. Constitutes a preferred stress reducing component.

  This extraction was performed by mixing fresh tea leaves that had passed through the second half of the picking with water and distilling under reduced pressure at 60 ° C. under 350 mmHg in a conventional manner.

  As described in Non-Patent Document 2, for example, the extract obtained by distillation in this way contributes greatly to stress reduction by its components hexenal and hexenol, but other tea-specific components also exist. Contribute.

  The green leaf alcohol added to the extract or mixed extract may be extracted from plants or synthesized. Examples of components of this green leaf alcohol include 3-hexenol (Z), 3-hexenol (E), 2-hexenol (E), and n-hexanol. Especially, as a component of this green leaf alcohol, 3-hexenol (Z) is preferable.

  The 3-hexenol (Z) is preferably a component extracted from peppermint. The 3-hexenol (Z) component extracted from peppermint has a peak of 3-hexenol (Z) (D) as seen in the chart obtained by measurement with a gas chromatograph mass spectrometer (GCMS) shown in FIG. In addition to the above, many other ingredients specific to peppermint are included, and it is considered that the other ingredients specific to peppermint have a subtle effect on the effect of reducing stress.

  Furthermore, the stress reducing agent of the present invention contains hexenal and hexenol and has not only an excellent stress reducing effect, but also an effect of tea leaf extract, that is, a deodorizing effect and an aromatherapy effect.

  The stress reducing agent of the present invention can be supported on a carrier and used as a stress reducing agent. For example, volatilization can be suppressed and sustained release can be imparted by inclusion of an active ingredient contained in the stress reducing agent in cyclodextrin, particularly α-type cyclodextrin. The active ingredient may be encapsulated in a resin capsule material such as a melamine resin.

  As a method for including this active ingredient in cyclodextrin, the stress reducing agent of the present invention or a mixture obtained by mixing a solution obtained by adding water to the stress reducing agent and cyclodextrin is stirred and then dried. Is mentioned. When cyclodextrin is added to the stress reducing agent of the present invention or a solution obtained by adding water to the stress reducing agent and stirred, the active ingredient mainly composed of hexenal and hexenol in the solution is included in the cyclodextrin. According to this method, about 20 parts by weight of hexenal, hexenol, or a mixture of hexenal and hexenol is clathrated with respect to 100 parts by weight of cyclodextrin, and when the liquid is dried, a powder of cyclodextrin in the clathrate state is obtained. This powder is used as a stress reducing agent.

  Although the stirring method is not limited, it is preferable to use, for example, a homogenizer. Also, the drying method is not limited, but spray drying with an atomizer is preferable because of its high efficiency. It is efficient and preferable that the inlet temperature in spray drying with an atomizer is 150 to 160 ° C. and the atomizer condition is 10,000 to 30,000 rpm.

  Furthermore, the stress reducing agent containing or including the stress reducing agent can be attached to another material, for example, a non-woven fabric as it is or via a binder.

  When a stress reducing agent obtained by distillation or a stress reducing agent supported on cyclodextrin or the like is put into an ultrasonic humidifier and sprayed by an ultrasonic vibrator, an effective stress reducing device is obtained. At this time, if a favorite perfume ingredient is added and enjoyed as aromatherapy, a synergistic effect can be expected for stress reduction.

  The volatilization and transpiration means of the stress reducing agent may be volatilized naturally as it is in a liquid or in a gel such as an agar gel or may be vaporized by heating. Alternatively, it may be a method of smelling a stress reducing agent component that is volatilized by mixing in a favorite product such as gum and chewing the favorite product or in the process of eating and drinking.

  In the following, some examples of the embodiment of the present invention will be described.

Extract Solution About 100 g of fresh tea leaves (picked state) were packed into a 2 liter Erlenmeyer flask, gradually heated with a Bunsen burner, and maintained at 70 to 90 ° C. At this time, a condenser glass tube and a thermometer are inserted into the flask, and the distillate is dropped from the tip of the glass tube. In about 30 minutes, 20 ml of extract was obtained. FIG. 3 shows a bar graph with the vertical axis representing the weight ratio (relative value) of the main components contained in the extract based on a gas chromatograph mass spectrometer (GCMS) chart of the extract. As shown in FIG. 3, this extract contains 1-butanol. In addition to 3-hexenol (Z) and 2-hexenal (E). It can be seen that 3 methyl, 1-hexanol, linalool oxide, benzaldehyde, linalool, 1-octanol, graniol, benzyl alcohol and the like are contained.
Aoba alcohol
A mixture of 90 parts by weight of 3-hexenol (Z) (composite) and 10 parts by weight of 3-hexenol (E) (composite) was used.

  50 parts by weight of the extract and 50 parts by weight of green leaf alcohol were mixed to obtain a stress reducing agent.

  A small ultrasonic humidifier was prepared, and a mixed liquid in which 20 ml of this stress reducing agent was added to 0.5 liter of tap water was prepared and put into the humidifier. When the humidifier was operated, it became a stress relieving agent spreading device with a faint scent of green leaves in the installed laboratory.

  About 1 kg of fresh tea leaves similar to Example 1 were put into a rotary evaporator and operated at 60 ° C. for 1 hour while reducing the pressure to 380 mmHg, and about 250 ml of an extract was obtained through a condenser. 20 parts by weight of this extract and 80 parts by weight of 3-hexenol (Z) extracted from peppermint were mixed to obtain a stress reducing agent. The chart by the gas chromatograph mass spectrometer (GCMS) of 3-hexenol (Z) extracted from this peppermint is shown in FIG.

  A small ultrasonic humidifier was prepared, and a mixed liquid in which 20 ml of this stress reducing agent was added to 0.5 liter of tap water was prepared and put into the humidifier. When the humidifier was operated, it became a stress relieving agent spreading device with a faint scent of green leaves in the installed laboratory.

  100 ml of the stress reducing agent obtained in Example 2 and 2 g of α-cyclodextrin were mixed and stirred with a homogenizer at 8000 rpm × 10 minutes to obtain a dispersion. This dispersion was dried with an atomizer to obtain a stress reducing agent. On the other hand, a small ultrasonic humidifier was prepared, and a mixed liquid in which 100 ml of this dispersion was added to 0.5 liter of tap water was prepared and put into the humidifier. When the humidifier was operated, it became a stress reducing agent spreading device with a faint scent of green leaves in the installed laboratory.

[Comparative Example 1]
A small ultrasonic humidifier was prepared, and a mixed liquid obtained by adding 20 ml of the extract obtained in Example 1 to 0.5 liter of tap water was prepared and put into the humidifier. When the humidifier was operated, it became a stress relieving agent spreading device with a faint scent of green leaves in the installed laboratory.

[Comparative Example 2]
A small ultrasonic humidifier was prepared, and a mixed liquid obtained by adding 20 ml of 3-hexenol (Z) extracted from peppermint used in Example 2 to 0.5 liter of tap water was prepared and put into the humidifier. . When the humidifier was operated, it became a stress relieving agent spreading device with a faint scent of green leaves in the installed laboratory.

  Table 1 shows the test results of five monitors for each of Examples 1 to 3 and Comparative Examples 1 and 2 using the stress-reducing agent diffusing device. After spending 20 minutes in the vicinity of the monitor about 1 m away from the stress-reducing agent spreading device, the monitor spent 2 hours in a separate room and experienced the degree of relaxation.

It is the chart obtained by measuring the extract extracted from tea leaves with a gas chromatograph mass spectrometer (GCMS). It is a graph of the content rate (relative value) of the main components contained in the extract extracted from tea leaves. It is the chart obtained by measuring the green leaf alcohol component (3-hexenol (Z)) extracted from peppermint with a gas chromatograph mass spectrometer (GCMS).

Claims (6)

Distilled liquid (A) obtained by cooling the gas generated by heating water mixed with fresh tea leaves under normal pressure or reduced pressure at a temperature lower than the temperature at which the water boils,
Distilled liquid (B) obtained by heating fresh tea leaves under normal pressure or reduced pressure at a temperature lower than the temperature at which water contained in the fresh tea leaves boils is cooled.
Distillate (A) and distillate (B) and is mixed mixed distillate,
A stress reducing agent comprising 10 parts by weight of a liquid selected from 1 and 1 to 100 parts by weight of green leaf alcohol in addition to the liquid. The stress reducing agent according to claim 1, wherein the green leaf alcohol contains 3-hexenol (Z). The stress relieving agent according to claim 2, wherein the 3-hexenol (Z) is extracted from peppermint. A stress relieving agent obtained by supporting the stress relieving agent according to claim 1 on a carrier. Preparing a stress relieving agent according to any one of claims 1 to 3,
Mixing the stress relieving agent and cyclodextrin to obtain a mixture;
A method for producing a stress reducing agent comprising the step of drying the mixture. Preparing a stress relieving agent according to any one of claims 1 to 3,
Mixing the stress relieving agent and water to obtain a mixture;
Mixing the mixture and cyclodextrin to obtain a mixture;
A method for producing a stress reducing agent comprising the step of drying the mixture.

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