JPH07316582A - Sleep-inducing perfume composition - Google Patents

Abstract

PURPOSE:To obtain a perfume composition capable of inducing sleep without having adverse effect on physical health, useful for e.g. perfuming beddings, comprising an oris-based perfume, sandalwood-based one and rose-based one. CONSTITUTION:This composition comprises (A) an oris-based perfume obtained by solvent extraction of the dried rhizome of e.g. Iris-pallida belonging to Iris, (B) a sandalwood perfume obtained by steam distillation of e.g. the root chips of Santalum-album, and (C) a rose-based perfume obtained by steam distillation or solvent extraction of the flowers such as of Rosa-damascena or Rosa- centifelia, at the weight ratio A:B:C=(1-8):(10-50):(2-10).

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fragrance composition, and more particularly to a sleep-inducing fragrance composition.

[0002]

2. Description of the Related Art In recent years, the number of patients complaining of insomnia reflecting various stresses has been increasing, and especially for people who complain of insomnia after remission of psychogenic insomnia or depression, a sleeping pill such as pentobarbital. Or, taking anxiolytics etc. is performed.

[0003]

However, these sleeping medicines often become habitual, or become ineffective after long-term continuous use, and it may be necessary to increase the dose, which is a physical health problem. Not desirable. The present invention has been made in view of the above problems of the prior art, and an object thereof is to provide a composition capable of promoting sleep without adversely affecting physical health.

[0004]

Means for Solving the Problems As a result of intensive studies by the present inventors in order to achieve the above object, it was found that a fragrance composition containing a specific fragrance has an excellent sleep-inducing effect,
The present invention has been completed.

That is, the sleep-inducing fragrance composition according to claim 1 of the present application is characterized in that it contains an Oris fragrance, a sandalwood fragrance, and a rose fragrance. The sleep-inducing fragrance composition according to claim 2 is characterized in that Oris-based fragrance: Sandalwood-based fragrance: Rose-based fragrance is 1 to 8:10 to 50: 2 to 10. The sleeping fragrance composition according to claim 3 is added to a gel base for perfuming.
The composition according to claim 4 is a composition for perfuming bedding.

The structure of the present invention will be described below. In the present invention, examples of the Oris-based fragrance include natural essential oils obtained by solvent extraction of dried rhizomes of Iris pallida belonging to the genus Iridaceae. Examples of the sandalwood fragrance in the present invention include natural essential oils obtained by steam distillation of Santalum album pieces, root pieces and the like belonging to the sandalwood genus Sandalwood. In addition, in the present invention, as the rose-based fragrance, Rosa damas
An example is natural essential oil obtained by steam distillation or solvent extraction from flowers of plants belonging to the genus Rose of the family Rosaceae such as cena and Rosa centifelia.

In the present invention, the composition ratio of each fragrance is not particularly limited, but in order to obtain a sensually preferable fragrance, Oris fragrance: Sandalwood fragrance: Rose fragrance is 1 to 8. : 10 to 50: 2 to 10 is preferable. Considering that the combination of fragrances produces an excellent sleep-inducing effect, it can be said that rather than a component in the fragrance producing a sleep-inducing effect, an aroma in a specific sensory sense causes the sleep-inducing effect. It is conceivable that the above-mentioned organoleptically preferable aroma range is excellent in obtaining a sleep-inducing effect.

The sleeping fragrance composition of the present invention contains, in addition to ethyl alcohol, which is the base of a usual fragrance composition, other fragrances, moisturizers, powders, oils, etc. within a range not impairing the effects of the present invention. Can be blended. Further, it is not limited to a liquid, it is also preferable to use by impregnating the sleep-inducing fragrance composition of the present invention into a porous solid base or gel-like base, and especially a gel-like base excellent in aroma retention. By using the sleep-inducing fragrance composition according to the present invention together with the agent, an excellent scent can be maintained, for example, for about 30 minutes to 1 hour 30 minutes required for falling asleep. The sleep-inducing fragrance composition according to the present invention is preferably applied to bedclothes such as pillows, for example, by holding the fragrance-retaining gel.

[0009]

The preferred embodiments of the present invention will be described below. The present invention is not limited to these examples. In addition, the hypnotic fragrance | flavor composition used for the following tests is as follows. The composition has a scent that is classified as floral oriental.

Effect test (1) Test by rat In order to examine the effect of the scent-imparting fragrance composition according to the present invention, the present inventors first carried out a pentobarbital sleep-extension test on a rat. That is, it has been reported that when a sedative scent is given to an anesthetized animal with pentobarbital, the sleeping time is prolonged (T. Tsuchiya, e.
t al, Brain Research Bulletin, Vol26,397-401,199
1). Therefore, in this test, the effect of the fragrance on sleep was evaluated using this method. 200-220g
Spraque-Dawley (SD) rats of 4 hours inhaling an air flow containing the test substance (perfuming liquid is supplied with perfuming air obtained by bubbling 2 l of air per minute). Differences in pentobarbital sleep time (50 mg / kg ip injection) between the groups that did not inhale the test substance were compared. As a result, sleep time was slightly prolonged in each group of Oris, Sandalwood, and Rose alone, compared with no scent. On the other hand, the mixed composition of Oris, sandalwood and rose (the product of this example) was greatly extended (see FIG. 1).
FIG. 2 shows the sleep extension ratio based on the scentless group. Although the sleep prolongation of each group of Rose, Oris, and Sandalwood was not significant, the sleep-inducing effect of the mixed composition was significant at a risk rate of 5% by analysis of variance (ANOVA). The results of the barbital sleep test using this animal are:
It suggests that the effect of the scenting composition according to the present invention is not only a placebo effect.

(2) Clinical test 16 insomnia patients were tested for their sleep-inducing effect by actually scenting them at bedtime. That is, patients with psychogenic insomnia and patients who mainly complain of insomnia after remission of depression, taking sleeping pills and anxiolytics for a long time before bedtime, targeting those patients whose weight loss is difficult,
After giving informed consent sufficiently, I tried to reduce the amount of sleeping pills by putting a liquid fragrance on a pillow or scented paper and letting it go to bed while drifting to the bedside. As a result of examining the effect over 16 weeks, all sleeping pills were stopped and sleep was possible 4 people Sleeping pills were reduced and sleep was possible 6 people No effect was observed 6 people, more than 60% of patients complaining of insomnia Was found to have a sleep-inducing effect. In addition, the effect was not diminished due to the scent becoming used.

Examination of Application Method The sleep-inducing fragrance composition according to the present invention can exert its effect by being inhaled as an aroma, and the necessity thereof is particularly high at bedtime. Therefore, it was examined to apply the above-mentioned hypnotic fragrance composition to bedding. (1) First, the fabric of the pillow is directly impregnated with the fragrance, and when the volatile content when left to stand is analyzed by headspace gas chromatography, it is impregnated because the volatile components volatilize at a considerably fast rate over time. Immediately after (Fig. 3)
On the other hand, after 1 hour, the component balance was largely lost, and the component having a particularly low boiling point did not remain (Fig. 4). The analysis conditions by gas chromatography are as follows.
That is, the components volatilized from the fragrance are concentrated on the Tenax adsorbent, heated to be desorbed, and directly injected into the GLC. G
The LC analysis condition was to keep the column temperature at -30 ° C for 4 minutes,
Increase the temperature to 30 ° C by increasing the temperature by 5 ° C / min, and then increase by 2
Raise to 30 ° C and hold at this temperature for 30 minutes. Column is P
EG20M was used. The detector used total ion chromatography.

(2) Gel perfuming to the same amount as in the case of direct impregnation when the gel base to which the perfume composition is added at a perfume rate of 30% is placed in a pillow and left to stand. When an object is collected and analyzed by headspace gas chromatography, almost no change in volatile components is observed even after 1 hour (FIG. 6) as compared with immediately after installation in a pillow (FIG. 5). Therefore, this method is considered to have a high comparative advantage in improving insomnia with fragrance.

[0014]

EFFECT OF THE INVENTION As described above, the hypnotic fragrance composition according to the present invention can exhibit an excellent hypnotic effect by containing the Oris fragrance, the sandalwood fragrance and the rose fragrance.

[Brief description of drawings]

FIG. 1 is an explanatory view showing the results of the sleep-inducing effect of the sleep-inducing fragrance composition according to the present invention on rats.

FIG. 2 is an explanatory view showing the results of the sleep-inducing effect on the rat of the sleep-inducing fragrance composition according to the present invention.

FIG. 3 is an explanatory diagram of an example of analysis by headspace gas chromatography immediately after applying the soothing fragrance composition according to the present invention to a pillow as it is.

FIG. 4 is an explanatory diagram of an example of analysis by headspace gas chromatography one hour after the sleep-inducing fragrance composition according to the present invention was applied to a pillow as it was.

FIG. 5 is an explanatory diagram of an example of analysis by headspace gas chromatography immediately after applying the sleep-inducing fragrance composition according to the present invention in a gel form to a pillow.

FIG. 6 is an explanatory diagram of an example of analysis by headspace gas chromatography one hour after applying the sleep-inducing fragrance composition according to the present invention in a gel form to a pillow.

Claims (4)

[Claims] 1. A hypnotic fragrance composition comprising an Oris fragrance, a sandalwood fragrance and a rose fragrance. 2. The composition according to claim 1, wherein the Oris fragrance: Sandalwood fragrance: Rose fragrance is 1 to
8: 10-50: 2-10 The hypnotic fragrance composition characterized by the above-mentioned. 3. A hypnotic fragrance composition, wherein the composition according to claim 1 or 2 is added to a gel base for perfuming. 4. A hypnotic fragrance composition, wherein the composition according to claim 3 is a composition for perfuming bedding.