JP5358095B2 - 糖尿病、メタボリック症候群、および他の状態を治療するための方法および組成物 - Google Patents

糖尿病、メタボリック症候群、および他の状態を治療するための方法および組成物 Download PDF

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JP5358095B2
JP5358095B2 JP2007549979A JP2007549979A JP5358095B2 JP 5358095 B2 JP5358095 B2 JP 5358095B2 JP 2007549979 A JP2007549979 A JP 2007549979A JP 2007549979 A JP2007549979 A JP 2007549979A JP 5358095 B2 JP5358095 B2 JP 5358095B2
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ketoconazole
enantiomer
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パー マーリン
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コーテンド アーベー （ピーユービーエル）
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007549979A 2005-01-10 2006-01-10 糖尿病、メタボリック症候群、および他の状態を治療するための方法および組成物 Active JP5358095B2 (ja)

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US64305505P 2005-01-10 2005-01-10
US60/643,055 2005-01-10
PCT/IB2006/000026 WO2006072881A1 (en) 2005-01-10 2006-01-10 Methods and compositions for treating diabetes, metabolic syndrome and other conditions

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JP2008526830A JP2008526830A (ja) 2008-07-24
JP2008526830A5 JP2008526830A5 (cg-RX-API-DMAC7.html) 2012-12-20
JP5358095B2 true JP5358095B2 (ja) 2013-12-04

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US (6) US20090233843A1 (cg-RX-API-DMAC7.html)
EP (1) EP1853266B1 (cg-RX-API-DMAC7.html)
JP (1) JP5358095B2 (cg-RX-API-DMAC7.html)
KR (2) KR20140030327A (cg-RX-API-DMAC7.html)
CN (1) CN101141964B (cg-RX-API-DMAC7.html)
AT (1) ATE528005T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006204334B2 (cg-RX-API-DMAC7.html)
CA (1) CA2594433C (cg-RX-API-DMAC7.html)
CY (1) CY1112519T1 (cg-RX-API-DMAC7.html)
DK (1) DK1853266T3 (cg-RX-API-DMAC7.html)
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MX (1) MX2007008331A (cg-RX-API-DMAC7.html)
NO (1) NO339007B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ560481A (cg-RX-API-DMAC7.html)
PL (1) PL1853266T3 (cg-RX-API-DMAC7.html)
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WO (1) WO2006072881A1 (cg-RX-API-DMAC7.html)
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Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060046996A1 (en) * 2004-08-31 2006-03-02 Kowa Co., Ltd. Method for treating hyperlipidemia
US20090233843A1 (en) * 2005-01-10 2009-09-17 Cortendo Invest Ab Methods and compositions for treating diabetes, metabolic syndrome and other conditions
AU2007204969A1 (en) * 2006-01-10 2007-07-19 Cortendo Invest Ab Methods and compositions for treating prostate cancer
AU2007303219A1 (en) * 2006-10-02 2008-04-10 Cortendo Ab (Publ) Ketoconazole enantiomer in humans
RU2337686C1 (ru) * 2007-04-05 2008-11-10 Илья Николаевич Медведев Способ оптимизации активности тромбоцитов при метаболическом синдроме
RU2337675C1 (ru) * 2007-04-05 2008-11-10 Илья Николаевич Медведев Способ нормализации первой фазы свертывания крови при метаболическом синдроме
RU2337683C1 (ru) * 2007-04-05 2008-11-10 Илья Николаевич Медведев Способ снижения активности кровяных пластинок при метаболическом синдроме
RU2337680C1 (ru) * 2007-04-05 2008-11-10 Илья Николаевич Медведев Способ восстановления функций тромбоцитов при метаболическом синдроме
AU2010241571B2 (en) 2009-04-29 2014-06-26 Amarin Pharmaceuticals Ireland Limited Stable pharmaceutical composition and methods of using same
CN102413825A (zh) 2009-04-29 2012-04-11 阿马里纳股份公司 含有epa和心血管剂的药物组合物以及使用其的方法
WO2010147994A1 (en) 2009-06-15 2010-12-23 Amarin Pharma, Inc. Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
AU2010298222B2 (en) 2009-09-23 2017-01-05 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
EP2547793A4 (en) * 2010-03-15 2013-08-21 Univ Duke IDENTIFICATION OF A GENETIC RISK FACTOR FOR DIABETES
NZ778131A (en) 2010-11-29 2023-03-31 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
EP2763688B1 (en) 2011-10-06 2018-06-27 Vanderbilt University Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome
US10272133B2 (en) 2011-10-06 2019-04-30 Vanderbilt University Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2775837A4 (en) 2011-11-07 2015-10-28 Amarin Pharmaceuticals Ie Ltd METHODS OF TREATING HYPERTRIGLYCERIDEMIA
AU2013207368A1 (en) 2012-01-06 2014-07-24 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-CRP) in a subject
LT3363433T (lt) 2012-06-29 2021-02-25 Amarin Pharmaceuticals Ireland Limited Širdies ir kraujagyslių sistemos sutrikimų rizikos sumažinimo būdas subjektui, gydomam statinais, panaudojant eikozapentaeno rūgšties etilo esterį
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US20150353530A1 (en) * 2013-02-06 2015-12-10 Cortendo Ab (Publ) Novel functionalized 4-(phenoxymethyl(-1,3-dioxolane analogs exhibiting cytochrome p450 inhibition and their method of use
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
JP2016514146A (ja) * 2013-03-12 2016-05-19 エイチエムアイ・メディカル・イノヴェイションズ・エルエルシー 抗糖尿病及び他の有用な活性を有する植物抽出物
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US11571455B2 (en) 2013-04-11 2023-02-07 Vanderbilt University Methods and compositions for treating alcoholic liver disease
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
CN103432135A (zh) * 2013-09-06 2013-12-11 天津市康婷生物工程有限公司 一种内源性洋地黄样因子抑制剂
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
US10172818B2 (en) 2014-06-16 2019-01-08 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
WO2016048984A1 (en) * 2014-09-25 2016-03-31 Cortendo Ab (Publ) Methods and compositions for the treatment of cushing's syndrome using 2s, 4r ketoconazole
US20170151202A1 (en) * 2015-09-09 2017-06-01 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
CN105441391A (zh) * 2015-12-10 2016-03-30 湖南中医药大学 一种糖尿病并发抑郁症的细胞模型及建立方法和应用
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US10966951B2 (en) 2017-05-19 2021-04-06 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
KR102114705B1 (ko) 2017-11-06 2020-05-25 연세대학교 산학협력단 스타틴에 의한 약물유해반응의 예방 또는 치료용 약학 조성물
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
MA50490A (fr) 2018-09-24 2020-09-02 Amarin Pharmaceuticals Ie Ltd Procédés de réduction du risque d'événements cardiovasculaires chez un sujet
WO2020067832A1 (ko) * 2018-09-28 2020-04-02 경북대학교 산학협력단 티아민 유도체를 포함하는 고코르티솔증 예방 또는 치료용 조성물
WO2020074958A1 (en) 2018-10-12 2020-04-16 Strongbridge Dublin Limited Levoketoconazole for treatment of congenital adrenal hyperplasia and primary aldosteronism
CN113710250A (zh) 2019-03-04 2021-11-26 斯特朗布里奇都柏林有限公司 用左旋酮康唑治疗疾病的方法
WO2020231909A1 (en) * 2019-05-11 2020-11-19 Steven Hoffman Compositions and methods for treating bile acid associated diseases
JP2022554020A (ja) 2019-11-12 2022-12-27 アマリン ファーマシューティカルズ アイルランド リミテッド 心房細動および／または心房粗動を患う対象における心血管イベントのリスクを低減する方法
US20210251939A1 (en) * 2020-02-19 2021-08-19 New Frontier Labs, Llc Azelaic acid esters in the treatment or prevention of dyslipidemia and associated conditions
KR102289381B1 (ko) * 2020-03-17 2021-08-17 주식회사 대웅테라퓨틱스 당뇨치료제 및 고지혈증 치료제를 포함하는 약학적 조성물
AU2022263358A1 (en) 2021-04-21 2023-11-30 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure
CN119317433A (zh) * 2022-05-20 2025-01-14 科赛普特治疗学股份有限公司 治疗库欣综合征和肝病以及降低患者服用的其他药物的肝毒性的方法
TWI862092B (zh) * 2022-08-19 2024-11-11 財團法人國家衛生研究院 用於預防或治療神經退化性疾病的藥物組合及方法
WO2024105519A1 (en) * 2022-11-14 2024-05-23 Piramal Pharma Limited A process for the preparation of levoketoconazole

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814333A (en) * 1987-07-28 1989-03-21 The Trustees Of Dartmouth College Method for treatment of hypercortisolemic, depressed patients
US5432176A (en) * 1988-11-29 1995-07-11 The John Hopkins University Method of retarding the progression of chronic renal failure
WO1994014446A1 (en) 1992-12-22 1994-07-07 Sepracor, Inc. Methods and compositions of (+) ketoconazole for treating fungal, yeast and dermatophyte infections
WO1994014447A1 (en) * 1992-12-22 1994-07-07 Sepracor, Inc. Methods and compositions of (-) ketoconazole for treating fungal yeast and dermatophyte infections
US5869255A (en) * 1994-02-01 1999-02-09 The Regents Of The University Of California Probes labeled with energy transfer couples dyes exemplified with DNA fragment analysis
US6642236B1 (en) * 1998-12-14 2003-11-04 Cortendo Ab Methods for prophylactic treatment of cardiovascular disease with inhibitor of cortisol synthesis
CA2196174C (en) 1994-08-09 2005-03-01 Per Marin Use of ketoconazole and related substances in medicaments for treatment of type ii diabetes
US5584790A (en) * 1995-09-08 1996-12-17 Beckman Instruments, Inc. Variable inclination centrifugation assembly for rapid separation of blood
WO1997028149A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Method for raising hdl cholesterol levels
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US5994334A (en) * 1997-02-05 1999-11-30 University Of Maryland Androgen synthesis inhibitors
SE9700642D0 (sv) * 1997-02-24 1997-02-24 Kronvall Stefan Med Ab Medel och sätt för förebyggande och behandling av det metabola syndromet
US6613942B1 (en) 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
WO1999001423A1 (en) 1997-07-01 1999-01-14 Novo Nordisk A/S Glucagon antagonists/inverse agonists
AU3033500A (en) 1999-01-15 2000-08-01 Agouron Pharmaceuticals, Inc. Non-peptide glp-1 agonists
AU3441400A (en) 1999-03-29 2000-10-16 Uutech Limited Peptide
WO2000059887A1 (en) 1999-04-02 2000-10-12 Neurogen Corporation Aryl and heteroaryl fused aminoalkyl-imidazole derivatives and their use as antidiabetics
BR0010651A (pt) 1999-05-17 2002-03-19 Novo Nordisk As Composto, uso de um composto, composição farmacêutica, e, método para o tratamento e/ou prevenção de distúrbios ou de doenças mediadas por uma ação antagonìstica de glucagon
GB9915625D0 (en) * 1999-07-02 1999-09-01 Cortendo Ab Method
ES2307534T3 (es) 1999-09-28 2008-12-01 Bayer Corporation Agonistas de receptores 3 (r3) del peptido activador de la adenilato ciclasa hipofisiaria (pacap) y sus metodos de uso farmacologicos.
GB0001449D0 (en) 2000-01-21 2000-03-08 Cortendo Ab Compositions
US20020055512A1 (en) * 2000-01-21 2002-05-09 Cortendo Ab. Compositions for delivery of a cortisol antagonist
GB0118300D0 (en) 2001-07-26 2001-09-19 Cortendo Ab Formulations
EP1471917A1 (en) * 2002-02-07 2004-11-03 Pfizer Limited Use of pde5 inhibitors such as sildenafil in the treatment of polycystic ovary syndrome
WO2004080414A2 (en) * 2003-03-12 2004-09-23 Mullally John P Composition and method for treating inflammations by reducing c-reactive protein
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
US20090233843A1 (en) * 2005-01-10 2009-09-17 Cortendo Invest Ab Methods and compositions for treating diabetes, metabolic syndrome and other conditions
AU2007204969A1 (en) * 2006-01-10 2007-07-19 Cortendo Invest Ab Methods and compositions for treating prostate cancer
AU2007303219A1 (en) * 2006-10-02 2008-04-10 Cortendo Ab (Publ) Ketoconazole enantiomer in humans

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DK1853266T3 (da) 2012-02-06
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