JP5349320B2 - Ｆｇｆｒ４は化学療法薬剤に対する応答において癌細胞の抵抗性を促進する - Google Patents
Ｆｇｆｒ４は化学療法薬剤に対する応答において癌細胞の抵抗性を促進する Download PDFInfo
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| EP06022946.5 | 2006-11-03 | ||
| EP20060022946 EP1918376A1 (en) | 2006-11-03 | 2006-11-03 | FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs |
| PCT/EP2007/009533 WO2008052798A2 (en) | 2006-11-03 | 2007-11-02 | Fgfr4 promotes cancer cell resistance in response to chemotherapeutic drugs |
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| JP2010508369A JP2010508369A (ja) | 2010-03-18 |
| JP2010508369A5 JP2010508369A5 (enExample) | 2010-12-24 |
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| JP2013126819A Pending JP2013224308A (ja) | 2006-11-03 | 2013-06-17 | Ｆｇｆｒ４は化学療法薬剤に対する応答において癌細胞の抵抗性を促進する |
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| WO2009046141A2 (en) | 2007-10-01 | 2009-04-09 | Isis Pharmaceuticals, Inc. | Antisense modulation of fibroblast growth factor receptor 4 expression |
| US8216783B2 (en) | 2008-04-14 | 2012-07-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Over-expression and mutation of a tyrosine kinase receptor FGFR4 in tumors |
| FR2933702A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Antagonistes specifiques du recepteur fgf-r4 |
| EP2169071A1 (en) * | 2008-09-29 | 2010-03-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Rodent cancer model for human FGFR4 Arg388 polymorphism |
| WO2012138975A1 (en) * | 2011-04-07 | 2012-10-11 | Genentech, Inc. | Anti-fgfr4 antibodies and methods of use |
| CA2839437A1 (en) * | 2011-06-16 | 2012-12-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of fibroblast growth factor receptor 4 expression |
| EP2723391B1 (en) | 2011-06-24 | 2018-06-13 | University of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| DE102011116613A1 (de) * | 2011-10-20 | 2013-04-25 | Atlas Elektronik Gmbh | Unbemanntes Unterwasserfahrzeug und Verfahren zum Lokalisieren und Untersuchen eines am Gewässergrund eines Gewässers angeordenten Objekts sowie System mit dem unbemannten Unterwasserfahrzeug |
| JP2015071566A (ja) * | 2013-10-03 | 2015-04-16 | 住友ベークライト株式会社 | Ｆｇｆ４遺伝子増幅腫瘍の医薬組成物 |
| CN110354128A (zh) | 2013-10-18 | 2019-10-22 | 卫材R&D管理有限公司 | 嘧啶fgfr4抑制剂 |
| MX367723B (es) | 2013-10-25 | 2019-09-03 | Novartis Ag | Compuestos de anillos fusionados bicíclicos derivados de piridilo como inhibidores de fgfr4. |
| TW201612518A (en) * | 2014-01-17 | 2016-04-01 | Sanofi Sa | Methods of identifying patients suffering from liver cancer who will most likely benefit from a treatment with an antagonist anti-FGFR4 antibody |
| US20170107578A1 (en) * | 2014-03-21 | 2017-04-20 | The Translational Genomics Research Institute | Compositions, methods and kits for characterizing and screening for small cell ovarian carcinoma |
| LT3198033T (lt) * | 2014-09-26 | 2022-05-10 | Janssen Pharmaceutica Nv | Fgfr mutantinių genų rinkinių panaudojimas identifikuojant vėžiu sergančius pacientus, kurie reaguos į gydymą fgfr inhibitoriumi |
| EP3200786B1 (en) | 2014-10-03 | 2019-08-28 | Novartis AG | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| RU2017134379A (ru) | 2015-03-25 | 2019-04-03 | Новартис Аг | Формилированные n-гетероциклические производные в качестве ингибиторов fgfr4 |
| CA2982562C (en) | 2015-04-14 | 2023-06-13 | Eisai R&D Management Co., Ltd. | Crystalline fgfr4 inhibitor compound and uses thereof |
| JP7372740B2 (ja) | 2016-05-10 | 2023-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 細胞生存性及び／又は細胞増殖を低減するための薬物の組み合わせ |
| IL264950B2 (en) * | 2016-08-23 | 2024-01-01 | Eisai R&D Man Co Ltd | Combined treatments for the treatment of malignant liver cell carcinoma |
| WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
| ES2934341T3 (es) | 2016-11-02 | 2023-02-21 | Novartis Ag | Combinaciones de inhibidores de FGFR4 y secuestrantes de ácidos biliares |
| EP3444275A1 (en) | 2017-08-16 | 2019-02-20 | Exiris S.r.l. | Monoclonal antibody anti-fgfr4 |
| CA3102334A1 (en) * | 2018-06-15 | 2019-12-19 | Mina Therapeutics Limited | Combination therapies comprising c/ebp alpha sarna |
| CN114763573A (zh) * | 2021-01-12 | 2022-07-19 | 浙江省肿瘤医院 | Fgf19扩增作为预测fgfr抑制剂在食管鳞癌中敏感性的生物标志物及其潜在应用 |
| CN114736966A (zh) * | 2022-05-07 | 2022-07-12 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 逆转乳腺癌耐药性的组合制剂及标志物应用 |
| EP4509142A1 (en) | 2023-08-16 | 2025-02-19 | Ona Therapeutics S.L. | Fgfr4 as target in cancer treatment |
Family Cites Families (6)
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| DE19802377A1 (de) * | 1998-01-22 | 1999-08-19 | Max Planck Gesellschaft | Verwendung von Inhibitoren für die Behandlung von RTK-Überfunktions-bedingten Störungen, insbesondere von Krebs |
| EP1206234A4 (en) * | 1999-06-03 | 2005-06-01 | Jessie L S Au | METHODS AND COMPOSITIONS FOR MODULATING PROLIFERATION AND CELL DEATH |
| ES2363765T3 (es) * | 2002-01-31 | 2011-08-16 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Agonistas de fgfr. |
| CA2550245A1 (en) * | 2003-12-19 | 2005-07-21 | Five Prime Therapeutics, Inc. | Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention |
| US20090247604A1 (en) * | 2004-02-05 | 2009-10-01 | Intradigm Corporation | RNAi Therapeutics for Treatment of Eye Neovascularization Diseases |
| TWI388568B (zh) * | 2006-02-10 | 2013-03-11 | Genentech Inc | 抗ｆｇｆ１９抗體及其使用方法 |
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2006
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2007
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- 2007-11-02 US US12/513,413 patent/US20100143386A1/en not_active Abandoned
- 2007-11-02 JP JP2009535610A patent/JP5349320B2/ja not_active Expired - Fee Related
- 2007-11-02 AU AU2007315213A patent/AU2007315213B2/en not_active Ceased
- 2007-11-02 WO PCT/EP2007/009533 patent/WO2008052798A2/en not_active Ceased
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2013
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|---|---|
| WO2008052798A3 (en) | 2008-07-10 |
| AU2007315213A1 (en) | 2008-05-08 |
| AU2007315213B2 (en) | 2013-06-13 |
| WO2008052798A2 (en) | 2008-05-08 |
| JP2010508369A (ja) | 2010-03-18 |
| CA2668027C (en) | 2018-07-31 |
| US20100143386A1 (en) | 2010-06-10 |
| JP2013224308A (ja) | 2013-10-31 |
| CA2668027A1 (en) | 2008-05-08 |
| EP2092066A2 (en) | 2009-08-26 |
| EP1918376A1 (en) | 2008-05-07 |
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