AU2007315213B2 - FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs - Google Patents

FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs Download PDF

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Publication number
AU2007315213B2
AU2007315213B2 AU2007315213A AU2007315213A AU2007315213B2 AU 2007315213 B2 AU2007315213 B2 AU 2007315213B2 AU 2007315213 A AU2007315213 A AU 2007315213A AU 2007315213 A AU2007315213 A AU 2007315213A AU 2007315213 B2 AU2007315213 B2 AU 2007315213B2
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fgfr4
agent
hyperproliferative disorder
inhibitor
treatment
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AU2007315213A1 (en
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Hans-Jurgen Berger
Andreas Roidl
Axel Ullrich
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Max Planck Gesellschaft zur Foerderung der Wissenschaften
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N2333/475—Assays involving growth factors
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AU2007315213A 2006-11-03 2007-11-02 FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs Ceased AU2007315213B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06022946.5 2006-11-03
EP20060022946 EP1918376A1 (en) 2006-11-03 2006-11-03 FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs
PCT/EP2007/009533 WO2008052798A2 (en) 2006-11-03 2007-11-02 Fgfr4 promotes cancer cell resistance in response to chemotherapeutic drugs

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AU2007315213A1 AU2007315213A1 (en) 2008-05-08
AU2007315213B2 true AU2007315213B2 (en) 2013-06-13

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US (1) US20100143386A1 (enExample)
EP (2) EP1918376A1 (enExample)
JP (2) JP5349320B2 (enExample)
AU (1) AU2007315213B2 (enExample)
CA (1) CA2668027C (enExample)
WO (1) WO2008052798A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009046141A2 (en) 2007-10-01 2009-04-09 Isis Pharmaceuticals, Inc. Antisense modulation of fibroblast growth factor receptor 4 expression
US8216783B2 (en) 2008-04-14 2012-07-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Over-expression and mutation of a tyrosine kinase receptor FGFR4 in tumors
FR2933702A1 (fr) * 2008-07-08 2010-01-15 Sanofi Aventis Antagonistes specifiques du recepteur fgf-r4
EP2169071A1 (en) * 2008-09-29 2010-03-31 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Rodent cancer model for human FGFR4 Arg388 polymorphism
WO2012138975A1 (en) * 2011-04-07 2012-10-11 Genentech, Inc. Anti-fgfr4 antibodies and methods of use
CA2839437A1 (en) * 2011-06-16 2012-12-20 Isis Pharmaceuticals, Inc. Antisense modulation of fibroblast growth factor receptor 4 expression
EP2723391B1 (en) 2011-06-24 2018-06-13 University of Miami Fibroblast growth factor receptor inhibition for the treatment of disease
DE102011116613A1 (de) * 2011-10-20 2013-04-25 Atlas Elektronik Gmbh Unbemanntes Unterwasserfahrzeug und Verfahren zum Lokalisieren und Untersuchen eines am Gewässergrund eines Gewässers angeordenten Objekts sowie System mit dem unbemannten Unterwasserfahrzeug
JP2015071566A (ja) * 2013-10-03 2015-04-16 住友ベークライト株式会社 Ｆｇｆ４遺伝子増幅腫瘍の医薬組成物
CN110354128A (zh) 2013-10-18 2019-10-22 卫材R&D管理有限公司 嘧啶fgfr4抑制剂
MX367723B (es) 2013-10-25 2019-09-03 Novartis Ag Compuestos de anillos fusionados bicíclicos derivados de piridilo como inhibidores de fgfr4.
TW201612518A (en) * 2014-01-17 2016-04-01 Sanofi Sa Methods of identifying patients suffering from liver cancer who will most likely benefit from a treatment with an antagonist anti-FGFR4 antibody
US20170107578A1 (en) * 2014-03-21 2017-04-20 The Translational Genomics Research Institute Compositions, methods and kits for characterizing and screening for small cell ovarian carcinoma
LT3198033T (lt) * 2014-09-26 2022-05-10 Janssen Pharmaceutica Nv Fgfr mutantinių genų rinkinių panaudojimas identifikuojant vėžiu sergančius pacientus, kurie reaguos į gydymą fgfr inhibitoriumi
EP3200786B1 (en) 2014-10-03 2019-08-28 Novartis AG Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
RU2017134379A (ru) 2015-03-25 2019-04-03 Новартис Аг Формилированные n-гетероциклические производные в качестве ингибиторов fgfr4
CA2982562C (en) 2015-04-14 2023-06-13 Eisai R&D Management Co., Ltd. Crystalline fgfr4 inhibitor compound and uses thereof
JP7372740B2 (ja) 2016-05-10 2023-11-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 細胞生存性及び／又は細胞増殖を低減するための薬物の組み合わせ
IL264950B2 (en) * 2016-08-23 2024-01-01 Eisai R&D Man Co Ltd Combined treatments for the treatment of malignant liver cell carcinoma
WO2018055503A1 (en) 2016-09-20 2018-03-29 Novartis Ag Combination comprising a pd-1 antagonist and an fgfr4 inhibitor
ES2934341T3 (es) 2016-11-02 2023-02-21 Novartis Ag Combinaciones de inhibidores de FGFR4 y secuestrantes de ácidos biliares
EP3444275A1 (en) 2017-08-16 2019-02-20 Exiris S.r.l. Monoclonal antibody anti-fgfr4
CA3102334A1 (en) * 2018-06-15 2019-12-19 Mina Therapeutics Limited Combination therapies comprising c/ebp alpha sarna
CN114763573A (zh) * 2021-01-12 2022-07-19 浙江省肿瘤医院 Fgf19扩增作为预测fgfr抑制剂在食管鳞癌中敏感性的生物标志物及其潜在应用
CN114736966A (zh) * 2022-05-07 2022-07-12 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 逆转乳腺癌耐药性的组合制剂及标志物应用
EP4509142A1 (en) 2023-08-16 2025-02-19 Ona Therapeutics S.L. Fgfr4 as target in cancer treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070248604A1 (en) * 2006-02-10 2007-10-25 Genentech, Inc. Anti-fgf19 antibodies and methods using same
US7625860B2 (en) * 1999-06-03 2009-12-01 Au Jessie L-S Methods and compositions for modulating cell proliferation and cell death

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19802377A1 (de) * 1998-01-22 1999-08-19 Max Planck Gesellschaft Verwendung von Inhibitoren für die Behandlung von RTK-Überfunktions-bedingten Störungen, insbesondere von Krebs
ES2363765T3 (es) * 2002-01-31 2011-08-16 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Agonistas de fgfr.
CA2550245A1 (en) * 2003-12-19 2005-07-21 Five Prime Therapeutics, Inc. Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention
US20090247604A1 (en) * 2004-02-05 2009-10-01 Intradigm Corporation RNAi Therapeutics for Treatment of Eye Neovascularization Diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625860B2 (en) * 1999-06-03 2009-12-01 Au Jessie L-S Methods and compositions for modulating cell proliferation and cell death
US20070248604A1 (en) * 2006-02-10 2007-10-25 Genentech, Inc. Anti-fgf19 antibodies and methods using same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLINICAL CANCER RESEARCH, vol. 11, no. 3, pages 1336- 1341 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 48, (26 November 2004), pages 50004-50011 *

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JP5349320B2 (ja) 2013-11-20
AU2007315213A1 (en) 2008-05-08
WO2008052798A2 (en) 2008-05-08
JP2010508369A (ja) 2010-03-18
CA2668027C (en) 2018-07-31
US20100143386A1 (en) 2010-06-10
JP2013224308A (ja) 2013-10-31
CA2668027A1 (en) 2008-05-08
EP2092066A2 (en) 2009-08-26
EP1918376A1 (en) 2008-05-07

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