JP5323680B2 - 結腸直腸細胞増殖性疾患を検出するための方法および核酸 - Google Patents
結腸直腸細胞増殖性疾患を検出するための方法および核酸 Download PDFInfo
- Publication number
- JP5323680B2 JP5323680B2 JP2009505769A JP2009505769A JP5323680B2 JP 5323680 B2 JP5323680 B2 JP 5323680B2 JP 2009505769 A JP2009505769 A JP 2009505769A JP 2009505769 A JP2009505769 A JP 2009505769A JP 5323680 B2 JP5323680 B2 JP 5323680B2
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- methylation
- nucleic acid
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
USPCT/US2006/014131 | 2006-04-17 | ||
PCT/US2006/014131 WO2006113466A2 (fr) | 2005-04-15 | 2006-04-17 | Methodes et acides nucleiques utilises dans des analyses de troubles proliferatifs cellulaires |
EP06090119.6 | 2006-06-27 | ||
EP06090119 | 2006-06-27 | ||
PCT/EP2007/003380 WO2007118704A2 (fr) | 2006-04-17 | 2007-04-17 | Procédés et acides nucléiques pour détecter des troubles de prolifération de cellules colorectales |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013123304A Division JP5846693B2 (ja) | 2006-04-17 | 2013-06-12 | 結腸直腸細胞増殖性疾患を検出するための方法および核酸 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009533066A JP2009533066A (ja) | 2009-09-17 |
JP2009533066A5 JP2009533066A5 (fr) | 2011-04-28 |
JP5323680B2 true JP5323680B2 (ja) | 2013-10-23 |
Family
ID=40030469
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009505769A Active JP5323680B2 (ja) | 2006-04-17 | 2007-04-17 | 結腸直腸細胞増殖性疾患を検出するための方法および核酸 |
JP2013123304A Expired - Fee Related JP5846693B2 (ja) | 2006-04-17 | 2013-06-12 | 結腸直腸細胞増殖性疾患を検出するための方法および核酸 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013123304A Expired - Fee Related JP5846693B2 (ja) | 2006-04-17 | 2013-06-12 | 結腸直腸細胞増殖性疾患を検出するための方法および核酸 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20220260570A1 (fr) |
EP (3) | EP2484778A3 (fr) |
JP (2) | JP5323680B2 (fr) |
AU (1) | AU2007237444B2 (fr) |
CA (1) | CA2649777C (fr) |
ES (1) | ES2587068T3 (fr) |
WO (1) | WO2007118704A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107663538B (zh) | 2005-04-15 | 2022-03-18 | Epi基因组股份公司 | 分析细胞增殖性病症的方法和核酸 |
WO2008122447A2 (fr) * | 2007-04-10 | 2008-10-16 | Epigenomics Ag | Dosage de méthylation d'adn permettant de réaliser le diagnostic ou le pronostic d'états pathologiques |
NZ608153A (en) * | 2010-09-13 | 2014-12-24 | Clinical Genomics Pty Ltd | Epigenetic markers of colorectal cancers and diagnostic methods using the same |
FR2967165B1 (fr) * | 2010-11-04 | 2014-10-10 | Assist Publ Hopitaux De Paris | Methode de depistage du cancer colorectal |
US10626462B2 (en) | 2011-07-08 | 2020-04-21 | Epigenomics Ag | Methods and nucleic acids for determining the prognosis of a cancer subject |
US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
CN104046680B (zh) * | 2013-03-11 | 2016-04-06 | 苏州承美生物科技有限公司 | 甲基化dna检测方法 |
KR102461235B1 (ko) * | 2014-06-04 | 2022-10-28 | 퀘스트 다이어그노스틱스 인베스트먼츠 인코포레이티드 | 결장직장암에 대한 메틸화된 마커 |
US20190352721A1 (en) * | 2016-09-29 | 2019-11-21 | Hanumat Co., Ltd. | Method for determining likelihood of sporadic colorectal cancer development |
WO2018087129A1 (fr) * | 2016-11-08 | 2018-05-17 | Region Nordjylland, Aalborg University Hospital | Marqueurs de méthylation du cancer colorectal |
EP3660172A1 (fr) * | 2018-11-28 | 2020-06-03 | Bioscreening and Diagnostics LLC | Procédés de diagnostic de lésions cérébrales traumatiques |
CN111826441A (zh) * | 2019-04-23 | 2020-10-27 | 博尔诚(北京)科技有限公司 | 用于体外检测消化道五癌的体系,在该体系中使用的组合物,以及包含该组合物的试剂盒 |
CN112195243A (zh) * | 2020-09-22 | 2021-01-08 | 北京华大吉比爱生物技术有限公司 | 一种检测多基因甲基化的试剂盒及其应用 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
US5457183A (en) | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
US5667976A (en) * | 1990-05-11 | 1997-09-16 | Becton Dickinson And Company | Solid supports for nucleic acid hybridization assays |
US5245022A (en) | 1990-08-03 | 1993-09-14 | Sterling Drug, Inc. | Exonuclease resistant terminally substituted oligonucleotides |
US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
EP0724646B1 (fr) * | 1991-01-04 | 2001-06-27 | Washington University | Sequences d'adn associees au syndrome de chromosome x fragile isole |
US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
US5364787A (en) * | 1992-03-23 | 1994-11-15 | Idaho Research Foundation | Genes and enzymes involved in the microbial degradation of pentachlorophenol |
US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
US6184211B1 (en) | 1993-11-30 | 2001-02-06 | Methylgene Inc. | Inhibition of DNA methyltransferase |
US5597696A (en) | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
US5514758A (en) | 1994-09-30 | 1996-05-07 | The Goodyear Tire & Rubber Company | Process for making latex for high performance masking tape |
US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
WO1998056952A1 (fr) | 1997-06-09 | 1998-12-17 | University Of Southern California | Methode de diagnostic du cancer basee sur des differences de methylation d'adn |
DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
US7700324B1 (en) | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
US5958773A (en) | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
US6331393B1 (en) | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
US6783933B1 (en) * | 1999-09-15 | 2004-08-31 | The Johns Hopkins University School Of Medicine | CACNA1G polynucleotide, polypeptide and methods of use therefor |
WO2005000087A2 (fr) * | 2003-06-03 | 2005-01-06 | Chiron Corporation | Produits genetiques exprimes de facon differentielle dans des cellules cancereuses du colon et leurs methodes d'utilisation ii |
AU2002212187A1 (en) * | 2000-09-01 | 2002-03-13 | Epigenomics Ag | Diagnosis of illnesses or predisposition to certain illnesses |
US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
WO2003042661A2 (fr) * | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methodes de diagnostic du cancer, compositions et methodes de criblage des modulateurs du cancer |
ATE437962T1 (de) | 2002-10-01 | 2009-08-15 | Epigenomics Ag | Verfahren für die behandlung von proliferativen erkrankungen von brustzellen |
WO2004074441A2 (fr) * | 2003-02-19 | 2004-09-02 | Government Of The United States Of America Represented By The Secretary Department Of Health And Human Services | Amplification ou surexpression de la fusion du type septine mll (msf), septine9 et procedes connexes |
CA2531451A1 (fr) * | 2003-06-23 | 2005-01-06 | Epigenomics Ag | Methodes et acides nucleiques pour l'analyse de troubles de la proliferation de cellules colorectales |
US8163488B2 (en) * | 2003-06-23 | 2012-04-24 | Epigenomics Ag | Methods and nucleic acids for analysis of colon proliferative disorders |
WO2005123945A2 (fr) * | 2004-06-21 | 2005-12-29 | Epigenomics Ag | Marqueurs epigenetiques destines au traitement du cancer du sein |
EP2281902A1 (fr) * | 2004-07-18 | 2011-02-09 | Epigenomics AG | Procédés épigénétiques et acides nucléiques pour la détection de troubles cellulaires proliférables du sein |
CN107663538B (zh) * | 2005-04-15 | 2022-03-18 | Epi基因组股份公司 | 分析细胞增殖性病症的方法和核酸 |
-
2007
- 2007-04-17 WO PCT/EP2007/003380 patent/WO2007118704A2/fr active Application Filing
- 2007-04-17 EP EP11009932A patent/EP2484778A3/fr not_active Withdrawn
- 2007-04-17 JP JP2009505769A patent/JP5323680B2/ja active Active
- 2007-04-17 ES ES11009931.4T patent/ES2587068T3/es active Active
- 2007-04-17 EP EP07724317A patent/EP2013360A2/fr not_active Withdrawn
- 2007-04-17 EP EP11009931.4A patent/EP2479283B1/fr not_active Not-in-force
- 2007-04-17 CA CA2649777A patent/CA2649777C/fr active Active
- 2007-04-17 AU AU2007237444A patent/AU2007237444B2/en active Active
-
2013
- 2013-06-12 JP JP2013123304A patent/JP5846693B2/ja not_active Expired - Fee Related
-
2022
- 2022-02-01 US US17/590,200 patent/US20220260570A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2587068T3 (es) | 2016-10-20 |
CA2649777A1 (fr) | 2007-10-25 |
EP2479283B1 (fr) | 2016-06-22 |
US20220260570A1 (en) | 2022-08-18 |
AU2007237444A1 (en) | 2007-10-25 |
EP2484778A2 (fr) | 2012-08-08 |
CA2649777C (fr) | 2018-08-14 |
JP2009533066A (ja) | 2009-09-17 |
AU2007237444B2 (en) | 2013-05-23 |
JP2013230153A (ja) | 2013-11-14 |
EP2479283A1 (fr) | 2012-07-25 |
EP2484778A3 (fr) | 2012-10-10 |
WO2007118704A3 (fr) | 2008-04-24 |
JP5846693B2 (ja) | 2016-01-20 |
WO2007118704A2 (fr) | 2007-10-25 |
EP2013360A2 (fr) | 2009-01-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11186879B2 (en) | Methods and nucleic acids for analyses of cellular proliferative disorders | |
JP5846693B2 (ja) | 結腸直腸細胞増殖性疾患を検出するための方法および核酸 | |
JP5818374B2 (ja) | 細胞増殖性障害の検出のための方法及び核酸 | |
US20090317810A1 (en) | Methods and nucleic acids for the detection of colorectal cell proliferative disorders | |
JP6017497B2 (ja) | 前立腺細胞増殖性障害の発症に関連する遺伝子の発現を解析する方法及び核酸 | |
JP4955385B2 (ja) | 結腸直腸細胞増殖障害の分析のための方法及び核酸 | |
WO2008011620A2 (fr) | Procédés et acides nucléiques destinés aux analyses de troubles associés à une prolifération cellulaire | |
US20100184027A1 (en) | Methods and nucleic acids for analyses of cellular proliferative disorders | |
WO2007115213A2 (fr) | Méthodes et acides nucléiques pour des analyses de troubles prolifératifs cellulaires | |
US20110171637A1 (en) | Methods and nucleic acids for analyses of cellular proliferative disorders |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100319 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100319 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110302 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120629 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120914 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120924 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121015 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121022 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121115 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121122 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121226 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130212 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130612 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20130619 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130708 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130717 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5323680 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |