JP5318874B2 - 放射性フッ素化方法 - Google Patents

放射性フッ素化方法 Download PDF

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Publication number
JP5318874B2
JP5318874B2 JP2010524233A JP2010524233A JP5318874B2 JP 5318874 B2 JP5318874 B2 JP 5318874B2 JP 2010524233 A JP2010524233 A JP 2010524233A JP 2010524233 A JP2010524233 A JP 2010524233A JP 5318874 B2 JP5318874 B2 JP 5318874B2
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JP
Japan
Prior art keywords
formula
compound
minutes
mmol
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2010524233A
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English (en)
Japanese (ja)
Other versions
JP2010539091A5 (enExample
JP2010539091A (ja
Inventor
カスヴァートソン，アラン
ソルバッケン，マグネ
オルベルグ，ダグ・エルランド
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of JP2010539091A publication Critical patent/JP2010539091A/ja
Publication of JP2010539091A5 publication Critical patent/JP2010539091A5/ja
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2010524233A 2007-09-10 2008-09-09 放射性フッ素化方法 Expired - Fee Related JP5318874B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97100707P 2007-09-10 2007-09-10
US60/971,007 2007-09-10
PCT/US2008/075684 WO2009035959A2 (en) 2007-09-10 2008-09-09 Radiofluorination methods

Publications (3)

Publication Number Publication Date
JP2010539091A JP2010539091A (ja) 2010-12-16
JP2010539091A5 JP2010539091A5 (enExample) 2011-11-10
JP5318874B2 true JP5318874B2 (ja) 2013-10-16

Family

ID=40343591

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010524233A Expired - Fee Related JP5318874B2 (ja) 2007-09-10 2008-09-09 放射性フッ素化方法

Country Status (5)

Country Link
US (1) US8444955B2 (enExample)
EP (1) EP2195037A2 (enExample)
JP (1) JP5318874B2 (enExample)
CN (1) CN101854957B (enExample)
WO (1) WO2009035959A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0905438D0 (en) * 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
GB201020314D0 (en) * 2010-12-01 2011-01-12 Ge Healthcare Ltd Apoptosis pet imaging agents
GB201201062D0 (en) 2012-01-23 2012-03-07 Ge Healthcare Ltd Radiofluorination method
CN103665114B (zh) * 2012-09-25 2015-08-05 国家纳米科学中心 一种肽及其制备方法和用途以及药物组合物及其制备方法
JP2016518311A (ja) 2013-03-08 2016-06-23 ユニヴァーシティー オブ サザン カリフォルニア ビニルスルホン系１８ｆ標識化組成物ならびにその方法およびその使用
GB201308053D0 (en) 2013-05-03 2013-06-12 Ge Healthcare Ltd Metal complexes and fluorination thereof
KR102458116B1 (ko) * 2014-12-04 2022-10-24 지이 헬쓰케어 리미티드 방사성 약제로부터의 아세트알데히드의 제거 방법
DE102016122273B4 (de) * 2016-11-18 2018-06-21 Abx Advanced Biochemical Compounds Gmbh Präkursoren für die Radiofluorierung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4225038C2 (de) * 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Herstellung und Verwendung von Antikörpern gegen Kollagen
JP3596041B2 (ja) * 1994-09-09 2004-12-02 住友化学工業株式会社 Ｏ−アルキル−Ｎ−（β−ニトロエチル）ヒドロキシルアミン誘導体およびその製造方法
CA2226303A1 (en) * 1995-07-07 1997-01-30 Sagami Chemical Research Center Peptide derivatives and angiotensin iv receptor agonist
JP2002049136A (ja) * 2000-05-25 2002-02-15 Konica Corp ハロゲン化銀感光材料および特定のヒドロキシルアミン化合物
EP1634086A2 (en) * 2003-05-30 2006-03-15 Genova Ltd. Secreted polypeptide species associated with cardiovascular disorders
GB0420344D0 (en) 2004-09-14 2004-10-13 Amersham Plc Diagnostic compounds
US8216548B2 (en) 2006-12-28 2012-07-10 Ge Healthcare As Radiofluorination methods

Also Published As

Publication number Publication date
US8444955B2 (en) 2013-05-21
US20100196270A1 (en) 2010-08-05
EP2195037A2 (en) 2010-06-16
WO2009035959A3 (en) 2009-12-23
WO2009035959A2 (en) 2009-03-19
CN101854957A (zh) 2010-10-06
JP2010539091A (ja) 2010-12-16
CN101854957B (zh) 2013-05-22

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