JP5307969B2 - Life extension agent containing white rice-derived ingredients as active ingredients - Google Patents

Description

  The present invention relates to a life extension agent containing a white rice-derived component as an active ingredient.

Individuals, including humans, are anxious to live a long life, usually in a situation where no one can avoid the reality that everyone dies and dies. By the way, it is well known that alcohol, which is said to be the head of a hundred medicines, has a particularly positive effect on the mental aspect, such as making people cheerful and relieving stress. And moderate liquor is thought to make people live longer through relieving stress. Here, in the case of liquor, alcohol (ethyl alcohol) contained in liquor is considered to be an effective component for stress relief. [Patent Document 1] JP2003-225080A
However, the above-mentioned alcohol itself does not directly have a life extension effect, and the effect is indirect. Also, it has been confirmed that alcohol oxides are toxic or ineffective. Moreover, continuous alcohol consumption tends to be alcoholic, and excessive alcohol consumption can lead to alcoholism, both of which can rather result in a shortened lifespan. The present invention is not a mechanism of action that has a positive effect on the mental aspects such as ethyl alcohol, but has an effect of prolonging the life span by directly acting on individuals, cells, etc. An object is to provide a life-extending agent derived from a product.

Until now, the present inventors have been conducting various studies focusing on white rice, which is a staple food and has the highest safety, from the viewpoint of combining plants and animals. In the middle of these studies, we discovered that the raw material had a significant life-longening effect at the cellular level, and we confirmed the life-longening effect of tissues and individuals using this as an opportunity. The present invention has been found.
In the present invention, as to what component derived from white rice (or a combination of a plurality of components, or a combination of a plurality of components at a predetermined abundance ratio) has a life extending effect, it has not yet been elucidated. It was found that all the water-treated products of white rice {present inventions (1) to (4)} exhibited a life extension effect. Hereinafter, the present inventions (1) to (4) are listed.
The present invention (1) is a life extending agent characterized by comprising as an active ingredient a component other than ethyl alcohol or its oxide contained in a water-treated product of rice raw material that essentially contains a white rice portion.
This invention (2) is a life extension agent of the said invention (1) whose said rice raw material is white rice, brown rice, germinated rice, white rice bran, and 1 or more types of these combinations.
In the present invention (3), the water-treated product is an aqueous extract of the rice raw material, a starch hydrolyzed product of the rice raw material or the water extract, the rice raw material, the water extract or the starch hydrolyzed treatment. It is a life extension agent of the said invention (1) or (2) which is a fermented product.
The present invention (4) is the life extension agent according to any one of the inventions (1) to (3), wherein the water-treated product is treated with starch hydrolyzing enzyme and / or koji.

FIG. 1 is a photomicrograph (cultured for 14 days) of cells to which the product of the present invention was not added in Test Example 1. It cannot be properly bonded to the bottom of the well and is peeled off.
FIG. 2 is a photomicrograph (14-day culture) of cells to which the product of the present invention was added in Test Example 1. It adheres normally to the bottom of the well.
Here, the meaning of each term in this specification is explained. For convenience of explanation, the meaning of some terms will be described in the section “Best Mode for Carrying Out the Invention”. First, “water-treated product” refers to a processed product of rice raw material using water. For example, a water extract of rice raw material, a starch hydrolyzed product of rice raw material in the presence of water (for example, rice raw material) Starch hydrolyzed with water added, rice hydrolyzed rice starch hydrolyzed starch, fermented rice raw material in the presence of water (eg, water added to rice fermented) Rice, fermented water extract of rice raw material, and fermented water extract of rice raw material hydrolyzed with starch). In addition, “water” here means an aqueous medium that essentially contains water, and includes, for example, water or a mixed liquid of an arbitrary ratio of water and ethyl alcohol. “Water extract” means physical treatment (for example, pressing, heat treatment), chemical treatment (for example, acid or alkali treatment), biological (biochemical) treatment (for example, sputum, microbial treatment, enzyme treatment). ) Is used alone or in combination. For example, rice raw material with water, rice raw material treated with acid or alkali, rice raw material hydrolyzed with enzyme (eg starch hydrolyzing enzyme) and / or koji (before or after extraction) Or an embodiment in which these treatments are performed under heating or non-heating. The “starch hydrolyzed product” is not particularly limited as long as it has been subjected to starch hydrolysis treatment, and may contain non-degraded starch. Here, the “starch hydrolysis treatment” is not particularly limited as long as it is a treatment that hydrolyzes starch and / or polysaccharides that are degradation products thereof, and examples thereof include an enzyme treatment and an acid treatment. . “Fermentation” refers to performing alcoholic fermentation or organic acid fermentation (for example, lactic acid fermentation) alone or in combination. “Organic acid fermentation” refers to, for example, lactic acid fermentation or acetic acid fermentation. “Contained as an active ingredient” means containing the component to the extent that it has a life extending effect, and not only when the component constitutes a part of the life extending agent, but the component is also a life extending agent. Including all of the above. “Life extension agent” means an agent that extends the life of a cell, tissue, organ or individual compared to when it is administered or not. Here, the living organisms related to cells, tissues, organs or individuals refer to multicellular organisms (including higher animals such as mammals including humans) and unicellular organisms. “Other than ethyl alcohol or its oxide” means that the active ingredient is different from ethyl alcohol or its oxide, and even if ethyl alcohol or its oxide is included, it is excluded from the present invention. Not exclusively. It should be noted that when determining whether a product containing ethyl alcohol or its oxide belongs to the scope of the present invention, both the product obtained by removing ethyl alcohol or its oxide from the product or not. In the case where the above-mentioned effect is obtained with respect to the product that has been subjected to the test and removed, the ethyl alcohol or its oxide-containing product is within the scope of the present invention.

The `` rice raw material essentially containing a white rice portion '' according to the present invention is not particularly limited as long as it contains at least a portion of white rice, for example, not only rice such as white rice, brown rice and germinated rice, but only white rice bran, It is a concept that includes a blend of white rabbit and red rabbit. Here, with respect to white rice and brown rice, it refers to brown rice and white rice such as glutinous rice and glutinous rice, regardless of japonica and indica rice, and any kind and kind. The white birch generally refers to 92% or less of white birch that appears at the time of whitening, and a portion within this range may be used as a raw material (for example, all 92% or less of white birch, 92-80% of white birch only) 60% or less white rabbit). Red coral generally refers to red coral of 92% or more. In addition, since the active ingredient is stable to heat and light, the above-mentioned raw materials are immersed, steamed, roasted (points to all of sand roasting, net roasting, hot air roasting, etc.), steaming roasting, freeze drying It may be subjected to raw material treatment such as surface modification such as UV irradiation, photo-modification such as UV irradiation, pressure roasting such as Patrice, frying.
When producing germinated rice, germinated rice is immersed in water or sprayed with water. The temperature at the time of germination is 5-70 degreeC. However, temperature and time are not limited as long as germination occurs. In addition, when there is a risk of water rot during germination, it is preferable to replace the water so that it does not rot or to perform some preservative. Here, germination refers to everything from just before germination to germination. The germinated rice is washed thoroughly before use. At this time, you may dry and use.
In the water treatment (for example, water extraction), the rice material is preferably in the form of granules or powder. In addition, when it is not a granule or powder form, processing time is lengthened. Hereinafter, each aspect of the water treatment product will be described.
First, the water extract will be described in detail. When the rice raw material is extracted with water, a high extraction temperature is efficient, but the extraction can be sufficiently performed even at a low temperature. However, in the case of a low temperature of 40 ° C. or lower, it is desirable that the pH is made acidic or alkaline, or a preservative or ethyl alcohol is added so that the rice raw material is not spoiled. The extraction time may be long or short as long as the active ingredient can be extracted, and may be determined by the extraction temperature. Moreover, water extraction may be performed under pressure, a normal pressure, or under reduced pressure. In the case of water extraction, the most serious problem is the gelatinization phenomenon. If it becomes paste-like, not only extraction efficiency will worsen but it will be extremely difficult in actual work. In order to prevent this, the starch may be decomposed by adding amylase to react or acidifying with hydrochloric acid or the like. By using this method, it can be solved sufficiently and there is no problem in practical use.
Since the active ingredient in the water extract is stable to acid and alkali, it is also effective to perform acid decomposition extraction or alkali decomposition extraction. In this case, neutralization and desalting are performed as necessary. Further, the rice raw material may be subjected to enzymatic degradation and / or koji. As used herein, enzymatic degradation refers to one or two types of enzymes that act on rice, such as starch hydrolyzing enzymes (liquefaction enzymes, saccharifying enzymes), proteolytic enzymes, lipolytic enzymes, fiber-degrading enzymes, lignin-degrading enzymes, and pectin-degrading enzymes. That means the above action. For example, the combination of a liquefying enzyme and a saccharifying enzyme can be mentioned. In addition, the type of koji mold, rice varieties and types are not limited. In addition, when performing extraction, the timing which acts an enzyme or a koji may be either before extraction or simultaneously with extraction.
Next, the starch hydrolyzed product will be described in detail. The starch hydrolyzed product preferably has a starch hydrolyzing enzyme and / or koji acting on rice ingredients in the presence of water, or a starch hydrolyzing enzyme and / or koji acting on the extract. It is a thing. The starch hydrolysis is not limited to the above treatment (water extraction treatment), and may be performed at the same time. In addition, as for the koji, the kind of koji mold and the variety and kind of rice are not limited. The embodiment in which starch hydrolase is allowed to act on the extract includes those in which the extract itself is already partially hydrolyzed with starch (for example, when a liquefaction enzyme is used in the extraction stage). However, this means that the partial starch hydrolyzate is further hydrolyzed.
Next, the fermented product will be described in detail. The fermented product is obtained by fermenting rice raw materials in the presence of water, fermenting the water extract, or fermenting the starch decomposition product. Here, the fermentation refers to alcohol fermentation or organic acid fermentation (lactic acid fermentation or the like), and the fermentation is not limited to the above treatment (water extraction treatment, starch decomposition treatment), and may be performed at the same time. . Here, with respect to the alcohol fermentation method, in order to achieve a higher life extension effect, single-line double fermentation is preferable to parallel double-fermentation, which is a method for producing sake. It should be noted that ethyl alcohol itself should not be present because it not only has no life-extending effect when it is taken too much, but rather has an inhibitory effect on life extension. However, as long as the active ingredient is present, the effect of extending the life is somewhat reduced, so that an embodiment in which ethyl alcohol is present also belongs to the present invention. Sugar may be removed by aeration fermentation with yeast, precipitation with ethyl alcohol, or the like. Moreover, when organic acid fermentation is performed, the lifetime extending effect is further enhanced. In particular, lactic acid fermentation is suitable.
The life extension agent according to the present invention obtained as described above is applied to an object (cell, tissue, organ or individual) as it is without being separated from the residue or after being squeezed or filtered. Apply. Here, when used as it is, it is preferable to perform sterilization or sterilization. The life extension agent according to the present invention may be used internally or externally, for example, when applied to an individual. Specifically, according to the actual application, according to conventional methods, cosmetics such as creams, facial cleansers, emulsions, lotions, cleansings, packs, soaps, ointments, pasta agents, lotions, tinctures, ligaments, Jelly, aerosol, liquid, jelly, elixir, capsule (soft capsule, hard capsule), granule, pill, suspension, emulsion, powder, fine granule, tablet, syrup, injection It is used in oral dosage forms such as pills, troches and limonades, and in dosage forms such as injections. Furthermore, the prescription added to a foodstuff and a drink is also included. Moreover, you may use it with the form of a bath agent. In addition, you may add another compounding component and a chemical | medical agent according to a use. The dose when administered to a human depends on the age, weight, severity, etc. of the user, but is, for example, 0.01-20 ml per kg of body weight per day. Moreover, in product manufacture, 0.1-30 weight part of this invention products are added per 100 weight part of products, for example.
In relation to the actual product, for example, an indication that the product is used for extending the life of the product, such as a drug, a cosmetic, a food and drink package, a pamphlet, and an instruction manual. Is preferred. By attaching such a display, it is obvious to the user that the product of the present invention has such an effect. In addition, if it cannot be displayed directly on the product due to restrictions of other laws (Pharmaceutical Affairs Law), for example, a method of indirectly informing the user of the effectiveness of the product in the form of the Internet or newspaper articles, etc. A method of verbally notifying the user of the effect is also assumed. Therefore, the “indication to be used for extending the life” includes not only the case where the life extension is specified, but also the indication and action suggesting the life extension including these methods. Further, as the life extension effect, in Test Example 1, in any culture days, it is preferable that the survival rate is increased by about 10% relative to the control, more preferably by about 30%, Most preferably, it rises by about 50%. In Test Example 2, the average life is preferably increased by about 5% relative to the control, more preferably by about 10%, and most preferably by about 20%.

表１のとおり、本発明品を添加した培地で培養した細胞の３０日間生存率は８５％以上であり、通常の培地のみで培養した細胞の３０日間生存率は０％で全て死滅していた。以上の試験より本発明品による寿命延長効果が実証された。コントロールは、１４日目程度より死滅が始めるため、一般的には週に２回培養液を交換している。従って本発明品は、寿命延長効果のみならず、細胞を使った実験にも多大な貢献をするものである。尚、３０日後の細胞は癌化しているものではなかった。また、細胞の形態は正常であった。
試験例２
実験動物を用いて本発明を摂食させたグループと摂食させないグループについて寿命を調査し、本発明の寿命延長効果を調べた。
方法：
４週齢の雄性ＢＡＬＢ／ａ系マウス１０匹を一匹ずつ個別にケージに入れ、通常の食餌、飲水を自由にさせた状態で３５週齢まで予備飼育した。その後（３５週令以降は）、１０匹中５匹は、予備飼育後、通常の餌に本発明品を０．６％（ｖ／ｗ）配合した餌を与え、残りの５匹は通常の餌を与え、各々死亡するまで飼育し、寿命を測定した。
試料：実施例１
結果：
長期飼育試験の結果、本発明品配合の餌を与えたＢＡＬＢ／ａ系マウス（本発明品群）は、６７、１２９、８７、１００、９２週まで生存した。一方、通常の餌を与えたＢＡＬＢ／ａ系マウス（コントロール群）は、７８、８４、８０、６４、６０週まで生存した。本発明群の平均寿命は９５週、コントロール群の平均寿命は７３．２週であり、本発明品を与えたマウスは、与えなかったマウスと比較して平均寿命が約３０％長かった。これより、本発明による寿命延長効果が動物においても証明された。[Example 1]
The white rice was put into a pulverizer to obtain 500 g of pulverized white rice. 10 g of liquefied enzyme and 1500 mL of water were added to the pulverized product. Thereafter, the temperature was gradually raised, boiling and extracting for 5 minutes, and then cooled. Then, it squeezed with the squeezer and obtained the product of the present invention.
[Example 2]
White rice was pulverized to obtain 500 g of pulverized white rice. To this pulverized product, 300 g of rice bran and 1500 mL of water were added and left at 55 ° C. for 20 hours. Thereafter, the product was squeezed with a squeezer to obtain the product of the invention.
[Example 3]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 5 g of saccharifying enzyme (glucoamylase) and 3 L of water were added and left at 55 ° C. for 16 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.5 L of a filtrate.
[Example 4]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 5 g of proteolytic enzyme and 3 L of water were added and allowed to stand at 50 ° C. for 16 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.3 L of a filtrate.
[Example 5]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 5 g of liquefied enzyme, 5 g of fiber-degrading enzyme and 3 L of water were added and left at 50 ° C. for 16 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.2 L of a filtrate.
[Example 6]
The white rice was put into a grinder to obtain 1 kg of white rice grind. 5 g of liquefied enzyme, 5 g of lipolytic enzyme, and 3 L of water were added to this pulverized product, and the mixture was allowed to stand at 50 ° C. for 16 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.1 L of a filtrate.
[Example 7]
White rice was pulverized to obtain 500 g of pulverized white rice. 10 g of liquefied enzyme and 1500 mL of water were added to the pulverized product. Thereafter, the temperature was gradually raised and the enzyme was allowed to act, followed by boiling extraction for 5 minutes and cooling. The extract was squeezed with a squeezer to obtain 1420 mL of the product of the present invention and 500 g of residue.
[Example 8]
White rice was pulverized to obtain 500 g of pulverized white rice. To this pulverized product, 2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of saccharifying enzyme, 2 g of pectin degrading enzyme and 1500 mL of water were added and left at 50 ° C. for 20 hours. Thereafter, the temperature was gradually raised, boiling and extracting for 5 minutes, and then cooled. The extract was squeezed with a squeezer to obtain 1470 mL of the product of the present invention and 450 g of residue.
[Example 9]
2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of saccharifying enzyme, 2 g of pectin degrading enzyme and 1500 mL of water are added to 490 g of white koji of 50 to 70% of whitening ratio and 10 g of red koji of 92% or more It was left at 20 ° C. for 20 hours. Thereafter, the temperature was gradually raised, boiled and extracted for 5 minutes, cooled to 30 ° C., and squeezed with a squeezer to obtain 1400 mL of the present product and 550 g of a residue.
[Example 10]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 5 g of liquefied enzyme and 3 L of water were added and left at 60 ° C. for 4 hours. Thereafter, the temperature was raised by heating and cooling, 5 g of saccharifying enzyme was added, and the mixture was allowed to stand at 55 ° C. for 4 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.6 L of a filtrate.
[Example 11]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 5 g of liquefied enzyme and 3 L of water were added and left at 60 ° C. for 4 hours. Then, after heating up and cooling, 50g of soot was added and it was left to stand at 55 degreeC for 4 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.6 L of a filtrate.
[Example 12]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 5 g of liquefied enzyme and 3 L of water were added and left at 60 ° C. for 4 hours. Then, after heating up and cooling, 5 g of proteolytic enzymes were added and left at 55 ° C. for 4 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.5 L of a filtrate.
[Example 13]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 5 g of liquefied enzyme and 3 L of water were added and left at 60 ° C. for 4 hours. Thereafter, the temperature was raised by heating, and after cooling, 5 g of lipolytic enzyme was added and left at 55 ° C. for 4 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.5 L of a filtrate.
[Example 14]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 5 g of liquefied enzyme and 3 L of water were added and left at 60 ° C. for 4 hours. Then, after heating up and cooling, 5 g of fiber-degrading enzymes were added and left at 55 ° C. for 4 hours. Thereafter, solid-liquid separation was performed using a filter to obtain 2.5 L of a filtrate.
[Example 15]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 3 L of 1 / 10N hydrochloric acid was added, stirred well and allowed to stand for 24 hours. Thereafter, solid-liquid separation was performed using a filter and neutralized with caustic soda to obtain 2.3 L of an extract.
[Example 16]
The white rice was put into a grinder to obtain 1 kg of white rice grind. To this pulverized product, 3 L of 95% ethanol was added, stirred well and left for 4 days. Thereafter, solid-liquid separation was performed using a filter to obtain a 2 L extract. 4 L of water was added to the filtrate, and ethanol was distilled off with a rotary evaporator to 2 L.
[Example 17]
Yeast was added to 1500 mL of the rice extract obtained in Example 2, and alcohol fermentation was performed for 7 days. Thereafter, the yeast was separated by a filter to obtain the product of the present invention.
[Example 18]
Lactic acid bacteria were added to 1500 mL of the rice extract obtained in Example 1, and lactic acid fermentation was performed for 2 days. Thereafter, lactic acid bacteria were filtered off with a filter to obtain a product of the present invention.
[Example 19]
White rice was pulverized to obtain 500 g of pulverized white rice. To this pulverized product, 2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of saccharifying enzyme, 2 g of pectin degrading enzyme and 1500 mL of water were added and left at 50 ° C. for 20 hours. Thereafter, the temperature was gradually raised and the mixture was boiled and extracted for 5 minutes and then cooled. Yeast was added to this enzymatic degradation extract, and alcohol fermentation was performed for 7 days. Then, it squeezed with the squeezer and obtained the product of the present invention.
[Example 20]
White rice was pulverized to obtain 500 g of pulverized white rice. To this pulverized product, 2 g of proteolytic enzyme, 2 g of lipolytic enzyme, 2 g of fiber degrading enzyme, 2 g of saccharifying enzyme, 2 g of pectin degrading enzyme and 1500 mL of water were added and left at 50 ° C. for 20 hours. Thereafter, the temperature was gradually raised and the mixture was boiled and extracted for 5 minutes and then cooled. Lactic acid bacteria were added to this enzymatic degradation extract, and lactic acid fermentation was performed for 2 days. Then, it squeezed with the squeezer and obtained the product of the present invention.
[Example 21]
The white rice was put into a pulverizer to obtain 500 g of pulverized white rice. 10 g of liquefied enzyme and 1500 mL of water were added to the pulverized product. Thereafter, the temperature was gradually raised and the enzyme was allowed to act, followed by boiling extraction for 5 minutes and cooling. To this was added 100 mL of 95% ethanol, and acetic acid fermentation was performed for 20 days. Thereafter, filtration was performed to obtain 1400 mL of the present product.
Test example 1
Method: Intestinal mucosal epithelial cells (IEC-6) cultured confluently were cultured in a culture medium supplemented with a 1% sample for 30 days, and the survival rate of the cells was examined for 30 days. The medium was not changed after the sample was added. The vessel was cultured at a normal 5% carbon dioxide gas at 36.5 ° C. using a 6-well plate (NUNC) and a medium using GIT medium (Nippon Pharmaceutical Co., Ltd.).
Sample: Examples 1, 10, 18
Result: As a result of observing IEC-6 after culturing for 14 days, it was found that the cells to which the product of the present invention was added had no abnormality and maintained a normal state and continued to survive. On the other hand, in the cells to which the product of the present invention was not added (control), dead cells were observed (for example, micrographs of the control cells after 14 days of culture and the cells to which Example 1 was added were respectively shown in FIGS. To show). As a result of observing IEC-6 after further culturing for 30 days, it was found that the cells to which the product of the present invention was added did not show any abnormality, and maintained a normal state and continued to survive. On the other hand, the cells to which no sample was added could not continue to survive. Table 1 shows the 30-day viability of the cells in each sample.

As shown in Table 1, the 30-day survival rate of the cells cultured in the medium to which the product of the present invention was added was 85% or more, and the 30-day survival rate of the cells cultured only in the normal medium was 0% and all were killed. . From the above test, the life extension effect by the product of the present invention was proved. Since the control begins to die from about the 14th day, the culture medium is generally changed twice a week. Therefore, the product of the present invention greatly contributes not only to the life extension effect but also to experiments using cells. The cells after 30 days were not cancerous. The cell morphology was normal.
Test example 2
Using experimental animals, the lifespan of the group fed with the present invention and the group not fed with the present invention were investigated, and the life extension effect of the present invention was examined.
Method:
Ten 4-week-old male BALB / a mice were individually placed in cages and preliminarily raised to 35-week-old with normal food and water ad libitum. Thereafter (after 35 weeks of age), 5 out of 10 animals were pre-bred and then fed a normal diet containing 0.6% (v / w) of the product of the present invention, and the remaining 5 animals were normal They were fed until they died and the life span was measured.
Sample: Example 1
result:
As a result of the long-term rearing test, BALB / a mice (product group of the present invention) fed with the diet of the product of the present invention survived to 67, 129, 87, 100, and 92 weeks. On the other hand, BALB / a mice (control group) fed with normal food survived to 78, 84, 80, 64, and 60 weeks. The average life span of the present invention group was 95 weeks, and the average life span of the control group was 73.2 weeks. The mice given the product of the present invention had an average life span of about 30% longer than those not given. From this, the life extension effect by this invention was proved also in the animal.

According to the present invention, when administered to an individual such as a human, the lifespan of the cells is extended, and the lifespan of various cell groups (tissues and organs) composed of the cells is extended. There is an effect that the life is extended. In addition, cell functions, cell activity, cell cycle, youthfulness, normalization of gene functions are brought about with respect to cells constituting an individual, and further, functions of organs, organs, tissues, and body fluids constituting an individual are also improved. Improves or improves, normalizes, restores health, prevents aging, maintains youthfulness or rejuvenates. Furthermore, as a result of these, many diseases are prevented and cured. For example, circulatory system (heart, blood vessel, blood / hematopoietic system), immune system (lymphoid tissue / organ, spleen, thymus), skin, skin appendages, digestive system (lip, tonsils, teeth, esophagus, stomach) , Small intestine, large intestine, liver, biliary system, spleen), respiratory system (nose, pharynx, larynx, trachea, lung), urinary system (kidney, urinary tract), sex breeding system (male genital organ, female genital organ), endocrine system (Pituitary gland, pineal gland, thyroid gland, adrenal gland), brain, nervous system (peripheral nerve, central nervous system), metabolic system (sugar, lipid, uric acid metabolism), balance / hearing apparatus, visual instrument, each mucous system, motor organ (Bone, joints, muscles, tendons, ligaments) function improvement or improvement, normalization, health, anti-aging, youthfulness retention or rejuvenation; life forms or individuals, organs, organs, tissues, body fluids or cells, etc. Prevention, prevention, improvement, treatment of diseases and symptoms in Japan; cardiovascular system (heart, blood vessel, blood / hematopoietic system), Epidemiological system (lymphoid tissue / organ, spleen, thymus), skin, skin appendages, digestive system (lips, tonsils, teeth, esophagus, stomach, small intestine, large intestine, liver, bile duct, spleen), respiratory system ( (Nose, pharynx, larynx, trachea, lungs), urinary system (kidney, urinary tract), sex breeding system (male genital organ, female genital organ), endocrine system (pituitary gland, pineal gland, thyroid gland, adrenal gland), brain, nervous system (Peripheral nerve, central nervous system), metabolic system (sugar, lipid, uric acid metabolism), balance / auditor, visual organ, each mucosal system, motor organs (bone, joint, muscle, tendon, ligament), etc. and various symptoms Prevention, deterioration prevention, improvement, treatment of skin; skin disorders caused by epidermis / dermis, cell disorders, DNA disorders, atopic dermatitis, dry skin symptoms such as dry skin (atopy skin, dry / sozoized skin, aging skin) , Ichthyosis, bulky skin, rough skin, sebum deficiency, xeroderma, dry eczema, progressive Palmokeratosis, erythema, sclerosis / keratinization, cracks, scales, bruises, itching, scarring), spots, buckwheat, pruritus, skin rash, roughness, wrinkles, cracks, redheads, skin aging symptoms (wrinkles, tension, elasticity Reduction, sagging, stains), oily skin, acne, dyschromia, UV-induced skin damage (stains, freckles), photoinflammation, dullness, darkening, physical / chemical skin disorders (cuts, burns, bedsores), water, Skin symptoms caused by the use of soaps, detergents, surfactants, solvents, side effects of pharmaceuticals such as topical skin preparations, biological skin disorders (skin infections), athlete's foot, dermatitis, eczema, wound healing, hair growth, hair restoration Prevention, deterioration prevention, improvement, treatment of hair growth, alopecia, etc .; prevention, deterioration prevention, improvement, treatment of spots, buckwheat, senile pigment spots, etc .; various inflammations, infections, allergies, immune dysfunction, mucosal disorders , Cell damage, DNA Disorder, tumor, ulcer, hyperlipidemia, obesity, diabetes, arteriosclerosis, gout, blood pressure restoration, improvement (high blood pressure, hypotension), blur, dementia, rhinitis, asthma, various symptoms of the eye, cold, blood vessels Disability, internal stiffness, stiff shoulders, lottery, neuralgia, low back pain, rheumatism, hemorrhoids, recovery from fatigue, prepartum cold disease, stomatitis, throat inflammation, pain, sore throat, laryngitis, tonsillitis, periodontitis, alveolar effusion, gingiva Flame, osteoporosis, nutritional tonic, frail constitution, physical fatigue, physical strength reduction, salt damage prevention, Helicobacter pylori growth inhibition, stress, prevention of side effects due to medicines, prevention, improvement, treatment; tumor prevention, prevention of deterioration, improvement; cancer Prevention, deterioration prevention, progress inhibition, metastasis prevention, improvement, treatment; sexual function improvement, improvement, normalization, restoration or prevention of aging, youthfulness retention or rejuvenation can be expected. Furthermore, it is also useful as an organ preservative or cell preservative (for example, used as a medium additive).
In addition, white rice has hardly been developed for new uses other than food. Furthermore, even if white rice is ingested daily as a staple food, there is no direction to regard it as dangerous, and safety has been demonstrated. In other words, the present invention has been found not only to have a very excellent life extension effect, but also to have a sufficiently demonstrated safety, various pharmaceuticals, quasi drugs, cosmetics, foods It can be said that it is a very significant invention that can be used for the above. In addition, it is extremely meaningful to find new uses for rice and to increase consumption by improving the image of rice.

Claims (2)

The water treatment product of rice raw material containing rice moiety essentially as an active ingredient, the water treatment product is Ri water extract der obtained by the action of liquefying enzyme rice material, small intestinal epithelium without exchanging the culture medium A survival prolonging agent that prolongs the survival period of cellular IEC-6 . The survival prolonging agent according to claim 1, wherein the rice raw material is white rice, brown rice, germinated rice, white rice bran, or a combination of one or more thereof .

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