JP5284092B2 - 腸溶コーティングに適したパンクレアチンマイクロペレットコア - Google Patents
腸溶コーティングに適したパンクレアチンマイクロペレットコア Download PDFInfo
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- JP5284092B2 JP5284092B2 JP2008526493A JP2008526493A JP5284092B2 JP 5284092 B2 JP5284092 B2 JP 5284092B2 JP 2008526493 A JP2008526493 A JP 2008526493A JP 2008526493 A JP2008526493 A JP 2008526493A JP 5284092 B2 JP5284092 B2 JP 5284092B2
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- pancreatin
- micropellet
- pancreatine
- enzyme
- core
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 1
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- 238000002156 mixing Methods 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000008203 oral pharmaceutical composition Substances 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
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- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
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- 229920000058 polyacrylate Polymers 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 229940113125 polyethylene glycol 3000 Drugs 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 229940085678 polyethylene glycol 8000 Drugs 0.000 description 1
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- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
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- 230000001568 sexual effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940087291 tridecyl alcohol Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Finger-Pressure Massage (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
a.下記のi〜ivを含む押出可能な混合物を調製する工程:
i.10〜95%パンクレアチン;
ii.5〜90%の少なくとも1種の製剤学的に認容性の結合剤;
iii.0〜10%の少なくとも1種の製剤学的に認容性の賦形剤;
iv.押出可能な混合物を形成するのに十分な量の1種以上の酵素に優しい有機溶媒;
その際、成分の割合はパンクレアチンマイクロペレットコアの質量に対する質量であり、それらの成分i)、ii)及びiii)(存在すれば)は足して100質量%となる;
b.前記押し出し可能な混合物からパンクレアチンマイクロペレットコアを作製する工程;
c. 該パンクレアチンマイクロペレットを追加の酵素に優しい有機溶媒の存在下で成形して、ほぼ球状又は楕円の形状にする工程;及び
d.そのパンクレアチンマイクロペレットコアが前記一種以上の酵素に優しい有機溶媒を実質的に含まなくなるように、パンクレアチンマイクロペレットコアから1種以上の酵素に優しい有機溶媒を除去する工程;
を含む、実質的に合成油不含のパンクレアチンマイクロペレットコアの製造方法である。
ポリエチレングリコール1500、ポリエチレングリコール2000、ポリエチレングリコール3000,ポリエチレングリコール4000、ポリエチレングリコール6000、ポリエチレングリコール8000、ポリエチレングリコール10000、ヒドロプロピルメチルセルロース、ポリオキシエチレン、ポリオキシエチレンーポリオキシプロピレンコポリマー及び上記有機高分子化合物の混合物を含む。前述の製剤学的に認容性の結合剤の一覧が全てではなく、単に説明を目的とするものであって、当業者には他の多くの製剤学的に認容性の結合剤又は結合剤の混合物も使用できると理解される。ポリエチレングリコール4000は好ましい製剤学的に認容性の結合剤である。本発明の開示のために、合成油は製剤学的に認容性の結合剤としてみなされるべきではない。
i)少なくとも一種の皮膜形成剤;
ii)少なくとも一種の可塑剤;及び
iii)場合により少なくとも一種の任意の粘着防止剤。
aa. 実質的に合成油不含のパンクレアチンマイクロペレットコアを提供する工程;
bb. 以下のi)〜iv)を含む腸溶コーティング溶液を提供する工程
i.少なくとも1種の皮膜形成剤;
ii.少なくとも1種の皮膜形成剤に対して、1.5質量%より多い量の可塑剤;及び
iii.場合により、少なくとも1種の粘着防止剤、及び
iv.1種以上の酵素に優しい有機溶媒;
cc. 腸溶コーティング溶液でパンクレアチンマイクロペレットコアをコーティングする工程、その際コーティングの間のパンクレアチンマイクロペレットコアの生成物温度を腸溶コーティング溶液を適用するのに適した温度に保つ;及び
dd. コーティングされたパンクレアチンマイクロペレットコアを乾燥する工程。
を含む方法を提供する。
下記の実施例は説明を意図するものであって、本発明の開示を意図するものではない。他の適した変更及び適合は、当業者が普通に遭遇する多様性のためであり、それらは完全に本発明の趣旨及び範囲内である。
1.コーティングされていないパンクレアチンマイクロペレットコアの調製
パンクレアチン15.9kgを、3.975kgのポリエチレングリコール4000と市販の高せん断混合機中で混合し、そして3.975kgの2−プロパノールで完全に湿潤させた。得られた混合物を、0.8mm内径を有する穴あけダイが備え付けられ、下流に切断装置が備え付けられた、市販の押出プレスによって押し出した。その温度は、加圧しながら50℃未満であった。押出された材料を、切断装置によって、約5mmの長さの押出し物断片に切断した。
コーティング溶液を1623.2gのヒドロキシプロピルメチルセルロースフタレート(HP55)、90.2gのトリエチルシトレート、34.3gのセチルアルコール及び38.9gのジメチコーン1000を14030gのアセトンに室温で攪拌しながら添加することにより調製した。
パンクレアチンマイクロペレットの胃酸耐性を測定した(上記表1参照)。
表1(上記参照)からの種々の腸溶コーティングされたパンクレアチンマイクロペレットの溶解プロフィールとは、単行本UnitedStatesPharmacopoeia(USP)「パンクレリパーゼ遅延放出性カプセル」に記載された試験方法によって、胃酸耐性段階の増加に伴って、決定した。
表3:リン酸バッファー中の腸溶コーティングされたパンクレアチンマイクロペレットの溶解プロフィール(n.a.:有効ではないデータ)
Claims (2)
- パンクレアチンマイクロペレットコアの製造方法において、次の工程:
a. 以下のi〜iiiを含む押し出し可能な混合物の調製をする工程:
i. パンクレアチン10〜95%;
ii.5〜90%のポリエチレングリコール4000;及び
iii.押出し可能な混合物を形作るのに十分な量の、アセトン、クロロホルム、ジクロロメタン、直鎖又は分岐鎖C 1 〜C 4 アルコール及びこれらの混合物から選択される有機溶媒;
その際、構成成分の割合は、パンクレアチンマイクロペレットコアの質量に対する質量であり、それらの構成成分i)及びii)は足して、100質量%となる、
b. 前記押出可能な混合物を押し出して、パンクレアチンマイクロペレットコアを製造する工程;
c. 追加のアセトン、クロロホルム、ジクロロメタン、直鎖又は分岐鎖C 1 〜C 4 アルコール及びこれらの混合物から選択される有機溶媒存在下で、パンクレアチンマイクロペレットコアをほぼ球形又はほぼ楕円形に成形する工程;及び
d. 前記有機溶媒をパンクレアチンマイクロペレットコアから除去して、パンクレアチンマイクロペレットコアを実質的に有機溶媒不含にする工程;
を含み、該パンクレアチンマイクロペレットコアが実質的に合成油不含である、パンクレアチンマイクロペレットコアの製造方法。 - パンクレアチンマイクロペレットコアの質量に対する質量で、パンクレアチンが70〜90%で存在し、結合剤が10〜30%存在する請求項1記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US70852605P | 2005-08-15 | 2005-08-15 | |
EP05107474 | 2005-08-15 | ||
US60/708,526 | 2005-08-15 | ||
EP05107474.8 | 2005-08-15 | ||
PCT/EP2006/065313 WO2007020260A2 (en) | 2005-08-15 | 2006-08-15 | Pancreatin micropellet cores suitable for enteric coating |
Publications (3)
Publication Number | Publication Date |
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JP2009504710A JP2009504710A (ja) | 2009-02-05 |
JP2009504710A5 JP2009504710A5 (ja) | 2009-07-09 |
JP5284092B2 true JP5284092B2 (ja) | 2013-09-11 |
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JP2008526493A Active JP5284092B2 (ja) | 2005-08-15 | 2006-08-15 | 腸溶コーティングに適したパンクレアチンマイクロペレットコア |
Country Status (16)
Country | Link |
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EP (1) | EP1931317B1 (ja) |
JP (1) | JP5284092B2 (ja) |
KR (1) | KR101302841B1 (ja) |
AT (1) | ATE418329T1 (ja) |
AU (1) | AU2006281415B2 (ja) |
CA (1) | CA2619477C (ja) |
DE (1) | DE602006004471D1 (ja) |
ES (1) | ES2320174T3 (ja) |
HK (1) | HK1119559A1 (ja) |
IL (1) | IL189457A (ja) |
MX (1) | MX2008001557A (ja) |
NO (1) | NO20081379L (ja) |
PL (1) | PL1931317T3 (ja) |
PT (1) | PT1931317E (ja) |
RU (1) | RU2408364C2 (ja) |
WO (1) | WO2007020260A2 (ja) |
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WO2011050135A1 (en) | 2009-10-21 | 2011-04-28 | Curemark Llc | Methods and compositions for the prevention and treatment of influenza |
CL2011002432A1 (es) | 2010-10-01 | 2012-04-20 | Aptalis Pharma Ltd | Composicion que comprende al menos una enzima digestiva y al menos un portador, en donde el portador comprende celulosa microcristalina que tiene un tamaño de particulas mayor que 100 um; una forma de dosificacion; el envase que la contiene; un proceso para preparar la composicion; y sus usos. |
PL2489349T3 (pl) | 2011-02-17 | 2014-09-30 | Nordmark Arzneimittel Gmbh & Co Kg | Granulki pankreatynowe, zwłaszcza mikrogranulki pankreatynowe, oraz sposób ich produkcji |
DE202011000728U1 (de) | 2011-03-30 | 2011-06-09 | Nordmark Arzneimittel GmbH & Co. KG, 25436 | Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets |
HUE050873T2 (hu) | 2011-04-21 | 2021-01-28 | Curemark Llc | Vegyületek neuropszichiátriai rendellenességek kezelésére |
ES2734221T3 (es) | 2011-08-08 | 2019-12-04 | Allergan Pharmaceuticals Int Ltd | Método para la prueba de disolución de composiciones sólidas que contienen enzimas digestivas |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
JP2016537387A (ja) | 2013-08-09 | 2016-12-01 | アラガン ファーマシューティカルズ インターナショナル リミテッド | 経腸投与に適した消化酵素組成物 |
MX2016016907A (es) | 2014-06-19 | 2018-04-26 | Aptalis Pharma Ltd | Metodo para eliminar contaminantes virales de extractos pancreaticos. |
MX2017005941A (es) | 2014-11-05 | 2018-02-13 | Abbott Laboratories Gmbh | Procesos para la producción de composiciones con perfil de seguridad mejorado teniendo actividad lipasa y composiciones adecuadas para medicamentos. |
DE102017104482A1 (de) * | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutische Zusammensetzung umfassend Pankreatin und einen lipasehaltigen Überzug |
RU2706003C1 (ru) * | 2019-09-09 | 2019-11-13 | Акционерное общество "АВВА РУС" | Микрогранулы, содержащие панкреатин |
MX2022014395A (es) * | 2020-06-10 | 2022-12-02 | Kusum Healthcare Pvt Ltd | Composicion farmaceutica de pancreatina. |
US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
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GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
DE4227385A1 (de) * | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pankreatinmikropellets |
KR19990072826A (ko) * | 1998-02-26 | 1999-09-27 | 우재영 | 판크레아틴장용코팅과립의제조방법 |
NZ514826A (en) * | 1999-03-17 | 2003-08-29 | Solvay Pharm Gmbh | Medicinal product for the treatment of diabetes |
IT1319655B1 (it) * | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
AR032392A1 (es) * | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
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2006
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- 2006-08-15 CA CA2619477A patent/CA2619477C/en active Active
- 2006-08-15 AT AT06778242T patent/ATE418329T1/de active
- 2006-08-15 AU AU2006281415A patent/AU2006281415B2/en active Active
- 2006-08-15 JP JP2008526493A patent/JP5284092B2/ja active Active
- 2006-08-15 WO PCT/EP2006/065313 patent/WO2007020260A2/en active Application Filing
- 2006-08-15 PL PL06778242T patent/PL1931317T3/pl unknown
- 2006-08-15 KR KR1020087006201A patent/KR101302841B1/ko active IP Right Grant
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RU2008109651A (ru) | 2009-09-27 |
AU2006281415B2 (en) | 2012-01-19 |
EP1931317B1 (en) | 2008-12-24 |
KR101302841B1 (ko) | 2013-09-02 |
PL1931317T3 (pl) | 2009-06-30 |
IL189457A (en) | 2014-05-28 |
NO20081379L (no) | 2008-05-14 |
CA2619477A1 (en) | 2007-02-22 |
AU2006281415A1 (en) | 2007-02-22 |
IL189457A0 (en) | 2008-06-05 |
WO2007020260A3 (en) | 2007-05-10 |
EP1931317A2 (en) | 2008-06-18 |
MX2008001557A (es) | 2008-02-15 |
HK1119559A1 (en) | 2009-03-13 |
ATE418329T1 (de) | 2009-01-15 |
JP2009504710A (ja) | 2009-02-05 |
RU2408364C2 (ru) | 2011-01-10 |
WO2007020260A2 (en) | 2007-02-22 |
ES2320174T3 (es) | 2009-05-19 |
PT1931317E (pt) | 2009-02-02 |
KR20080034516A (ko) | 2008-04-21 |
CA2619477C (en) | 2015-05-26 |
DE602006004471D1 (de) | 2009-02-05 |
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